16690-1-AP

antibody from Proteintech Group

Targeting: ALYREF ALY, ALY/REF, BEF, REF, THOC4

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

16690-1-AP

Provider

Proteintech Group

Product name

ALY antibody

Antibody type

Polyclonal

Description

ALY antibody (Cat. #16690-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

ALYREF condensation stabilizes m(5)C-modified PARP10 mRNA and promotes PI3K-AKT signaling in ovarian cancer.

Zhao H, Wei Q, Luo Z, Liu X, Yang C, Chen N, Wang Y, Luo X, Zuo X, Luo Q, Yang Y, Zhou Y, Liu J, Zhang T, Yang D, Long Y, Mobet Y, Xu J, Wang W, Liu T, Yi P
The EMBO journal 2026 Jan;45(2):471-503

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YBX1 Modulated Corneal Neovascularization Induced by Alkali Burn via m5C-Dependent Regulation of the STAT3/HIF-1α/VEGFA Axis.

Yang Z, Yan Y, Deng Q, Gao Y, Mao J, Ke L, Wan S, Yang Y
Investigative ophthalmology & visual science 2026 Feb 2;67(2):42

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Nuclear envelope budding enables export of large transcripts in muscle cells.

Zaganelli S, Meehl JB, Abrisch RG, Voeltz GK
Cell 2026 Apr 24;

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Comprehensive analysis of ALYREF gene expression and its correlation with immunotherapy efficacy and circulating tumor cells in bladder cancer.

Tang Z, Peng J, Wei Z, Wu S, Guan G, Lu F, Lu B, Zeng S
Scientific reports 2025 Nov 14;15(1):40032

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FOXA1-dependent NSUN2 facilitates the advancement of prostate cancer by preserving TRIM28 mRNA stability in a m5C-dependent manner.

Wang Z, Mierxiati A, Zhu W, Li T, Xu H, Wan F, Ye D
NPJ precision oncology 2025 May 3;9(1):127

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Proteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma.

Liu Z, Zhao Z, Xie L, Xiao Z, Li M, Li Y, Luo T
Journal of translational medicine 2025 Feb 26;23(1):234

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Multi-omics analysis reveals that ALYREF-mediated m(5)C modification promotes platinum resistance in ovarian cancer via the NSUN2/ALYREF/LGR4 axis.

Yang S, He P, Wang W, Xu X, Xi X, Li Y
Cell death & disease 2025 Dec 5;17(1):77

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NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming.

Li H, Gong T, Zhao Y, Luo Y, Tang S, Wang T, Lin H, Zhong M
Cancer & metabolism 2025 Aug 14;13(1):37

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RNA m(5)C modification upregulates E2F1 expression in a manner dependent on YBX1 phase separation and promotes tumor progression in ovarian cancer.

Liu X, Wei Q, Yang C, Zhao H, Xu J, Mobet Y, Luo Q, Yang D, Zuo X, Chen N, Yang Y, Li L, Wang W, Yu J, Xu J, Liu T, Yi P
Experimental & molecular medicine 2024 Mar;56(3):600-615

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Changes of RNA m(6)A/m(5)C Modification Regulatory Molecules in Ferroptosis of T2DM Rat Pancreas.

Liu X, Wang N, Gu S, He Z
Cell biochemistry and biophysics 2024 Jun;82(2):1279-1289

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Niujiao Dihuang Jiedu decoction promotes SLC7A11 m5C methylation modification against ferroptosis in acute-on-chronic liver failure.

Huang L, Liu J, Jin Y, Qiu Y, Qin X, Wu S, Chen D, Bie C, Kuang W, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;122:155136

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Epigenetic addition of m(5)C to HBV transcripts promotes viral replication and evasion of innate antiviral responses.

Ding S, Liu H, Liu L, Ma L, Chen Z, Zhu M, Liu L, Zhang X, Hao H, Zuo L, Yang J, Wu X, Zhou P, Huang F, Zhu F, Guan W
Cell death & disease 2024 Jan 12;15(1):39

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Glycolytic Pfkp acts as a Lin41 protein kinase to promote endodermal differentiation of embryonic stem cells.

Cao L, Wang R, Liu G, Zhang Y, Thorne RF, Zhang XD, Li J, Xia Y, Guo L, Shao F, Gu H, Wu M
EMBO reports 2023 Mar 6;24(3):e55683

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mRNA recognition and packaging by the human transcription-export complex.

Pacheco-Fiallos B, Vorländer MK, Riabov-Bassat D, Fin L, O'Reilly FJ, Ayala FI, Schellhaas U, Rappsilber J, Plaschka C
Nature 2023 Apr;616(7958):828-835

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TREX (transcription/export)-NP complex exerts a dual effect on regulating polymerase activity and replication of influenza A virus.

Zhao L, Liu Q, Huang J, Lu Y, Zhao Y, Ping J
PLoS pathogens 2022 Sep;18(9):e1010835

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Porcine ZC3H11A Is Essential for the Proliferation of Pseudorabies Virus and Porcine Circovirus 2.

Yang L, Wang Z, Ouyang H, Zhang Y, Xiao W, Liu Y, Deng J, Li M, Ma L, Qi C, Pang D, Yuan H
ACS infectious diseases 2022 Jun 10;8(6):1179-1190

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NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS
Cell metabolism 2021 Dec 7;33(12):2380-2397.e9