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- Antigen structure
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- Product number
- 66674-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- PARK2/Parkin antibody
- Antibody type
- Monoclonal
- Description
- PARK2/Parkin antibody (Cat. #66674-1-Ig) is a mouse monoclonal antibody that shows reactivity with Human, Mouse and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2H5A7
- Vial size
- 20ul, 150ul
Submitted references Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury.
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Gentiana szechenyii Kanitz Compounds Regulate Lipopolysaccharide-Induced Inflammation and Mitochondrial Autophagy Via the Toll-Like Receptor 4-Nuclear Factor Kappa B Pathway.
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis.
The Protective Effect of Naringenin against Lead-Induced Hepatotoxicity in Rats: Mechanisms Involving Oxidative Stress Mitigation, Activation of PINK1/Parkin and Nrf2/NQO1 Pathways, and Autophagy Induction.
MG132-mediated inhibition of rabies virus replication via the Nrf2/SQSTM1/PINK1/Parkin autophagy pathway.
Morroniside maintains mitochondrial homeostasis in microglia and mitigates neuroinflammation in experimental autoimmune encephalomyelitis.
Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis.
Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway.
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal.
Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis.
Role of neuroglia cell-derived microvesicles in cobalt chloride-induced mitochondrial autophagy in neurons.
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
SIRT5 modulates mitochondria function via mitophagy and antioxidant mechanisms to facilitate oocyte maturation in mice.
The Ercc1(-/Δ) mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration.
Melatonin refines ovarian mitochondrial dysfunction in PCOS by regulating the circadian rhythm gene Clock.
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus.
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates.
Dl-3-n-Butylphthalide Alleviates Cognitive Impairment in Chronic Cerebral Hypoperfusion: Associations with Mitochondrial Permeability Transition Pore Closure and Suppression of Excessive Mitophagy.
TP53INP2 promotes mitophagic degradation of YAP to impede dedifferentiated liposarcoma development.
Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism.
Gestational exposure to carbon black nanoparticles triggered fetal growth restriction in mice: The mediation of inactivating autophagy-lysosomal degradation system in placental ferroptosis.
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle.
MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.
Dual activation of PPARα/γ by bezafibrate triggers PINK1/Parkin-Mediated mitophagy to enhance lenvatinib sensitivity in hepatocellular carcinoma.
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
TSPO participates in the pathogenesis of diabetic periodontitis related to mitophagy.
Remodeling adipocytes' lipid metabolism with a polycation loaded enzyme-active framework reverses osteoporotic bone marrow.
AIMP1 exerts hearing protection role in age related hearing loss mice by regulating SIRT1 expression.
Cordycepin Ameliorates Kainic Acid-Induced HT22 Cell Neurotoxicity by Activating GPR120-Mediated Mitophagy.
Engineered Extracellular Vesicles Derived from Juvenile Mice Enhance Mitochondrial Function in the Aging Bone Microenvironment and Achieve Rejuvenation.
Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin-Mediated Mitophagy.
NLRP3 Inflammasome Deficiency Alleviates Inflammation and Oxidative Stress by Promoting PINK1/Parkin-Mediated Mitophagy in Allergic Rhinitis Mice and Nasal Epithelial Cells.
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
Mutant NOTCH3ECD Triggers Defects in Mitochondrial Function and Mitophagy in CADASIL Cell Models.
PKD regulates mitophagy to prevent oxidative stress and mitochondrial dysfunction during mouse oocyte maturation.
Targeting translocator protein protects against myocardial ischemia/reperfusion injury by alleviating mitochondrial dysfunction.
PRDM1 promotes nucleus pulposus cell pyroptosis leading to intervertebral disc degeneration via activating CASP1 transcription.
Morusin, a novel inhibitor of ACLY, induces mitochondrial apoptosis in hepatocellular carcinoma cells through ROS-mediated mitophagy.
Protection of Ndrg2 deficiency on renal ischemia-reperfusion injury via activating PINK1/Parkin-mediated mitophagy.
Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.
Mechanism of cigarette smoke in promoting small airway remodeling in mice via STAT 3 / PINK 1-Parkin / EMT.
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA(2).
Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1/Parkin signaling and intestinal flora.
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
PARK2 suppresses the proliferation of high-grade serous ovarian carcinoma via inducing the proteasomal degradation of ZNF703.
SMYD3 activates the TCA cycle to promote M1-M2 conversion in macrophages.
ErZhiTianGui Decoction alleviates age-related ovarian aging by regulating mitochondrial homeostasis and inhibiting ferroptosis.
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy.
Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.
Grape seed proanthocyanidins regulate mitophagy of endothelial cells and promote wound healing in mice through p-JNK/FOXO3a/ROS signal pathway.
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.
Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells.
Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells.
Mitophagy-dependent cardioprotection of resistance training on heart failure.
Ubiquitination of Ku70 by Parkin promotes apoptosis of lens epithelial cells.
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.
Long non-coding RNA VAL facilitates PKM2 enzymatic activity to promote glycolysis and malignancy of gastric cancer.
IL-17A promotes lung fibrosis through impairing mitochondrial homeostasis in type II alveolar epithelial cells.
Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1/Parkin pathway in rats.
Resveratrol alleviates enterotoxigenic Escherichia coli K88-induced damage by regulating SIRT-1 signaling in intestinal porcine epithelial cells.
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics.
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.
The SMYD3-MTHFD1L-formate metabolic regulatory axis mediates mitophagy to inhibit M1 polarization in macrophages.
Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes.
SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment.
Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates.
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.
Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway.
Quantitative Mitochondrial Proteomics Reveals ANXA7 as a Crucial Factor in Mitophagy.
Yao M, Wang X, Wei H, Wang L, Zhang D, Liang Z, He R, He Y, Jiang L, Cui Y
Frontiers in pharmacology 2026;17:1716078
Frontiers in pharmacology 2026;17:1716078
Astragalus membranaceus Polysaccharides Attenuate Osteoarthritis in Human Primary Chondrocytes and in Animal Model: Mechanism Study Using RNA-Seq and Network Pharmacology.
Xu H, Li Y, Wang J, Xin Y, Xu Q, Qin X, Yang X, Yan Y, Chen Q, Chen Y, Zhang Y, Lu C, Xu K, Wang X
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Phytotherapy research : PTR 2026 May;40(5):2249-2269
Gentiana szechenyii Kanitz Compounds Regulate Lipopolysaccharide-Induced Inflammation and Mitochondrial Autophagy Via the Toll-Like Receptor 4-Nuclear Factor Kappa B Pathway.
Zhang H, Zhang Z, Hu J, Li Y, Nan X, Yang F
Chemistry & biodiversity 2026 Mar;23(3):e03838
Chemistry & biodiversity 2026 Mar;23(3):e03838
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Zhang Y, Shen X, Shen Y, Wang C, Yu C, Han J, Cao S, Qian L, Ma M, Huang S, Wen W, Yin M, Lei QY
Nature 2026 Jan;649(8098):1022-1031
Nature 2026 Jan;649(8098):1022-1031
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fu T, Sun S, Wang Z, Zhao F, Zhen J, Ji X, Xue F, Mu Q, Wang Y, Liu Y, Wan Q
Cardiovascular diabetology 2026 Feb 3;25(1)
Cardiovascular diabetology 2026 Feb 3;25(1)
The parkin-γ-tubulin axis regulates epidermal homeostasis and is associated with the susceptibility to psoriasis.
Liu Y, Yan S, Wang J, Dong D, Yan S, Yin H, Liu K, Liu M, Liu H, Li D, Gao J, Xie W, Zhou J
Cell death and differentiation 2026 Feb 27;
Cell death and differentiation 2026 Feb 27;
The Protective Effect of Naringenin against Lead-Induced Hepatotoxicity in Rats: Mechanisms Involving Oxidative Stress Mitigation, Activation of PINK1/Parkin and Nrf2/NQO1 Pathways, and Autophagy Induction.
Ngwe PK, Zhu J, Ling H, Gao M, Guo C, Hu Y, Wang J
Biological trace element research 2026 Feb 19;
Biological trace element research 2026 Feb 19;
MG132-mediated inhibition of rabies virus replication via the Nrf2/SQSTM1/PINK1/Parkin autophagy pathway.
Chi YL, Yang N, Xie Y, Tao X, Yu P, Liu Q, Zhang M, Liu SQ, Zhu WY
Virology journal 2026 Apr 29;
Virology journal 2026 Apr 29;
Morroniside maintains mitochondrial homeostasis in microglia and mitigates neuroinflammation in experimental autoimmune encephalomyelitis.
Zhai S, Jiang T, Cheng X, Li X, Wang Q, Fu Q, Yuan B, Wu F, Wang M
Journal of neuropathology and experimental neurology 2026 Apr 20;
Journal of neuropathology and experimental neurology 2026 Apr 20;
Targeting Dio3 to enhance mitophagy and ameliorate skeletal muscle wasting in sepsis.
Wang G, Chen M, Zhang Y, Wang D, Gao T, Duan J, Lu H, Cheng M, Xu Y, Li X, Wang Y, Cao K, Yu W
Redox biology 2025 Sep;85:103751
Redox biology 2025 Sep;85:103751
Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway.
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Cell proliferation 2025 Oct;58(10):e70044
Cell proliferation 2025 Oct;58(10):e70044
Spontaneous hydrogen-releasing nanoenzyme alleviates osteoarthritis via oxidative stress reduction and mitochondrial dysfunction reversal.
Wang Q, Zhang M, Jiang W, Li D, Qi B, Shi S, Shi S, Yi C
Journal of nanobiotechnology 2025 Oct 11;23(1):662
Journal of nanobiotechnology 2025 Oct 11;23(1):662
Targeting SIRT3 to regulate mitophagy-dependent ferroptosis for preventing glucocorticoid-induced osteoporosis.
Hu Y, Lu H, Fang H, Chen B, Chen Z, Jiang M, Zhou Y, Li Z, Gao S, Huang Z, Zhou C, Liu Y, Chen Z, Fan Y
International journal of surgery (London, England) 2025 Oct 1;111(10):6647-6662
International journal of surgery (London, England) 2025 Oct 1;111(10):6647-6662
Role of neuroglia cell-derived microvesicles in cobalt chloride-induced mitochondrial autophagy in neurons.
Li H, Zheng F, Shao W, Yu G, Hu H, Guo Z, Wu S, Tang Y, Li H
Toxicology 2025 Nov;517:154214
Toxicology 2025 Nov;517:154214
Deletion of ABIN1-LIR motifs impairs hepatic lipid homeostasis and mitophagy via AMPK-TFEB axis in mice.
Huber LS, Merline R, Zeng-Brouwers J, Vutukuri R, Kraus N, Ortiz C, Guenther S, Buhl EM, Hahnefeld L, Gurke R, Bein J, Karimova M, Wurzel P, Boor P, Welsch C, Wild P, Pfeilschifter J, Kögel D, Wygrecka M, Trebicka J, Bartoszewski R, Dikic I, Schaefer L
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1360-C1379
American journal of physiology. Cell physiology 2025 Nov 1;329(5):C1360-C1379
SIRT5 modulates mitochondria function via mitophagy and antioxidant mechanisms to facilitate oocyte maturation in mice.
Yan JJ, Wang YY, Shi ZY, Ding YY, Wen HQ, Wu MP, Sun SC, Cai YF, Zhang Y
International journal of biological macromolecules 2025 May;306(Pt 2):141488
International journal of biological macromolecules 2025 May;306(Pt 2):141488
The Ercc1(-/Δ) mouse model of XFE progeroid syndrome undergoes accelerated retinal degeneration.
Narasimhan A, Min SH, Johnson LL, Roehrich H, Cho W, Her TK, Windschitl C, O'Kelly RD, Angelini L, Yousefzadeh MJ, McLoon LK, Hauswirth WW, Robbins PD, Skowronska-Krawczyk D, Niedernhofer LJ
Aging cell 2025 Mar;24(3):e14419
Aging cell 2025 Mar;24(3):e14419
Melatonin refines ovarian mitochondrial dysfunction in PCOS by regulating the circadian rhythm gene Clock.
Chen W, Zhang H, Guo B, Tao Y, Zhang J, Wang J, Chen G, Cheng M, Hong Q, Cao Y, Xie F
Cellular and molecular life sciences : CMLS 2025 Mar 6;82(1):104
Cellular and molecular life sciences : CMLS 2025 Mar 6;82(1):104
Enhanced SIRT3 expression restores mitochondrial quality control mechanism to reverse osteogenic impairment in type 2 diabetes mellitus.
Xian Y, Liu B, Shen T, Yang L, Peng R, Shen H, An X, Wang Y, Ben Y, Jiang Q, Guo B
Bone research 2025 Mar 3;13(1):30
Bone research 2025 Mar 3;13(1):30
P2Y6R Inhibition Induces Microglial M2 Polarization by Promoting PINK1/Parkin-Dependent Mitophagy After Spinal Cord Injury.
Lin J, Sun Y, Huang H, Yu C, Kuang W, Wang Y, Zhu L
Molecular neurobiology 2025 Jun;62(6):7054-7074
Molecular neurobiology 2025 Jun;62(6):7054-7074
An AI-assisted fluorescence microscopic system for screening mitophagy inducers by simultaneous analysis of mitophagic intermediates.
Wang Y, Song P, Zhou H, Wang P, Li Y, Shao Z, Wang L, You Y, Lei Z, Yu J, Li C
Nature communications 2025 Jun 4;16(1):5179
Nature communications 2025 Jun 4;16(1):5179
Dl-3-n-Butylphthalide Alleviates Cognitive Impairment in Chronic Cerebral Hypoperfusion: Associations with Mitochondrial Permeability Transition Pore Closure and Suppression of Excessive Mitophagy.
Li Y, Shang J, Zhang H, Lu Y, Zhao Y, Wang Y, Yan X, Zhang J
ACS chemical neuroscience 2025 Jun 18;16(12):2208-2216
ACS chemical neuroscience 2025 Jun 18;16(12):2208-2216
TP53INP2 promotes mitophagic degradation of YAP to impede dedifferentiated liposarcoma development.
Wang Y, Huang Y, Wang L, Chen Z, Zhou L, Xiang F, Li G, Yang J, Chen R, Xu Q, Shen Y
Oncogene 2025 Jul;44(25):2054-2063
Oncogene 2025 Jul;44(25):2054-2063
Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism.
Zhou R, Wang Y, Liu S, Su Y, Liu Z, Yang B, Li X, Zhao J, Xu J, Liu Q, Song F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156774
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156774
Gestational exposure to carbon black nanoparticles triggered fetal growth restriction in mice: The mediation of inactivating autophagy-lysosomal degradation system in placental ferroptosis.
Li J, Gao H, Xu Z, Gao B, Zhang L, Su B, Yang S, Liu J, Liu Y, Wang X, Wang H, Lin Y, Shen H
The Science of the total environment 2025 Jan 10;959:178167
The Science of the total environment 2025 Jan 10;959:178167
Ginsenoside Rg1 ameliorates stress-exacerbated Parkinson's disease in mice by eliminating RTP801 and α-synuclein autophagic degradation obstacle.
Wang SS, Peng Y, Fan PL, Ye JR, Ma WY, Wu QL, Wang HY, Tian YJ, He WB, Yan X, Zhang Z, Chu SF, Chen NH
Acta pharmacologica Sinica 2025 Feb;46(2):308-325
Acta pharmacologica Sinica 2025 Feb;46(2):308-325
MAPK14/AIFM2 pathway regulates mitophagy-dependent apoptosis to improve atrial fibrillation.
Wang L, Sang W, Jian Y, Han Y, Wang F, Wubulikasimu S, Yang L, Tang B, Li Y
Journal of molecular and cellular cardiology 2025 Feb;199:1-11
Journal of molecular and cellular cardiology 2025 Feb;199:1-11
Dual activation of PPARα/γ by bezafibrate triggers PINK1/Parkin-Mediated mitophagy to enhance lenvatinib sensitivity in hepatocellular carcinoma.
Wang J, Chen L, Jiang L, Wang Y, Xue W, Cai X, Li H, Wang T
Biochemical pharmacology 2025 Dec;242(Pt 3):117367
Biochemical pharmacology 2025 Dec;242(Pt 3):117367
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Cai T, Liang Z, Chen Z, Li Y, Xiao W, Liang W, Xie H, Liu H, Zeng Z, Yang X, Luo S, Zheng X, Zhong K, Huang L, Xiong L, Kang L
Autophagy 2025 Dec;21(12):2982-3003
Autophagy 2025 Dec;21(12):2982-3003
TSPO participates in the pathogenesis of diabetic periodontitis related to mitophagy.
Jin W, Lu D, Wei W, Wang M, Chen R, Yan F, Li Y
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167866
Biochimica et biophysica acta. Molecular basis of disease 2025 Aug;1871(6):167866
Remodeling adipocytes' lipid metabolism with a polycation loaded enzyme-active framework reverses osteoporotic bone marrow.
Lin W, Gu S, Zhang X, Li K, Zhao D, Ma B, Pan C, Xu Z, Liu T, Wang H, Hu S, Chen H
Nature communications 2025 Aug 27;16(1):8009
Nature communications 2025 Aug 27;16(1):8009
AIMP1 exerts hearing protection role in age related hearing loss mice by regulating SIRT1 expression.
Peng H, Liu J, Liu Y, Li C, Zhang Z, Hu S, Xie W
BMC geriatrics 2025 Aug 20;25(1):645
BMC geriatrics 2025 Aug 20;25(1):645
Cordycepin Ameliorates Kainic Acid-Induced HT22 Cell Neurotoxicity by Activating GPR120-Mediated Mitophagy.
San Y, Wang M
Developmental neurobiology 2025 Apr;85(2):e22961
Developmental neurobiology 2025 Apr;85(2):e22961
Engineered Extracellular Vesicles Derived from Juvenile Mice Enhance Mitochondrial Function in the Aging Bone Microenvironment and Achieve Rejuvenation.
Zheng J, Ren Y, Ke J, Zhu G, Wang Z, Shi X, Wang Y
ACS nano 2025 Apr 15;19(14):13952-13967
ACS nano 2025 Apr 15;19(14):13952-13967
Blockade of Hepatocyte PCSK9 Ameliorates Hepatic Ischemia-Reperfusion Injury by Promoting Pink1-Parkin-Mediated Mitophagy.
Zhang Y, Wang Z, Jia C, Yu W, Li X, Xia N, Nie H, Wikana LP, Chen M, Ni Y, Han S, Pu L
Cellular and molecular gastroenterology and hepatology 2024;17(1):149-169
Cellular and molecular gastroenterology and hepatology 2024;17(1):149-169
NLRP3 Inflammasome Deficiency Alleviates Inflammation and Oxidative Stress by Promoting PINK1/Parkin-Mediated Mitophagy in Allergic Rhinitis Mice and Nasal Epithelial Cells.
Ding H, Lu X, Wang H, Chen W, Niu B
Journal of asthma and allergy 2024;17:717-731
Journal of asthma and allergy 2024;17:717-731
Ailanthone blocks mitophagy to promote mtDNA leakage through BAX-BAK1 pores and suppress hepatocellular carcinoma cell proliferation.
Qin Y, Gao Y, Wu D, Liu QQ, Su C, Liu G, Yang L, Zhao MG, Yao JY
Frontiers in pharmacology 2024;15:1509482
Frontiers in pharmacology 2024;15:1509482
Mutant NOTCH3ECD Triggers Defects in Mitochondrial Function and Mitophagy in CADASIL Cell Models.
Wang W, Gong Z, Wang Y, Zhao Y, Lu Y, Sun R, Zhang H, Shang J, Zhang J
Journal of Alzheimer's disease : JAD 2024;100(4):1299-1314
Journal of Alzheimer's disease : JAD 2024;100(4):1299-1314
PKD regulates mitophagy to prevent oxidative stress and mitochondrial dysfunction during mouse oocyte maturation.
Liu YP, He B, Wang WX, Pan WL, Jiao L, Yan JJ, Sun SC, Zhang Y
Mitochondrion 2024 Sep;78:101946
Mitochondrion 2024 Sep;78:101946
Targeting translocator protein protects against myocardial ischemia/reperfusion injury by alleviating mitochondrial dysfunction.
Wen C, Jiang Y, Chen W, Xu Y, Chen G, Zhou Q, Liu Q, Jiang H, Liu Y, Cao X, Yao Y, Zhang R, Qiu Z, Liu S
Experimental and therapeutic medicine 2024 Sep;28(3):349
Experimental and therapeutic medicine 2024 Sep;28(3):349
PRDM1 promotes nucleus pulposus cell pyroptosis leading to intervertebral disc degeneration via activating CASP1 transcription.
Yu C, Li J, Kuang W, Ni S, Cao Y, Duan Y
Cell biology and toxicology 2024 Oct 21;40(1):89
Cell biology and toxicology 2024 Oct 21;40(1):89
Morusin, a novel inhibitor of ACLY, induces mitochondrial apoptosis in hepatocellular carcinoma cells through ROS-mediated mitophagy.
Li D, Yuan X, Ma J, Lu T, Zhang J, Liu H, Zhang G, Wang Y, Liu X, Xie Q, Zhou L, Xu M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117510
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117510
Protection of Ndrg2 deficiency on renal ischemia-reperfusion injury via activating PINK1/Parkin-mediated mitophagy.
Liu M, Chen J, Sun M, Zhang L, Yu Y, Mi W, Ma Y, Wang G
Chinese medical journal 2024 Nov 5;137(21):2603-2614
Chinese medical journal 2024 Nov 5;137(21):2603-2614
Trehalose Alleviates D-Galactose-Induced Aging-Related Granulosa Cell Death in Ovaries.
Xi H, Chen X, Liang K, Wang X, Jiang F, Li Y, Niu D
International journal of molecular sciences 2024 Nov 25;25(23)
International journal of molecular sciences 2024 Nov 25;25(23)
Mechanism of cigarette smoke in promoting small airway remodeling in mice via STAT 3 / PINK 1-Parkin / EMT.
Wei Y, Li Q, He K, Liao G, Cheng L, Li M, He Z
Free radical biology & medicine 2024 Nov 1;224:447-456
Free radical biology & medicine 2024 Nov 1;224:447-456
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
Liu X, Devadiga SA, Stanley RF, Morrow RM, Janssen KA, Quesnel-Vallières M, Pomp O, Moverley AA, Li C, Skuli N, Carroll M, Huang J, Wallace DC, Lynch KW, Abdel-Wahab O, Klein PS
The Journal of clinical investigation 2024 May 7;134(12)
The Journal of clinical investigation 2024 May 7;134(12)
Varespladib mitigates acute liver injury via suppression of excessive mitophagy on Naja atra envenomed mice by inhibiting PLA(2).
Zhao W, Liu J, Wang S, Tao Q, Lei Q, Huang C
Toxicon : official journal of the International Society on Toxinology 2024 May 6;242:107694
Toxicon : official journal of the International Society on Toxinology 2024 May 6;242:107694
Microbial metabolite sodium butyrate enhances the anti-tumor efficacy of 5-fluorouracil against colorectal cancer by modulating PINK1/Parkin signaling and intestinal flora.
Li Y, He P, Chen Y, Hu J, Deng B, Liu C, Yu B, Dong W
Scientific reports 2024 Jun 6;14(1):13063
Scientific reports 2024 Jun 6;14(1):13063
HTR1B regulates mitochondrial homeostasis and mitophagy by activating the ERK/ MAPK signalling pathway during human embryonic arrest.
Ding SM, Shi LG, Cao ZP, Zhu NN, Liu YY, Wang MY, Cui SS, Cheng HR, Liang D, Cao YX, Liu YJ
Heliyon 2024 Jun 30;10(12):e33132
Heliyon 2024 Jun 30;10(12):e33132
Paeoniflorin Promotes Ovarian Development in Mice by Activating Mitophagy and Preventing Oxidative Stress.
Xi H, Wang Z, Li M, Duan X, Li Y
International journal of molecular sciences 2024 Jul 30;25(15)
International journal of molecular sciences 2024 Jul 30;25(15)
PARK2 suppresses the proliferation of high-grade serous ovarian carcinoma via inducing the proteasomal degradation of ZNF703.
Wang F, Li Y, Han Y, Zhang Y, Wang H, Wang L, Wang C, Guo M, Li P
Medical oncology (Northwood, London, England) 2024 Jul 23;41(8):207
Medical oncology (Northwood, London, England) 2024 Jul 23;41(8):207
SMYD3 activates the TCA cycle to promote M1-M2 conversion in macrophages.
Zhu W, Liu L, Wu J, Gao R, Fu L, Yang X, Zou Y, Zhang S, Luo D
International immunopharmacology 2024 Jan 25;127:111329
International immunopharmacology 2024 Jan 25;127:111329
ErZhiTianGui Decoction alleviates age-related ovarian aging by regulating mitochondrial homeostasis and inhibiting ferroptosis.
Zhicheng J, Yongqian L, Peixuan W, Kai Y, Mengyu S, Wen C, Qihui L, Ying G
Journal of ovarian research 2024 Jan 10;17(1):12
Journal of ovarian research 2024 Jan 10;17(1):12
VDR regulates mitochondrial function as a protective mechanism against renal tubular cell injury in diabetic rats.
Chen H, Zhang H, Li AM, Liu YT, Liu Y, Zhang W, Yang C, Song N, Zhan M, Yang S
Redox biology 2024 Apr;70:103062
Redox biology 2024 Apr;70:103062
Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.
Zhang H, Wang H, Hu Y, Gao Y, Chen J, Meng Y, Qiu Y, Hu R, Liao P, Li M, He Y, Liang Z, Xie X, Li Y
Cancer letters 2024 Apr 28;588:216802
Cancer letters 2024 Apr 28;588:216802
A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.
Liu X, Devadiga SA, Stanley RF, Morrow R, Janssen K, Quesnel-Vallières M, Pomp O, Moverley AA, Li C, Skuli N, Carroll MP, Huang J, Wallace DC, Lynch KW, Abdel-Wahab O, Klein PS
bioRxiv : the preprint server for biology 2024 Apr 23;
bioRxiv : the preprint server for biology 2024 Apr 23;
CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy.
Zhou Y, Liu Y, Kang Z, Yao H, Song N, Wang M, Song C, Zhang K, Ding J, Tang J, Hu G, Lu M
Autophagy 2023 Sep;19(9):2520-2537
Autophagy 2023 Sep;19(9):2520-2537
Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis.
Hou L, Wang G, Zhang X, Lu F, Xu J, Guo Z, Lin J, Zheng Z, Liu H, Hou Y, Sun K, Guo F
iScience 2023 Sep 15;26(9):107647
iScience 2023 Sep 15;26(9):107647
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis.
Yang Q, Zou Y, Wei X, Ye P, Wu Y, Ai H, Zhang Z, Tan J, Zhou J, Yang Y, Dai Q, Dou C, Luo F
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795
Biochimica et biophysica acta. Molecular basis of disease 2023 Oct;1869(7):166795
Grape seed proanthocyanidins regulate mitophagy of endothelial cells and promote wound healing in mice through p-JNK/FOXO3a/ROS signal pathway.
Chen L, Hao L, Yanshuo C, FangFang W, Daqin C, Weidong X, Jian X, Shaodong C, Hongyu Z, Ke X
Archives of biochemistry and biophysics 2023 Nov;749:109790
Archives of biochemistry and biophysics 2023 Nov;749:109790
Melatonin exerts a protective effect in ameliorating nephrolithiasis via targeting AMPK/PINK1-Parkin mediated mitophagy and inhibiting ferroptosis in vivo and in vitro.
Zhou J, Meng L, He Z, Song Q, Liu J, Su X, Wang C, Ke H, Dong C, Liao W, Yang S
International immunopharmacology 2023 Nov;124(Pt A):110801
International immunopharmacology 2023 Nov;124(Pt A):110801
Extracellular vesicle-derived silk fibroin nanoparticles loaded with MFGE8 accelerate skin ulcer healing by targeting the vascular endothelial cells.
Luo L, Zhang H, Zhang S, Luo C, Kan X, Lv J, Zhao P, Tian Z, Li C
Journal of nanobiotechnology 2023 Nov 29;21(1):455
Journal of nanobiotechnology 2023 Nov 29;21(1):455
Exosomes derived from schwann cells alleviate mitochondrial dysfunction and necroptosis after spinal cord injury via AMPK signaling pathway-mediated mitophagy.
Xu B, Zhou Z, Fang J, Wang J, Tao K, Liu J, Liu S
Free radical biology & medicine 2023 Nov 1;208:319-333
Free radical biology & medicine 2023 Nov 1;208:319-333
Mechanical force induces mitophagy-mediated anaerobic oxidation in periodontal ligament stem cells.
Zhang Z, Cui S, Fu Y, Wang J, Liu J, Wei F
Cellular & molecular biology letters 2023 Jul 21;28(1):57
Cellular & molecular biology letters 2023 Jul 21;28(1):57
Multi-Targeting Intranasal Nanoformulation as a Therapeutic for Alzheimer's Disease.
Fihurka O, Wang Y, Hong Y, Lin X, Shen N, Yang H, Brown B, Mommer M, Zieneldien T, Li Y, Kim J, Li M, Cai J, Zhou Q, Cao C
Biomolecules 2023 Jan 25;13(2)
Biomolecules 2023 Jan 25;13(2)
Alamandine/MrgD axis prevents TGF-β1-mediated fibroblast activation via regulation of aerobic glycolysis and mitophagy.
Wang W, Zhang Y, Huang W, Yuan Y, Hong Q, Xie Z, Li L, Chen Y, Li X, Meng Y
Journal of translational medicine 2023 Jan 13;21(1):24
Journal of translational medicine 2023 Jan 13;21(1):24
Stomatin-like protein 2 deficiency exacerbates adverse cardiac remodeling.
Hu Y, Jiang H, Xu Y, Chen G, Fan R, Zhou Y, Liu Y, Yao Y, Liu R, Chen W, Zhang K, Chen X, Wang R, Qiu Z
Cell death discovery 2023 Feb 14;9(1):63
Cell death discovery 2023 Feb 14;9(1):63
The nonstructural protein 1 of respiratory syncytial virus hijacks host mitophagy as a novel mitophagy receptor to evade the type I IFN response in HEp-2 cells.
Cheng J, Wang Y, Yin L, Liang W, Zhang J, Ma C, Zhang Y, Liu B, Wang J, Zhao W, Li M, Wei L
mBio 2023 Dec 19;14(6):e0148023
mBio 2023 Dec 19;14(6):e0148023
Mitophagy-dependent cardioprotection of resistance training on heart failure.
Guo C, Wu RY, Dou JH, Song SF, Sun XL, Hu YW, Guo FS, Wei J, Lin L, Wei J
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Dec 1;135(6):1390-1401
Journal of applied physiology (Bethesda, Md. : 1985) 2023 Dec 1;135(6):1390-1401
Ubiquitination of Ku70 by Parkin promotes apoptosis of lens epithelial cells.
Zhang W, Wu A, Zhang G, Ding X, Kang L, Zhou T, Ji M, Guan H
The FEBS journal 2023 Aug;290(15):3828-3842
The FEBS journal 2023 Aug;290(15):3828-3842
Xuesaitong Combined with Dexmedetomidine Improves Cerebral Ischemia-Reperfusion Injury in Rats by Activating Keap1/Nrf2 Signaling and Mitophagy in Hippocampal Tissue.
Han GJ, Min XZ, Ma SS, Ding C, Wang XQ
Oxidative medicine and cellular longevity 2022;2022:5126042
Oxidative medicine and cellular longevity 2022;2022:5126042
San-Huang-Yi-Shen Capsule Ameliorates Diabetic Kidney Disease through Inducing PINK1/Parkin-Mediated Mitophagy and Inhibiting the Activation of NLRP3 Signaling Pathway.
Li H, Wang Y, Su X, Wang Q, Zhang S, Sun W, Zhang T, Dong M, Zhang Z, Lv S
Journal of diabetes research 2022;2022:2640209
Journal of diabetes research 2022;2022:2640209
Long non-coding RNA VAL facilitates PKM2 enzymatic activity to promote glycolysis and malignancy of gastric cancer.
Dai T, Zhang X, Zhou X, Hu X, Huang X, Xing F, Tian H, Li Y
Clinical and translational medicine 2022 Oct;12(10):e1088
Clinical and translational medicine 2022 Oct;12(10):e1088
IL-17A promotes lung fibrosis through impairing mitochondrial homeostasis in type II alveolar epithelial cells.
Xiao H, Peng L, Jiang D, Liu Y, Zhu L, Li Z, Geng J, Xie B, Huang X, Wang J, Dai H, Wang C
Journal of cellular and molecular medicine 2022 Nov;26(22):5728-5741
Journal of cellular and molecular medicine 2022 Nov;26(22):5728-5741
Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1/Parkin pathway in rats.
Zhang D, Zheng N, Fu X, Shi J, Zhang J
Journal of thoracic disease 2022 May;14(5):1651-1662
Journal of thoracic disease 2022 May;14(5):1651-1662
Resveratrol alleviates enterotoxigenic Escherichia coli K88-induced damage by regulating SIRT-1 signaling in intestinal porcine epithelial cells.
Luo X, Wu S, Jia H, Si X, Song Z, Zhai Z, Bai J, Li J, Yang Y, Wu Z
Food & function 2022 Jul 4;13(13):7346-7360
Food & function 2022 Jul 4;13(13):7346-7360
Melatonin and verteporfin synergistically suppress the growth and stemness of head and neck squamous cell carcinoma through the regulation of mitochondrial dynamics.
Shin YY, Seo Y, Oh SJ, Ahn JS, Song MH, Kang MJ, Oh JM, Lee D, Kim YH, Sung ES, Kim HS
Journal of pineal research 2022 Jan;72(1):e12779
Journal of pineal research 2022 Jan;72(1):e12779
Hypoxic training upregulates mitochondrial turnover and angiogenesis of skeletal muscle in mice.
Zhao YC, Guo W, Gao BH
Life sciences 2022 Feb 15;291:119340
Life sciences 2022 Feb 15;291:119340
The SMYD3-MTHFD1L-formate metabolic regulatory axis mediates mitophagy to inhibit M1 polarization in macrophages.
Zhu W, Wang C, Xue L, Liu L, Yang X, Liu Z, Zhang S, Luo D
International immunopharmacology 2022 Dec;113(Pt A):109352
International immunopharmacology 2022 Dec;113(Pt A):109352
Resveratrol Relieves Gouty Arthritis by Promoting Mitophagy to Inhibit Activation of NLRP3 Inflammasomes.
Fan W, Chen S, Wu X, Zhu J, Li J
Journal of inflammation research 2021;14:3523-3536
Journal of inflammation research 2021;14:3523-3536
SARS-CoV-2 Causes Mitochondrial Dysfunction and Mitophagy Impairment.
Shang C, Liu Z, Zhu Y, Lu J, Ge C, Zhang C, Li N, Jin N, Li Y, Tian M, Li X
Frontiers in microbiology 2021;12:780768
Frontiers in microbiology 2021;12:780768
Hepatic expression of GAA results in enhanced enzyme bioavailability in mice and non-human primates.
Costa-Verdera H, Collaud F, Riling CR, Sellier P, Nordin JML, Preston GM, Cagin U, Fabregue J, Barral S, Moya-Nilges M, Krijnse-Locker J, van Wittenberghe L, Daniele N, Gjata B, Cosette J, Abad C, Simon-Sola M, Charles S, Li M, Crosariol M, Antrilli T, Quinn WJ 3rd, Gross DA, Boyer O, Anguela XM, Armour SM, Colella P, Ronzitti G, Mingozzi F
Nature communications 2021 Nov 4;12(1):6393
Nature communications 2021 Nov 4;12(1):6393
Neurotoxicity of a pyrethroid pesticide deltamethrin is associated with the imbalance in proteolytic systems caused by mitophagy activation and proteasome inhibition.
Hirano T, Suzuki N, Ikenaka Y, Hoshi N, Tabuchi Y
Toxicology and applied pharmacology 2021 Nov 1;430:115723
Toxicology and applied pharmacology 2021 Nov 1;430:115723
Ginseng-Sanqi-Chuanxiong (GSC) Extracts Ameliorate Diabetes-Induced Endothelial Cell Senescence through Regulating Mitophagy via the AMPK Pathway.
Wang X, Zhang JQ, Xiu CK, Yang J, Fang JY, Lei Y
Oxidative medicine and cellular longevity 2020;2020:7151946
Oxidative medicine and cellular longevity 2020;2020:7151946
Quantitative Mitochondrial Proteomics Reveals ANXA7 as a Crucial Factor in Mitophagy.
Meng K, Lu S, Yan X, Sun Y, Gao J, Wang Y, Yin X, Sun Z, He QY
Journal of proteome research 2020 Mar 6;19(3):1275-1284
Journal of proteome research 2020 Mar 6;19(3):1275-1284
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