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- Antibody Data
- Antigen structure
- References [115]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 55070-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55070-1-AP, RRID:AB_10859832
- Product name
- MTCO2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MTCO2 antibody (Cat. #55070-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Loss of MTX2 causes mitochondrial dysfunction, podocyte injury, nephrotic proteinuria and glomerulopathy in mice and patients.
Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.
Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures.
Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells.
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity.
Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation.
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses.
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
MT-TN mutations lead to progressive mitochondrial encephalopathy and promotes mitophagy.
LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.
CCDC50 promotes tumor growth through regulation of lysosome homeostasis.
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Correction of a homoplasmic mitochondrial tRNA mutation in patient-derived iPSCs via a mitochondrial base editor.
Mitochondrial gene expression is required for platelet function and blood clotting.
DNA repair byproduct 8-oxoguanine base promotes myoblast differentiation.
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m(3)C modification.
High Expression of COA6 Is Related to Unfavorable Prognosis and Enhanced Oxidative Phosphorylation in Lung Adenocarcinoma.
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival.
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency.
Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells.
Cardioprotective effect of Interleukin-11 against warm ischemia-reperfusion injury in a rat heart donor model.
SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria.
Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerization.
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy.
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
P53 regulates mitochondrial biogenesis via transcriptionally induction of mitochondrial ribosomal protein L12.
THRIFTY: a novel high-throughput method for rapid fibre type identification of isolated skeletal muscle fibres.
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
Pentatricopeptide Protein PTCD2 Regulates COIII Translation in Mitochondria of the HeLa Cell Line.
Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2.
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Characterization of lncRNA functioning in ovine conceptuses and endometria during the peri-implantation period.
Butyrate Ameliorates Mitochondrial Respiratory Capacity of The Motor-Neuron-like Cell Line NSC34-G93A, a Cellular Model for ALS.
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
A novel nonsense variant in MT-CO3 causes MELAS syndrome.
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Mitochondrial functional resilience after TFAM ablation in the adult heart.
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Active RNA interference in mitochondria.
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth.
Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments.
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy.
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
The lysosomal membrane protein LAMP-2 is dispensable for PINK1/Parkin-mediated mitophagy.
The human mitochondrial 12S rRNA m(4)C methyltransferase METTL15 is required for mitochondrial function.
Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts.
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
The Circadian Protein Nocturnin Regulates Metabolic Adaptation in Brown Adipose Tissue.
Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.
EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease.
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
Protein coding mitochondrial-targeted RNAs rescue mitochondrial disease in vivo.
In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization.
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Cryo-EM structure of human mitochondrial trifunctional protein.
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.
Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury.
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.
Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts.
Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.
Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats.
A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway.
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6.
Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.
Li T, Bao Y, Xia Y, Meng H, Zhou C, Huang L, Wang X, Lai EY, Jiang P, Mao J
International journal of biological sciences 2024;20(3):937-952
International journal of biological sciences 2024;20(3):937-952
Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.
He C, An Y, Shi L, Huang Y, Zhang H, Fu W, Wang M, Shan Z, Du Y, Xie J, Huang Z, Sun W, Zhao Y, Zhao B
Frontiers in pharmacology 2024;15:1371929
Frontiers in pharmacology 2024;15:1371929
Mitochondrial Dysfunction due to Novel COQ8A Variation with Poor Response to CoQ10 Treatment: A Comprehensive Study and Review of Literatures.
Wang J, Lin Y, Xu Z, Yan C, Zhao Y, Ji K
Cerebellum (London, England) 2024 Oct;23(5):1824-1838
Cerebellum (London, England) 2024 Oct;23(5):1824-1838
Miro1 improves the exogenous engraftment efficiency and therapeutic potential of mitochondria transfer using Wharton's jelly mesenchymal stem cells.
Lin YH, Lin KL, Wang XW, Lee JJ, Wang FS, Wang PW, Lan MY, Liou CW, Lin TK
Mitochondrion 2024 May;76:101856
Mitochondrion 2024 May;76:101856
Deafness-associated tRNA(Phe) mutation impaired mitochondrial and cellular integrity.
Chen X, Meng F, Chen C, Li S, Chou Z, Xu B, Mo JQ, Guo Y, Guan MX
The Journal of biological chemistry 2024 May;300(5):107235
The Journal of biological chemistry 2024 May;300(5):107235
Endurance training increases mitochondrial myoglobin and enhances its interaction with complex IV in rat plantaris muscle.
Koma R, Shibaguchi T, Yamada T, Nonaka Y, Jue T, Yamazaki A, Masuda K
Acta physiologica (Oxford, England) 2024 May;240(5):e14139
Acta physiologica (Oxford, England) 2024 May;240(5):e14139
Aging-induced tRNA(Glu)-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization.
Li D, Gao X, Ma X, Wang M, Cheng C, Xue T, Gao F, Shen Y, Zhang J, Liu Q
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Cell metabolism 2024 May 7;36(5):1059-1075.e9
Transketolase promotes MAFLD by limiting inosine-induced mitochondrial activity.
Tong L, Chen Z, Li Y, Wang X, Yang C, Li Y, Zhu Y, Lu Y, Liu Q, Xu N, Shao S, Wu L, Zhang P, Wu G, Wu X, Chen X, Fang J, Jia R, Xu T, Li B, Zheng L, Liu J, Tong X
Cell metabolism 2024 May 7;36(5):1013-1029.e5
Cell metabolism 2024 May 7;36(5):1013-1029.e5
Pseudouridine synthase 1 regulates erythropoiesis via transfer RNAs pseudouridylation and cytoplasmic translation.
Shi D, Wang B, Li H, Lian Y, Ma Q, Liu T, Cao M, Ma Y, Shi L, Yuan W, Shi J, Chu Y
iScience 2024 Mar 15;27(3):109265
iScience 2024 Mar 15;27(3):109265
ZLN005 alleviates PBDE-47 induced impairment of mitochondrial translation and neurotoxicity through PGC-1α/ERRα axis.
Tian Z, Li J, Tang H, Liu W, Hou H, Wang C, Li D, Chen G, Xia T, Wang A
Journal of hazardous materials 2024 Jun 5;471:134331
Journal of hazardous materials 2024 Jun 5;471:134331
SFTSV nucleoprotein mediates DNA sensor cGAS degradation to suppress cGAS-dependent antiviral responses.
Jiang Z-z, Chu M, Yan L-n, Zhang W-k, Li B, Xu J, Zhao Z-x, Han H-J, Zhou C-m, Yu X-j
Microbiology spectrum 2024 Jun 4;12(6):e0379623
Microbiology spectrum 2024 Jun 4;12(6):e0379623
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294
Free radical biology & medicine 2024 Feb 20;212:284-294
MT-TN mutations lead to progressive mitochondrial encephalopathy and promotes mitophagy.
Duan H, Pan C, Wu T, Peng J, Yang L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167043
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167043
LonP1 Links Mitochondria-ER Interaction to Regulate Heart Function.
Li Y, Huang D, Jia L, Shangguan F, Gong S, Lan L, Song Z, Xu J, Yan C, Chen T, Tan Y, Liu Y, Huang X, Suzuki CK, Yang Z, Yang G, Lu B
Research (Washington, D.C.) 2023;6:0175
Research (Washington, D.C.) 2023;6:0175
CCDC50 promotes tumor growth through regulation of lysosome homeostasis.
Jia P, Tian T, Li Z, Wang Y, Lin Y, Zeng W, Ye Y, He M, Ni X, Pan J, Dong X, Huang J, Li CM, Guo D, Hou P
EMBO reports 2023 Oct 9;24(10):e56948
EMBO reports 2023 Oct 9;24(10):e56948
End binding-3 inhibitor activates regenerative program in age-related macular degeneration.
Lee Q, Chan WC, Qu X, Sun Y, Abdelkarim H, Le J, Saqib U, Sun MY, Kruse K, Banerjee A, Hitchinson B, Geyer M, Huang F, Guaiquil V, Mutso AA, Sanders M, Rosenblatt MI, Maienschein-Cline M, Lawrence MS, Gaponenko V, Malik AB, Komarova YA
Cell reports. Medicine 2023 Oct 17;4(10):101223
Cell reports. Medicine 2023 Oct 17;4(10):101223
FAM210A is essential for cold-induced mitochondrial remodeling in brown adipocytes.
Qiu J, Yue F, Zhu P, Chen J, Xu F, Zhang L, Kim KH, Snyder MM, Luo N, Xu HW, Huang F, Tao WA, Kuang S
Nature communications 2023 Oct 10;14(1):6344
Nature communications 2023 Oct 10;14(1):6344
Correction of a homoplasmic mitochondrial tRNA mutation in patient-derived iPSCs via a mitochondrial base editor.
Chen X, Chen M, Zhu Y, Sun H, Wang Y, Xie Y, Ji L, Wang C, Hu Z, Guo X, Xu Z, Zhang J, Yang S, Liang D, Shen B
Communications biology 2023 Nov 3;6(1):1116
Communications biology 2023 Nov 3;6(1):1116
Mitochondrial gene expression is required for platelet function and blood clotting.
Richman TR, Ermer JA, Baker J, Siira SJ, Kile BT, Linden MD, Rackham O, Filipovska A
Cell reports 2023 Nov 28;42(11):113312
Cell reports 2023 Nov 28;42(11):113312
DNA repair byproduct 8-oxoguanine base promotes myoblast differentiation.
Zheng X, Zhang W, Hu Y, Zhao Z, Wu J, Zhang X, Hao F, Han J, Xu J, Hao W, Wang R, Tian M, Radak Z, Nakabeppu Y, Boldogh I, Ba X
Redox biology 2023 May;61:102634
Redox biology 2023 May;61:102634
MRPL12-ANT3 interaction involves in acute kidney injury via regulating MPTP of tubular epithelial cells.
Ji X, Chu L, Su D, Sun J, Song P, Sun S, Wang Y, Mu Q, Liu Y, Wan Q
iScience 2023 May 19;26(5):106656
iScience 2023 May 19;26(5):106656
A regulatory circuit comprising the CBP and SIRT7 regulates FAM134B-mediated ER-phagy.
Wang X, Jiang X, Li B, Zheng J, Guo J, Gao L, Du M, Weng X, Li L, Chen S, Zhang J, Fang L, Liu T, Wang L, Liu W, Neculai D, Sun Q
The Journal of cell biology 2023 May 1;222(5)
The Journal of cell biology 2023 May 1;222(5)
Epitranscriptomic regulation of cortical neurogenesis via Mettl8-dependent mitochondrial tRNA m(3)C modification.
Zhang F, Yoon K, Zhang DY, Kim NS, Ming GL, Song H
Cell stem cell 2023 Mar 2;30(3):300-311.e11
Cell stem cell 2023 Mar 2;30(3):300-311.e11
High Expression of COA6 Is Related to Unfavorable Prognosis and Enhanced Oxidative Phosphorylation in Lung Adenocarcinoma.
Zhang M, Liao X, Ji G, Fan X, Wu Q
International journal of molecular sciences 2023 Mar 16;24(6)
International journal of molecular sciences 2023 Mar 16;24(6)
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Qin W, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
Cell 2023 Jul 20;186(15):3307-3324.e30
Cell 2023 Jul 20;186(15):3307-3324.e30
PBDE-47 induces impairment of mitochondrial biogenesis and subsequent neurotoxicity through miR-128-3p/PGC-1α axis.
Tian Z, Li J, Song L, Xie L, Li D, Xia T, Wang A
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Toxicological sciences : an official journal of the Society of Toxicology 2023 Jan 31;191(1):123-134
Loss of hepatic phosphoenolpyruvate carboxykinase 1 dysregulates metabolic responses to acute exercise but enhances adaptations to exercise training in mice.
Rome FI, Shobert GL, Voigt WC, Stagg DB, Puchalska P, Burgess SC, Crawford PA, Hughey CC
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
American journal of physiology. Endocrinology and metabolism 2023 Jan 1;324(1):E9-E23
Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival.
Yang J, Chen Y, Zou T, Xue B, Yang F, Wang X, Huo Y, Yan B, Xu Y, He S, Yin Y, Wang J, Zhu X, Zhang L, Zhou Y, Tai Z, Shuai P, Yu M, Luo Q, Cheng Y, Gong B, Zhu X, Zhang J, Sun X, Lin Y, Zhang H, Yang Z
Science China. Life sciences 2023 Feb;66(2):211-225
Science China. Life sciences 2023 Feb;66(2):211-225
Dynamic mapping of proteome trafficking within and between living cells by TransitID.
Xu WQ, Cheah JS, Xu C, Messing J, Freibaum BD, Boeynaems S, Taylor JP, Udeshi ND, Carr SA, Ting AY
bioRxiv : the preprint server for biology 2023 Feb 8;
bioRxiv : the preprint server for biology 2023 Feb 8;
A Missense Variant in AIFM1 Caused Mitochondrial Dysfunction and Intolerance to Riboflavin Deficiency.
Zhao Y, Lin Y, Wang B, Liu F, Zhao D, Wang W, Ren H, Wang J, Xu Z, Yan C, Ji K
Neuromolecular medicine 2023 Dec;25(4):489-500
Neuromolecular medicine 2023 Dec;25(4):489-500
Mitochondrial Protein SLIRP Affects Biosynthesis of Cytochrome c Oxidase Subunits in HEK293T Cells.
Baleva MV, Piunova U, Chicherin I, Vasilev R, Levitskii S, Kamenski P
International journal of molecular sciences 2023 Dec 20;25(1)
International journal of molecular sciences 2023 Dec 20;25(1)
Cardioprotective effect of Interleukin-11 against warm ischemia-reperfusion injury in a rat heart donor model.
Sakata T, Kohno H, Inui T, Ikeuchi H, Shiko Y, Kawasaki Y, Suzuki S, Tanaka S, Obana M, Ishikawa K, Fujio Y, Matsumiya G
European journal of pharmacology 2023 Dec 15;961:176145
European journal of pharmacology 2023 Dec 15;961:176145
SARS-CoV-2 Nsp8 induces mitophagy by damaging mitochondria.
Zong S, Wu Y, Li W, You Q, Peng Q, Wang C, Wan P, Bai T, Ma Y, Sun B, Qiao J
Virologica Sinica 2023 Aug;38(4):520-530
Virologica Sinica 2023 Aug;38(4):520-530
Phospholipase A2-activating protein induces mitophagy through anti-apoptotic MCL1-mediated NLRX1 oligomerization.
Zheng Z, Han L, Li Y, Chen Z, Yang W, Liu C, Tao M, Jiang Y, Ke X, Liu Y, Guo X
Biochimica et biophysica acta. Molecular cell research 2023 Aug;1870(6):119487
Biochimica et biophysica acta. Molecular cell research 2023 Aug;1870(6):119487
NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity.
Zhao T, Zhang J, Lei H, Meng Y, Cheng H, Zhao Y, Geng G, Mu C, Chen L, Liu Q, Luo Q, Zhang C, Long Y, Su J, Wang Y, Li Z, Sun J, Chen G, Li Y, Liao X, Shang Y, Hu G, Chen Q, Zhu Y
The EMBO journal 2023 Aug 15;42(16):e113258
The EMBO journal 2023 Aug 15;42(16):e113258
Fluoride impairs mitochondrial translation by targeting miR-221-3p/c-Fos/RMND1 axis contributing to neurodevelopment defects.
Li D, Zhao Q, Xie L, Wang C, Tian Z, Tang H, Xia T, Wang A
The Science of the total environment 2023 Apr 15;869:161738
The Science of the total environment 2023 Apr 15;869:161738
A conditional knockout rat resource of mitochondrial protein-coding genes via a DdCBE-induced premature stop codon.
Tan L, Qi X, Kong W, Jin J, Lu D, Zhang X, Wang Y, Wang S, Dong W, Shi X, Chen W, Wang J, Li K, Xie Y, Gao L, Guan F, Gao K, Li C, Wang C, Hu Z, Zhang L, Guo X, Shen B, Ma Y
Science advances 2023 Apr 14;9(15):eadf2695
Science advances 2023 Apr 14;9(15):eadf2695
Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy.
Luo L, Luo J, Cai Y, Fu M, Li W, Shi L, Liu J, Dong R, Xu X, Tu L, Yang Y
Pharmacological research 2022 Sep;183:106367
Pharmacological research 2022 Sep;183:106367
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro.
Jia Z, Meng F, Chen H, Zhu G, Li X, He Y, Zhang L, He X, Zhan H, Chen M, Ji Y, Wang M, Guan MX
Nucleic acids research 2022 Sep 9;50(16):9368-9381
Nucleic acids research 2022 Sep 9;50(16):9368-9381
P53 regulates mitochondrial biogenesis via transcriptionally induction of mitochondrial ribosomal protein L12.
Han Y, Liu Y, Zhen J, Hou S, Zhang B, Cui Z, Wan Q, Feng H
Experimental cell research 2022 Sep 1;418(1):113249
Experimental cell research 2022 Sep 1;418(1):113249
THRIFTY: a novel high-throughput method for rapid fibre type identification of isolated skeletal muscle fibres.
Horwath O, Edman S, Andersson A, Larsen FJ, Apró W
The Journal of physiology 2022 Oct;600(20):4421-4438
The Journal of physiology 2022 Oct;600(20):4421-4438
The oncoprotein MUC1 facilitates breast cancer progression by promoting Pink1-dependent mitophagy via ATAD3A destabilization.
Li Q, Chu Y, Li S, Yu L, Deng H, Liao C, Liao X, Yang C, Qi M, Cheng J, Chen G, Huang L
Cell death & disease 2022 Oct 26;13(10):899
Cell death & disease 2022 Oct 26;13(10):899
The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism.
Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert AS, Stühler K, Proksch P, Stork B, Wesselborg S
Cell death & disease 2022 Nov 8;13(11):938
Cell death & disease 2022 Nov 8;13(11):938
Lipopolysaccharide induces placental mitochondrial dysfunction in murine and human systems by reducing MNRR1 levels via a TLR4-independent pathway.
Purandare N, Kunji Y, Xi Y, Romero R, Gomez-Lopez N, Fribley A, Grossman LI, Aras S
iScience 2022 Nov 18;25(11):105342
iScience 2022 Nov 18;25(11):105342
Pentatricopeptide Protein PTCD2 Regulates COIII Translation in Mitochondria of the HeLa Cell Line.
Baleva MV, Chicherin I, Piunova U, Zgoda V, Patrushev MV, Levitskii S, Kamenski P
International journal of molecular sciences 2022 Nov 17;23(22)
International journal of molecular sciences 2022 Nov 17;23(22)
Glycyrrhetinic acid restricts mitochondrial energy metabolism by targeting SHMT2.
Jin X, Li L, Peng Q, Gan C, Gao L, He S, Tan S, Pu W, Liu Y, Gong Y, Yao Y, Wang G, Liu X, Gong M, Lei P, Zhang H, Qi S, Xu H, Hu H, Dong B, Peng Y, Su D, Dai L
iScience 2022 May 20;25(5):104349
iScience 2022 May 20;25(5):104349
ATAD3A oligomerization promotes neuropathology and cognitive deficits in Alzheimer's disease models.
Zhao Y, Hu D, Wang R, Sun X, Ropelewski P, Hubler Z, Lundberg K, Wang Q, Adams DJ, Xu R, Qi X
Nature communications 2022 Mar 2;13(1):1121
Nature communications 2022 Mar 2;13(1):1121
LONP1-mediated mitochondrial quality control safeguards metabolic shifts in heart development.
Zhao K, Huang X, Zhao W, Lu B, Yang Z
Development (Cambridge, England) 2022 Mar 15;149(6)
Development (Cambridge, England) 2022 Mar 15;149(6)
Characterization of lncRNA functioning in ovine conceptuses and endometria during the peri-implantation period.
Matsuno Y, Kusama K, Imakawa K
Biochemical and biophysical research communications 2022 Feb 26;594:22-30
Biochemical and biophysical research communications 2022 Feb 26;594:22-30
Butyrate Ameliorates Mitochondrial Respiratory Capacity of The Motor-Neuron-like Cell Line NSC34-G93A, a Cellular Model for ALS.
Li X, Dong L, Li A, Yi J, Brotto M, Zhou J
Biomolecules 2022 Feb 19;12(2)
Biomolecules 2022 Feb 19;12(2)
Metabolon formation regulates branched-chain amino acid oxidation and homeostasis.
Patrick M, Gu Z, Zhang G, Wynn RM, Kaphle P, Cao H, Vu H, Cai F, Gao X, Zhang Y, Chen M, Ni M, Chuang DT, DeBerardinis RJ, Xu J
Nature metabolism 2022 Dec;4(12):1775-1791
Nature metabolism 2022 Dec;4(12):1775-1791
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis.
Liang C, Zhang S, Robinson D, Ploeg MV, Wilson R, Nah J, Taylor D, Beh S, Lim R, Sun L, Muoio DM, Stroud DA, Ho L
Cell reports 2022 Aug 16;40(7):111204
Cell reports 2022 Aug 16;40(7):111204
Disrupted liver oxidative metabolism in glycine N-methyltransferase-deficient mice is mitigated by dietary methionine restriction.
Rome FI, Hughey CC
Molecular metabolism 2022 Apr;58:101452
Molecular metabolism 2022 Apr;58:101452
ING2 Controls Mitochondrial Respiration via Modulating MRPL12 Ubiquitination in Renal Tubular Epithelial Cells.
Yang Y, Li C, Gu X, Zhen J, Zhu S, Lv T, Wan Q, Liu Y
Frontiers in cell and developmental biology 2021;9:700195
Frontiers in cell and developmental biology 2021;9:700195
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
Punicalagin Protects Against Diabetic Cardiomyopathy by Promoting Opa1-Mediated Mitochondrial Fusion via Regulating PTP1B-Stat3 Pathway.
Fu F, Liu C, Shi R, Li M, Zhang M, Du Y, Wang Q, Li J, Wang G, Pei J, Ding M
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Antioxidants & redox signaling 2021 Sep;35(8):618-641
Brown adipocyte ATF4 activation improves thermoregulation and systemic metabolism.
Paulo E, Zhang Y, Masand R, Huynh TL, Seo Y, Swaney DL, Soucheray M, Stevenson E, Jimenez-Morales D, Krogan NJ, Wang B
Cell reports 2021 Sep 21;36(12):109742
Cell reports 2021 Sep 21;36(12):109742
Melatonin protects against excessive autophagy-induced mitochondrial and ovarian reserve function deficiency though ERK signaling pathway in Chinese hamster ovary (CHO) cells.
Xie QE, Wang MY, Cao ZP, Du X, Ji DM, Liang D, Cao YX, Liu YJ
Mitochondrion 2021 Nov;61:44-53
Mitochondrion 2021 Nov;61:44-53
Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Zhang Q, He X, Yao S, Lin T, Zhang L, Chen D, Chen C, Yang Q, Li F, Zhu YM, Guan MX
Nucleic acids research 2021 May 7;49(8):4689-4704
Nucleic acids research 2021 May 7;49(8):4689-4704
Malic enzyme 2 connects the Krebs cycle intermediate fumarate to mitochondrial biogenesis.
Wang YP, Sharda A, Xu SN, van Gastel N, Man CH, Choi U, Leong WZ, Li X, Scadden DT
Cell metabolism 2021 May 4;33(5):1027-1041.e8
Cell metabolism 2021 May 4;33(5):1027-1041.e8
A novel nonsense variant in MT-CO3 causes MELAS syndrome.
Wang W, Sun Y, Lin Y, Xu X, Zhao D, Ji K, Li W, Zhao Y, Yan C
Neuromuscular disorders : NMD 2021 Jun;31(6):558-565
Neuromuscular disorders : NMD 2021 Jun;31(6):558-565
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import.
Lin BC, Phung TH, Higgins NR, Greenslade JE, Prado MA, Finley D, Karbowski M, Polster BM, Monteiro MJ
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Human molecular genetics 2021 Jun 17;30(13):1230-1246
Mitochondrial functional resilience after TFAM ablation in the adult heart.
Ghazal N, Peoples JN, Mohiuddin TA, Kwong JQ
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C929-C942
American journal of physiology. Cell physiology 2021 Jun 1;320(6):C929-C942
miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes.
Tai Y, Pu M, Yuan L, Guo H, Qiao J, Lu H, Wang G, Chen J, Qi X, Tao Z, Ren J
Life sciences 2021 Jul 1;276:119415
Life sciences 2021 Jul 1;276:119415
An animal model for mitochondrial tyrosyl-tRNA synthetase deficiency reveals links between oxidative phosphorylation and retinal function.
Jin X, Zhang Z, Nie Z, Wang C, Meng F, Yi Q, Chen M, Sun J, Zou J, Jiang P, Guan MX
The Journal of biological chemistry 2021 Jan-Jun;296:100437
The Journal of biological chemistry 2021 Jan-Jun;296:100437
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development.
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, He H, Lu B, Song Z
EMBO reports 2021 Jan 7;22(1):e50827
EMBO reports 2021 Jan 7;22(1):e50827
Deficiency of β-carotene oxygenase 2 induces mitochondrial fragmentation and activates the STING-IRF3 pathway in the mouse hypothalamus.
Wu L, Guo X, Wong SY, Lu P, Hartson SD, Medeiros DM, Wang W, Clarke SL, Lucas EA, Smith BJ, Chowanadisai W, Lin D
The Journal of nutritional biochemistry 2021 Feb;88:108542
The Journal of nutritional biochemistry 2021 Feb;88:108542
Active RNA interference in mitochondria.
Gao K, Cheng M, Zuo X, Lin J, Hoogewijs K, Murphy MP, Fu XD, Zhang X
Cell research 2021 Feb;31(2):219-228
Cell research 2021 Feb;31(2):219-228
NPC1-mTORC1 Signaling Couples Cholesterol Sensing to Organelle Homeostasis and Is a Targetable Pathway in Niemann-Pick Type C.
Davis OB, Shin HR, Lim CY, Wu EY, Kukurugya M, Maher CF, Perera RM, Ordonez MP, Zoncu R
Developmental cell 2021 Feb 8;56(3):260-276.e7
Developmental cell 2021 Feb 8;56(3):260-276.e7
Transcription of MRPL12 regulated by Nrf2 contributes to the mitochondrial dysfunction in diabetic kidney disease.
Gu X, Liu Y, Wang N, Zhen J, Zhang B, Hou S, Cui Z, Wan Q, Feng H
Free radical biology & medicine 2021 Feb 20;164:329-340
Free radical biology & medicine 2021 Feb 20;164:329-340
Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth.
Deng Z, Li X, Blanca Ramirez M, Purtell K, Choi I, Lu JH, Yu Q, Yue Z
Proceedings of the National Academy of Sciences of the United States of America 2021 Apr 6;118(14)
Proceedings of the National Academy of Sciences of the United States of America 2021 Apr 6;118(14)
Celecoxib Exerts a Therapeutic Effect Against Demyelination by Improving the Immune and Inflammatory Microenvironments.
Cao P, Zhang H, Meng H, Cheng Y, Xu H, Zang S, Li Z, Cui J, Li Y
Journal of inflammation research 2020;13:1043-1055
Journal of inflammation research 2020;13:1043-1055
SIRT1-dependent mitochondrial biogenesis supports therapeutic effects of resveratrol against neurodevelopment damage by fluoride.
Zhao Q, Tian Z, Zhou G, Niu Q, Chen J, Li P, Dong L, Xia T, Zhang S, Wang A
Theranostics 2020;10(11):4822-4838
Theranostics 2020;10(11):4822-4838
miR-29a Modulates GSK3β/SIRT1-Linked Mitochondrial Proteostatic Stress to Ameliorate Mouse Non-Alcoholic Steatohepatitis.
Yang YL, Wang PW, Wang FS, Lin HY, Huang YH
International journal of molecular sciences 2020 Sep 19;21(18)
International journal of molecular sciences 2020 Sep 19;21(18)
δ-opioid receptor activation protects against Parkinson's disease-related mitochondrial dysfunction by enhancing PINK1/Parkin-dependent mitophagy.
Xu Y, Zhi F, Mao J, Peng Y, Shao N, Balboni G, Yang Y, Xia Y
Aging 2020 Nov 10;12(24):25035-25059
Aging 2020 Nov 10;12(24):25035-25059
DIPK2A promotes STX17- and VAMP7-mediated autophagosome-lysosome fusion by binding to VAMP7B.
Tian X, Zheng P, Zhou C, Wang X, Ma H, Ma W, Zhou X, Teng J, Chen J
Autophagy 2020 May;16(5):797-810
Autophagy 2020 May;16(5):797-810
The lysosomal membrane protein LAMP-2 is dispensable for PINK1/Parkin-mediated mitophagy.
Liu X, Liao X, Rao X, Wang B, Zhang J, Xu G, Jiang X, Qin X, Chen C, Zou Z
FEBS letters 2020 Mar;594(5):823-840
FEBS letters 2020 Mar;594(5):823-840
The human mitochondrial 12S rRNA m(4)C methyltransferase METTL15 is required for mitochondrial function.
Chen H, Shi Z, Guo J, Chang KJ, Chen Q, Yao CH, Haigis MC, Shi Y
The Journal of biological chemistry 2020 Jun 19;295(25):8505-8513
The Journal of biological chemistry 2020 Jun 19;295(25):8505-8513
Transketolase Deficiency in Adipose Tissues Protects Mice From Diet-Induced Obesity by Promoting Lipolysis.
Tian N, Liu Q, Li Y, Tong L, Lu Y, Zhu Y, Zhang P, Chen H, Hu L, Meng J, Feng M, Li M, Zheng L, Li B, Xu T, Wu L, Tong X
Diabetes 2020 Jul;69(7):1355-1367
Diabetes 2020 Jul;69(7):1355-1367
Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.
Lou F, Sun Y, Xu Z, Niu L, Wang Z, Deng S, Liu Z, Zhou H, Bai J, Yin Q, Cai X, Sun L, Wang H, Li Q, Wu Z, Chen X, Gu J, Shi YL, Tao W, Ginhoux F, Wang H
Immunity 2020 Jul 14;53(1):204-216.e10
Immunity 2020 Jul 14;53(1):204-216.e10
Mitochondrial miR-181a-5p promotes glucose metabolism reprogramming in liver cancer by regulating the electron transport chain.
Zhuang X, Chen Y, Wu Z, Xu Q, Chen M, Shao M, Cao X, Zhou Y, Xie M, Shi Y, Zeng Y, Bu H
Carcinogenesis 2020 Jul 14;41(7):972-983
Carcinogenesis 2020 Jul 14;41(7):972-983
Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction.
Liu L, Wang F, Tong Y, Li LF, Liu Y, Gao WQ
Cell proliferation 2020 Jan;53(1):e12718
Cell proliferation 2020 Jan;53(1):e12718
SQSTM1/p62 Controls mtDNA Expression and Participates in Mitochondrial Energetic Adaption via MRPL12.
Ma Y, Zhu S, Lv T, Gu X, Feng H, Zhen J, Xin W, Wan Q
iScience 2020 Aug 21;23(8):101428
iScience 2020 Aug 21;23(8):101428
Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts.
Lin TK, Chen SD, Chuang YC, Lan MY, Chuang JH, Wang PW, Hsu TY, Wang FS, Tsai MH, Huang ST, Wang XW, Tsai PC, Lin HY, Liou CW
Oxidative medicine and cellular longevity 2019;2019:9537504
Oxidative medicine and cellular longevity 2019;2019:9537504
Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells.
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, Xiao F, Guo L
Oxidative medicine and cellular longevity 2019;2019:4508762
Oxidative medicine and cellular longevity 2019;2019:4508762
The Circadian Protein Nocturnin Regulates Metabolic Adaptation in Brown Adipose Tissue.
Onder Y, Laothamatas I, Berto S, Sewart K, Kilaru G, Bordieanu B, Stubblefield JJ, Konopka G, Mishra P, Green CB
iScience 2019 Sep 27;19:83-92
iScience 2019 Sep 27;19:83-92
Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.
Wu H, Wang Y, Li W, Chen H, Du L, Liu D, Wang X, Xu T, Liu L, Chen Q
Autophagy 2019 Nov;15(11):1882-1898
Autophagy 2019 Nov;15(11):1882-1898
EGFL9 promotes breast cancer metastasis by inducing cMET activation and metabolic reprogramming.
Meng F, Wu L, Dong L, Mitchell AV, James Block C, Liu J, Zhang H, Lu Q, Song WM, Zhang B, Chen W, Hu J, Wang J, Yang Q, Hüttemann M, Wu G
Nature communications 2019 Nov 6;10(1):5033
Nature communications 2019 Nov 6;10(1):5033
The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
Wang K, Ma H, Liu H, Ye W, Li Z, Cheng L, Zhang L, Lei Y, Shen L, Zhang F
Cell reports 2019 May 14;27(7):2075-2091.e5
Cell reports 2019 May 14;27(7):2075-2091.e5
ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects.
Zhao Y, Sun X, Hu D, Prosdocimo DA, Hoppel C, Jain MK, Ramachandran R, Qi X
Nature communications 2019 Mar 26;10(1):1371
Nature communications 2019 Mar 26;10(1):1371
Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism.
Chen D, Zhang Z, Chen C, Yao S, Yang Q, Li F, He X, Ai C, Wang M, Guan MX
Nucleic acids research 2019 Jun 4;47(10):5341-5355
Nucleic acids research 2019 Jun 4;47(10):5341-5355
Avenanthramide A triggers potent ROS-mediated anti-tumor effects in colorectal cancer by directly targeting DDX3.
Fu R, Yang P, Li Z, Liu W, Amin S, Li Z
Cell death & disease 2019 Aug 7;10(8):593
Cell death & disease 2019 Aug 7;10(8):593
Protective effects of β- nicotinamide adenine dinucleotide against motor deficits and dopaminergic neuronal damage in a mouse model of Parkinson's disease.
Shan C, Gong YL, Zhuang QQ, Hou YF, Wang SM, Zhu Q, Huang GR, Tao B, Sun LH, Zhao HY, Li ST, Liu JM
Progress in neuro-psychopharmacology & biological psychiatry 2019 Aug 30;94:109670
Progress in neuro-psychopharmacology & biological psychiatry 2019 Aug 30;94:109670
Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling.
Tang Y, Huang W, Song Q, Zheng X, He R, Liu J
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
Evidence-based complementary and alternative medicine : eCAM 2018;2018:3063145
Protein coding mitochondrial-targeted RNAs rescue mitochondrial disease in vivo.
Markantone DM, Towheed A, Crain AT, Collins JM, Celotto AM, Palladino MJ
Neurobiology of disease 2018 Sep;117:203-210
Neurobiology of disease 2018 Sep;117:203-210
In vitro rejuvenation of brain mitochondria by the inhibition of actin polymerization.
Takahashi K, Miura Y, Ohsawa I, Shirasawa T, Takahashi M
Scientific reports 2018 Oct 22;8(1):15585
Scientific reports 2018 Oct 22;8(1):15585
Deletion of Mtu1 (Trmu) in zebrafish revealed the essential role of tRNA modification in mitochondrial biogenesis and hearing function.
Zhang Q, Zhang L, Chen D, He X, Yao S, Zhang Z, Chen Y, Guan MX
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Nucleic acids research 2018 Nov 16;46(20):10930-10945
Proteome Imbalance of Mitochondrial Electron Transport Chain in Brown Adipocytes Leads to Metabolic Benefits.
Masand R, Paulo E, Wu D, Wang Y, Swaney DL, Jimenez-Morales D, Krogan NJ, Wang B
Cell metabolism 2018 Mar 6;27(3):616-629.e4
Cell metabolism 2018 Mar 6;27(3):616-629.e4
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis.
Ziegler PK, Bollrath J, Pallangyo CK, Matsutani T, Canli Ö, De Oliveira T, Diamanti MA, Müller N, Gamrekelashvili J, Putoczki T, Horst D, Mankan AK, Öner MG, Müller S, Müller-Höcker J, Kirchner T, Slotta-Huspenina J, Taketo MM, Reinheckel T, Dröse S, Larner AC, Wels WS, Ernst M, Greten TF, Arkan MC, Korn T, Wirth D, Greten FR
Cell 2018 Jun 28;174(1):88-101.e16
Cell 2018 Jun 28;174(1):88-101.e16
Cryo-EM structure of human mitochondrial trifunctional protein.
Liang K, Li N, Wang X, Dai J, Liu P, Wang C, Chen XW, Gao N, Xiao J
Proceedings of the National Academy of Sciences of the United States of America 2018 Jul 3;115(27):7039-7044
Proceedings of the National Academy of Sciences of the United States of America 2018 Jul 3;115(27):7039-7044
Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis.
Paulo E, Wu D, Wang Y, Zhang Y, Wu Y, Swaney DL, Soucheray M, Jimenez-Morales D, Chawla A, Krogan NJ, Wang B
Scientific reports 2018 Jul 20;8(1):11001
Scientific reports 2018 Jul 20;8(1):11001
Quantitative proteomics in Friedreich's ataxia B-lymphocytes: A valuable approach to decipher the biochemical events responsible for pathogenesis.
Télot L, Rousseau E, Lesuisse E, Garcia C, Morlet B, Léger T, Camadro JM, Serre V
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):997-1009
Biochimica et biophysica acta. Molecular basis of disease 2018 Apr;1864(4 Pt A):997-1009
Phospholipase A2 of Peroxiredoxin 6 Plays a Critical Role in Cerebral Ischemia/Reperfusion Inflammatory Injury.
Shanshan Y, Beibei J, Li T, Minna G, Shipeng L, Li P, Yong Z
Frontiers in cellular neuroscience 2017;11:99
Frontiers in cellular neuroscience 2017;11:99
Florfenicol-induced Mitochondrial Dysfunction Suppresses Cell Proliferation and Autophagy in Fibroblasts.
Hu D, Cao S, Zhang G, Xiao Y, Liu S, Shang Y
Scientific reports 2017 Oct 19;7(1):13554
Scientific reports 2017 Oct 19;7(1):13554
DJ-1 modulates mitochondrial response to oxidative stress: clues from a novel diagnosis of PARK7.
Di Nottia M, Masciullo M, Verrigni D, Petrillo S, Modoni A, Rizzo V, Di Giuda D, Rizza T, Niceta M, Torraco A, Bianchi M, Santoro M, Bentivoglio AR, Bertini E, Piemonte F, Carrozzo R, Silvestri G
Clinical genetics 2017 Jul;92(1):18-25
Clinical genetics 2017 Jul;92(1):18-25
Base-Resolution Mapping Reveals Distinct m(1)A Methylome in Nuclear- and Mitochondrial-Encoded Transcripts.
Li X, Xiong X, Zhang M, Wang K, Chen Y, Zhou J, Mao Y, Lv J, Yi D, Chen XW, Wang C, Qian SB, Yi C
Molecular cell 2017 Dec 7;68(5):993-1005.e9
Molecular cell 2017 Dec 7;68(5):993-1005.e9
Bovine and murine models highlight novel roles for SLC25A46 in mitochondrial dynamics and metabolism, with implications for human and animal health.
Duchesne A, Vaiman A, Castille J, Beauvallet C, Gaignard P, Floriot S, Rodriguez S, Vilotte M, Boulanger L, Passet B, Albaric O, Guillaume F, Boukadiri A, Richard L, Bertaud M, Timsit E, Guatteo R, Jaffrézic F, Calvel P, Helary L, Mahla R, Esquerré D, Péchoux C, Liuu S, Vallat JM, Boichard D, Slama A, Vilotte JL
PLoS genetics 2017 Apr;13(4):e1006597
PLoS genetics 2017 Apr;13(4):e1006597
Neuroprotective effects of Kaempferide-7-O-(4″-O-acetylrhamnosyl)-3-O-rutinoside on cerebral ischemia-reperfusion injury in rats.
Wang S, Xu H, Xin Y, Li M, Fu W, Wang Y, Lu Z, Yu X, Sui D
European journal of pharmacology 2016 Oct 5;788:335-342
European journal of pharmacology 2016 Oct 5;788:335-342
A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway.
Jiang X, Li L, Ying Z, Pan C, Huang S, Li L, Dai M, Yan B, Li M, Jiang H, Chen S, Zhang Z, Wang X
Molecular cell 2016 Jul 21;63(2):229-239
Molecular cell 2016 Jul 21;63(2):229-239
COA7 (C1orf163/RESA1) mutations associated with mitochondrial leukoencephalopathy and cytochrome c oxidase deficiency.
Martinez Lyons A, Ardissone A, Reyes A, Robinson AJ, Moroni I, Ghezzi D, Fernandez-Vizarra E, Zeviani M
Journal of medical genetics 2016 Dec;53(12):846-849
Journal of medical genetics 2016 Dec;53(12):846-849
Prolyl Hydroxylase 3 Attenuates MCL-1-Mediated ATP Production to Suppress the Metastatic Potential of Colorectal Cancer Cells.
Radhakrishnan P, Ruh N, Harnoss JM, Kiss J, Mollenhauer M, Scherr AL, Platzer LK, Schmidt T, Podar K, Opferman JT, Weitz J, Schulze-Bergkamen H, Koehler BC, Ulrich A, Schneider M
Cancer research 2016 Apr 15;76(8):2219-30
Cancer research 2016 Apr 15;76(8):2219-30
EglN2 associates with the NRF1-PGC1α complex and controls mitochondrial function in breast cancer.
Zhang J, Wang C, Chen X, Takada M, Fan C, Zheng X, Wen H, Liu Y, Wang C, Pestell RG, Aird KM, Kaelin WG Jr, Liu XS, Zhang Q
The EMBO journal 2015 Dec 2;34(23):2953-70
The EMBO journal 2015 Dec 2;34(23):2953-70
Acetaminophen-induced liver damage in mice is associated with gender-specific adduction of peroxiredoxin-6.
Mohar I, Stamper BD, Rademacher PM, White CC, Nelson SD, Kavanagh TJ
Redox biology 2014;2:377-87
Redox biology 2014;2:377-87
Small mitochondrial-targeted RNAs modulate endogenous mitochondrial protein expression in vivo.
Towheed A, Markantone DM, Crain AT, Celotto AM, Palladino MJ
Neurobiology of disease 2014 Sep;69:15-22
Neurobiology of disease 2014 Sep;69:15-22
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HepG2 cells were subjected to SDS PAGE followed by western blot with 55070-1-AP(COX2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 55070-1-AP(COX2 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 55070-1-AP(COX2 antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MTCO2 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human MTCO2. This antibody recognizes human,mouse,rat antigen. The MTCO2 antibody has been validated for the following applications: ELISA, IHC, WB, FC analysis.
