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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN358083 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-beta-Site APP-Cleaving Enzyme 1 (BACE) (pSer498) antibody
- Antibody type
- Polyclonal
- Description
- Protein G Affinity Chromatography. Then, the antibody fraction is peptide affinity purified in a 2-step procedure with control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- pSer498
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references GGA proteins mediate the recycling pathway of memapsin 2 (BACE).
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.
Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.
Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
He X, Li F, Chang WP, Tang J
The Journal of biological chemistry 2005 Mar 25;280(12):11696-703
The Journal of biological chemistry 2005 Mar 25;280(12):11696-703
PAR-4 is involved in regulation of beta-secretase cleavage of the Alzheimer amyloid precursor protein.
Xie J, Guo Q
The Journal of biological chemistry 2005 Apr 8;280(14):13824-32
The Journal of biological chemistry 2005 Apr 8;280(14):13824-32
Internalization of exogenously added memapsin 2 (beta-secretase) ectodomain by cells is mediated by amyloid precursor protein.
Huang XP, Chang WP, Koelsch G, Turner RT 3rd, Lupu F, Tang J
The Journal of biological chemistry 2004 Sep 3;279(36):37886-94
The Journal of biological chemistry 2004 Sep 3;279(36):37886-94
Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1.
Yang HC, Chai X, Mosior M, Kohn W, Boggs LN, Erickson JA, McClure DB, Yeh WK, Zhang L, Gonzalez-DeWhitt P, Mayer JP, Martin JA, Hu J, Chen SH, Bueno AB, Little SP, McCarthy JR, May PC
Journal of neurochemistry 2004 Dec;91(6):1249-59
Journal of neurochemistry 2004 Dec;91(6):1249-59
Altered amyloid-beta metabolism and deposition in genomic-based beta-secretase transgenic mice.
Chiocco MJ, Kulnane LS, Younkin L, Younkin S, Evin G, Lamb BT
The Journal of biological chemistry 2004 Dec 10;279(50):52535-42
The Journal of biological chemistry 2004 Dec 10;279(50):52535-42
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