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- Antigen structure
- References [9]
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- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16169-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16169-1-AP, RRID:AB_10733889
- Product name
- SLC30A8/ZNT8-Specific antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated SLC30A8/ZNT8-Specific antibody (Cat. #16169-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Lack of ZnT8 protects pancreatic islets from hypoxia- and cytokine-induced cell death.
Syngeneically transplanted insulin producing cells differentiated from adipose derived stem cells undergo delayed damage by autoimmune responses in NOD mice.
Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco.
A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.
Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8.
A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells.
Coupling of Insulin Secretion and Display of a Granule-resident Zinc Transporter ZnT8 on the Surface of Pancreatic Beta Cells.
Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes.
Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1α Expression.
Karsai M, Zuellig RA, Lehmann R, Cuozzo F, Nasteska D, Luca E, Hantel C, Hodson DJ, Spinas GA, Rutter GA, Gerber PA
The Journal of endocrinology 2022 Feb 11;253(1):1-11
The Journal of endocrinology 2022 Feb 11;253(1):1-11
Syngeneically transplanted insulin producing cells differentiated from adipose derived stem cells undergo delayed damage by autoimmune responses in NOD mice.
Tokuda K, Ikemoto T, Yamashita S, Miyazaki K, Okikawa S, Yamada S, Saito Y, Morine Y, Shimada M
Scientific reports 2022 Apr 7;12(1):5852
Scientific reports 2022 Apr 7;12(1):5852
Transcriptional responses of four slc30a/znt family members and their roles in Zn homeostatic modulation in yellow catfish Pelteobagrus fulvidraco.
Song CC, Chen GH, Zhong CC, Chen F, Chen SW, Luo Z
Biochimica et biophysica acta. Gene regulatory mechanisms 2021 Aug;1864(8):194723
Biochimica et biophysica acta. Gene regulatory mechanisms 2021 Aug;1864(8):194723
A change in the zinc ion concentration reflects the maturation of insulin-producing cells generated from adipose-derived mesenchymal stem cells.
Ohta S, Ikemoto T, Wada Y, Saito Y, Yamada S, Imura S, Morine Y, Shimada M
Scientific reports 2019 Dec 10;9(1):18731
Scientific reports 2019 Dec 10;9(1):18731
Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8.
Merriman C, Li H, Li H, Fu D
The Journal of biological chemistry 2018 Oct 19;293(42):16206-16216
The Journal of biological chemistry 2018 Oct 19;293(42):16206-16216
A subclass of serum anti-ZnT8 antibodies directed to the surface of live pancreatic β-cells.
Merriman C, Huang Q, Gu W, Yu L, Fu D
The Journal of biological chemistry 2018 Jan 12;293(2):579-587
The Journal of biological chemistry 2018 Jan 12;293(2):579-587
Coupling of Insulin Secretion and Display of a Granule-resident Zinc Transporter ZnT8 on the Surface of Pancreatic Beta Cells.
Huang Q, Merriman C, Zhang H, Fu D
The Journal of biological chemistry 2017 Mar 10;292(10):4034-4043
The Journal of biological chemistry 2017 Mar 10;292(10):4034-4043
Lipid-tuned Zinc Transport Activity of Human ZnT8 Protein Correlates with Risk for Type-2 Diabetes.
Merriman C, Huang Q, Rutter GA, Fu D
The Journal of biological chemistry 2016 Dec 30;291(53):26950-26957
The Journal of biological chemistry 2016 Dec 30;291(53):26950-26957
Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1α Expression.
Xu G, Kang D, Zhang C, Lou H, Sun C, Yang Q, Lu L, Xu GT, Zhang J, Wang F
Investigative ophthalmology & visual science 2015 Dec;56(13):8166-78
Investigative ophthalmology & visual science 2015 Dec;56(13):8166-78
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse pancreas tissue were subjected to SDS PAGE followed by western blot with 16169-1-AP(SLC30A8-Specific antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human pancreas using 16169-1-AP(SLC30A8-Specific antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The SLC30A8/ZNT8-Specific antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human SLC30A8/ZNT8-Specific. This antibody recognizes human,mouse,rat antigen. The SLC30A8/ZNT8-Specific antibody has been validated for the following applications: ELISA, WB, IHC analysis.
