12807-1-AP

antibody from Proteintech Group

Targeting: BACE1 BACE

Provider product page for 12807-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [33]
Comments [0]
Validations
Western blot [1]
Immunoprecipitation [1]
Immunohistochemistry [1]

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Product number: 12807-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#12807-1-AP, RRID:AB_10638760
Product name: BACE1 antibody
Antibody type: Polyclonal
Description: KD/KO validated BACE1 antibody (Cat. #12807-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, zebrafish, rat and has been validated for the following applications: IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat, Zebrafish
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

BACE1 protein structure - 12807-1-AP shown in red.

Submitted references Ginsenoside ompound K reduces neuronal damage and improves neuronal synaptic dysfunction by targeting Aβ.

Li N, Pang Q, Zhang Y, Lin J, Li H, Li Z, Liu Y, Fang X, An Y, Bai H, Li D, Cao Z, Liu J, Yang Q, Hu S
Frontiers in pharmacology 2023;14:1103012

Application of Dominant Gut Microbiota Promises to Replace Fecal Microbiota Transplantation as a New Treatment for Alzheimer's Disease.

Li M, Yang H, Shao C, Liu Y, Wen S, Tang L
Microorganisms 2023 Nov 24;11(12)

Hyperoside alleviates toxicity of β-amyloid via endoplasmic reticulum-mitochondrial calcium signal transduction cascade in APP/PS1 double transgenic Alzheimer's disease mice.

Song LL, Qu YQ, Tang YP, Chen X, Lo HH, Qu LQ, Yun YX, Wong VKW, Zhang RL, Wang HM, Liu MH, Zhang W, Zhang HX, Chan JTW, Wang CR, Wu JH, Law BYK
Redox biology 2023 May;61:102637

A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease.

Sun Y, Xu L, Zheng D, Wang J, Liu G, Mo Z, Liu C, Zhang W, Yu J, Xing C, He L, Zhuang C
Redox biology 2023 Aug;64:102793

Ketogenic diet alleviates brain iron deposition and cognitive dysfunction via Nrf2-mediated ferroptosis pathway in APP/PS1 mouse.

Qin Y, Bai D, Tang M, Zhang M, Zhao L, Li J, Yang R, Jiang G
Brain research 2023 Aug 1;1812:148404

Targeting Aβ and p-Tau Clearance in Methamphetamine-Induced Alzheimer's Disease-Like Pathology: Roles of Syntaxin 17 in Autophagic Degradation in Primary Hippocampal Neurons.

Zhu Y, Wang X, Hu M, Yang T, Xu H, Kang X, Chen X, Jiang L, Gao R, Wang J
Oxidative medicine and cellular longevity 2022;2022:3344569

Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer's disease.

Li J, Zou B, Cheng XY, Yang XH, Li J, Zhao CH, Ma RX, Tian JX, Yao Y
Frontiers in pharmacology 2022;13:940999

Thiamine insufficiency induces Hypoxia Inducible Factor-1α as an upstream mediator for neurotoxicity and AD-like pathology.

Valle ML, Anderson YT, Grimsey N, Zastre J
Molecular and cellular neurosciences 2022 Dec;123:103785

Brain-Penetration and Neuron-Targeting DNA Nanoflowers Co-Delivering miR-124 and Rutin for Synergistic Therapy of Alzheimer's Disease.

Ouyang Q, Liu K, Zhu Q, Deng H, Le Y, Ouyang W, Yan X, Zhou W, Tong J
Small (Weinheim an der Bergstrasse, Germany) 2022 Apr;18(14):e2107534

Lovastatin attenuates sevoflurane-induced cognitive disorder in aged rats via reducing Aβ accumulation.

Xu Y, Dong Y, Wang C, Jiang Q, Chu H, Tian Y
Neurochemistry international 2021 Sep;148:105078

Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus.

Inoue Y, Masuda T, Misumi Y, Ando Y, Ueda M
Neuroscience letters 2021 Sep 25;762:136136

Modified Low-Temperature Extraction Method for Isolation of Bletilla striata Polysaccharide as Antioxidant for the Prevention of Alzheimer's Disease.

Lin YW, Fang CH, Liang YJ, Liao HH, Lin FH
International journal of molecular sciences 2021 Nov 25;22(23)

N-linoleyltyrosine exerts neuroprotective effects in APP/PS1 transgenic mice via cannabinoid receptor-mediated autophagy.

Long CM, Zheng QX, Zhou Y, Liu YT, Gong LP, Zeng YC, Liu S
Journal of pharmacological sciences 2021 Dec;147(4):315-324

Bone marrow mesenchymal stem cells-derived exosomes reduce Aβ deposition and improve cognitive function recovery in mice with Alzheimer's disease by activating sphingosine kinase/sphingosine-1-phosphate signaling pathway.

Wang X, Yang G
Cell biology international 2021 Apr;45(4):775-784

Tetramethylpyrazine Attenuated Sevoflurane-Induced Neurotoxicity by Enhancing Autophagy through GPR50/CREB Pathway in SH-SY5Y Cells.

Xu L, Shen J, Dai S, Sun L, Chen X
The American journal of Chinese medicine 2020;48(4):945-966

Effect of Moxibustion on Behavioral Changes and Expression of APP and BACE1 in Hippocampus of SAMP8 Mice.

Ha L, Yang B, Wang S, An Y, Wang H, Cui Y
Evidence-based complementary and alternative medicine : eCAM 2020;2020:3598930

Opposite Roles of δ- and μ-Opioid Receptors in BACE1 Regulation and Alzheimer's Injury.

Xu Y, Zhi F, Balboni G, Yang Y, Xia Y
Frontiers in cellular neuroscience 2020;14:88

Activating transcription factor 6 reduces Aβ1-42 and restores memory in Alzheimer's disease model mice.

Du Y, Liu X, Zhu X, Liu Y, Wang X, Wu X
The International journal of neuroscience 2020 Oct;130(10):1015-1023

Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.

Wei H, Zhang HL, Wang XC, Xie JZ, An DD, Wan L, Wang JZ, Zeng Y, Shu XJ, Westermarck J, Lu YM, Ohlmeyer M, Liu R
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2020 Jul;17(3):1087-1103

p35 Hemizygous Deletion in 5xFAD Mice Increases Aβ Plaque Load in Males but Not in Females.

Barrett T, Marchalant Y, Park KHJ
Neuroscience 2019 Oct 1;417:45-56

Brain-derived neurotrophic factor modified human umbilical cord mesenchymal stem cells-derived cholinergic-like neurons improve spatial learning and memory ability in Alzheimer's disease rats.

Hu W, Feng Z, Xu J, Jiang Z, Feng M
Brain research 2019 May 1;1710:61-73

Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments.

Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, Chen X, Lan X, Li X, Shi X, Li N, Qu X
Journal of molecular neuroscience : MN 2019 Jan;67(1):62-71

Memantine, a Noncompetitive N-Methyl-D-Aspartate Receptor Antagonist, Attenuates Cerebral Amyloid Angiopathy by Increasing Insulin-Degrading Enzyme Expression.

Inoue Y, Ueda M, Masuda T, Misumi Y, Yamashita T, Ando Y
Molecular neurobiology 2019 Dec;56(12):8573-8588

Liraglutide Ameliorates Hyperhomocysteinemia-Induced Alzheimer-Like Pathology and Memory Deficits in Rats via Multi-molecular Targeting.

Zhang Y, Xie JZ, Xu XY, Hu J, Xu T, Jin S, Yang SJ, Wang JZ
Neuroscience bulletin 2019 Aug;35(4):724-734

Effects of chain length of saturated fatty acids on Aβ generation in SH-SY5Y cells.

Liu JJ, Zhang W, Wang SS, Jia ZQ, Shi YH, Yang L, Shi RL
Neuroscience letters 2019 Apr 17;698:169-172

Geniposide attenuates Aβ(25-35)-induced neurotoxicity via the TLR4/NF-κB pathway in HT22 cells.

Huang XF, Li JJ, Tao YG, Wang XQ, Zhang RL, Zhang JL, Su ZQ, Huang QH, Deng YH
RSC advances 2018 May 22;8(34):18926-18937

Ceruloplasmin, a Potential Therapeutic Agent for Alzheimer's Disease.

Zhao YS, Zhang LH, Yu PP, Gou YJ, Zhao J, You LH, Wang ZY, Zheng X, Yan LJ, Yu P, Chang YZ
Antioxidants & redox signaling 2018 May 10;28(14):1323-1337

CIP2A Causes Tau/APP Phosphorylation, Synaptopathy, and Memory Deficits in Alzheimer's Disease.

Shentu YP, Huo Y, Feng XL, Gilbert J, Zhang Q, Liuyang ZY, Wang XL, Wang G, Zhou H, Wang XC, Wang JZ, Lu YM, Westermarck J, Man HY, Liu R
Cell reports 2018 Jul 17;24(3):713-723

BACE1 Deficiency Causes Abnormal Neuronal Clustering in the Dentate Gyrus.

Hou H, Fan Q, He W, Suh H, Hu X, Yan R
Stem cell reports 2017 Jul 11;9(1):217-230

Cystatin C Shifts APP Processing from Amyloid-β Production towards Non-Amyloidgenic Pathway in Brain Endothelial Cells.

Wang XF, Liu DX, Liang Y, Xing LL, Zhao WH, Qin XX, Shang DS, Li B, Fang WG, Cao L, Zhao WD, Chen YH
PloS one 2016;11(8):e0161093

Polysaccharides from Pleurotus ostreatus alleviate cognitive impairment in a rat model of Alzheimer's disease.

Zhang Y, Yang X, Jin G, Yang X, Zhang Y
International journal of biological macromolecules 2016 Nov;92:935-941

Quercetin reduces eIF2α phosphorylation by GADD34 induction.

Hayakawa M, Itoh M, Ohta K, Li S, Ueda M, Wang MX, Nishida E, Islam S, Suzuki C, Ohzawa K, Kobori M, Inuzuka T, Nakagawa T
Neurobiology of aging 2015 Sep;36(9):2509-18

Aβ-induced Golgi fragmentation in Alzheimer's disease enhances Aβ production.

Joshi G, Chi Y, Huang Z, Wang Y
Proceedings of the National Academy of Sciences of the United States of America 2014 Apr 1;111(13):E1230-9

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse brain tissue were subjected to SDS PAGE followed by western blot with 12807-1-AP(BACE1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-BACE1 (IP:12807-1-AP, 3ug; Detection:12807-1-AP 1:500) with mouse brain tissue lysate 7500ug.
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The BACE1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BACE1. This antibody recognizes human, mouse, zebrafish antigen. The BACE1 antibody has been validated for the following applications: ELISA, WB, IP, IHC analysis.
Appendix: 12807-1-AP.pdf

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