55070-1-AP

antibody from Proteintech Group

Targeting: MT-CO2 CO2, COX2, MTCO2

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

55070-1-AP

Provider

Proteintech Group

Proper citation

Proteintech Cat#55070-1-AP, RRID:AB_10859832

Product name

MTCO2 antibody

Antibody type

Polyclonal

Description

KD/KO validated MTCO2 antibody (Cat. #55070-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

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Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments.

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SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.

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miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.

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δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy.

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Autophagy 2020 May;16(5):797-810

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Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.

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Diabetes 2020 Jul;69(7):1355-1367

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Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

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Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.

Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983

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Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.

Liu L, Wang F, Tong Y, Li LF, Liu Y, Gao WQ
Cell proliferation 2020 Jan;53(1):e12718

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SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.

Ma Y, Zhu S, Lv T, Gu X, Feng H, Zhen J, Xin W, Wan Q
iScience 2020 Aug 21;23(8):101428

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Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts.

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Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.

Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L
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Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.

Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L, Chen Q
Autophagy 2019 Nov;15(11):1882-1898

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EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.

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Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X
Nature communications 2019 Mar 26;10(1):1371

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Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.

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Nucleic acids research 2019 Jun 4;47(10):5341-5355

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Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.

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Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease.

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Progress in neuro-psychopharmacology & biological psychiatry 2019 Aug 30;94:109670

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Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.

Tang Y, Huang W, Song Q, Zheng X, He R, Liu J
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145

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Protein coding mitochondrial-targeted RNAs rescue mitochondrial disease in vivo.

Markantone DM, Towheed A, Crain AT, Collins JM, Celotto AM, Palladino MJ
Neurobiology of disease 2018 Sep;117:203-210

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In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization.

Takahashi K, Miura Y, Ohsawa I, Shirasawa T, Takahashi M
Scientific reports 2018 Oct 22;8(1):15585

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Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.

Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y, Guan MX
Nucleic acids research 2018 Nov 16;46(20):10930-10945

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Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.

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Cell 2018 Jun 28;174(1):88-101.e16

---

Cryo-EM structure of human mitochondrial trifunctional protein.

Liang K, Li N, Wang X, Dai J, Liu P, Wang C, Chen XW, Gao N, Xiao J
Proceedings of the National Academy of Sciences of the United States of America 2018 Jul 3;115(27):7039-7044

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Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.

Paulo E, Wu D, Wang Y, Zhang Y, Wu Y, Swaney DL, Soucheray M, Jimenez-Morales D, Chawla A, Krogan NJ, Wang B
Scientific reports 2018 Jul 20;8(1):11001

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Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.

Télot L, Rousseau E, Lesuisse E, Garcia C, Morlet B, Léger T, Camadro JM, Serre V
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Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury.

Shanshan Y, Beibei J, Li T, Minna G, Shipeng L, Li P, Yong Z
Frontiers in cellular neuroscience 2017;11:99

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Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.

Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y
Scientific reports 2017 Oct 19;7(1):13554

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DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.

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Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts.

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Molecular cell 2017 Dec 7;68(5):993-1005.e9

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Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.

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PLoS genetics 2017 Apr;13(4):e1006597

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Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.

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Cancer research 2016 Apr 15;76(8):2219-30

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EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.

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Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6.

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Redox biology 2014;2:377-87

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Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.

Towheed A, Markantone DM, Crain AT, Celotto AM, Palladino MJ
Neurobiology of disease 2014 Sep;69:15-22

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

HepG2 cells were subjected to SDS PAGE followed by western blot with 55070-1-AP(COX2 antibody) at dilution of 1:1000

Sample type

cell line

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human colon cancer using 55070-1-AP(COX2 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human colon cancer using 55070-1-AP(COX2 antibody) at dilution of 1:50 (under 40x lens)

Sample type

tissue

Flow cytometry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The MTCO2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MTCO2. This antibody recognizes human,mouse,rat antigen. The MTCO2 antibody has been validated for the following applications: ELISA, IHC, WB, FC analysis.

Appendix

55070-1-AP.pdf

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