BS1382

antibody from Bioworld Technology, Inc
Targeting: BACE1 BACE
Provider product page for BS1382
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS1382 - Provider product page
Provider
Bioworld Technology, Inc
Proper citation
Bioworld Technology Cat#BS1382, RRID:AB_1662097
Product name
BACE (D492) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 480-520 of Human BACE.
Description
Autosomal dominant Alzheimer£ªs disease is caused by mutations in the gene encoding the ÉÇ-amyloid protein precursor (APP). Amyloid ÉÇ-peptide(AÉÇ), the major feature of amyloid plaques in Alzheimer£ªs patients, is the product of APP cleavage by ÉÇ- and ÎÛ-secretases. BACE is the transmembrane protease which cleaves AÉÇ from APP. BACE and the related protein Asp1 are both widely expressed in human tissue with the highest levels in the pancreas. BACE has a molecular mass of ~70 kDa, larger than predicted due to glycosylation, and is localized within Golgi and endosomes.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
BACE1 protein structure - BS1382 shown in red.