66674-1-Ig

antibody from Proteintech Group

Targeting: PRKN AR-JP, PARK2, parkin, PDJ

Provider product page for 66674-1-Ig

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Antibody data

Antibody Data
Antigen structure
References [36]
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Product number: 66674-1-Ig - Provider product page
Provider: Proteintech Group
Product name: PARK2/Parkin antibody
Antibody type: Monoclonal
Description: PARK2/Parkin antibody (Cat. #66674-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
Reactivity: Human, Mouse
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2H5A7
Vial size: 20ul, 150ul

PRKN protein structure - 66674-1-Ig shown in red.

Submitted references Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin-Mediated Mitophagy.

Zhang Y, Wang Z, Jia C, Yu W, Li X, Xia N, Nie H, Wikana LP, Chen M, Ni Y, Han S, Pu L
Cellular and molecular gastroenterology and hepatology 2024;17(1):149-169

Protection of Ndrg2 deficiency on renal ischemia-reperfusion injury via activating PINK1/Parkin-mediated mitophagy.

Liu M, Chen J, Sun M, Zhang L, Yu Y, Mi W, Ma Y, Wang G
Chinese medical journal 2024 Nov 5;137(21):2603-2614

Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA(2).

Zhao W, Liu J, Wang S, Tao Q, Lei Q, Huang C
Toxicon : official journal of the International Society on Toxinology 2024 May 6;242:107694

ErZhiTianGui Decoction alleviates age-related ovarian aging by regulating mitochondrial homeostasis and inhibiting ferroptosis.

Zhicheng J, Yongqian L, Peixuan W, Kai Y, Mengyu S, Wen C, Qihui L, Ying G
Journal of ovarian research 2024 Jan 10;17(1):12

VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.

Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S
Redox biology 2024 Apr;70:103062

Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.

Zhang H, Wang H, Hu Y, Gao Y, Chen J, Meng Y, Qiu Y, Hu R, Liao P, Li M, He Y, Liang Z, Xie X, Li Y
Cancer letters 2024 Apr 28;588:216802

A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.

Liu X, Devadiga SA, Stanley RF, Morrow R, Janssen K, Quesnel-Vallières M, Pomp O, Moverley AA, Li C, Skuli N, Carroll MP, Huang J, Wallace DC, Lynch KW, Abdel-Wahab O, Klein PS
bioRxiv : the preprint server for biology 2024 Apr 23;

CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy.

Zhou Y, Liu Y, Kang Z, Yao H, Song N, Wang M, Song C, Zhang K, Ding J, Tang J, Hu G, Lu M
Autophagy 2023 Sep;19(9):2520-2537

Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.

Hou L, Wang G, Zhang X, Lu F, Xu J, Guo Z, Lin J, Zheng Z, Liu H, Hou Y, Sun K, Guo F
iScience 2023 Sep 15;26(9):107647

PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.

Yang Q, Zou Y, Wei X, Ye P, Wu Y, Ai H, Zhang Z, Tan J, Zhou J, Yang Y, Dai Q, Dou C, Luo F
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795

Grape seed proanthocyanidins regulate mitophagy of endothelial cells and promote wound healing in mice through p-JNK/FOXO3a/ROS signal pathway.

Chen L, Hao L, Yanshuo C, FangFang W, Daqin C, Weidong X, Jian X, Shaodong C, Hongyu Z, Ke X
Archives of biochemistry and biophysics 2023 Nov;749:109790

Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.

Zhou J, Meng L, He Z, Song Q, Liu J, Su X, Wang C, Ke H, Dong C, Liao W, Yang S
International immunopharmacology 2023 Nov;124(Pt A):110801

Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.

Luo L, Zhang H, Zhang S, Luo C, Kan X, Lv J, Zhao P, Tian Z, Li C
Journal of nanobiotechnology 2023 Nov 29;21(1):455

Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.

Xu B, Zhou Z, Fang J, Wang J, Tao K, Liu J, Liu S
Free radical biology & medicine 2023 Nov 1;208:319-333

Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells.

Zhang Z, Cui S, Fu Y, Wang J, Liu J, Wei F
Cellular & molecular biology letters 2023 Jul 21;28(1):57

Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.

Fihurka O, Wang Y, Hong Y, Lin X, Shen N, Yang H, Brown B, Mommer M, Zieneldien T, Li Y, Kim J, Li M, Cai J, Zhou Q, Cao C
Biomolecules 2023 Jan 25;13(2)

Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.

Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y
Journal of translational medicine 2023 Jan 13;21(1):24

Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.

Hu Y, Jiang H, Xu Y, Chen G, Fan R, Zhou Y, Liu Y, Yao Y, Liu R, Chen W, Zhang K, Chen X, Wang R, Qiu Z
Cell death discovery 2023 Feb 14;9(1):63

The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells.

Cheng J, Wang Y, Yin L, Liang W, Zhang J, Ma C, Zhang Y, Liu B, Wang J, Zhao W, Li M, Wei L
mBio 2023 Dec 19;14(6):e0148023

Mitophagy-dependent cardioprotection of resistance training on heart failure.

Guo C, Wu RY, Dou JH, Song SF, Sun XL, Hu YW, Guo FS, Wei J, Lin L, Wei J
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Dec 1;135(6):1390-1401

Ubiquitination of Ku70 by Parkin promotes apoptosis of lens epithelial cells.

Zhang W, Wu A, Zhang G, Ding X, Kang L, Zhou T, Ji M, Guan H
The FEBS journal 2023 Aug;290(15):3828-3842

Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.

Han GJ, Min XZ, Ma SS, Ding C, Wang XQ
Oxidative medicine and cellular longevity 2022;2022:5126042

San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.

Li H, Wang Y, Su X, Wang Q, Zhang S, Sun W, Zhang T, Dong M, Zhang Z, Lv S
Journal of diabetes research 2022;2022:2640209

Long non-coding RNA VAL facilitates PKM2 enzymatic activity to promote glycolysis and malignancy of gastric cancer.

Dai T, Zhang X, Zhou X, Hu X, Huang X, Xing F, Tian H, Li Y
Clinical and translational medicine 2022 Oct;12(10):e1088

IL-17A promotes lung fibrosis through impairing mitochondrial homeostasis in type II alveolar epithelial cells.

Xiao H, Peng L, Jiang D, Liu Y, Zhu L, Li Z, Geng J, Xie B, Huang X, Wang J, Dai H, Wang C
Journal of cellular and molecular medicine 2022 Nov;26(22):5728-5741

Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1/Parkin pathway in rats.

Zhang D, Zheng N, Fu X, Shi J, Zhang J
Journal of thoracic disease 2022 May;14(5):1651-1662

Resveratrol alleviates enterotoxigenic Escherichia coli K88-induced damage by regulating SIRT-1 signaling in intestinal porcine epithelial cells.

Luo X, Wu S, Jia H, Si X, Song Z, Zhai Z, Bai J, Li J, Yang Y, Wu Z
Food & function 2022 Jul 4;13(13):7346-7360

Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics.

Shin YY, Seo Y, Oh SJ, Ahn JS, Song MH, Kang MJ, Oh JM, Lee D, Kim YH, Sung ES, Kim HS
Journal of pineal research 2022 Jan;72(1):e12779

Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.

Zhao YC, Guo W, Gao BH
Life sciences 2022 Feb 15;291:119340

The SMYD3-MTHFD1L-formate metabolic regulatory axis mediates mitophagy to inhibit M1 polarization in macrophages.

Zhu W, Wang C, Xue L, Liu L, Yang X, Liu Z, Zhang S, Luo D
International immunopharmacology 2022 Dec;113(Pt A):109352

Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes.

Fan W, Chen S, Wu X, Zhu J, Li J
Journal of inflammation research 2021;14:3523-3536

SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment.

Shang C, Liu Z, Zhu Y, Lu J, Ge C, Zhang C, Li N, Jin N, Li Y, Tian M, Li X
Frontiers in microbiology 2021;12:780768

Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates.

Costa-Verdera H, Collaud F, Riling CR, Sellier P, Nordin JML, Preston GM, Cagin U, Fabregue J, Barral S, Moya-Nilges M, Krijnse-Locker J, van Wittenberghe L, Daniele N, Gjata B, Cosette J, Abad C, Simon-Sola M, Charles S, Li M, Crosariol M, Antrilli T, Quinn WJ 3rd, Gross DA, Boyer O, Anguela XM, Armour SM, Colella P, Ronzitti G, Mingozzi F
Nature communications 2021 Nov 4;12(1):6393

Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.

Hirano T, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
Toxicology and applied pharmacology 2021 Nov 1;430:115723

Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway.

Wang X, Zhang JQ, Xiu CK, Yang J, Fang JY, Lei Y
Oxidative medicine and cellular longevity 2020;2020:7151946

Quantitative Mitochondrial Proteomics Reveals ANXA7 as a Crucial Factor in Mitophagy.

Meng K, Lu S, Yan X, Sun Y, Gao J, Wang Y, Yin X, Sun Z, He QY
Journal of proteome research 2020 Mar 6;19(3):1275-1284

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