14-1819-80

antibody from Invitrogen Antibodies
Targeting: CXCR1 CD181, CDw128a, CKR-1, CMKAR1, IL8RA
Provider product page for 14-1819-80

Antibody data

Product number
14-1819-80 - Provider product page
Provider
Invitrogen Antibodies
Product name
CD181 (CXCR1) Monoclonal Antibody (eBio8F1-1-4 (8F1-1-4)), eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: The eBio8F1-1-4 monoclonal antibody reacts with human CD181 (CXCR1, IL-8Ralpha). CD181 is a 67-70 kDa member of the 7-transmembrane spanning G-protein coupled receptor (GPCR) family. CD181 is expressed as a homodimer, or a heterodimer with CD182 (CXCR2, IL-8Rbeta) and is expressed on granulocytes, NK cells, a subset of T cells, mast cells, monocytes, endothelial cells, megakaryocytes and oligodendrocytes. Binding of it's ligands, which include IL-8, NAP-2, GCP-2 and GRO-alpha, induces several biological outcomes such as cell activation, chemotaxis, proliferation and angiogenesis. There are several functional differences between CD181 and CD182. Both receptors are able to mediate chemotaxis and intracellular calcium changes, but only CD181 mediates phospolipase D activation and respiratory burst. Furthermore, studies have shown that IL-8 predominantly mediates its effects on neutrophil function through CD181.
Antibody clone number
eBio8F1-1-4 (8F1-1-4)
Concentration
0.5 mg/mL
CXCR1 protein structure - 14-1819-80 shown in red.