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ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [39]
- Comments [0]
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- Product number
- MAB330 - Provider product page
- Provider
- R&D Systems
- Product name
- Anti-Human CXCR1/IL-8 RA Monoclonal Antibody (Clone 42705)
- Antibody type
- Monoclonal
- Antigen
- NS0 mouse myeloma cell line transfected with human CXCR1/IL-8 RA, Met1-Leu350
- Description
- Protein A or G purified from hybridoma culture supernatant
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
AAA59159- Isotype
- IgG
- Vial size
- 500 µg
Submitted references IL-8/CXCR1/2 signalling promotes tumor cell proliferation, invasion and vascular mimicry in glioblastoma.
Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer.
Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs.
Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients.
Role of Autophagy in HIV-1 Matrix Protein p17-Driven Lymphangiogenesis.
Chinese herbal medicine suppresses invasion-promoting capacity of cancer-associated fibroblasts in pancreatic cancer.
Hypoxia promotes the proliferation of cervical carcinoma cells through stimulating the secretion of IL-8.
Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth.
CXCL1/CXCL8 (GROα/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro.
Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis.
Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients.
The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases.
CXCL1 inhibits airway smooth muscle cell migration through the decoy receptor Duffy antigen receptor for chemokines.
The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells.
Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche.
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients.
IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells.
Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.
Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis.
CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion.
Expression of CXCL8, CXCR1, and CXCR2 in neurons and glial cells of the human and rabbit retina.
Potential role of high-mobility group box 1 in cystic fibrosis airway disease.
A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression.
Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells.
Shear-induced capping of L-selectin on the neutrophil surface during centrifugation.
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation.
Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines.
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Chemokine receptor expression in rat adjuvant-induced arthritis.
The activation of IL-8 receptors in cultured guinea pig Müller glial cells is modified by signals from retinal pigment epithelium.
Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL.
Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.
Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.
Expression of functional CCR and CXCR chemokine receptors in podocytes.
Expression of functional CCR and CXCR chemokine receptors in podocytes.
Sharma I, Singh A, Siraj F, Saxena S
Journal of biomedical science 2018 Aug 8;25(1):62
Journal of biomedical science 2018 Aug 8;25(1):62
Altered monocyte differentiation and macrophage polarization patterns in patients with breast cancer.
Hung CH, Chen FM, Lin YC, Tsai ML, Wang SL, Chen YC, Chen YT, Hou MF
BMC cancer 2018 Apr 3;18(1):366
BMC cancer 2018 Apr 3;18(1):366
Mycobacteria Manipulate G-Protein-Coupled Receptors to Increase Mucosal Rac1 Expression in the Lungs.
Alaridah N, Lutay N, Tenland E, Rönnholm A, Hallgren O, Puthia M, Westergren-Thorsson G, Godaly G
Journal of innate immunity 2017;9(3):318-329
Journal of innate immunity 2017;9(3):318-329
Proteomic profiling of peripheral blood neutrophils identifies two inflammatory phenotypes in stable COPD patients.
Loi ALT, Hoonhorst S, van Aalst C, Langereis J, Kamp V, Sluis-Eising S, Ten Hacken N, Lammers JW, Koenderman L
Respiratory research 2017 May 22;18(1):100
Respiratory research 2017 May 22;18(1):100
Role of Autophagy in HIV-1 Matrix Protein p17-Driven Lymphangiogenesis.
Mazzuca P, Marsico S, Schulze K, Mitola S, Pils MC, Giagulli C, Guzman CA, Caruso A, Caccuri F
Journal of virology 2017 Aug 15;91(16)
Journal of virology 2017 Aug 15;91(16)
Chinese herbal medicine suppresses invasion-promoting capacity of cancer-associated fibroblasts in pancreatic cancer.
Chen L, Qu C, Chen H, Xu L, Qi Q, Luo J, Wang K, Meng Z, Chen Z, Wang P, Liu L
PloS one 2014;9(4):e96177
PloS one 2014;9(4):e96177
Hypoxia promotes the proliferation of cervical carcinoma cells through stimulating the secretion of IL-8.
Liu LB, Xie F, Chang KK, Li MQ, Meng YH, Wang XH, Li H, Li DJ, Yu JJ
International journal of clinical and experimental pathology 2014;7(2):575-83
International journal of clinical and experimental pathology 2014;7(2):575-83
Simian immunodeficiency virus and human immunodeficiency virus type 1 matrix proteins specify different capabilities to modulate B cell growth.
Caccuri F, Giagulli C, Reichelt J, Martorelli D, Marsico S, Bugatti A, Barone I, Rusnati M, Guzman CA, Dolcetti R, Caruso A
Journal of virology 2014 May;88(10):5706-17
Journal of virology 2014 May;88(10):5706-17
CXCL1/CXCL8 (GROα/IL-8) in human diabetic ketoacidosis plasma facilitates leukocyte recruitment to cerebrovascular endothelium in vitro.
Omatsu T, Cepinskas G, Clarson C, Patterson EK, Alharfi IM, Summers K, Couraud PO, Romero IA, Weksler B, Fraser DD, Canadian Critical Care Translational Biology Group.
American journal of physiology. Endocrinology and metabolism 2014 May 1;306(9):E1077-84
American journal of physiology. Endocrinology and metabolism 2014 May 1;306(9):E1077-84
Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis.
Cartwright A, Schmutz C, Askari A, Kuiper JH, Middleton J
Cytokine 2014 Jun;67(2):53-9
Cytokine 2014 Jun;67(2):53-9
Expansion of activated regulatory T cells by myeloid-specific chemokines via an alternative pathway in CSF of bacterial meningitis patients.
Shi G, Han J, Liu G, Hao Y, Ma Y, Li T, Wu X, Zhang H, Liu Y, Wang B, Kong Y, Zhou J, Zeng H
European journal of immunology 2014 Feb;44(2):420-30
European journal of immunology 2014 Feb;44(2):420-30
The IL-8/CXCR1 axis is associated with cancer stem cell-like properties and correlates with clinical prognosis in human pancreatic cancer cases.
Chen L, Fan J, Chen H, Meng Z, Chen Z, Wang P, Liu L
Scientific reports 2014 Aug 1;4:5911
Scientific reports 2014 Aug 1;4:5911
CXCL1 inhibits airway smooth muscle cell migration through the decoy receptor Duffy antigen receptor for chemokines.
Al-Alwan LA, Chang Y, Rousseau S, Martin JG, Eidelman DH, Hamid Q
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 1;193(3):1416-26
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 1;193(3):1416-26
The endothelin-integrin axis is involved in macrophage-induced breast cancer cell chemotactic interactions with endothelial cells.
Chen CC, Chen LL, Hsu YT, Liu KJ, Fan CS, Huang TS
The Journal of biological chemistry 2014 Apr 4;289(14):10029-44
The Journal of biological chemistry 2014 Apr 4;289(14):10029-44
Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche.
Infanger DW, Cho Y, Lopez BS, Mohanan S, Liu SC, Gursel D, Boockvar JA, Fischbach C
Cancer research 2013 Dec 1;73(23):7079-89
Cancer research 2013 Dec 1;73(23):7079-89
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E
Nature medicine 2011 Oct 30;17(11):1498-503
Nature medicine 2011 Oct 30;17(11):1498-503
Reduced expression of chemoattractant receptors by polymorphonuclear leukocytes in Hyper IgE Syndrome patients.
Mintz R, Garty BZ, Meshel T, Marcus N, Katanov C, Cohen-Hillel E, Ben-Baruch A
Immunology letters 2010 May 4;130(1-2):97-106
Immunology letters 2010 May 4;130(1-2):97-106
IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells.
Weiss N, Deboux C, Chaverot N, Miller F, Baron-Van Evercooren A, Couraud PO, Cazaubon S
Journal of neuroimmunology 2010 Jun;223(1-2):131-4
Journal of neuroimmunology 2010 Jun;223(1-2):131-4
Enrichment of Foxp3+ CD4 regulatory T cells in migrated T cells to IL-6- and IL-8-expressing tumors through predominant induction of CXCR1 by IL-6.
Eikawa S, Ohue Y, Kitaoka K, Aji T, Uenaka A, Oka M, Nakayama E
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 1;185(11):6734-40
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 1;185(11):6734-40
Spatiotemporal expression of chemokines and chemokine receptors in experimental anti-myeloperoxidase antibody-mediated glomerulonephritis.
van der Veen BS, Petersen AH, Belperio JA, Satchell SC, Mathieson PW, Molema G, Heeringa P
Clinical and experimental immunology 2009 Oct;158(1):143-53
Clinical and experimental immunology 2009 Oct;158(1):143-53
CXCR1 and CXCR2 enhances human melanoma tumourigenesis, growth and invasion.
Singh S, Nannuru KC, Sadanandam A, Varney ML, Singh RK
British journal of cancer 2009 May 19;100(10):1638-46
British journal of cancer 2009 May 19;100(10):1638-46
Expression of CXCL8, CXCR1, and CXCR2 in neurons and glial cells of the human and rabbit retina.
Goczalik I, Ulbricht E, Hollborn M, Raap M, Uhlmann S, Weick M, Pannicke T, Wiedemann P, Bringmann A, Reichenbach A, Francke M
Investigative ophthalmology & visual science 2008 Oct;49(10):4578-89
Investigative ophthalmology & visual science 2008 Oct;49(10):4578-89
Potential role of high-mobility group box 1 in cystic fibrosis airway disease.
Rowe SM, Jackson PL, Liu G, Hardison M, Livraghi A, Solomon GM, McQuaid DB, Noerager BD, Gaggar A, Clancy JP, O'Neal W, Sorscher EJ, Abraham E, Blalock JE
American journal of respiratory and critical care medicine 2008 Oct 15;178(8):822-31
American journal of respiratory and critical care medicine 2008 Oct 15;178(8):822-31
A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Gaggar A, Jackson PL, Noerager BD, O'Reilly PJ, McQuaid DB, Rowe SM, Clancy JP, Blalock JE
Journal of immunology (Baltimore, Md. : 1950) 2008 Apr 15;180(8):5662-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Apr 15;180(8):5662-9
A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Gaggar A, Jackson PL, Noerager BD, O'Reilly PJ, McQuaid DB, Rowe SM, Clancy JP, Blalock JE
Journal of immunology (Baltimore, Md. : 1950) 2008 Apr 15;180(8):5662-9
Journal of immunology (Baltimore, Md. : 1950) 2008 Apr 15;180(8):5662-9
Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression.
Kline M, Donovan K, Wellik L, Lust C, Jin W, Moon-Tasson L, Xiong Y, Witzig TE, Kumar S, Rajkumar SV, Lust JA
Leukemia research 2007 May;31(5):591-8
Leukemia research 2007 May;31(5):591-8
Role of interleukin-8 and growth-regulated oncogene-alpha in the chemotactic migration of all-trans retinoic acid-treated promyelocytic leukemic cells toward alveolar epithelial cells.
Tsai WH, Hsu HC, Lin CC, Ho CK, Kou YR
Critical care medicine 2007 Mar;35(3):879-85
Critical care medicine 2007 Mar;35(3):879-85
Shear-induced capping of L-selectin on the neutrophil surface during centrifugation.
Lee D, King MR
Journal of immunological methods 2007 Dec 1;328(1-2):97-105
Journal of immunological methods 2007 Dec 1;328(1-2):97-105
Increased levels of neutrophil-activating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation.
Smith C, Damås JK, Otterdal K, Øie E, Sandberg WJ, Yndestad A, Waehre T, Scholz H, Endresen K, Olofsson PS, Halvorsen B, Gullestad L, Frøland SS, Hansson GK, Aukrust P
Journal of the American College of Cardiology 2006 Oct 17;48(8):1591-9
Journal of the American College of Cardiology 2006 Oct 17;48(8):1591-9
Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines.
Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B
Clinical immunology (Orlando, Fla.) 2006 Aug;120(2):220-31
Clinical immunology (Orlando, Fla.) 2006 Aug;120(2):220-31
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
Journal of immunology (Baltimore, Md. : 1950) 2005 Nov 1;175(9):6177-89
Journal of immunology (Baltimore, Md. : 1950) 2005 Nov 1;175(9):6177-89
IL-17 enhances the net angiogenic activity and in vivo growth of human non-small cell lung cancer in SCID mice through promoting CXCR-2-dependent angiogenesis.
Numasaki M, Watanabe M, Suzuki T, Takahashi H, Nakamura A, McAllister F, Hishinuma T, Goto J, Lotze MT, Kolls JK, Sasaki H
Journal of immunology (Baltimore, Md. : 1950) 2005 Nov 1;175(9):6177-89
Journal of immunology (Baltimore, Md. : 1950) 2005 Nov 1;175(9):6177-89
Chemokine receptor expression in rat adjuvant-induced arthritis.
Haas CS, Martinez RJ, Attia N, Haines GK 3rd, Campbell PL, Koch AE
Arthritis and rheumatism 2005 Dec;52(12):3718-30
Arthritis and rheumatism 2005 Dec;52(12):3718-30
The activation of IL-8 receptors in cultured guinea pig Müller glial cells is modified by signals from retinal pigment epithelium.
Malgorzata Goczalik I, Raap M, Weick M, Milenkovic I, Heidmann J, Enzmann V, Wiedemann P, Reichenbach A, Francke M
Journal of neuroimmunology 2005 Apr;161(1-2):49-60
Journal of neuroimmunology 2005 Apr;161(1-2):49-60
Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL.
Annels NE, Willemze AJ, van der Velden VH, Faaij CM, van Wering E, Sie-Go DM, Egeler RM, van Tol MJ, Révész T
Blood 2004 Apr 1;103(7):2806-8
Blood 2004 Apr 1;103(7):2806-8
Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.
Doubrovina ES, Doubrovin MM, Vider E, Sisson RB, O'Reilly RJ, Dupont B, Vyas YM
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6891-9
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6891-9
Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.
Doubrovina ES, Doubrovin MM, Vider E, Sisson RB, O'Reilly RJ, Dupont B, Vyas YM
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6891-9
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6891-9
Expression of functional CCR and CXCR chemokine receptors in podocytes.
Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstädt H
Journal of immunology (Baltimore, Md. : 1950) 2002 Jun 15;168(12):6244-52
Journal of immunology (Baltimore, Md. : 1950) 2002 Jun 15;168(12):6244-52
Expression of functional CCR and CXCR chemokine receptors in podocytes.
Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstädt H
Journal of immunology (Baltimore, Md. : 1950) 2002 Jun 15;168(12):6244-52
Journal of immunology (Baltimore, Md. : 1950) 2002 Jun 15;168(12):6244-52
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