BS6365

antibody from Bioworld Technology, Inc
Targeting: GSK3B
Provider product page for BS6365
Western blot
Immunohistochemistry

Antibody data

Product number
BS6365 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GSK3ÉÇ (phospho S9) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic phosphopeptide derived from human GSK3ÉÇ around the phosphorylation site of Serine 9.
Description
Glycogen synthase kinase-3Ï«(GSK-3Ï«) and GSK-3ÉÇ are highly similar isoforms of serine/ threonine kinases that regulate metabolic enzymes and transcription factors, which are responsible for coordinating processes such as glycogen synthesis and cell adhesion. GSK-3ÉÇ activity is also required for nuclear activity of Rel dimers, which mediate an anti-apoptotic response to TNFÏ« in mice. GSK-3 catalytic kinase activity is controlled through differential phosphorylation of serine/threonine residues, which have an inhibitory effect, and tyrosine residues, which have an activating effect. Growth factor stimulation of mammalian cells expressing GSK-3Ï« and GSK-3ÉÇ induces phosphorylation of Ser 21 and Ser 9, respectively, through a phosphatidylinositol 3-kinase (PI 3-K)-protein kinase B (PKB)-dependent pathway, thereby enhancing proliferative signals. Additionally, GSK-3 physically associates with cAMP-dependent protein kinase A (PKA), which phosphorylates Ser 21 of GSK-3Ï« or Ser 9 of GSK-3ÉÇ and inactivates both forms. GSK-3Ï«/ÉÇ is positively regulated by phosphorylation on Tyr 279 and Tyr 216, respectively. Activated GSK-3Ï«/ÉÇ participates in energy metabolism, neuronal cell development, and body pattern formation. Tyrosine dephosphorylation of GSK-3 is involved in its extracellular signal-dependent inactivation.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GSK3B protein structure - BS6365 shown in red.