Antibody data
- Antibody Data
- Antigen structure
- References [5]
- Comments [0]
- Validations
- Western blot [2]
- Immunohistochemistry [1]
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- Product number
- ABIN2841902 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (AA 38-70), (N-Term) antibody
- Antibody type
- Polyclonal
- Description
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Epitope
- AA 38-70, N-Term
- Antibody clone number
- RB16874
- Vial size
- 80 μL
- Storage
- Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Submitted references Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 nAChR-APP695 cells.
GGA proteins mediate the recycling pathway of memapsin 2 (BACE).
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.
Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
Nie HZ, Li ZQ, Yan QX, Wang ZJ, Zhao WJ, Guo LC, Yin M
Neurochemical research 2011 May;36(5):904-12
Neurochemical research 2011 May;36(5):904-12
GGA proteins mediate the recycling pathway of memapsin 2 (BACE).
He X, Li F, Chang WP, Tang J
The Journal of biological chemistry 2005 Mar 25;280(12):11696-703
The Journal of biological chemistry 2005 Mar 25;280(12):11696-703
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.
Xie J, Guo Q
The Journal of biological chemistry 2005 Apr 8;280(14):13824-32
The Journal of biological chemistry 2005 Apr 8;280(14):13824-32
Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.
Huang XP, Chang WP, Koelsch G, Turner RT 3rd, Lupu F, Tang J
The Journal of biological chemistry 2004 Sep 3;279(36):37886-94
The Journal of biological chemistry 2004 Sep 3;279(36):37886-94
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT
The Journal of biological chemistry 2004 Dec 10;279(50):52535-42
The Journal of biological chemistry 2004 Dec 10;279(50):52535-42
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Supportive validation
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- antibodies-online (provider)
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- Experimental details
- WB
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- WB
Supportive validation
- Submitted by
- antibodies-online (provider)
- Main image
- Experimental details
- IHC