MYH8

Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is predominantly expressed in fetal skeletal muscle. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in trismus-pseudocamptodactyly syndrome. [provided by RefSeq, Sep 2009]

Description

Myosin heavy chain 8

Tissue specificity

Group enriched (esophagus, lymphoid tissue, skeletal muscle, tongue)

Subcell location

Focal adhesion sites

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

17 (10390322 - 10421950)

Ensembl ID

ENSG00000133020  (ver. 103.38)

Orthologs

Mouse Myh8: ENSMUSG00000055775

UniProt

P13535

neXtProt

NX_P13535

Human splice variants
Mouse splice variants

Protein structure