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- Antibody Data
- Antigen structure
- References [137]
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- Validations
- Western blot [1]
- Immunoprecipitation [2]
- Immunohistochemistry [1]
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- Product number
- 12780-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#12780-1-AP, RRID:AB_10638480
- Product name
- CP110 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CP110 antibody (Cat. #12780-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat, Canine and has been validated for the following applications: FC, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat, Canine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Centriole structural integrity defects are a crucial feature of Hydrolethalus Syndrome.
Extra centrosomes delay DNA damage-driven tumorigenesis.
Molecular basis promoting centriole triplet microtubule assembly.
DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling.
Dual roles of CCDC102A in governing centrosome duplication and cohesion.
Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells.
Time-series reconstruction of the molecular architecture of human centriole assembly.
ODF2 Negatively Regulates CP110 Levels at the Centrioles/Basal Bodies to Control the Biogenesis of Primary Cilia.
Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method.
CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis.
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
A hierarchical pathway for assembly of the distal appendages that organize primary cilia.
Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages.
HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells.
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.
Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis.
Centrosomal organization of Cep152 provides flexibility in Plk4 and procentriole positioning.
Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to Severe Acromesomelic Dysplasia.
Zika virus alters centrosome organization to suppress the innate immune response.
The mechanism of acentrosomal spindle assembly in human oocytes.
Postmitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells.
ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
The retromer complex regulates C. elegans development and mammalian ciliogenesis.
Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis.
Self-assembly of pericentriolar material in interphase cells lacking centrioles.
Centrosome function is critical during terminal erythroid differentiation.
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis.
TFEB- and TFE3-dependent autophagy activation supports cancer proliferation in the absence of centrosomes.
FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation.
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
Analyzing Centrioles and Cilia by Expansion Microscopy.
Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase.
Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold.
The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis.
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.
Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells.
CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.
Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis.
RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.
Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.
Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.
The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels.
WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.
Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis.
The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression.
Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis.
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome.
Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.
Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis.
ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.
NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells.
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila.
Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5.
Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1.
Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.
Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.
A theory of centriole duplication based on self-organized spatial pattern formation.
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.
Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells.
Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.
HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates.
Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.
Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.
The Cep57-pericentrin module organizes PCM expansion and centriole engagement.
Rab7 regulates primary cilia disassembly through cilia excision.
NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.
Self-organization of Plk4 regulates symmetry breaking in centriole duplication.
CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis.
Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow-Resident Melanoma CTCs.
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
The dual role of the centrosome in organizing the microtubule network in interphase.
PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion.
Aberrant epithelial remodeling with impairment of cilia architecture in non-cystic fibrosis bronchiectasis.
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
The small GTPase RSG1 controls a final step in primary cilia initiation.
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
VPS4 is a dynamic component of the centrosome that regulates centrosome localization of γ-tubulin, centriolar satellite stability and ciliogenesis.
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.
Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication.
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN.
Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.
Centrobin controls primary ciliogenesis in vertebrates.
Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.
The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning.
Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.
Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.
Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein.
Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis.
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.
MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
CEP295 interacts with microtubules and is required for centriole elongation.
Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.
SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function.
MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition.
Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
The Tumor Suppressor Cdkn3 Is Required for Maintaining the Proper Number of Centrosomes by Regulating the Centrosomal Stability of Mps1.
Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.
Centrin2 regulates CP110 removal in primary cilium formation.
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
Lineage specificity of primary cilia in the mouse embryo.
The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.
Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis.
Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells.
PIPKIγ targets to the centrosome and restrains centriole duplication.
SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication.
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.
Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion.
USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
CCDC41 is required for ciliary vesicle docking to the mother centriole.
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
Curinha A, Huang Z, Anglen T, Strong MA, Gliech CR, Jewett CE, Friskes A, Holland AJ
bioRxiv : the preprint server for biology 2024 Mar 6;
bioRxiv : the preprint server for biology 2024 Mar 6;
Extra centrosomes delay DNA damage-driven tumorigenesis.
Braun VZ, Karbon G, Schuler F, Schapfl MA, Weiss JG, Petermann PY, Spierings DCJ, Tijhuis AE, Foijer F, Labi V, Villunger A
Science advances 2024 Mar 29;10(13):eadk0564
Science advances 2024 Mar 29;10(13):eadk0564
Molecular basis promoting centriole triplet microtubule assembly.
Takeda Y, Chinen T, Honda S, Takatori S, Okuda S, Yamamoto S, Fukuyama M, Takeuchi K, Tomita T, Hata S, Kitagawa D
Nature communications 2024 Mar 22;15(1):2216
Nature communications 2024 Mar 22;15(1):2216
DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signaling.
Mao YQ, Seraphim TV, Wan Y, Wu R, Coyaud E, Bin Munim M, Mollica A, Laurent E, Babu M, Mennella V, Raught B, Houry WA
Cell reports 2024 Feb 27;43(2):113713
Cell reports 2024 Feb 27;43(2):113713
Dual roles of CCDC102A in governing centrosome duplication and cohesion.
Wang T, Fan G, Xia Y, Zou Y, Liu Y, Wang J, Hu Y, Teng J, Huang N, Chen J
Cell reports 2024 Feb 27;43(2):113696
Cell reports 2024 Feb 27;43(2):113696
Mouse SAS-6 is required for centriole formation in embryos and integrity in embryonic stem cells.
Grzonka M, Bazzi H
eLife 2024 Feb 26;13
eLife 2024 Feb 26;13
Time-series reconstruction of the molecular architecture of human centriole assembly.
Laporte MH, Gambarotto D, Bertiaux É, Bournonville L, Louvel V, Nunes JM, Borgers S, Hamel V, Guichard P
Cell 2024 Apr 25;187(9):2158-2174.e19
Cell 2024 Apr 25;187(9):2158-2174.e19
ODF2 Negatively Regulates CP110 Levels at the Centrioles/Basal Bodies to Control the Biogenesis of Primary Cilia.
Otto M, Hoyer-Fender S
Cells 2023 Sep 1;12(17)
Cells 2023 Sep 1;12(17)
Proteomic profiling of centrosomes across multiple mammalian cell and tissue types by an affinity capture method.
Carden S, Vitiello E, Rosa E Silva I, Holder J, Quarantotti V, Kishore K, Roamio Franklin VN, D'Santos C, Ochi T, van Breugel M, Gergely F
Developmental cell 2023 Nov 6;58(21):2393-2410.e9
Developmental cell 2023 Nov 6;58(21):2393-2410.e9
CCP5 and CCP6 retain CP110 and negatively regulate ciliogenesis.
Wang Y, Zhang Y, Guo X, Zheng Y, Zhang X, Feng S, Wu HY
BMC biology 2023 May 24;21(1):124
BMC biology 2023 May 24;21(1):124
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
Xie S, Naslavsky N, Caplan S
EMBO reports 2023 Jun 5;24(6):e56317
EMBO reports 2023 Jun 5;24(6):e56317
A hierarchical pathway for assembly of the distal appendages that organize primary cilia.
Kanie T, Love JF, Fisher SD, Gustavsson AK, Jackson PK
bioRxiv : the preprint server for biology 2023 Jan 10;
bioRxiv : the preprint server for biology 2023 Jan 10;
Myristoylated Neuronal Calcium Sensor-1 captures the ciliary vesicle at distal appendages.
Kanie T, Ng R, Abbott KL, Pongs O, Jackson PK
bioRxiv : the preprint server for biology 2023 Jan 10;
bioRxiv : the preprint server for biology 2023 Jan 10;
HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells.
Hoffman HK, Prekeris R
bioRxiv : the preprint server for biology 2023 Feb 8;
bioRxiv : the preprint server for biology 2023 Feb 8;
Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.
Hall EA, Kumar D, Prosser SL, Yeyati PL, Herranz-Pérez V, García-Verdugo JM, Rose L, McKie L, Dodd DO, Tennant PA, Megaw R, Murphy LC, Ferreira MF, Grimes G, Williams L, Quidwai T, Pelletier L, Reiter JF, Mill P
eLife 2023 Feb 15;12
eLife 2023 Feb 15;12
Phosphorylation of MIF by PIP4K2a is necessary for cilia biogenesis.
Zhang L, Zhang H, Agborbesong E, Zhou JX, Li X
Cell death & disease 2023 Dec 5;14(12):795
Cell death & disease 2023 Dec 5;14(12):795
Centrosomal organization of Cep152 provides flexibility in Plk4 and procentriole positioning.
Sullenberger C, Kong D, Avazpour P, Luvsanjav D, Loncarek J
The Journal of cell biology 2023 Dec 4;222(12)
The Journal of cell biology 2023 Dec 4;222(12)
Biallelic KIF24 Variants Are Responsible for a Spectrum of Skeletal Disorders Ranging From Lethal Skeletal Ciliopathy to Severe Acromesomelic Dysplasia.
Reilly ML, Ain NU, Muurinen M, Tata A, Huber C, Simon M, Ishaq T, Shaw N, Rusanen S, Pekkinen M, Högler W, Knapen MFCM, van den Born M, Saunier S, Naz S, Cormier-Daire V, Benmerah A, Makitie O
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Sep;37(9):1642-1652
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2022 Sep;37(9):1642-1652
Zika virus alters centrosome organization to suppress the innate immune response.
Kodani A, Knopp KA, Di Lullo E, Retallack H, Kriegstein AR, DeRisi JL, Reiter JF
EMBO reports 2022 Sep 5;23(9):e52211
EMBO reports 2022 Sep 5;23(9):e52211
The mechanism of acentrosomal spindle assembly in human oocytes.
Wu T, Dong J, Fu J, Kuang Y, Chen B, Gu H, Luo Y, Gu R, Zhang M, Li W, Dong X, Sun X, Sang Q, Wang L
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Science (New York, N.Y.) 2022 Nov 18;378(6621):eabq7361
Postmitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells.
Buss G, Stratton MB, Milenkovic L, Stearns T
Molecular biology of the cell 2022 Nov 1;33(13):ar118
Molecular biology of the cell 2022 Nov 1;33(13):ar118
ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis.
Song T, Yang Y, Zhou P, Ran J, Zhang L, Wu X, Xie W, Zhong T, Liu H, Liu M, Li D, Zhao H, Zhou J
EMBO reports 2022 May 4;23(5):e54090
EMBO reports 2022 May 4;23(5):e54090
The retromer complex regulates C. elegans development and mammalian ciliogenesis.
Xie S, Dierlam C, Smith E, Duran R, Williams A, Davis A, Mathew D, Naslavsky N, Iyer J, Caplan S
Journal of cell science 2022 May 15;135(10)
Journal of cell science 2022 May 15;135(10)
Differential requirements for the Eps15 homology domain proteins EHD4 and EHD2 in the regulation of mammalian ciliogenesis.
Jones T, Naslavsky N, Caplan S
Traffic (Copenhagen, Denmark) 2022 Jul;23(7):360-373
Traffic (Copenhagen, Denmark) 2022 Jul;23(7):360-373
Self-assembly of pericentriolar material in interphase cells lacking centrioles.
Chen F, Wu J, Iwanski MK, Jurriens D, Sandron A, Pasolli M, Puma G, Kromhout JZ, Yang C, Nijenhuis W, Kapitein LC, Berger F, Akhmanova A
eLife 2022 Jul 5;11
eLife 2022 Jul 5;11
Centrosome function is critical during terminal erythroid differentiation.
Tátrai P, Gergely F
The EMBO journal 2022 Jul 18;41(14):e108739
The EMBO journal 2022 Jul 18;41(14):e108739
LUBAC regulates ciliogenesis by promoting CP110 removal from the mother centriole.
Shen XL, Yuan JF, Qin XH, Song GP, Hu HB, Tu HQ, Song ZQ, Li PY, Xu YL, Li S, Jian XX, Li JN, He CY, Yu XP, Liang LY, Wu M, Han QY, Wang K, Li AL, Zhou T, Zhang YC, Wang N, Li HY
The Journal of cell biology 2022 Jan 3;221(1)
The Journal of cell biology 2022 Jan 3;221(1)
A cell-based GEF assay reveals new substrates for DENN domains and a role for DENND2B in primary ciliogenesis.
Kumar R, Francis V, Kulasekaran G, Khan M, Armstrong GAB, McPherson PS
Science advances 2022 Feb 25;8(8):eabk3088
Science advances 2022 Feb 25;8(8):eabk3088
TFEB- and TFE3-dependent autophagy activation supports cancer proliferation in the absence of centrosomes.
Kao CH, Su TY, Huang WS, Lu XY, Jane WN, Huang CY, Huang HH, Wang WJ
Autophagy 2022 Dec;18(12):2830-2850
Autophagy 2022 Dec;18(12):2830-2850
FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation.
Czerny CC, Borschel A, Cai M, Otto M, Hoyer-Fender S
Scientific reports 2022 Dec 12;12(1):21468
Scientific reports 2022 Dec 12;12(1):21468
GJA1 depletion causes ciliary defects by affecting Rab11 trafficking to the ciliary base.
Jang DG, Kwon KY, Kweon YC, Kim BG, Myung K, Lee HS, Young Park C, Kwon T, Park TJ
eLife 2022 Aug 25;11
eLife 2022 Aug 25;11
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
Bernatik O, Paclikova P, Kotrbova A, Bryja V, Cajanek L
Frontiers in cell and developmental biology 2021;9:623753
Frontiers in cell and developmental biology 2021;9:623753
Analyzing Centrioles and Cilia by Expansion Microscopy.
Kong D, Loncarek J
Methods in molecular biology (Clifton, N.J.) 2021;2329:249-263
Methods in molecular biology (Clifton, N.J.) 2021;2329:249-263
Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase.
Shao X, Ding Z, Zhou W, Li Y, Li Z, Cui H, Lin X, Cao G, Cheng B, Sun H, Li M, Liu K, Lu D, Geng S, Shi W, Zhang G, Song Q, Chen L, Wang G, Su W, Cai L, Fang L, Leong DT, Li Y, Yu XF, Li H
Nature nanotechnology 2021 Oct;16(10):1150-1160
Nature nanotechnology 2021 Oct;16(10):1150-1160
Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold.
Schweizer N, Haren L, Dutto I, Viais R, Lacasa C, Merdes A, Lüders J
Nature communications 2021 Oct 15;12(1):6042
Nature communications 2021 Oct 15;12(1):6042
The SON RNA splicing factor is required for intracellular trafficking structures that promote centriole assembly and ciliogenesis.
Stemm-Wolf AJ, O'Toole ET, Sheridan RM, Morgan JT, Pearson CG
Molecular biology of the cell 2021 Oct 1;32(20):ar4
Molecular biology of the cell 2021 Oct 1;32(20):ar4
NudCL2 is an autophagy receptor that mediates selective autophagic degradation of CP110 at mother centrioles to promote ciliogenesis.
Liu M, Zhang W, Li M, Feng J, Kuang W, Chen X, Yang F, Sun Q, Xu Z, Hua J, Yang C, Liu W, Shu Q, Yang Y, Zhou T, Xie S
Cell research 2021 Nov;31(11):1199-1211
Cell research 2021 Nov;31(11):1199-1211
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Dhekne HS, Yanatori I, Vides EG, Sobu Y, Diez F, Tonelli F, Pfeffer SR
Life science alliance 2021 May;4(5)
Life science alliance 2021 May;4(5)
Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins.
Sobu Y, Wawro PS, Dhekne HS, Yeshaw WM, Pfeffer SR
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 9;118(10)
Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle.
Ito KK, Watanabe K, Ishida H, Matsuhashi K, Chinen T, Hata S, Kitagawa D
The Journal of cell biology 2021 Mar 1;220(3)
The Journal of cell biology 2021 Mar 1;220(3)
Trace Amine-Associated Receptor 1 Trafficking to Cilia of Thyroid Epithelial Cells.
Qatato M, Venugopalan V, Al-Hashimi A, Rehders M, Valentine AD, Hein Z, Dallto U, Springer S, Brix K
Cells 2021 Jun 16;10(6)
Cells 2021 Jun 16;10(6)
CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels.
Gonçalves AB, Hasselbalch SK, Joensen BB, Patzke S, Martens P, Ohlsen SK, Quinodoz M, Nikopoulos K, Suleiman R, Damsø Jeppesen MP, Weiss C, Christensen ST, Rivolta C, Andersen JS, Farinelli P, Pedersen LB
eLife 2021 Jul 14;10
eLife 2021 Jul 14;10
Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.
Ganga AK, Kennedy MC, Oguchi ME, Gray S, Oliver KE, Knight TA, De La Cruz EM, Homma Y, Fukuda M, Breslow DK
Current biology : CB 2021 Jul 12;31(13):2895-2905.e7
Current biology : CB 2021 Jul 12;31(13):2895-2905.e7
TRIM37 prevents formation of centriolar protein assemblies by regulating Centrobin.
Balestra FR, Domínguez-Calvo A, Wolf B, Busso C, Buff A, Averink T, Lipsanen-Nyman M, Huertas P, Ríos RM, Gönczy P
eLife 2021 Jan 25;10
eLife 2021 Jan 25;10
EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis.
Partisani M, Baron CL, Ghossoub R, Fayad R, Pagnotta S, Abélanet S, Macia E, Brau F, Lacas-Gervais S, Benmerah A, Luton F, Franco M
Journal of cell science 2021 Jan 22;134(2)
Journal of cell science 2021 Jan 22;134(2)
RAB19 Directs Cortical Remodeling and Membrane Growth for Primary Ciliogenesis.
Jewett CE, Soh AWJ, Lin CH, Lu Q, Lencer E, Westlake CJ, Pearson CG, Prekeris R
Developmental cell 2021 Feb 8;56(3):325-340.e8
Developmental cell 2021 Feb 8;56(3):325-340.e8
Centriole and PCM cooperatively recruit CEP192 to spindle poles to promote bipolar spindle assembly.
Chinen T, Yamazaki K, Hashimoto K, Fujii K, Watanabe K, Takeda Y, Yamamoto S, Nozaki Y, Tsuchiya Y, Takao D, Kitagawa D
The Journal of cell biology 2021 Feb 1;220(2)
The Journal of cell biology 2021 Feb 1;220(2)
Aurora Kinase A proximity map reveals centriolar satellites as regulators of its ciliary function.
Arslanhan MD, Rauniyar N, Yates JR 3rd, Firat-Karalar EN
EMBO reports 2021 Aug 4;22(8):e51902
EMBO reports 2021 Aug 4;22(8):e51902
The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels.
Porter AP, Reed H, White GRM, Ogg EL, Whalley HJ, Malliri A
Journal of cell science 2021 Apr 1;134(7)
Journal of cell science 2021 Apr 1;134(7)
WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.
Steib E, Laporte MH, Gambarotto D, Olieric N, Zheng C, Borgers S, Olieric V, Le Guennec M, Koll F, Tassin AM, Steinmetz MO, Guichard P, Hamel V
eLife 2020 Sep 18;9
eLife 2020 Sep 18;9
Lamin A-mediated nuclear lamina integrity is required for proper ciliogenesis.
Fan JR, You LR, Wang WJ, Huang WS, Chu CT, Chi YH, Chen HC
EMBO reports 2020 Oct 5;21(10):e49680
EMBO reports 2020 Oct 5;21(10):e49680
The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression.
Takeda Y, Yamazaki K, Hashimoto K, Watanabe K, Chinen T, Kitagawa D
Journal of cell science 2020 Oct 1;133(19)
Journal of cell science 2020 Oct 1;133(19)
Growth disadvantage associated with centrosome amplification drives population-level centriole number homeostasis.
Sala R, Farrell KC, Stearns T
Molecular biology of the cell 2020 Nov 15;31(24):2646-2656
Molecular biology of the cell 2020 Nov 15;31(24):2646-2656
LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome.
Bozal-Basterra L, Gonzalez-Santamarta M, Muratore V, Bermejo-Arteagabeitia A, Da Fonseca C, Barroso-Gomila O, Azkargorta M, Iloro I, Pampliega O, Andrade R, Martín-Martín N, Branon TC, Ting AY, Rodríguez JA, Carracedo A, Elortza F, Sutherland JD, Barrio R
eLife 2020 Jun 18;9
eLife 2020 Jun 18;9
Ciliogenesis and Hedgehog signalling are suppressed downstream of KRAS during acinar-ductal metaplasia in mouse.
Bangs FK, Miller P, O'Neill E
Disease models & mechanisms 2020 Jul 30;13(7)
Disease models & mechanisms 2020 Jul 30;13(7)
Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis.
Zhao H, Yang S, Chen Q, Duan X, Li G, Huang Q, Zhu X, Yan X
Journal of cell science 2020 Jul 3;133(13)
Journal of cell science 2020 Jul 3;133(13)
ESCRT subunit CHMP4B localizes to primary cilia and is required for the structural integrity of the ciliary membrane.
Jung E, Choi TI, Lee JE, Kim CH, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1331-1344
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jan;34(1):1331-1344
NuMA assemblies organize microtubule asters to establish spindle bipolarity in acentrosomal human cells.
Chinen T, Yamamoto S, Takeda Y, Watanabe K, Kuroki K, Hashimoto K, Takao D, Kitagawa D
The EMBO journal 2020 Jan 15;39(2):e102378
The EMBO journal 2020 Jan 15;39(2):e102378
Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function.
Flynn M, Whitton L, Donohoe G, Morrison CG, Morris DW
Human molecular genetics 2020 Feb 1;29(3):407-417
Human molecular genetics 2020 Feb 1;29(3):407-417
PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.
Sladky VC, Knapp K, Szabo TG, Braun VZ, Bongiovanni L, van den Bos H, Spierings DC, Westendorp B, Curinha A, Stojakovic T, Scharnagl H, Timelthaler G, Tsuchia K, Pinter M, Semmler G, Foijer F, de Bruin A, Reiberger T, Rohr-Udilova N, Villunger A
EMBO reports 2020 Dec 3;21(12):e50893
EMBO reports 2020 Dec 3;21(12):e50893
The novel ciliogenesis regulator DYRK2 governs Hedgehog signaling during mouse embryogenesis.
Yoshida S, Aoki K, Fujiwara K, Nakakura T, Kawamura A, Yamada K, Ono M, Yogosawa S, Yoshida K
eLife 2020 Aug 6;9
eLife 2020 Aug 6;9
Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila.
Dobbelaere J, Schmidt Cernohorska M, Huranova M, Slade D, Dammermann A
Current biology : CB 2020 Aug 3;30(15):3045-3056.e7
Current biology : CB 2020 Aug 3;30(15):3045-3056.e7
Posterior Neocortex-Specific Regulation of Neuronal Migration by CEP85L Identifies Maternal Centriole-Dependent Activation of CDK5.
Kodani A, Kenny C, Lai A, Gonzalez DM, Stronge E, Sejourne GM, Isacco L, Partlow JN, O'Donnell A, McWalter K, Byrne AB, Barkovich AJ, Yang E, Hill RS, Gawlinski P, Wiszniewski W, Cohen JS, Fatemi SA, Baranano KW, Sahin M, Vossler DG, Yuskaitis CJ, Walsh CA
Neuron 2020 Apr 22;106(2):246-255.e6
Neuron 2020 Apr 22;106(2):246-255.e6
Neddylation inhibitor MLN4924 suppresses cilia formation by modulating AKT1.
Mao H, Tang Z, Li H, Sun B, Tan M, Fan S, Zhu Y, Sun Y
Protein & cell 2019 Oct;10(10):726-744
Protein & cell 2019 Oct;10(10):726-744
Phosphorylation of CEP83 by TTBK2 is necessary for cilia initiation.
Lo CH, Lin IH, Yang TT, Huang YC, Tanos BE, Chou PC, Chang CW, Tsay YG, Liao JC, Wang WJ
The Journal of cell biology 2019 Oct 7;218(10):3489-3505
The Journal of cell biology 2019 Oct 7;218(10):3489-3505
Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair.
Khouj EM, Prosser SL, Tada H, Chong WM, Liao JC, Sugasawa K, Morrison CG
Journal of cell science 2019 Oct 3;132(19)
Journal of cell science 2019 Oct 3;132(19)
A theory of centriole duplication based on self-organized spatial pattern formation.
Takao D, Yamamoto S, Kitagawa D
The Journal of cell biology 2019 Nov 4;218(11):3537-3547
The Journal of cell biology 2019 Nov 4;218(11):3537-3547
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium.
Xie S, Farmer T, Naslavsky N, Caplan S
Journal of cell science 2019 Nov 14;132(22)
Journal of cell science 2019 Nov 14;132(22)
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation.
Odabasi E, Gul S, Kavakli IH, Firat-Karalar EN
EMBO reports 2019 Jun;20(6)
EMBO reports 2019 Jun;20(6)
A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes.
So C, Seres KB, Steyer AM, Mönnich E, Clift D, Pejkovska A, Möbius W, Schuh M
Science (New York, N.Y.) 2019 Jun 28;364(6447)
Science (New York, N.Y.) 2019 Jun 28;364(6447)
Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells.
Wolf B, Busso C, Gönczy P
Nature communications 2019 Jun 28;10(1):2859
Nature communications 2019 Jun 28;10(1):2859
Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs.
Clijsters L, Hoencamp C, Calis JJA, Marzio A, Handgraaf SM, Cuitino MC, Rosenberg BR, Leone G, Pagano M
Molecular cell 2019 Jun 20;74(6):1264-1277.e7
Molecular cell 2019 Jun 20;74(6):1264-1277.e7
HsSAS-6-dependent cartwheel assembly ensures stabilization of centriole intermediates.
Yoshiba S, Tsuchiya Y, Ohta M, Gupta A, Shiratsuchi G, Nozaki Y, Ashikawa T, Fujiwara T, Natsume T, Kanemaki MT, Kitagawa D
Journal of cell science 2019 Jun 20;132(12)
Journal of cell science 2019 Jun 20;132(12)
Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis.
Walia V, Cuenca A, Vetter M, Insinna C, Perera S, Lu Q, Ritt DA, Semler E, Specht S, Stauffer J, Morrison DK, Lorentzen E, Westlake CJ
Developmental cell 2019 Jul 22;50(2):229-246.e7
Developmental cell 2019 Jul 22;50(2):229-246.e7
Investigation of F-BAR domain PACSIN proteins uncovers membrane tubulation function in cilia assembly and transport.
Insinna C, Lu Q, Teixeira I, Harned A, Semler EM, Stauffer J, Magidson V, Tiwari A, Kenworthy AK, Narayan K, Westlake CJ
Nature communications 2019 Jan 25;10(1):428
Nature communications 2019 Jan 25;10(1):428
The Cep57-pericentrin module organizes PCM expansion and centriole engagement.
Watanabe K, Takao D, Ito KK, Takahashi M, Kitagawa D
Nature communications 2019 Feb 25;10(1):931
Nature communications 2019 Feb 25;10(1):931
Rab7 regulates primary cilia disassembly through cilia excision.
Wang G, Hu HB, Chang Y, Huang Y, Song ZQ, Zhou SB, Chen L, Zhang YC, Wu M, Tu HQ, Yuan JF, Wang N, Pan X, Li AL, Zhou T, Zhang XM, He K, Li HY
The Journal of cell biology 2019 Dec 2;218(12):4030-4041
The Journal of cell biology 2019 Dec 2;218(12):4030-4041
NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.
Li M, Xu X, Zhang J, Liu M, Wang W, Gao Y, Sun Q, Zhang J, Lu Y, Wang F, Liu W, Zhou T, Yang Y
Cell death & disease 2019 Aug 19;10(9):628
Cell death & disease 2019 Aug 19;10(9):628
A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling.
Frikstad KM, Molinari E, Thoresen M, Ramsbottom SA, Hughes F, Letteboer SJF, Gilani S, Schink KO, Stokke T, Geimer S, Pedersen LB, Giles RH, Akhmanova A, Roepman R, Sayer JA, Patzke S
Cell reports 2019 Aug 13;28(7):1907-1922.e6
Cell reports 2019 Aug 13;28(7):1907-1922.e6
Self-organization of Plk4 regulates symmetry breaking in centriole duplication.
Yamamoto S, Kitagawa D
Nature communications 2019 Apr 18;10(1):1810
Nature communications 2019 Apr 18;10(1):1810
CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis.
Tsai JJ, Hsu WB, Liu JH, Chang CW, Tang TK
Scientific reports 2019 Apr 15;9(1):6037
Scientific reports 2019 Apr 15;9(1):6037
Targeting USP7 Identifies a Metastasis-Competent State within Bone Marrow-Resident Melanoma CTCs.
Vishnoi M, Boral D, Liu H, Sprouse ML, Yin W, Goswami-Sewell D, Tetzlaff MT, Davies MA, Oliva ICG, Marchetti D
Cancer research 2018 Sep 15;78(18):5349-5362
Cancer research 2018 Sep 15;78(18):5349-5362
M-Phase Phosphoprotein 9 regulates ciliogenesis by modulating CP110-CEP97 complex localization at the mother centriole.
Huang N, Zhang D, Li F, Chai P, Wang S, Teng J, Chen J
Nature communications 2018 Oct 30;9(1):4511
Nature communications 2018 Oct 30;9(1):4511
The dual role of the centrosome in organizing the microtubule network in interphase.
Gavilan MP, Gandolfo P, Balestra FR, Arias F, Bornens M, Rios RM
EMBO reports 2018 Nov;19(11)
EMBO reports 2018 Nov;19(11)
PPP1R35 ensures centriole homeostasis by promoting centriole-to-centrosome conversion.
Fong CS, Ozaki K, Tsou MB
Molecular biology of the cell 2018 Nov 15;29(23):2801-2808
Molecular biology of the cell 2018 Nov 15;29(23):2801-2808
Aberrant epithelial remodeling with impairment of cilia architecture in non-cystic fibrosis bronchiectasis.
Chen ZG, Li YY, Wang ZN, Li M, Lim HF, Zhou YQ, Cai LM, Li YT, Yang LF, Zhang TT, Wang DY
Journal of thoracic disease 2018 Mar;10(3):1753-1764
Journal of thoracic disease 2018 Mar;10(3):1753-1764
Super-Resolution Imaging Reveals TCTN2 Depletion-Induced IFT88 Lumen Leakage and Ciliary Weakening.
Weng RR, Yang TT, Huang CE, Chang CW, Wang WJ, Liao JC
Biophysical journal 2018 Jul 17;115(2):263-275
Biophysical journal 2018 Jul 17;115(2):263-275
The small GTPase RSG1 controls a final step in primary cilia initiation.
Agbu SO, Liang Y, Liu A, Anderson KV
The Journal of cell biology 2018 Jan 2;217(1):413-427
The Journal of cell biology 2018 Jan 2;217(1):413-427
Export of membrane proteins from the Golgi complex to the primary cilium requires the kinesin motor, KIFC1.
Lee SH, Joo K, Jung EJ, Hong H, Seo J, Kim J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 Feb;32(2):957-968
VPS4 is a dynamic component of the centrosome that regulates centrosome localization of γ-tubulin, centriolar satellite stability and ciliogenesis.
Ott C, Nachmias D, Adar S, Jarnik M, Sherman S, Birnbaum RY, Lippincott-Schwartz J, Elia N
Scientific reports 2018 Feb 20;8(1):3353
Scientific reports 2018 Feb 20;8(1):3353
Truncated SALL1 Impedes Primary Cilia Function in Townes-Brocks Syndrome.
Bozal-Basterra L, Martín-Ruíz I, Pirone L, Liang Y, Sigurðsson JO, Gonzalez-Santamarta M, Giordano I, Gabicagogeascoa E, de Luca A, Rodríguez JA, Wilkie AOM, Kohlhase J, Eastwood D, Yale C, Olsen JV, Rauchman M, Anderson KV, Sutherland JD, Barrio R
American journal of human genetics 2018 Feb 1;102(2):249-265
American journal of human genetics 2018 Feb 1;102(2):249-265
Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication.
Ling H, Peng L, Wang J, Rahhal R, Seto E
Cell reports 2018 Dec 4;25(10):2851-2865.e3
Cell reports 2018 Dec 4;25(10):2851-2865.e3
Microtubule asters anchored by FSD1 control axoneme assembly and ciliogenesis.
Tu HQ, Qin XH, Liu ZB, Song ZQ, Hu HB, Zhang YC, Chang Y, Wu M, Huang Y, Bai YF, Wang G, Han QY, Li AL, Zhou T, Liu F, Zhang XM, Li HY
Nature communications 2018 Dec 11;9(1):5277
Nature communications 2018 Dec 11;9(1):5277
PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTN.
Sydor AM, Coyaud E, Rovelli C, Laurent E, Liu H, Raught B, Mennella V
eLife 2018 Aug 31;7
eLife 2018 Aug 31;7
Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease.
Barny I, Perrault I, Michel C, Soussan M, Goudin N, Rio M, Thomas S, Attié-Bitach T, Hamel C, Dollfus H, Kaplan J, Rozet JM, Gerard X
Human molecular genetics 2018 Aug 1;27(15):2689-2702
Human molecular genetics 2018 Aug 1;27(15):2689-2702
Centrobin controls primary ciliogenesis in vertebrates.
Ogungbenro YA, Tena TC, Gaboriau D, Lalor P, Dockery P, Philipp M, Morrison CG
The Journal of cell biology 2018 Apr 2;217(4):1205-1215
The Journal of cell biology 2018 Apr 2;217(4):1205-1215
Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells.
Wang JT, Kong D, Hoerner CR, Loncarek J, Stearns T
eLife 2017 Sep 14;6
eLife 2017 Sep 14;6
The daughter centriole controls ciliogenesis by regulating Neurl-4 localization at the centrosome.
Loukil A, Tormanen K, Sütterlin C
The Journal of cell biology 2017 May 1;216(5):1287-1300
The Journal of cell biology 2017 May 1;216(5):1287-1300
USP9X regulates centrosome duplication and promotes breast carcinogenesis.
Li X, Song N, Liu L, Liu X, Ding X, Song X, Yang S, Shan L, Zhou X, Su D, Wang Y, Zhang Q, Cao C, Ma S, Yu N, Yang F, Wang Y, Yao Z, Shang Y, Shi L
Nature communications 2017 Mar 31;8:14866
Nature communications 2017 Mar 31;8:14866
Zika virus causes supernumerary foci with centriolar proteins and impaired spindle positioning.
Wolf B, Diop F, Ferraris P, Wichit S, Busso C, Missé D, Gönczy P
Open biology 2017 Jan;7(1)
Open biology 2017 Jan;7(1)
Asymmetric Centriole Numbers at Spindle Poles Cause Chromosome Missegregation in Cancer.
Cosenza MR, Cazzola A, Rossberg A, Schieber NL, Konotop G, Bausch E, Slynko A, Holland-Letz T, Raab MS, Dubash T, Glimm H, Poppelreuther S, Herold-Mende C, Schwab Y, Krämer A
Cell reports 2017 Aug 22;20(8):1906-1920
Cell reports 2017 Aug 22;20(8):1906-1920
Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
Hamel V, Steib E, Hamelin R, Armand F, Borgers S, Flückiger I, Busso C, Olieric N, Sorzano COS, Steinmetz MO, Guichard P, Gönczy P
Current biology : CB 2017 Aug 21;27(16):2486-2498.e6
Current biology : CB 2017 Aug 21;27(16):2486-2498.e6
Human microcephaly protein RTTN interacts with STIL and is required to build full-length centrioles.
Chen HY, Wu CT, Tang CC, Lin YN, Wang WJ, Tang TK
Nature communications 2017 Aug 15;8(1):247
Nature communications 2017 Aug 15;8(1):247
Fidgetin-like 1 is a ciliogenesis-inhibitory centrosome protein.
Zhao X, Jin M, Wang M, Sun L, Hong X, Cao Y, Wang C
Cell cycle (Georgetown, Tex.) 2016 Sep;15(17):2367-75
Cell cycle (Georgetown, Tex.) 2016 Sep;15(17):2367-75
Ciliary transcription factors and miRNAs precisely regulate Cp110 levels required for ciliary adhesions and ciliogenesis.
Walentek P, Quigley IK, Sun DI, Sajjan UK, Kintner C, Harland RM
eLife 2016 Sep 13;5
eLife 2016 Sep 13;5
A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.
Nechipurenko IV, Olivier-Mason A, Kazatskaya A, Kennedy J, McLachlan IG, Heiman MG, Blacque OE, Sengupta P
Developmental cell 2016 Sep 12;38(5):493-506
Developmental cell 2016 Sep 12;38(5):493-506
KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification.
Fournier M, Orpinell M, Grauffel C, Scheer E, Garnier JM, Ye T, Chavant V, Joint M, Esashi F, Dejaegere A, Gönczy P, Tora L
Nature communications 2016 Oct 31;7:13227
Nature communications 2016 Oct 31;7:13227
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis.
Yadav SP, Sharma NK, Liu C, Dong L, Li T, Swaroop A
Development (Cambridge, England) 2016 May 1;143(9):1491-501
Development (Cambridge, England) 2016 May 1;143(9):1491-501
MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.
Lee SH, Lee MS, Choi TI, Hong H, Seo JY, Kim CH, Kim J
Scientific reports 2016 Jun 6;6:27284
Scientific reports 2016 Jun 6;6:27284
CEP295 interacts with microtubules and is required for centriole elongation.
Chang CW, Hsu WB, Tsai JJ, Tang CJ, Tang TK
Journal of cell science 2016 Jul 1;129(13):2501-13
Journal of cell science 2016 Jul 1;129(13):2501-13
Cep295 is a conserved scaffold protein required for generation of a bona fide mother centriole.
Tsuchiya Y, Yoshiba S, Gupta A, Watanabe K, Kitagawa D
Nature communications 2016 Aug 26;7:12567
Nature communications 2016 Aug 26;7:12567
SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz SH, Pfreundschuh M, Hosner S, Flückiger I, Jaussi R, Wieser MM, Thieltges KM, Deupi X, Müller DJ, Kammerer RA, Gönczy P, Hirono M, Steinmetz MO
Nature cell biology 2016 Apr;18(4):393-403
Nature cell biology 2016 Apr;18(4):393-403
Mutations in human C2CD3 cause skeletal dysplasia and provide new insights into phenotypic and cellular consequences of altered C2CD3 function.
Cortés CR, McInerney-Leo AM, Vogel I, Rondón Galeano MC, Leo PJ, Harris JE, Anderson LK, Keith PA, Brown MA, Ramsing M, Duncan EL, Zankl A, Wicking C
Scientific reports 2016 Apr 20;6:24083
Scientific reports 2016 Apr 20;6:24083
MiR-129-3p promotes docetaxel resistance of breast cancer cells via CP110 inhibition.
Zhang Y, Wang Y, Wei Y, Li M, Yu S, Ye M, Zhang H, Chen S, Liu W, Zhang J
Scientific reports 2015 Oct 21;5:15424
Scientific reports 2015 Oct 21;5:15424
Specific CP110 Phosphorylation Sites Mediate Anaphase Catastrophe after CDK2 Inhibition: Evidence for Cooperation with USP33 Knockdown.
Hu S, Lu Y, Orr B, Godek K, Mustachio LM, Kawakami M, Sekula D, Compton DA, Freemantle S, Dmitrovsky E
Molecular cancer therapeutics 2015 Nov;14(11):2576-85
Molecular cancer therapeutics 2015 Nov;14(11):2576-85
The Tumor Suppressor Cdkn3 Is Required for Maintaining the Proper Number of Centrosomes by Regulating the Centrosomal Stability of Mps1.
Srinivas V, Kitagawa M, Wong J, Liao PJ, Lee SH
Cell reports 2015 Nov 24;13(8):1569-77
Cell reports 2015 Nov 24;13(8):1569-77
Myosin heavy chain 10 (MYH10) is required for centriole migration during the biogenesis of primary cilia.
Hong H, Kim J, Kim J
Biochemical and biophysical research communications 2015 May 22;461(1):180-5
Biochemical and biophysical research communications 2015 May 22;461(1):180-5
Centrin2 regulates CP110 removal in primary cilium formation.
Prosser SL, Morrison CG
The Journal of cell biology 2015 Mar 16;208(6):693-701
The Journal of cell biology 2015 Mar 16;208(6):693-701
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing.
Pagan JK, Marzio A, Jones MJ, Saraf A, Jallepalli PV, Florens L, Washburn MP, Pagano M
Nature cell biology 2015 Jan;17(1):31-43
Nature cell biology 2015 Jan;17(1):31-43
Lineage specificity of primary cilia in the mouse embryo.
Bangs FK, Schrode N, Hadjantonakis AK, Anderson KV
Nature cell biology 2015 Feb;17(2):113-22
Nature cell biology 2015 Feb;17(2):113-22
The Microtubule-Depolymerizing Activity of a Mitotic Kinesin Protein KIF2A Drives Primary Cilia Disassembly Coupled with Cell Proliferation.
Miyamoto T, Hosoba K, Ochiai H, Royba E, Izumi H, Sakuma T, Yamamoto T, Dynlacht BD, Matsuura S
Cell reports 2015 Feb 10;10(5):664-673
Cell reports 2015 Feb 10;10(5):664-673
Mother Centriole Distal Appendages Mediate Centrosome Docking at the Immunological Synapse and Reveal Mechanistic Parallels with Ciliogenesis.
Stinchcombe JC, Randzavola LO, Angus KL, Mantell JM, Verkade P, Griffiths GM
Current biology : CB 2015 Dec 21;25(24):3239-44
Current biology : CB 2015 Dec 21;25(24):3239-44
Deacetylation of α-tubulin and cortactin is required for HDAC6 to trigger ciliary disassembly.
Ran J, Yang Y, Li D, Liu M, Zhou J
Scientific reports 2015 Aug 6;5:12917
Scientific reports 2015 Aug 6;5:12917
Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication.
Kodani A, Yu TW, Johnson JR, Jayaraman D, Johnson TL, Al-Gazali L, Sztriha L, Partlow JN, Kim H, Krup AL, Dammermann A, Krogan NJ, Walsh CA, Reiter JF
eLife 2015 Aug 22;4
eLife 2015 Aug 22;4
CYLD mediates ciliogenesis in multiple organs by deubiquitinating Cep70 and inactivating HDAC6.
Yang Y, Ran J, Liu M, Li D, Li Y, Shi X, Meng D, Pan J, Ou G, Aneja R, Sun SC, Zhou J
Cell research 2014 Nov;24(11):1342-53
Cell research 2014 Nov;24(11):1342-53
The MST1/2-SAV1 complex of the Hippo pathway promotes ciliogenesis.
Kim M, Kim M, Lee MS, Kim CH, Lim DS
Nature communications 2014 Nov 4;5:5370
Nature communications 2014 Nov 4;5:5370
Mechanisms of HsSAS-6 assembly promoting centriole formation in human cells.
Keller D, Orpinell M, Olivier N, Wachsmuth M, Mahen R, Wyss R, Hachet V, Ellenberg J, Manley S, Gönczy P
The Journal of cell biology 2014 Mar 3;204(5):697-712
The Journal of cell biology 2014 Mar 3;204(5):697-712
PIPKIγ targets to the centrosome and restrains centriole duplication.
Xu Q, Zhang Y, Xiong X, Huang Y, Salisbury JL, Hu J, Ling K
Journal of cell science 2014 Mar 15;127(Pt 6):1293-305
Journal of cell science 2014 Mar 15;127(Pt 6):1293-305
SAS-6 assembly templated by the lumen of cartwheel-less centrioles precedes centriole duplication.
Fong CS, Kim M, Yang TT, Liao JC, Tsou MF
Developmental cell 2014 Jul 28;30(2):238-45
Developmental cell 2014 Jul 28;30(2):238-45
C2cd3 is critical for centriolar distal appendage assembly and ciliary vesicle docking in mammals.
Ye X, Zeng H, Ning G, Reiter JF, Liu A
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 11;111(6):2164-9
Proceedings of the National Academy of Sciences of the United States of America 2014 Feb 11;111(6):2164-9
Stabilization of cartwheel-less centrioles for duplication requires CEP295-mediated centriole-to-centrosome conversion.
Izquierdo D, Wang WJ, Uryu K, Tsou MF
Cell reports 2014 Aug 21;8(4):957-65
Cell reports 2014 Aug 21;8(4):957-65
USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.
Li J, D'Angiolella V, Seeley ES, Kim S, Kobayashi T, Fu W, Campos EI, Pagano M, Dynlacht BD
Nature 2013 Mar 14;495(7440):255-9
Nature 2013 Mar 14;495(7440):255-9
CEP162 is an axoneme-recognition protein promoting ciliary transition zone assembly at the cilia base.
Wang WJ, Tay HG, Soni R, Perumal GS, Goll MG, Macaluso FP, Asara JM, Amack JD, Tsou MF
Nature cell biology 2013 Jun;15(6):591-601
Nature cell biology 2013 Jun;15(6):591-601
Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages.
Kodani A, Salomé Sirerol-Piquer M, Seol A, Garcia-Verdugo JM, Reiter JF
The EMBO journal 2013 Feb 20;32(4):597-607
The EMBO journal 2013 Feb 20;32(4):597-607
The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis.
Zhao H, Zhu L, Zhu Y, Cao J, Li S, Huang Q, Xu T, Huang X, Yan X, Zhu X
Nature cell biology 2013 Dec;15(12):1434-44
Nature cell biology 2013 Dec;15(12):1434-44
CCDC41 is required for ciliary vesicle docking to the mother centriole.
Joo K, Kim CG, Lee MS, Moon HY, Lee SH, Kim MJ, Kweon HS, Park WY, Kim CH, Gleeson JG, Kim J
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92
Proceedings of the National Academy of Sciences of the United States of America 2013 Apr 9;110(15):5987-92
miR-129-3p controls cilia assembly by regulating CP110 and actin dynamics.
Cao J, Shen Y, Zhu L, Xu Y, Zhou Y, Wu Z, Li Y, Yan X, Zhu X
Nature cell biology 2012 Jun 10;14(7):697-706
Nature cell biology 2012 Jun 10;14(7):697-706
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 12780-1-AP(CP110 antibody) at dilution of 1:400
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP Result of anti-CP110 (IP:12780-1-AP, 3ug; Detection:12780-1-AP 1:1000) with HeLa cells lysate 3000ug.
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- IP result of CP110(12780-1-AP) by Dr. Corbit, Kevin.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 12780-1-AP(CP110 antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
