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- Antibody Data
- Antigen structure
- References [195]
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- Western blot [1]
- Immunohistochemistry [2]
- Flow cytometry [1]
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- Product number
- 55070-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55070-1-AP, RRID:AB_10859832
- Product name
- MTCO2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MTCO2 antibody (Cat. #55070-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting tRNA-dependent tyrosine usage unveils a metabolic vulnerability in hepatocellular carcinoma.
Resveratrol alleviates neuropathic pain associated with restoration of mitochondrial fission-fusion balance in CCI mice.
One-step generation of heritable mitochondrial DNA multiplex-engineered rats using DddA-derived cytosine base editor.
Immunohistochemical Markers of Mitochondrial Electron Transport Chain Instability in Human Brain Regions: A Study of Aging and Alzheimer's Disease.
Hyperacetylation escalates myocardial susceptibility to ischemia reperfusion injury by mediating mitochondrial supercomplexes assembly in T2DM.
Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis.
Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function.
Activation of the integrated stress response contributes to developmental delay and seizures caused by mitochondrial prolyl-tRNA synthetase (PARS2) deficiency.
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
AMPK Deficiency Induces Corneal Epithelial Barrier Dysfunction by Modulating Energy Homeostasis.
Mitochondrial protein Mrpl4 is required for zebrafish intestinal development.
Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation.
Targeting Tumour Microtubes to Disrupt Glioma Networks.
African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral innate immunity to promote viral replication.
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.
C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer.
FGL2-induced metabolic dysregulation in enteric neural crest cells provides insight into Hirschsprung disease pathogenesis.
A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.
Mitochondrial electron transport chain gene-based prognostic model identifies SDHB as a key regulator of low-grade glioma progression and therapeutic target.
Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice.
Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits.
Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism-Dependent and -Independent Mechanisms.
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.
Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration.
Rab GTPases are evolutionarily conserved signals mediating selective autophagy.
Enhanced mitochondrial biogenesis facilitates the development of cutaneous squamous cell carcinoma.
Defective Mitochondrial Respiration in Hereditary Thoracic Aneurysms.
Selenoprotein K Confers Protection against Iron Dyshomeostasis-Related Neurotoxicity by Regulating the Palmitoylation of TfR-1.
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.
Engineering mtDNA deletions by reconstituting end joining in human mitochondria.
PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma.
Leucine 7 is a key residue for mutant huntingtin-induced mitochondrial pathology and neurotoxicity in Huntington's disease.
Novel biallelic TK2 mutations cause mitochondrial DNA depletion syndrome with infantile early-onset lipid storage myopathy.
Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration.
HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway.
Melatonin ameliorates Pb-induced mitochondrial homeostasis and ovarian damage through regulating the p38 signaling pathway.
Neurotoxicity of Realgar: Crosstalk Between UBXD8-DRP1-Regulated Mitochondrial Fission and PINK1-Parkin-Mediated Mitophagy.
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition.
Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff.
Methods for Mitochondrial DNA Damage and Depletion in Immortalized Trabecular Meshwork Cells.
MitCOM-based prognostic model identifies GLUD1 as a key suppressor of glioblastoma growth and invasion through regulation of mitochondrial structure and metabolism.
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma.
PRDX6 Drives Breast Cancer Progression Through Mitochondrial Biosynthesis and Oxidative Phosphorylation.
Pseudohypoxia-Stabilized HIF2α Transcriptionally Inhibits MNRR1, a Druggable Target in MELAS.
Astragalus polysaccharide alleviates mastitis disrupted by Staphylococcus aureus infection by regulating gut microbiota and SCFAs metabolism.
Bunyavirus SFTSV nucleoprotein exploits TUFM-mediated mitophagy to impair antiviral innate immunity.
Cimicifuga heracleifolia kom. Attenuates ulcerative colitis through the PI3K/AKT/NF-κB signaling pathway.
hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling.
Selection of initiator tRNA and start codon by mammalian mitochondrial initiation factor 3 in leaderless mRNA translation.
ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling.
CISD2-mediated mitochondrial dysfunction and iron redistribution contributes to ferroptosis in arsenic-induced nonalcoholic steatohepatitis.
Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.
Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency.
Blocking the CCL5/CCL7-CCR1 axis regulates macrophage polarization through NF-κB pathway to alleviate the progression of osteoarthritis.
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.
MDPAO1 peptide from human milk enhances brown adipose tissue thermogenesis and mitigates obesity.
MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses.
Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression.
FASN regulates CSE-induced apoptosis, oxidative stress and mitochondrial damage in type 2 alveolar epithelial cells by regulating NRF2 expression and nuclear translocation.
NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.
Darunavir analog precursors target mitochondrial metabolism in multiple myeloma and CLL.
Exosome-Mediated Mitochondrial Delivery of Antisense Oligonucleotides.
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis.
MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase.
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis.
UBASH3B-mediated MRPL12 Y60 dephosphorylation inhibits LUAD development by driving mitochondrial metabolism reprogramming.
Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures.
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells.
LETMD1 regulates mitochondrial protein synthesis and import to guard brown fat mitochondrial integrity and function.
Mitochondrial tRNA(Glu) 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.
Taurine hypomodification underlies mitochondrial tRNATrp-related genetic diseases.
Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells.
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity.
Carfilzomib activates ER stress and JNK/p38 MAPK signaling to promote apoptosis in hepatocellular carcinoma cells.
Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation.
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses.
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling.
MT-TN mutations lead to progressive mitochondrial encephalopathy and promotes mitophagy.
LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.
CCDC50 promotes tumor growth through regulation of lysosome homeostasis.
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Correction of a homoplasmic mitochondrial tRNA mutation in patient-derived iPSCs via a mitochondrial base editor.
Mitochondrial gene expression is required for platelet function and blood clotting.
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.
DNA repair byproduct 8-oxoguanine base promotes myoblast differentiation.
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m(3)C modification.
High Expression of COA6 Is Related to Unfavorable Prognosis and Enhanced Oxidative Phosphorylation in Lung Adenocarcinoma.
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival.
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency.
Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells.
Cardioprotective effect of Interleukin-11 against warm ischemia-reperfusion injury in a rat heart donor model.
SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria.
Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerization.
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy.
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
P53 regulates mitochondrial biogenesis via transcriptionally induction of mitochondrial ribosomal protein L12.
THRIFTY: a novel high-throughput method for rapid fibre type identification of isolated skeletal muscle fibres.
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
Pentatricopeptide Protein PTCD2 Regulates COIII Translation in Mitochondria of the HeLa Cell Line.
Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2.
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Characterization of lncRNA functioning in ovine conceptuses and endometria during the peri-implantation period.
Butyrate Ameliorates Mitochondrial Respiratory Capacity of The Motor-Neuron-like Cell Line NSC34-G93A, a Cellular Model for ALS.
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
DDB1 prepares brown adipocytes for cold-induced thermogenesis.
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
A novel nonsense variant in MT-CO3 causes MELAS syndrome.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Mitochondrial functional resilience after TFAM ablation in the adult heart.
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Active RNA interference in mitochondria.
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth.
Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy.
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
The lysosomal membrane protein LAMP-2 is dispensable for PINK1/Parkin-mediated mitophagy.
The human mitochondrial 12S rRNA m(4)C methyltransferase METTL15 is required for mitochondrial function.
Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts.
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
The Circadian Protein Nocturnin Regulates Metabolic Adaptation in Brown Adipose Tissue.
Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.
EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease.
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
Protein coding mitochondrial-targeted RNAs rescue mitochondrial disease in vivo.
In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization.
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cryo-EM structure of human mitochondrial trifunctional protein.
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.
Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury.
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.
Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts.
Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.
Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats.
Ibuprofen attenuates nephropathy in streptozotocin‑induced diabetic rats.
A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway.
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6.
Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.
Zhang H, Wang Z, Zhao Y, Deng X, Zhang J, Shang F, Zhang H, Liu Y, Wang H, Yang Y, Lin H, Zhang B, Liu C, Guo F, Zhang R, Yuan Q, Feng Y, Luo SZ, Chen WD, Wang YD
Nature communications 2026 Mar 6;17(1)
Nature communications 2026 Mar 6;17(1)
Resveratrol alleviates neuropathic pain associated with restoration of mitochondrial fission-fusion balance in CCI mice.
Xie L, Xu Y, Yang Q, Chang W, Song L, Sun Y
Scientific reports 2026 Mar 4;16(1)
Scientific reports 2026 Mar 4;16(1)
One-step generation of heritable mitochondrial DNA multiplex-engineered rats using DddA-derived cytosine base editor.
Zhang X, Li K, Tan L, Chen W, Gao S, Liu C, Pan S, He J, Liu N, Wan G, Dong W, Kong W, Shen B, Qi X, Ma Y
Animal models and experimental medicine 2026 Mar 27;
Animal models and experimental medicine 2026 Mar 27;
Immunohistochemical Markers of Mitochondrial Electron Transport Chain Instability in Human Brain Regions: A Study of Aging and Alzheimer's Disease.
Baranich TI, Sukhorukov VS, Velts OV, Voronkov DN, Shcherbak EV, Egorova AV, Romanenko AS, Lazarev DS, Raksha AP, Charyeva IG, Yatskovskiy AN, Glinkina VV, Illarioshkin SN
International journal of molecular sciences 2026 Mar 20;27(6)
International journal of molecular sciences 2026 Mar 20;27(6)
Hyperacetylation escalates myocardial susceptibility to ischemia reperfusion injury by mediating mitochondrial supercomplexes assembly in T2DM.
Deng Y, Yang W, Yang J, Ji L, Xie M, Tang K, He Q, Hu G, Shangguan W, Jiang C, Li T
Redox biology 2026 Jun;93:104163
Redox biology 2026 Jun;93:104163
Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis.
Pang H, Chen H, Chen P, Wei X, Liu H, He X, Yang Y, Zhang J, Li D, Lou L, Xie W, Qiu C, Xia F, Guo Q, Shen S, Shi Q, Li W, Han G, Wang X, Wang J, Xu C
Acta pharmaceutica Sinica. B 2026 Jan;16(1):337-351
Acta pharmaceutica Sinica. B 2026 Jan;16(1):337-351
Mitochondrial protein carboxyl-terminal alanine-threonine tailing promotes human glioblastoma growth by regulating mitochondrial function.
Zhang B, Cai T, Reddy E, Wu Y, Mondal I, Tang Y, Gbufor AS, Wang J, Shen Y, Liu Q, Sun R, Ho WS, Lu RO, Wu Z
eLife 2026 Jan 29;13
eLife 2026 Jan 29;13
Activation of the integrated stress response contributes to developmental delay and seizures caused by mitochondrial prolyl-tRNA synthetase (PARS2) deficiency.
Xu M, Liu Y, Ma R, Fan W, Duan J, Deng H, Ma Y, Ge W
Redox biology 2026 Feb;89:103966
Redox biology 2026 Feb;89:103966
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fu T, Sun S, Wang Z, Zhao F, Zhen J, Ji X, Xue F, Mu Q, Wang Y, Liu Y, Wan Q
Cardiovascular diabetology 2026 Feb 3;25(1)
Cardiovascular diabetology 2026 Feb 3;25(1)
AMPK Deficiency Induces Corneal Epithelial Barrier Dysfunction by Modulating Energy Homeostasis.
Yang Y, Yan K, Tang Y, Liu Z, Zhu L, Wei M, Huang C, Liu Z, Zhao D, Ren S
Investigative ophthalmology & visual science 2026 Feb 2;67(2):47
Investigative ophthalmology & visual science 2026 Feb 2;67(2):47
Mitochondrial protein Mrpl4 is required for zebrafish intestinal development.
Li L, Cheng X, Liu C, Fang S, Lin L, Su Y, Zhao L
FEBS letters 2026 Feb 18;
FEBS letters 2026 Feb 18;
Lactiplantibacillus plantarum GUANKE ameliorates influenza a virus-induced inflammation and lung barrier dysfunction through enhancing mitophagy and improving oxidative phosphorylation.
Lu S, Yue K, He S, Mi J, Yang T, Yang Y, Ma H, Ren Z, Ren L, Xu J
Cellular and molecular life sciences : CMLS 2026 Feb 10;83(1):107
Cellular and molecular life sciences : CMLS 2026 Feb 10;83(1):107
Targeting Tumour Microtubes to Disrupt Glioma Networks.
Huang T, Zhang P, Taori S, Wang S, Wang D, Chen Z, Yuan H, Wu X, Duan T, Yuan F, Wu W, Wang R, Li H, Mi H, Lv D, Dixit D, Winkler F, Wu Q, Rich JN
Research square 2026 Apr 7;
Research square 2026 Apr 7;
African swine fever virus pE199L, as a mitophagy receptor, suppresses antiviral innate immunity to promote viral replication.
Li X, Ren B, Zhang D, Dan M, Liu D, Zhang Z, Zhao J, Nan Y, Hiscox JA, Stewart JP, Zhu Z, Zhao Q, Sun Y
Autophagy 2026 Apr 11;:1-20
Autophagy 2026 Apr 11;:1-20
Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.
Hu P, Liu M, Wu T, Zhang Y, Liu C, Wang L, Zhang W, Que Y, You J, Yu W, Tong X
Theranostics 2025;15(15):7567-7583
Theranostics 2025;15(15):7567-7583
C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer.
Liu R, Zhao M, Zhang X, Wu H, Ren L, Lv J, Liu Z, Wang Q, Yao Z
Cell reports 2025 Sep 23;44(9):116163
Cell reports 2025 Sep 23;44(9):116163
FGL2-induced metabolic dysregulation in enteric neural crest cells provides insight into Hirschsprung disease pathogenesis.
Han J, Liu X, Wang Y, Xu Q, Sun D, Zhang X, He X, Ma C, Ren X, Wang J, Mou Y, Zhang Q, Wang D, Mu W, Hou P, Li A
iScience 2025 Sep 19;28(9):113423
iScience 2025 Sep 19;28(9):113423
A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.
Sun Y, Ni W, Wang D, Ren J, Zhao D, Yu S, Liu S, Zhang S, Wang S, Wang W, Liu M
Carbohydrate polymers 2025 Sep 1;363:123708
Carbohydrate polymers 2025 Sep 1;363:123708
Mitochondrial electron transport chain gene-based prognostic model identifies SDHB as a key regulator of low-grade glioma progression and therapeutic target.
Li Y, Liu Q, Su J, Jiang L, Li Z, Peng H
Cancer cell international 2025 Oct 8;25(1):343
Cancer cell international 2025 Oct 8;25(1):343
Iron accumulation in hypothalamus promotes age-dependent obesity and metabolic dysfunction of male mice.
Wang X, Xiong X, Xuan Y, Tian W, Chen L, Chen Z, Zhang Y, Shen WL, Hu C
Molecular biomedicine 2025 Oct 2;6(1):75
Molecular biomedicine 2025 Oct 2;6(1):75
Mitochondrial translation impairment-triggered neuroinflammation mediates fluoride-induced cognitive deficits.
Liu W, Wang C, Tang H, Tian Z, Li D, Chen G, Wang A
Ecotoxicology and environmental safety 2025 Oct 15;305:119187
Ecotoxicology and environmental safety 2025 Oct 15;305:119187
Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism-Dependent and -Independent Mechanisms.
Ji X, Zhang W, Xue F, Zeng J, Zhao Q, Sun X, Sun J, Zhou H, Xu Q, Ma G, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e07533
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(42):e07533
The ER thioredoxin-related transmembrane protein TMX2 controls redox-mediated tethering of ER-mitochondria contacts.
Chen J, Yap MC, Bassot A, Pascual DM, Makio T, Zimmermann J, Mast H, Bhat R, Fleury SG, Fan Y, Buzatto AZ, Moore J, Ballanyi K, Li L, Overduin M, Lemieux MJ, Lemieux H, Mancini GMS, Morgan B, Marcogliese PC, Simmen T
Cell reports 2025 Nov 25;44(11):116486
Cell reports 2025 Nov 25;44(11):116486
Dental pulp stem cells alleviate Schwann cell pyroptosis via mitochondrial transfer to enhance facial nerve regeneration.
Zheng X, Wang J, Zhou H, Chai Y, Li Z, Chen M, Yang Z, Xu C, Lei C, He Y, Zou D, Ye Q
Bioactive materials 2025 May;47:313-326
Bioactive materials 2025 May;47:313-326
Rab GTPases are evolutionarily conserved signals mediating selective autophagy.
Zhao P, Tian R, Song D, Zhu Q, Ding X, Zhang J, Cao B, Zhang M, Xu Y, Fang J, Tan J, Yi C, Xia H, Liu W, Zou W, Sun Q
The Journal of cell biology 2025 May 5;224(5)
The Journal of cell biology 2025 May 5;224(5)
Enhanced mitochondrial biogenesis facilitates the development of cutaneous squamous cell carcinoma.
Wang Z, He K, Liu M, Lv W, Cheng B, Zhang G, Wang X, Zeng M, Jiao L, Han S, Zheng Y, Feng Z
Cancer letters 2025 May 28;618:217623
Cancer letters 2025 May 28;618:217623
Defective Mitochondrial Respiration in Hereditary Thoracic Aneurysms.
Marcos-Ríos D, Rochano-Ortiz A, Méndez-Barbero N, Oller J
Cells 2025 May 23;14(11)
Cells 2025 May 23;14(11)
Selenoprotein K Confers Protection against Iron Dyshomeostasis-Related Neurotoxicity by Regulating the Palmitoylation of TfR-1.
Jia SZ, Li Y, Xu XW, Huang YP, Deng XY, Zhang ZH, Song GL
Journal of agricultural and food chemistry 2025 May 21;73(20):12233-12246
Journal of agricultural and food chemistry 2025 May 21;73(20):12233-12246
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS.
Schweingruber C, Nijssen J, Mechtersheimer J, Reber S, Lebœuf M, O'Brien NL, Mei I, Hedges E, Keuper M, Benitez JA, Radoi V, Jastroch M, Ruepp MD, Hedlund E
Nature communications 2025 May 19;16(1):4633
Nature communications 2025 May 19;16(1):4633
Engineering mtDNA deletions by reconstituting end joining in human mitochondria.
Fu Y, Land M, Kavlashvili T, Cui R, Kim M, DeBitetto E, Lieber T, Ryu KW, Choi E, Masilionis I, Saha R, Takizawa M, Baker D, Tigano M, Lareau CA, Reznik E, Sharma R, Chaligne R, Thompson CB, Pe'er D, Sfeir A
Cell 2025 May 15;188(10):2778-2793.e21
Cell 2025 May 15;188(10):2778-2793.e21
PAX translocations remodel mitochondrial metabolism through altered leucine usage in rhabdomyosarcoma.
Kalita B, Martinez-Cebrian G, McEvoy J, Allensworth M, Knight M, Magli A, Perlingeiro RCR, Dyer MA, Stewart E, Dynlacht BD
Cell 2025 May 15;188(10):2757-2777.e22
Cell 2025 May 15;188(10):2757-2777.e22
Leucine 7 is a key residue for mutant huntingtin-induced mitochondrial pathology and neurotoxicity in Huntington's disease.
Zhang S, Wang S, Yang Z, Li Y, Li J, Chen X, Yao H, Zheng Z, Guo X
The Journal of biological chemistry 2025 Mar;301(3):108297
The Journal of biological chemistry 2025 Mar;301(3):108297
Novel biallelic TK2 mutations cause mitochondrial DNA depletion syndrome with infantile early-onset lipid storage myopathy.
Li D, Shi Y, Sun H, Yan C, Lin Y
Orphanet journal of rare diseases 2025 Mar 17;20(1):130
Orphanet journal of rare diseases 2025 Mar 17;20(1):130
Organelle-tuning condition robustly fabricates energetic mitochondria for cartilage regeneration.
Chen X, Zhou Y, Yao W, Gao C, Sha Z, Yi J, Wang J, Liu X, Dai C, Zhang Y, Wu Z, Yao X, Zhou J, Liu H, Chen Y, Ouyang H
Bone research 2025 Mar 17;13(1):37
Bone research 2025 Mar 17;13(1):37
HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway.
Mohanty S, Suklabaidya S, Mnatsakanyan N, Jacobson S, Harhaj EW
bioRxiv : the preprint server for biology 2025 Mar 15;
bioRxiv : the preprint server for biology 2025 Mar 15;
Melatonin ameliorates Pb-induced mitochondrial homeostasis and ovarian damage through regulating the p38 signaling pathway.
Yang ZN, Du X, Wang A, Zhao YH, Xia YH, Shi LG, Ding SM, Yue XY, Xing F, Ji DM, Liang D, Zha ZB, Liang CM, Cao YX, Liu YJ
Ecotoxicology and environmental safety 2025 Mar 1;292:117937
Ecotoxicology and environmental safety 2025 Mar 1;292:117937
Neurotoxicity of Realgar: Crosstalk Between UBXD8-DRP1-Regulated Mitochondrial Fission and PINK1-Parkin-Mediated Mitophagy.
Feng R, Liu J, Yao T, Yang Z, Jiang H
Molecular neurobiology 2025 Jun;62(6):7041-7053
Molecular neurobiology 2025 Jun;62(6):7041-7053
Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.
Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L, Gao P, Zhang H
Nature chemical biology 2025 Jun;21(6):926-938
Nature chemical biology 2025 Jun;21(6):926-938
The crucial function of IDO1 in pulmonary fibrosis: From the perspective of mitochondrial fusion in lung fibroblasts and targeted molecular inhibition.
Wang L, Ge S, Zhang Y, Feng D, Zhu T, Zhang L, Zhang C
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3125-3148
Acta pharmaceutica Sinica. B 2025 Jun;15(6):3125-3148
Distinct non-canonical translation initiation modes arise for specific host and viral mRNAs during poxvirus-induced shutoff.
Park C, Ferrell AJ, Meade N, Shen PS, Walsh D
Nature microbiology 2025 Jun;10(6):1535-1549
Nature microbiology 2025 Jun;10(6):1535-1549
Methods for Mitochondrial DNA Damage and Depletion in Immortalized Trabecular Meshwork Cells.
Kennedy SP, Tsaturian E, Zhao L, Morgan JT
International journal of molecular sciences 2025 Jun 28;26(13)
International journal of molecular sciences 2025 Jun 28;26(13)
MitCOM-based prognostic model identifies GLUD1 as a key suppressor of glioblastoma growth and invasion through regulation of mitochondrial structure and metabolism.
Li Y, Qin C, Jiang L, Su J, Li Z, Liu Q, Yao Y
Cancer cell international 2025 Jun 21;25(1):222
Cancer cell international 2025 Jun 21;25(1):222
Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma.
Zhu L, Liu F, Shi C, Su X, Tan M, Xie S, Yu M, Zou S, Tan Y, Xie S, Liu J, Yan Q, Neculai D, Sun Q, Liu W, Ding Y, Fu X, Shao J, Li X, Ding K, Yuan Y, Zhou T, Lin A
Molecular cell 2025 Jun 19;85(12):2303-2319.e7
Molecular cell 2025 Jun 19;85(12):2303-2319.e7
PRDX6 Drives Breast Cancer Progression Through Mitochondrial Biosynthesis and Oxidative Phosphorylation.
Dai M, Zhang D
Cancer medicine 2025 Jul;14(13):e71005
Cancer medicine 2025 Jul;14(13):e71005
Pseudohypoxia-Stabilized HIF2α Transcriptionally Inhibits MNRR1, a Druggable Target in MELAS.
Purandare N, Pasupathi V, Xi Y, Rajan V, Vegh C, Firestine S, Kozicz T, Fribley AM, Grossman LI, Aras S
Cells 2025 Jul 15;14(14)
Cells 2025 Jul 15;14(14)
Astragalus polysaccharide alleviates mastitis disrupted by Staphylococcus aureus infection by regulating gut microbiota and SCFAs metabolism.
Li K, Ran X, Han J, Ding H, Wang X, Li Y, Guo W, Li X, Guo W, Fu S, Bi J
International journal of biological macromolecules 2025 Jan;286:138422
International journal of biological macromolecules 2025 Jan;286:138422
Bunyavirus SFTSV nucleoprotein exploits TUFM-mediated mitophagy to impair antiviral innate immunity.
Zhang WK, Yan JM, Chu M, Li B, Gu XL, Jiang ZZ, Li ZM, Liu PP, Yu TM, Zhou CM, Yu XJ
Autophagy 2025 Jan;21(1):102-119
Autophagy 2025 Jan;21(1):102-119
Cimicifuga heracleifolia kom. Attenuates ulcerative colitis through the PI3K/AKT/NF-κB signaling pathway.
Wu XY, Dong QW, Zhang YB, Li JX, Zhang MQ, Zhang DQ, Cui YL
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118892
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118892
hUC-MSC preserves erectile function by restoring mitochondrial mass of penile smooth muscle cells in a rat model of cavernous nerve injury via SIRT1/PGC-1a/TFAM signaling.
Yang M, Chen X, Zhang M, Zhang X, Xiao D, Xu H, Lu M
Biological research 2025 Jan 27;58(1):8
Biological research 2025 Jan 27;58(1):8
Selection of initiator tRNA and start codon by mammalian mitochondrial initiation factor 3 in leaderless mRNA translation.
Lee M, Wakigawa T, Jia Q, Liu C, Huang R, Huang S, Nagao A, Suzuki T, Tomita K, Iwasaki S, Takeuchi-Tomita N
Nucleic acids research 2025 Jan 24;53(3)
Nucleic acids research 2025 Jan 24;53(3)
ZFAND6 promotes TRAF2-dependent mitophagy to restrain cGAS-STING signaling.
Shaikh K, Bowman M, McCormick SM, Gao L, Zhang J, White J, Tawil J, Kapoor A, Arav-Boger R, Norbury CC, Harhaj EW
iScience 2025 Jan 17;28(1):111544
iScience 2025 Jan 17;28(1):111544
CISD2-mediated mitochondrial dysfunction and iron redistribution contributes to ferroptosis in arsenic-induced nonalcoholic steatohepatitis.
Zhang J, Wang L, Lu Y, Zheng F, Ding X, Yao X, Bai J, Wang N, Yang G, Qiu T, Sun X
Ecotoxicology and environmental safety 2025 Jan 1;289:117694
Ecotoxicology and environmental safety 2025 Jan 1;289:117694
Aptamer-Conjugated Exosomes Ameliorate Diabetes-Induced Muscle Atrophy by Enhancing SIRT1/FoxO1/3a-Mediated Mitochondrial Function.
Song J, Yang M, Xia L, Wang L, Wang K, Xiang Y, Cheng J, Chen J, Liu J, Zhao R, Liu F, Sun Z, Hou X, Zang N, Chen L
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717
Journal of cachexia, sarcopenia and muscle 2025 Feb;16(1):e13717
Drosophila modeling to identify causative genes and reveal the underlying molecular mechanisms for primary ovarian insufficiency.
Ma Y, Liu Y, Xu M, Yin X, Hu C, Yang X, Ge W
Journal of molecular medicine (Berlin, Germany) 2025 Feb;103(2):239-253
Journal of molecular medicine (Berlin, Germany) 2025 Feb;103(2):239-253
Blocking the CCL5/CCL7-CCR1 axis regulates macrophage polarization through NF-κB pathway to alleviate the progression of osteoarthritis.
Xu H, He Y, Chen S, Meng C, Liu Q, Huang XJ, You HB
International immunopharmacology 2025 Feb 6;147:114027
International immunopharmacology 2025 Feb 6;147:114027
CRIP1 inhibits cutaneous melanoma progression through TFAM-mediated mitochondrial biogenesis.
Wu J, Chen L, Wen P
Scientific reports 2025 Feb 4;15(1):4298
Scientific reports 2025 Feb 4;15(1):4298
MDPAO1 peptide from human milk enhances brown adipose tissue thermogenesis and mitigates obesity.
Gao Y, Zhang J, Cao M, Zhang Y, Cao M, Gu W, Wang M
Molecular and cellular endocrinology 2025 Feb 1;597:112443
Molecular and cellular endocrinology 2025 Feb 1;597:112443
MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses.
Aasumets K, Hangas A, Fragkoulis G, Bader CPJ, Erdinc D, Wanrooij S, Wanrooij PH, Goffart S, Pohjoismäki JLO
Molecular biology of the cell 2025 Feb 1;36(2):ar11
Molecular biology of the cell 2025 Feb 1;36(2):ar11
Oxidative modification of G-quadruplex triggers CLIC4-associated mitochondrial dysfunction to promote glioblastoma progression.
Li X, Fu Y, Luo Y, Wang S, Zhao M, Chen Y
Redox biology 2025 Dec;88:103917
Redox biology 2025 Dec;88:103917
FASN regulates CSE-induced apoptosis, oxidative stress and mitochondrial damage in type 2 alveolar epithelial cells by regulating NRF2 expression and nuclear translocation.
Yang K, Zhu G, Peng T, Cheng Y, Guo X
Redox report : communications in free radical research 2025 Dec;30(1):2550412
Redox report : communications in free radical research 2025 Dec;30(1):2550412
NAD(+) Enhanced Mesenchymal Stromal Cells Effect on Muscle Atrophy by Improving SIRT1-Mediated Mitochondrial Function via NAMPT.
Song J, Sun Y, Zang N, Liu X, Chen J, Wang K, Xia L, Chen J, Zhao R, Liu F, Hou X, Chen L, Cheng J, Zhang W
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142
Journal of cachexia, sarcopenia and muscle 2025 Dec;16(6):e70142
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models.
Dong C, Finigan A, Figg N, Jenkins B, Koulman A, Chowdhury SR, Tricolici AM, Lambert J, Oc S, Jørgensen HF, Prudent J, Murphy MP, Bennett M, Yu E
Nature communications 2025 Dec 4;16(1):10909
Nature communications 2025 Dec 4;16(1):10909
Darunavir analog precursors target mitochondrial metabolism in multiple myeloma and CLL.
Mecca M, Sichetti M, Spina E, Giuseffi M, Giglio E, Picerno S, Valvano L, Statuto T, Santarsiere A, Funicello M, Armentano MF, Chiummiento L, Lupattelli P, Romano A, Giordano A, Cortellino S
Cancer cell international 2025 Dec 23;26(1):44
Cancer cell international 2025 Dec 23;26(1):44
Exosome-Mediated Mitochondrial Delivery of Antisense Oligonucleotides.
von Trentini D, Dmochowski IJ
Nucleic acid therapeutics 2025 Aug;35(4):198-208
Nucleic acid therapeutics 2025 Aug;35(4):198-208
Leber's hereditary optic neuropathy-associated ND1 3733G>C mutation ameliorates the mitochondrial quality control and cellular homeostasis.
Yasheng M, Ji Y, He Y, Yi Q, Zhang H, Shan W, Wang K, Zhang J, Li Y, Meng F, Zhang M, Mo JQ, Wei S, Guan MX
The Journal of biological chemistry 2025 Aug;301(8):110464
The Journal of biological chemistry 2025 Aug;301(8):110464
MRPL12 K163 acetylation inhibits ccRCC via driving mitochondrial metabolic reprogramming.
Ji X, Xue F, Wang Y, Gao D, Sun J, Dong T, Mu Q, Xu Q, Sun S, Liu Y, Wan Q
Cell death & disease 2025 Aug 26;16(1):646
Cell death & disease 2025 Aug 26;16(1):646
Clioquinol induces mitochondrial toxicity in SH-SY5Y neuroblastoma cells by affecting the respiratory chain complex IV and OPA1 dynamin-like GTPase.
Katsuyama M, Arakawa N, Yaoi T, Kimura E, Matsumoto M, Iwata K, Umemura A, Yabe-Nishimura C
FEBS letters 2025 Apr;599(8):1135-1145
FEBS letters 2025 Apr;599(8):1135-1145
Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.
He C, An Y, Shi L, Huang Y, Zhang H, Fu W, Wang M, Shan Z, Du Y, Xie J, Huang Z, Sun W, Zhao Y, Zhao B
Frontiers in pharmacology 2024;15:1371929
Frontiers in pharmacology 2024;15:1371929
SIRT1 Regulates Mitochondrial Damage in N2a Cells Treated with the Prion Protein Fragment 106-126 via PGC-1α-TFAM-Mediated Mitochondrial Biogenesis.
Zhao M, Li J, Li Z, Yang D, Wang D, Sun Z, Wen P, Gou F, Dai Y, Ji Y, Li W, Zhao D, Yang L
International journal of molecular sciences 2024 Sep 7;25(17)
International journal of molecular sciences 2024 Sep 7;25(17)
UBASH3B-mediated MRPL12 Y60 dephosphorylation inhibits LUAD development by driving mitochondrial metabolism reprogramming.
Ji X, Zhang T, Sun J, Song X, Ma G, Xu L, Cao X, Jing Y, Xue F, Zhang W, Sun S, Wan Q, Liu Y
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):268
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):268
Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures.
Wang J, Lin Y, Xu Z, Yan C, Zhao Y, Ji K
Cerebellum (London, England) 2024 Oct;23(5):1824-1838
Cerebellum (London, England) 2024 Oct;23(5):1824-1838
Context-dependent roles of mitochondrial LONP1 in orchestrating the balance between airway progenitor versus progeny cells.
Xu L, Tan C, Barr J, Talaba N, Verheyden J, Chin JS, Gaboyan S, Kasaraneni N, Elgamal RM, Gaulton KJ, Lin G, Afshar K, Golts E, Meier A, Crotty Alexander LE, Borok Z, Shen Y, Chung WK, McCulley DJ, Sun X
Cell stem cell 2024 Oct 3;31(10):1465-1483.e6
Cell stem cell 2024 Oct 3;31(10):1465-1483.e6
LETMD1 regulates mitochondrial protein synthesis and import to guard brown fat mitochondrial integrity and function.
Snyder M, Liu YK, Shang R, Xu H, Thrift C, Chen X, Chen J, Kim KH, Qiu J, Bi P, Tao WA, Kuang S
iScience 2024 Oct 18;27(10):110944
iScience 2024 Oct 18;27(10):110944
Mitochondrial tRNA(Glu) 14693A > G Mutation, an "Enhancer" to the Phenotypic Expression of Leber's Hereditary Optic Neuropathy.
Jin L, Gan D, He W, Wu N, Xiang S, Wei Y, Eriani G, Ji Y, Guan MX, Wang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2401856
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2401856
Taurine hypomodification underlies mitochondrial tRNATrp-related genetic diseases.
Lu JL, Dai Y, Ji K, Peng GX, Li H, Yan C, Shen B, Zhou XL
Nucleic acids research 2024 Nov 27;52(21):13351-13367
Nucleic acids research 2024 Nov 27;52(21):13351-13367
Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells.
Lin YH, Lin KL, Wang XW, Lee JJ, Wang FS, Wang PW, Lan MY, Liou CW, Lin TK
Mitochondrion 2024 May;76:101856
Mitochondrion 2024 May;76:101856
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
Chen X, Meng F, Chen C, Li S, Chou Z, Xu B, Mo JQ, Guo Y, Guan MX
The Journal of biological chemistry 2024 May;300(5):107235
The Journal of biological chemistry 2024 May;300(5):107235
Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.
Koma R, Shibaguchi T, Yamada T, Nonaka Y, Jue T, Yamazaki A, Masuda K
Acta physiologica (Oxford, England) 2024 May;240(5):e14139
Acta physiologica (Oxford, England) 2024 May;240(5):e14139
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity.
Tong L, Chen Z, Li Y, Wang X, Yang C, Li Y, Zhu Y, Lu Y, Liu Q, Xu N, Shao S, Wu L, Zhang P, Wu G, Wu X, Chen X, Fang J, Jia R, Xu T, Li B, Zheng L, Liu J, Tong X
Cell metabolism 2024 May 7;36(5):1013-1029.e5
Cell metabolism 2024 May 7;36(5):1013-1029.e5
Carfilzomib activates ER stress and JNK/p38 MAPK signaling to promote apoptosis in hepatocellular carcinoma cells.
Deng Y, Li Y, Yang M, Gao Y, Luo X, Chen H, Guo M, Yang X, Liu Y, He J, Lu B, Liu N
Acta biochimica et biophysica Sinica 2024 May 25;56(5):697-708
Acta biochimica et biophysica Sinica 2024 May 25;56(5):697-708
Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation.
Shi D, Wang B, Li H, Lian Y, Ma Q, Liu T, Cao M, Ma Y, Shi L, Yuan W, Shi J, Chu Y
iScience 2024 Mar 15;27(3):109265
iScience 2024 Mar 15;27(3):109265
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
Tian Z, Li J, Tang H, Liu W, Hou H, Wang C, Li D, Chen G, Xia T, Wang A
Journal of hazardous materials 2024 Jun 5;471:134331
Journal of hazardous materials 2024 Jun 5;471:134331
SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses.
Jiang Z-z, Chu M, Yan L-n, Zhang W-k, Li B, Xu J, Zhao Z-x, Han H-J, Zhou C-m, Yu X-j
Microbiology spectrum 2024 Jun 4;12(6):e0379623
Microbiology spectrum 2024 Jun 4;12(6):e0379623
Mic19 depletion impairs endoplasmic reticulum-mitochondrial contacts and mitochondrial lipid metabolism and triggers liver disease.
Dong J, Chen L, Ye F, Tang J, Liu B, Lin J, Zhou PH, Lu B, Wu M, Lu JH, He JJ, Engelender S, Meng Q, Song Z, He H
Nature communications 2024 Jan 2;15(1):168
Nature communications 2024 Jan 2;15(1):168
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294
Free radical biology & medicine 2024 Feb 20;212:284-294
LARP1, an RNA-binding protein, participates in ovarian cancer cell survival by regulating mitochondrial oxidative phosphorylation in response to the influence of the PI3K/mTOR pathway.
Ma J, Dong D, Qi H, Li J, Yu H, Hu X, Sun L, Shen L
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167453
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167453
Mesenchymal stromal cells ameliorate mitochondrial dysfunction in α cells and hyperglucagonemia in type 2 diabetes via SIRT1/FoxO3a signaling.
Song J, Wang L, Wang L, Guo X, He Q, Cui C, Hu H, Zang N, Yang M, Yan F, Liang K, Wang C, Liu F, Sun Y, Sun Z, Lai H, Hou X, Chen L
Stem cells translational medicine 2024 Aug 16;13(8):776-790
Stem cells translational medicine 2024 Aug 16;13(8):776-790
MT-TN mutations lead to progressive mitochondrial encephalopathy and promotes mitophagy.
Duan H, Pan C, Wu T, Peng J, Yang L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167043
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167043
LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.
Li Y, Huang D, Jia L, Shangguan F, Gong S, Lan L, Song Z, Xu J, Yan C, Chen T, Tan Y, Liu Y, Huang X, Suzuki CK, Yang Z, Yang G, Lu B
Research (Washington, D.C.) 2023;6:0175
Research (Washington, D.C.) 2023;6:0175
CCDC50 promotes tumor growth through regulation of lysosome homeostasis.
Jia P, Tian T, Li Z, Wang Y, Lin Y, Zeng W, Ye Y, He M, Ni X, Pan J, Dong X, Huang J, Li CM, Guo D, Hou P
EMBO reports 2023 Oct 9;24(10):e56948
EMBO reports 2023 Oct 9;24(10):e56948
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
Lee Q, Chan WC, Qu X, Sun Y, Abdelkarim H, Le J, Saqib U, Sun MY, Kruse K, Banerjee A, Hitchinson B, Geyer M, Huang F, Guaiquil V, Mutso AA, Sanders M, Rosenblatt MI, Maienschein-Cline M, Lawrence MS, Gaponenko V, Malik AB, Komarova YA
Cell reports. Medicine 2023 Oct 17;4(10):101223
Cell reports. Medicine 2023 Oct 17;4(10):101223
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S
Nature communications 2023 Oct 10;14(1):6344
Nature communications 2023 Oct 10;14(1):6344
Correction of a homoplasmic mitochondrial tRNA mutation in patient-derived iPSCs via a mitochondrial base editor.
Chen X, Chen M, Zhu Y, Sun H, Wang Y, Xie Y, Ji L, Wang C, Hu Z, Guo X, Xu Z, Zhang J, Yang S, Liang D, Shen B
Communications biology 2023 Nov 3;6(1):1116
Communications biology 2023 Nov 3;6(1):1116
Mitochondrial gene expression is required for platelet function and blood clotting.
Richman TR, Ermer JA, Baker J, Siira SJ, Kile BT, Linden MD, Rackham O, Filipovska A
Cell reports 2023 Nov 28;42(11):113312
Cell reports 2023 Nov 28;42(11):113312
MUC1-C integrates aerobic glycolysis with suppression of oxidative phosphorylation in triple-negative breast cancer stem cells.
Yamashita N, Withers H, Morimoto Y, Bhattacharya A, Haratake N, Daimon T, Fushimi A, Nakashoji A, Thorner AR, Isenhart E, Rosario S, Long MD, Kufe D
iScience 2023 Nov 17;26(11):108168
iScience 2023 Nov 17;26(11):108168
DNA repair byproduct 8-oxoguanine base promotes myoblast differentiation.
Zheng X, Zhang W, Hu Y, Zhao Z, Wu J, Zhang X, Hao F, Han J, Xu J, Hao W, Wang R, Tian M, Radak Z, Nakabeppu Y, Boldogh I, Ba X
Redox biology 2023 May;61:102634
Redox biology 2023 May;61:102634
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Ji X, Chu L, Su D, Sun J, Song P, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
iScience 2023 May 19;26(5):106656
iScience 2023 May 19;26(5):106656
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Wang X, Jiang X, Li B, Zheng J, Guo J, Gao L, Du M, Weng X, Li L, Chen S, Zhang J, Fang L, Liu T, Wang L, Liu W, Neculai D, Sun Q
The Journal of cell biology 2023 May 1;222(5)
The Journal of cell biology 2023 May 1;222(5)
Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m(3)C modification.
Zhang F, Yoon K, Zhang DY, Kim NS, Ming GL, Song H
Cell stem cell 2023 Mar 2;30(3):300-311.e11
Cell stem cell 2023 Mar 2;30(3):300-311.e11
High Expression of COA6 Is Related to Unfavorable Prognosis and Enhanced Oxidative Phosphorylation in Lung Adenocarcinoma.
Zhang M, Liao X, Ji G, Fan X, Wu Q
International journal of molecular sciences 2023 Mar 16;24(6)
International journal of molecular sciences 2023 Mar 16;24(6)
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Qin W, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
Cell 2023 Jul 20;186(15):3307-3324.e30
Cell 2023 Jul 20;186(15):3307-3324.e30
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Tian Z, Li J, Song L, Xie L, Li D, Xia T, Wang A
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival.
Yang J, Chen Y, Zou T, Xue B, Yang F, Wang X, Huo Y, Yan B, Xu Y, He S, Yin Y, Wang J, Zhu X, Zhang L, Zhou Y, Tai Z, Shuai P, Yu M, Luo Q, Cheng Y, Gong B, Zhu X, Zhang J, Sun X, Lin Y, Zhang H, Yang Z
Science China. Life sciences 2023 Feb;66(2):211-225
Science China. Life sciences 2023 Feb;66(2):211-225
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Xu WQ, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
bioRxiv : the preprint server for biology 2023 Feb 8;
bioRxiv : the preprint server for biology 2023 Feb 8;
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency.
Zhao Y, Lin Y, Wang B, Liu F, Zhao D, Wang W, Ren H, Wang J, Xu Z, Yan C, Ji K
Neuromolecular medicine 2023 Dec;25(4):489-500
Neuromolecular medicine 2023 Dec;25(4):489-500
Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells.
Baleva MV, Piunova U, Chicherin I, Vasilev R, Levitskii S, Kamenski P
International journal of molecular sciences 2023 Dec 20;25(1)
International journal of molecular sciences 2023 Dec 20;25(1)
Cardioprotective effect of Interleukin-11 against warm ischemia-reperfusion injury in a rat heart donor model.
Sakata T, Kohno H, Inui T, Ikeuchi H, Shiko Y, Kawasaki Y, Suzuki S, Tanaka S, Obana M, Ishikawa K, Fujio Y, Matsumiya G
European journal of pharmacology 2023 Dec 15;961:176145
European journal of pharmacology 2023 Dec 15;961:176145
SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria.
Zong S, Wu Y, Li W, You Q, Peng Q, Wang C, Wan P, Bai T, Ma Y, Sun B, Qiao J
Virologica Sinica 2023 Aug;38(4):520-530
Virologica Sinica 2023 Aug;38(4):520-530
Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerization.
Zheng Z, Han L, Li Y, Chen Z, Yang W, Liu C, Tao M, Jiang Y, Ke X, Liu Y, Guo X
Biochimica et biophysica acta. Molecular cell research 2023 Aug;1870(6):119487
Biochimica et biophysica acta. Molecular cell research 2023 Aug;1870(6):119487
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y
The EMBO journal 2023 Aug 15;42(16):e113258
The EMBO journal 2023 Aug 15;42(16):e113258
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
Li D, Zhao Q, Xie L, Wang C, Tian Z, Tang H, Xia T, Wang A
The Science of the total environment 2023 Apr 15;869:161738
The Science of the total environment 2023 Apr 15;869:161738
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Tan L, Qi X, Kong W, Jin J, Lu D, Zhang X, Wang Y, Wang S, Dong W, Shi X, Chen W, Wang J, Li K, Xie Y, Gao L, Guan F, Gao K, Li C, Wang C, Hu Z, Zhang L, Guo X, Shen B, Ma Y
Science advances 2023 Apr 14;9(15):eadf2695
Science advances 2023 Apr 14;9(15):eadf2695
Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy.
Luo L, Luo J, Cai Y, Fu M, Li W, Shi L, Liu J, Dong R, Xu X, Tu L, Yang Y
Pharmacological research 2022 Sep;183:106367
Pharmacological research 2022 Sep;183:106367
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Nucleic acids research 2022 Sep 9;50(16):9368-9381
P53 regulates mitochondrial biogenesis via transcriptionally induction of mitochondrial ribosomal protein L12.
Han Y, Liu Y, Zhen J, Hou S, Zhang B, Cui Z, Wan Q, Feng H
Experimental cell research 2022 Sep 1;418(1):113249
Experimental cell research 2022 Sep 1;418(1):113249
THRIFTY: a novel high-throughput method for rapid fibre type identification of isolated skeletal muscle fibres.
Horwath O, Edman S, Andersson A, Larsen FJ, Apró W
The Journal of physiology 2022 Oct;600(20):4421-4438
The Journal of physiology 2022 Oct;600(20):4421-4438
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Li Q, Chu Y, Li S, Yu L, Deng H, Liao C, Liao X, Yang C, Qi M, Cheng J, Chen G, Huang L
Cell death & disease 2022 Oct 26;13(10):899
Cell death & disease 2022 Oct 26;13(10):899
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert AS, Stühler K, Proksch P, Stork B, Wesselborg S
Cell death & disease 2022 Nov 8;13(11):938
Cell death & disease 2022 Nov 8;13(11):938
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
Purandare N, Kunji Y, Xi Y, Romero R, Gomez-Lopez N, Fribley A, Grossman LI, Aras S
iScience 2022 Nov 18;25(11):105342
iScience 2022 Nov 18;25(11):105342
Pentatricopeptide Protein PTCD2 Regulates COIII Translation in Mitochondria of the HeLa Cell Line.
Baleva MV, Chicherin I, Piunova U, Zgoda V, Patrushev MV, Levitskii S, Kamenski P
International journal of molecular sciences 2022 Nov 17;23(22)
International journal of molecular sciences 2022 Nov 17;23(22)
Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2.
Jin X, Li L, Peng Q, Gan C, Gao L, He S, Tan S, Pu W, Liu Y, Gong Y, Yao Y, Wang G, Liu X, Gong M, Lei P, Zhang H, Qi S, Xu H, Hu H, Dong B, Peng Y, Su D, Dai L
iScience 2022 May 20;25(5):104349
iScience 2022 May 20;25(5):104349
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X
Nature communications 2022 Mar 2;13(1):1121
Nature communications 2022 Mar 2;13(1):1121
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Zhao K, Huang X, Zhao W, Lu B, Yang Z
Development (Cambridge, England) 2022 Mar 15;149(6)
Development (Cambridge, England) 2022 Mar 15;149(6)
Characterization of lncRNA functioning in ovine conceptuses and endometria during the peri-implantation period.
Matsuno Y, Kusama K, Imakawa K
Biochemical and biophysical research communications 2022 Feb 26;594:22-30
Biochemical and biophysical research communications 2022 Feb 26;594:22-30
Butyrate Ameliorates Mitochondrial Respiratory Capacity of The Motor-Neuron-like Cell Line NSC34-G93A, a Cellular Model for ALS.
Li X, Dong L, Li A, Yi J, Brotto M, Zhou J
Biomolecules 2022 Feb 19;12(2)
Biomolecules 2022 Feb 19;12(2)
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.
Patrick M, Gu Z, Zhang G, Wynn RM, Kaphle P, Cao H, Vu H, Cai F, Gao X, Zhang Y, Chen M, Ni M, Chuang DT, DeBerardinis RJ, Xu J
Nature metabolism 2022 Dec;4(12):1775-1791
Nature metabolism 2022 Dec;4(12):1775-1791
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
DDB1 prepares brown adipocytes for cold-induced thermogenesis.
Wang X, Liu SY, Hu GS, Wang HY, Zhang GL, Cen X, Xiang ST, Liu W, Li P, Ye H, Zhao TJ
Life metabolism 2022 Aug;1(1):39-53
Life metabolism 2022 Aug;1(1):39-53
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Liang C, Zhang S, Robinson D, Ploeg MV, Wilson R, Nah J, Taylor D, Beh S, Lim R, Sun L, Muoio DM, Stroud DA, Ho L
Cell reports 2022 Aug 16;40(7):111204
Cell reports 2022 Aug 16;40(7):111204
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Rome FI, Hughey CC
Molecular metabolism 2022 Apr;58:101452
Molecular metabolism 2022 Apr;58:101452
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Fu F, Liu C, Shi R, Li M, Zhang M, Du Y, Wang Q, Li J, Wang G, Pei J, Ding M
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
Paulo E, Zhang Y, Masand R, Huynh TL, Seo Y, Swaney DL, Soucheray M, Stevenson E, Jimenez-Morales D, Krogan NJ, Wang B
Cell reports 2021 Sep 21;36(12):109742
Cell reports 2021 Sep 21;36(12):109742
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Xie QE, Wang MY, Cao ZP, Du X, Ji DM, Liang D, Cao YX, Liu YJ
Mitochondrion 2021 Nov;61:44-53
Mitochondrion 2021 Nov;61:44-53
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Zhang Q, He X, Yao S, Lin T, Zhang L, Chen D, Chen C, Yang Q, Li F, Zhu YM, Guan MX
Nucleic acids research 2021 May 7;49(8):4689-4704
Nucleic acids research 2021 May 7;49(8):4689-4704
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT
Cell metabolism 2021 May 4;33(5):1027-1041.e8
Cell metabolism 2021 May 4;33(5):1027-1041.e8
A novel nonsense variant in MT-CO3 causes MELAS syndrome.
Wang W, Sun Y, Lin Y, Xu X, Zhao D, Ji K, Li W, Zhao Y, Yan C
Neuromuscular disorders : NMD 2021 Jun;31(6):558-565
Neuromuscular disorders : NMD 2021 Jun;31(6):558-565
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Mitochondrial functional resilience after TFAM ablation in the adult heart.
Ghazal N, Peoples JN, Mohiuddin TA, Kwong JQ
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C929-C942
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C929-C942
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, Wang G, Chen J, Qi X, Tao Z, Ren J
Life sciences 2021 Jul 1;276:119415
Life sciences 2021 Jul 1;276:119415
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437
The Journal of biological chemistry 2021 Jan-Jun;296:100437
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827
EMBO reports 2021 Jan 7;22(1):e50827
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
Active RNA interference in mitochondria.
Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X
Cell research 2021 Feb;31(2):219-228
Cell research 2021 Feb;31(2):219-228
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Davis OB, Shin HR, Lim CY, Wu EY, Kukurugya M, Maher CF, Perera RM, Ordonez MP, Zoncu R
Developmental cell 2021 Feb 8;56(3):260-276.e7
Developmental cell 2021 Feb 8;56(3):260-276.e7
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Gu X, Liu Y, Wang N, Zhen J, Zhang B, Hou S, Cui Z, Wan Q, Feng H
Free radical biology & medicine 2021 Feb 20;164:329-340
Free radical biology & medicine 2021 Feb 20;164:329-340
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth.
Deng Z, Li X, Blanca Ramirez M, Purtell K, Choi I, Lu JH, Yu Q, Yue Z
Proceedings of the National Academy of Sciences of the United States of America 2021 Apr 6;118(14)
Proceedings of the National Academy of Sciences of the United States of America 2021 Apr 6;118(14)
Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments.
Cao P, Zhang H, Meng H, Cheng Y, Xu H, Zang S, Li Z, Cui J, Li Y
Journal of inflammation research 2020;13:1043-1055
Journal of inflammation research 2020;13:1043-1055
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Zhao Q, Tian Z, Zhou G, Niu Q, Chen J, Li P, Dong L, Xia T, Zhang S, Wang A
Theranostics 2020;10(11):4822-4838
Theranostics 2020;10(11):4822-4838
miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
Yang YL, Wang PW, Wang FS, Lin HY, Huang YH
International journal of molecular sciences 2020 Sep 19;21(18)
International journal of molecular sciences 2020 Sep 19;21(18)
δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy.
Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, Yang Y, Xia Y
Aging 2020 Nov 10;12(24):25035-25059
Aging 2020 Nov 10;12(24):25035-25059
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, Zhou X, Teng J, Chen J
Autophagy 2020 May;16(5):797-810
Autophagy 2020 May;16(5):797-810
The lysosomal membrane protein LAMP-2 is dispensable for PINK1/Parkin-mediated mitophagy.
Liu X, Liao X, Rao X, Wang B, Zhang J, Xu G, Jiang X, Qin X, Chen C, Zou Z
FEBS letters 2020 Mar;594(5):823-840
FEBS letters 2020 Mar;594(5):823-840
The human mitochondrial 12S rRNA m(4)C methyltransferase METTL15 is required for mitochondrial function.
Chen H, Shi Z, Guo J, Chang KJ, Chen Q, Yao CH, Haigis MC, Shi Y
The Journal of biological chemistry 2020 Jun 19;295(25):8505-8513
The Journal of biological chemistry 2020 Jun 19;295(25):8505-8513
Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X
Diabetes 2020 Jul;69(7):1355-1367
Diabetes 2020 Jul;69(7):1355-1367
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10
Immunity 2020 Jul 14;53(1):204-216.e10
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983
Carcinogenesis 2020 Jul 14;41(7):972-983
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
Liu L, Wang F, Tong Y, Li LF, Liu Y, Gao WQ
Cell proliferation 2020 Jan;53(1):e12718
Cell proliferation 2020 Jan;53(1):e12718
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Ma Y, Zhu S, Lv T, Gu X, Feng H, Zhen J, Xin W, Wan Q
iScience 2020 Aug 21;23(8):101428
iScience 2020 Aug 21;23(8):101428
Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts.
Lin TK, Chen SD, Chuang YC, Lan MY, Chuang JH, Wang PW, Hsu TY, Wang FS, Tsai MH, Huang ST, Wang XW, Tsai PC, Lin HY, Liou CW
Oxidative medicine and cellular longevity 2019;2019:9537504
Oxidative medicine and cellular longevity 2019;2019:9537504
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L
Oxidative medicine and cellular longevity 2019;2019:4508762
Oxidative medicine and cellular longevity 2019;2019:4508762
The Circadian Protein Nocturnin Regulates Metabolic Adaptation in Brown Adipose Tissue.
Onder Y, Laothamatas I, Berto S, Sewart K, Kilaru G, Bordieanu B, Stubblefield JJ, Konopka G, Mishra P, Green CB
iScience 2019 Sep 27;19:83-92
iScience 2019 Sep 27;19:83-92
Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.
Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L, Chen Q
Autophagy 2019 Nov;15(11):1882-1898
Autophagy 2019 Nov;15(11):1882-1898
EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.
Meng F, Wu L, Dong L, Mitchell AV, James Block C, Liu J, Zhang H, Lu Q, Song WM, Zhang B, Chen W, Hu J, Wang J, Yang Q, Hüttemann M, Wu G
Nature communications 2019 Nov 6;10(1):5033
Nature communications 2019 Nov 6;10(1):5033
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5
Cell reports 2019 May 14;27(7):2075-2091.e5
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X
Nature communications 2019 Mar 26;10(1):1371
Nature communications 2019 Mar 26;10(1):1371
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
Chen D, Zhang Z, Chen C, Yao S, Yang Q, Li F, He X, Ai C, Wang M, Guan MX
Nucleic acids research 2019 Jun 4;47(10):5341-5355
Nucleic acids research 2019 Jun 4;47(10):5341-5355
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Fu R, Yang P, Li Z, Liu W, Amin S, Li Z
Cell death & disease 2019 Aug 7;10(8):593
Cell death & disease 2019 Aug 7;10(8):593
Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease.
Shan C, Gong YL, Zhuang QQ, Hou YF, Wang SM, Zhu Q, Huang GR, Tao B, Sun LH, Zhao HY, Li ST, Liu JM
Progress in neuro-psychopharmacology & biological psychiatry 2019 Aug 30;94:109670
Progress in neuro-psychopharmacology & biological psychiatry 2019 Aug 30;94:109670
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
Tang Y, Huang W, Song Q, Zheng X, He R, Liu J
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
Protein coding mitochondrial-targeted RNAs rescue mitochondrial disease in vivo.
Markantone DM, Towheed A, Crain AT, Collins JM, Celotto AM, Palladino MJ
Neurobiology of disease 2018 Sep;117:203-210
Neurobiology of disease 2018 Sep;117:203-210
In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization.
Takahashi K, Miura Y, Ohsawa I, Shirasawa T, Takahashi M
Scientific reports 2018 Oct 22;8(1):15585
Scientific reports 2018 Oct 22;8(1):15585
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y, Guan MX
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.
Masand R, Paulo E, Wu D, Wang Y, Swaney DL, Jimenez-Morales D, Krogan NJ, Wang B
Cell metabolism 2018 Mar 6;27(3):616-629.e4
Cell metabolism 2018 Mar 6;27(3):616-629.e4
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR
Cell 2018 Jun 28;174(1):88-101.e16
Cell 2018 Jun 28;174(1):88-101.e16
Cryo-EM structure of human mitochondrial trifunctional protein.
Liang K, Li N, Wang X, Dai J, Liu P, Wang C, Chen XW, Gao N, Xiao J
Proceedings of the National Academy of Sciences of the United States of America 2018 Jul 3;115(27):7039-7044
Proceedings of the National Academy of Sciences of the United States of America 2018 Jul 3;115(27):7039-7044
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Paulo E, Wu D, Wang Y, Zhang Y, Wu Y, Swaney DL, Soucheray M, Jimenez-Morales D, Chawla A, Krogan NJ, Wang B
Scientific reports 2018 Jul 20;8(1):11001
Scientific reports 2018 Jul 20;8(1):11001
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.
Télot L, Rousseau E, Lesuisse E, Garcia C, Morlet B, Léger T, Camadro JM, Serre V
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):997-1009
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):997-1009
Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury.
Shanshan Y, Beibei J, Li T, Minna G, Shipeng L, Li P, Yong Z
Frontiers in cellular neuroscience 2017;11:99
Frontiers in cellular neuroscience 2017;11:99
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y
Scientific reports 2017 Oct 19;7(1):13554
Scientific reports 2017 Oct 19;7(1):13554
DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.
Di Nottia M, Masciullo M, Verrigni D, Petrillo S, Modoni A, Rizzo V, Di Giuda D, Rizza T, Niceta M, Torraco A, Bianchi M, Santoro M, Bentivoglio AR, Bertini E, Piemonte F, Carrozzo R, Silvestri G
Clinical genetics 2017 Jul;92(1):18-25
Clinical genetics 2017 Jul;92(1):18-25
Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts.
Li X, Xiong X, Zhang M, Wang K, Chen Y, Zhou J, Mao Y, Lv J, Yi D, Chen XW, Wang C, Qian SB, Yi C
Molecular cell 2017 Dec 7;68(5):993-1005.e9
Molecular cell 2017 Dec 7;68(5):993-1005.e9
Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.
Duchesne A, Vaiman A, Castille J, Beauvallet C, Gaignard P, Floriot S, Rodriguez S, Vilotte M, Boulanger L, Passet B, Albaric O, Guillaume F, Boukadiri A, Richard L, Bertaud M, Timsit E, Guatteo R, Jaffrézic F, Calvel P, Helary L, Mahla R, Esquerré D, Péchoux C, Liuu S, Vallat JM, Boichard D, Slama A, Vilotte JL
PLoS genetics 2017 Apr;13(4):e1006597
PLoS genetics 2017 Apr;13(4):e1006597
Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats.
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Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 55070-1-AP(COX2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 55070-1-AP(COX2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 55070-1-AP(COX2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MTCO2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MTCO2. This antibody recognizes human,mouse,rat antigen. The MTCO2 antibody has been validated for the following applications: ELISA, IHC, WB, FC analysis.
