Antibody data
- Antibody Data
- Antigen structure
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- Product number
- BS1382 - Provider product page
- Provider
- Bioworld Technology, Inc
- Proper citation
- Bioworld Technology Cat#BS1382, RRID:AB_1662097
- Product name
- BACE (D492) polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide, corresponding to amino acids 480-520 of Human BACE.
- Description
- Autosomal dominant Alzheimer£ªs disease is caused by mutations in the gene encoding the ÉÇ-amyloid protein precursor (APP). Amyloid ÉÇ-peptide(AÉÇ), the major feature of amyloid plaques in Alzheimer£ªs patients, is the product of APP cleavage by ÉÇ- and ÎÛ-secretases. BACE is the transmembrane protease which cleaves AÉÇ from APP. BACE and the related protein Asp1 are both widely expressed in human tissue with the highest levels in the pancreas. BACE has a molecular mass of ~70 kDa, larger than predicted due to glycosylation, and is localized within Golgi and endosomes.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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