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- Antigen structure
- References [133]
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- Product number
- 20139-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- MCT1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MCT1 antibody (Cat. #20139-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Targeting Myeloid FoxO1 Ameliorates Sepsis-induced Intestinal Injury by Modulating Tim4(+) Macrophage Glycolysis.
Lactate-Driven IL8+ Tumor-Associated Macrophages Mediate Immunosuppression and Resistance to Immunotherapy in Clear-Cell Renal Cell Carcinoma.
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Lactate supplementation modulates molecular and functional responses during chronic neuromuscular electrical stimulation in male rats.
CXCL2 Mediates Lactate Secretion and Promotes Aortic Dissection Formation through the p38/JNK/C-myc Pathways.
Comprehensive single-cell metabolic profiling identifies targets to sensitize triple-negative breast cancer to chemo-immunotherapy.
tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular Dementia Based on Multi-Omics Approach.
Machine learning-based signature for prognosis and drug sensitivity in hepatocellular carcinoma using glycolysis-related gene.
Astragaloside IV represses the immune evasion and acidic microenvironment of oral squamous cell carcinoma.
Lactate-induced miR-7-5p/TRIM33 reprograms metabolic flux to suppress tumor growth and viral reactivation.
Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy.
The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.
Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis.
Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development.
High throughput screening identifies sanguinarine chloride as a multi-faceted therapeutic agent for PRCC-TFE3 rRCC by targeting lactylation-driven VEGFB-VEGFR2 signaling and PMN-MDSC infiltration.
Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation.
Lactate-driven pyrimidine synthesis promotes ferroptosis resistance in hepatocellular carcinoma.
Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation.
SLC16A1 Inhibits Ferroptosis and Promotes the Progression of Head and Neck Squamous Cell Carcinoma.
Identification and validation of biomarkers related to centrosome replication in ulcerative colitis based on bulk transcriptome, single-cell RNA sequencing and experiments.
Acute whole-body vibration as a recovery strategy did not alter the content of gluteus medius monocarboxylate-transporters, lactatemia, and acidosis induced by intense exercise in horses.
Browning of Aldosterone-Producing Adenoma Adjacent Adipose Tissue Involved in Aldosterone Synthesis Regulation.
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.
Linoleic acid co-administration promotes oral delivery of exenatide-loaded butyrate-decorated nanocapsules.
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.
Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy.
Multilayer cascade-response nanoplatforms as metabolic symbiotic disruptors to reprogram the immunosuppressive microenvironment.
Focal adhesion kinase promotes aerobic glycolysis in hepatic stellate cells via the cyclin D1/c-Myc/MCT-1 pathway to induce liver fibrosis.
Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila.
Lactate mitochondrial oxidation drives stemness potential in metastatic breast cancer.
The role of lactate metabolism in retinoblastoma tumorigenesis and ferroptosis resistance.
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis.
One-step Radiosynthesis and Preclinical Evaluation of Molecular Tracer [(18)F]FEtO-CHC Targeting Monocarboxylate Transporters for PET Imaging in Tumor-bearing Mice.
Gestational TCBPA exposure impairs placental function and fetal Development: Mechanisms of syncytialization disruption and fetal growth restriction.
Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions.
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Inhibition of Lactate Accumulation via USP38-Mediated MCT1 Deubiquitination Activates AKT/mTOR Signaling to Mitigate PM2.5-Induced Lung Injury.
Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood-brain barrier disruption in Alzheimer's disease: an autopsy study.
Monitoring Acidification Preceding Aβ Deposition in Alzheimer's Disease.
Regulation of nanoparticle exocytosis direction via receptors transfer: A novel strategy to enhance therapeutic efficacy of semaglutide.
ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma.
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Exploring SLC16A1 as an Oncogenic Regulator and Therapeutic Target in Cholangiocarcinoma.
MCT1-mediated endothelial cell lactate shuttle as a target for promoting axon regeneration after spinal cord injury.
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma.
Lactate promotes fatty acid oxidation by the tricarboxylic acid cycle and mitochondrial respiration in muscles of obese mice.
ITCH inhibits alkaliptosis in human pancreatic cancer cells through YAP1-dependent SLC16A1 activation.
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.
Enhanced glycolysis causes extracellular acidification and activates acid-sensing ion channel 1a in hypoxic pulmonary hypertension.
Deregulation of lactate permeability using a small-molecule transporter (Lactrans-1) disturbs intracellular pH and triggers cancer cell death.
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats.
Identification of feature genes in intestinal epithelial cell types.
Knockdown of SLC16A3 decreases extracellular lactate concentration in hepatocellular carcinoma, alleviates hypoxia and induces ferroptosis.
Autophagy mediates the impact of Porphyromonas gingivalis on short-chain fatty acids metabolism in periodontitis-induced gut dysbiosis.
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc.
Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina.
Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression.
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture.
CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise.
Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth.
Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis.
Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.
Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis.
Hepcidin depending on astrocytic NEO1 ameliorates blood-brain barrier dysfunction after subarachnoid hemorrhage.
Sodium Acetate Enhances Neutrophil Extracellular Trap Formation via Histone Acetylation Pathway in Neutrophil-like HL-60 Cells.
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Solute carrier family 16 member 1 as a potential prognostic factor for pancreatic ductal adenocarcinoma and its influence on tumor immunity.
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis.
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma.
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease.
Acidification of intracellular pH in MM tumor cells overcomes resistance to hypoxia-mediated apoptosis in vitro and in vivo.
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis.
Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma.
Aquaporin-4 Deficiency is Associated with Cognitive Impairment and Alterations in astrocyte-neuron Lactate Shuttle.
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
SLC16a6, mTORC1, and Autophagy Regulate Ketone Body Excretion in the Intestinal Cells.
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.
Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
Lactate metabolism is essential in early-onset mitochondrial myopathy.
ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis.
Hyperpolarized (13)C-Pyruvate to Assess Response to Anti-PD1 Immune Checkpoint Inhibition in YUMMER 1.7 Melanoma Xenografts.
Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.
Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study.
Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of Mitochondria.
Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.
Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline.
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma.
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation.
Lactate Activates AMPK Remodeling of the Cellular Metabolic Profile and Promotes the Proliferation and Differentiation of C2C12 Myoblasts.
Combined HP (13)C Pyruvate and (13)C-Glucose Fluxomic as a Potential Marker of Response to Targeted Therapies in YUMM1.7 Melanoma Xenografts.
Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway.
Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer.
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer.
1,25(OH)(2)D(3) alleviates LPS-induced preeclampsia-like rats impairment in the protective effect by TLR4/NF-kB pathway.
Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders.
Voglibose Regulates the Secretion of GLP-1 Accompanied by Amelioration of Ileal Inflammatory Damage and Endoplasmic Reticulum Stress in Diabetic KKAy Mice.
Monocarboxylate transporter 1 is a novel target for breast cancer stem like-cell inhibition by diallyl trisulfide.
A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer.
Combination of Exercise and Intake of Amino Acid Mixture Synergistically Induces Beige Adipocyte Formation in Mice.
MCT2 overexpression promotes recovery of cognitive function by increasing mitochondrial biogenesis in a rat model of stroke.
Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate.
Ramulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Glucose Metabolism Accompanied by the Modulation of Gut Microbiota and Ileal Inflammatory Damage in Type 2 Diabetic KKAy Mice.
Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.
Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis.
Immunoreactivity and a new staining method of monocarboxylate transporter 1 located in endothelial cells of cerebral vessels of human brain in distinguishing cerebral venules from arterioles.
Monocarboxylate transporter 1 promotes proliferation and invasion of renal cancer cells by mediating acetate transport.
hCINAP serves a critical role in hypoxia‑induced cardiomyocyte apoptosis via modulating lactate production and mitochondrial‑mediated apoptosis signaling.
In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer Treatment.
Wogonin inhibits the growth of HT144 melanoma via regulating hedgehog signaling-mediated inflammation and glycolysis.
Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites.
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Lowering the increased intracellular pH of human-induced pluripotent stem cell-derived endothelial cells induces formation of mature Weibel-Palade bodies.
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Acidic Stress Triggers Sodium-Coupled Bicarbonate Transport and Promotes Survival in A375 Human Melanoma Cells.
Subacute ruminal acidosis suppressed the expression of MCT1 in rumen of cows.
Rno-miR-425-5p targets the DLST and SLC16A1 genes to reduce liver damage caused by excessive energy mobilization under cold stress.
Monocarboxylate transporter 1 is an independent prognostic factor in esophageal squamous cell carcinoma.
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells.
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.
Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus.
Ni J, Zhang R, Pu Y, He Y, Hu W, Su L, Hou Y, Dou H
International journal of biological sciences 2026;22(1):239-257
International journal of biological sciences 2026;22(1):239-257
Lactate-Driven IL8+ Tumor-Associated Macrophages Mediate Immunosuppression and Resistance to Immunotherapy in Clear-Cell Renal Cell Carcinoma.
Dong Y, Jiang W, Qiu Y, Xu Z, Cheng J, Ke P, Dai S, Qu Y, Xia Y, Guo J, Liu L, Xu J
Clinical cancer research : an official journal of the American Association for Cancer Research 2026 May 1;32(9):1860-1873
Clinical cancer research : an official journal of the American Association for Cancer Research 2026 May 1;32(9):1860-1873
Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice.
Ji K, Wei H, Wang R, Wu Y, Li C, Gao H, Zhao L
Aging cell 2026 Mar;25(3):e70423
Aging cell 2026 Mar;25(3):e70423
Lactate supplementation modulates molecular and functional responses during chronic neuromuscular electrical stimulation in male rats.
Yoshihara T, Koriyama Y, Ogawa S, Naito H
Physiological reports 2026 Mar;14(5):e70790
Physiological reports 2026 Mar;14(5):e70790
CXCL2 Mediates Lactate Secretion and Promotes Aortic Dissection Formation through the p38/JNK/C-myc Pathways.
Li J, Qiu Z, Xie R, Ma L, Tang L, Yao M, Zhang Z, Chen L, Zhang L
Thrombosis and haemostasis 2026 Mar;126(3):260-275
Thrombosis and haemostasis 2026 Mar;126(3):260-275
Comprehensive single-cell metabolic profiling identifies targets to sensitize triple-negative breast cancer to chemo-immunotherapy.
Xu Y, Liu XY, Zhang H, Chen L, Wang H, Shao ZM, Xiao Y, Jiang YZ
Cell reports. Medicine 2026 Mar 17;7(3):102659
Cell reports. Medicine 2026 Mar 17;7(3):102659
tLyP-1 peptide-modified MnO₂ co-delivering si-SLC16A1 and temozolomide synergistically suppresses glioblastoma via hypoxia modulation and metabolic stress.
Zhao H, Meng L, Du P, Chen Y, Gong M, Zan B, Chen J, Zeng M, Liao Y
Journal of nanobiotechnology 2026 Mar 16;
Journal of nanobiotechnology 2026 Mar 16;
LCN2 aggravates sepsis-induced ALI by inhibiting MUC1 to activate ER-stress-autophagy induced ferroptosis via lactate/MCT1/AMPK/mTOR axis.
Chen SX, Qi X, Zheng XT, Bi ZM, Zhang Y, Wang YM
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Apoptosis : an international journal on programmed cell death 2026 Mar 15;31(3)
Investigating the Effect and Mechanism of Protocatechuic Aldehyde on Vascular Dementia Based on Multi-Omics Approach.
Xiao T, Tao J, Tan J, Yi X, Wang Z, Duan X
Biomolecules 2026 Mar 11;16(3)
Biomolecules 2026 Mar 11;16(3)
Machine learning-based signature for prognosis and drug sensitivity in hepatocellular carcinoma using glycolysis-related gene.
Zhou Y, Liu W, Fang Z, Zhou K, Huang X, Lu S, Zhang W, Wen Q, Chen X, Xiao Z
Oncology letters 2026 Jan;31(1):31
Oncology letters 2026 Jan;31(1):31
Astragaloside IV represses the immune evasion and acidic microenvironment of oral squamous cell carcinoma.
Zhao W, Zheng H, Chang Y, Shang T, Wang L, Liu J, Deng J, Pan Z, Hu X, Huang X, Cui Y
Cellular & molecular biology letters 2026 Feb 24;31(1)
Cellular & molecular biology letters 2026 Feb 24;31(1)
Lactate-induced miR-7-5p/TRIM33 reprograms metabolic flux to suppress tumor growth and viral reactivation.
Xu Y, Min X, Zhang Z, Zhang Y, Chen X, Wang X, Zhu C, Robertson E, Zhang Q, Tong Y, Zhang L, Wang Y, Cai Q
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 23;
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 23;
Targeting AARS1-dependent lactylation improves neuronal process plasticity and mitigates cognitive deficits in sepsis-associated encephalopathy.
Luo S, Lyu Z, Huang H, Zhao J, Li Y, Luo Y
Brain, behavior, and immunity 2026 Feb 17;135:106493
Brain, behavior, and immunity 2026 Feb 17;135:106493
The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.
Pang Y, Li S, Zhang Q, Liu Y, Kong Y, Cao J
Free radical biology & medicine 2026 Feb 16;244:296-311
Free radical biology & medicine 2026 Feb 16;244:296-311
Designed bone-targeting ROS-responsive nanoplatform for precision glycolysis inhibition in postmenopausal osteoporosis.
Wu Q, Miao J, Chen Y, Yang Y, Liang H, Yu C, Wang C, Tu Y, Wu Y, Xu Y, Yang X, Kwan KYH, Shi C, Wang X, Xu J, Jin H
Bioactive materials 2026 Apr;58:1-18
Bioactive materials 2026 Apr;58:1-18
Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development.
Chen G, Liu Z, Wei M, Li Q, Wu L, Yu K, Xu Y, Yu D, Ma W, Wang H, Shyh-Chang N, Zhai J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e07928
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(19):e07928
High throughput screening identifies sanguinarine chloride as a multi-faceted therapeutic agent for PRCC-TFE3 rRCC by targeting lactylation-driven VEGFB-VEGFR2 signaling and PMN-MDSC infiltration.
Liu X, Chen Y, Liu W, Pan J, Liu J, Dong X, Ma W, Feng F, Liu N, Xu J, Gan W, Li D
Journal of advanced research 2026 Apr 7;
Journal of advanced research 2026 Apr 7;
Mechanisms of Mechanical Stress-Induced Vascular Remodeling via the Lactate-PKM2 Axis and Implications for Microgravity Adaptation.
Li N, Liu L, Wang D, Wang J, Tie Y, Li X, Li J, Gao Y, Yang C, Wang Y
International journal of molecular sciences 2026 Apr 5;27(7)
International journal of molecular sciences 2026 Apr 5;27(7)
Lactate-driven pyrimidine synthesis promotes ferroptosis resistance in hepatocellular carcinoma.
Park MJ, Lee S, Kim DH, Kim MK, Jang BK, Yoon G, Park M, Jeong GH, Byun JK, Choi YK, Park KG
Molecular biomedicine 2026 Apr 17;7(1)
Molecular biomedicine 2026 Apr 17;7(1)
Lactate Facilitates the Survival and Invasion of Pancreatic Cancer Cells Under Glucose Deprivation.
Wang F, Hu P, Han S, Zhang Y, Li Y, Zhuo W, Zhao Y, Huang Y, Lv G, Wang H, Zhao G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 15;40(7):e71726
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 15;40(7):e71726
SLC16A1 Inhibits Ferroptosis and Promotes the Progression of Head and Neck Squamous Cell Carcinoma.
Zong H, Teng L, Chen L, Qiu J, Tian C
Journal of Cancer 2025;16(7):2184-2196
Journal of Cancer 2025;16(7):2184-2196
Identification and validation of biomarkers related to centrosome replication in ulcerative colitis based on bulk transcriptome, single-cell RNA sequencing and experiments.
Yang Z, Wu X, Luo L, Wu X, Wang Y, Huang T, Dang Z, Nie S
Frontiers in immunology 2025;16:1627926
Frontiers in immunology 2025;16:1627926
Acute whole-body vibration as a recovery strategy did not alter the content of gluteus medius monocarboxylate-transporters, lactatemia, and acidosis induced by intense exercise in horses.
Carvalho JRG, Sales NAA, Littiere TO, Costa GB, Castro CM, Polisel EEC, Orsi JB, Ramos GV, Santos IFC, Gobatto CA, Manchado-Gobatto FB, Ferraz GC
Frontiers in veterinary science 2025;12:1538195
Frontiers in veterinary science 2025;12:1538195
Browning of Aldosterone-Producing Adenoma Adjacent Adipose Tissue Involved in Aldosterone Synthesis Regulation.
Xie L, Yang S, Chen M, Li J, He Y, Peng C, Xu Y, Huang W, Luo T, Fang Y, Hu J, Li Q, Ma L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70722
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70722
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3.
Qu Y, Wang X, Li J, Luo H, Liu H, Wang T, Han X
International immunopharmacology 2025 Jun 26;159:114947
International immunopharmacology 2025 Jun 26;159:114947
Linoleic acid co-administration promotes oral delivery of exenatide-loaded butyrate-decorated nanocapsules.
Yuan H, Xiao P, Wang F, Guo C, Pan S, Jiang M, Hou S, Sun Y, Wang Y, Zhang Y, Yin T, He H, Gou J, Tang X
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113744
Journal of controlled release : official journal of the Controlled Release Society 2025 Jun 10;382:113744
Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.
Yu H, Du Y, He Y, Sun Y, Li J, Jia B, Chen J, Peng X, An T, Li J, Chi Y, Wang M, Cao L, Tai Y, Zhai X, Nuersulitan R, Li S, Wu N, Wang J, Xiong H, Wan S, Liu J, Yang X, Hu X, Lin D, Sun W, Wang Y, An G, Ji X, Kong L, Ding L, Ma Y, Tian Z, Dong B, Bi Y, Wu J, Wang Z
Cell host & microbe 2025 Jul 9;33(7):1089-1105.e7
Cell host & microbe 2025 Jul 9;33(7):1089-1105.e7
Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy.
Kim TW, Oum SJ, Lim JH, Kim Y, Kim EN, Jin Y, Hong YA, Chae SY, Choi BS, Kim HW, Park CW
Cell communication and signaling : CCS 2025 Jul 16;23(1):342
Cell communication and signaling : CCS 2025 Jul 16;23(1):342
Multilayer cascade-response nanoplatforms as metabolic symbiotic disruptors to reprogram the immunosuppressive microenvironment.
Liu R, Guo L, Shi D, Sun X, Shang M, Zhao Y, Wang X, Yang Y, Xiao S, Li J
Journal of controlled release : official journal of the Controlled Release Society 2025 Jul 10;383:113797
Journal of controlled release : official journal of the Controlled Release Society 2025 Jul 10;383:113797
Focal adhesion kinase promotes aerobic glycolysis in hepatic stellate cells via the cyclin D1/c-Myc/MCT-1 pathway to induce liver fibrosis.
Huang T, Zhou MY, Zou GL, Hu RH, Han L, Zhang QX, Zhao XK
Scientific reports 2025 Feb 7;15(1):4552
Scientific reports 2025 Feb 7;15(1):4552
Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila.
Pan M, Qian C, Huo S, Wu Y, Zhao X, Ying Y, Wang B, Yang H, Yeerken A, Wang T, Fu M, Wang L, Wei Y, Zhao Y, Shao C, Wang H, Zhao C
Gut microbes 2025 Dec;17(1):2447834
Gut microbes 2025 Dec;17(1):2447834
Lactate mitochondrial oxidation drives stemness potential in metastatic breast cancer.
Zhang JJ, Tian RF, Song CG, Liu R, He D, Zhang GQ, Fan XY, Duan ZC, Zhang K, Zhang TJ, Chen YT, Zhang J, Wang K, Zhao JM, Yang XM, Chen ZN, Li L
Nature communications 2025 Dec 18;17(1):399
Nature communications 2025 Dec 18;17(1):399
The role of lactate metabolism in retinoblastoma tumorigenesis and ferroptosis resistance.
Zhang Z, Tang J, Liu Y, Wang Y, Li J, Gao Y, Cheng C, Su S, Chen S, Ai S, Zhang P, Lu R
Tissue & cell 2025 Aug;95:102893
Tissue & cell 2025 Aug;95:102893
Silybin inhibits succinate production and secretion in hepatocytes to reverse liver fibrosis.
Yang X, Lou Y, Li H, Ma Y, Wang Z, Aa J, Wang G, Xie Y
Archives of pharmacal research 2025 Aug;48(7-8):782-797
Archives of pharmacal research 2025 Aug;48(7-8):782-797
One-step Radiosynthesis and Preclinical Evaluation of Molecular Tracer [(18)F]FEtO-CHC Targeting Monocarboxylate Transporters for PET Imaging in Tumor-bearing Mice.
Shi D, Liu L, Zhang D, Zheng Y, Hu W, Wu P, Hao X, Liu H, Gao J, Li J, Wu Z, Li S, Wang H
Molecular imaging and biology 2025 Aug;27(4):587-596
Molecular imaging and biology 2025 Aug;27(4):587-596
Gestational TCBPA exposure impairs placental function and fetal Development: Mechanisms of syncytialization disruption and fetal growth restriction.
Wang S, Wang S, Zhang X, Lyu Z, Lu C, Long Z, Chen X, Zhuang T, Xu X
Placenta 2025 Aug;168:88-97
Placenta 2025 Aug;168:88-97
Extracellular lactate improves neurogenesis by modulating H3K9 lactylation and SnoN expression under hypoxic conditions.
Xu W, Zhao A, Han R, Wei J, Yu Q, Wang M, Li H, Xu B, Li M, Chi G
Stem cell research & therapy 2025 Aug 27;16(1):462
Stem cell research & therapy 2025 Aug 27;16(1):462
A CD147-targeted small-molecule inhibitor potentiates gemcitabine efficacy by triggering ferroptosis in pancreatic ductal adenocarcinoma.
Li J, Ma C, Cao P, Guo W, Wang P, Yang Y, Ding B, Yin F, Li Z, Wang Y, Li S, Huang C, Wang X, Zhou T, Chang A, Zhao L, Gao S, Zhao T, Wang H, Yu J, Xu J, Feng Y, Hao J
Cell reports. Medicine 2025 Aug 19;6(8):102292
Cell reports. Medicine 2025 Aug 19;6(8):102292
Inhibition of Lactate Accumulation via USP38-Mediated MCT1 Deubiquitination Activates AKT/mTOR Signaling to Mitigate PM2.5-Induced Lung Injury.
Chen Z, Cao J, Hou S, Chao L, Li J, Jia Z, Han S, Chen J, Yan X
Journal of clinical laboratory analysis 2025 Apr;39(8):e70028
Journal of clinical laboratory analysis 2025 Apr;39(8):e70028
Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood-brain barrier disruption in Alzheimer's disease: an autopsy study.
Cao Y, Huang MY, Mao CH, Wang X, Xu YY, Qian XJ, Ma C, Qiu WY, Zhu YC
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Apr;21(4):e70103
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Apr;21(4):e70103
Monitoring Acidification Preceding Aβ Deposition in Alzheimer's Disease.
Zhu G, Zhang H, Xie R, Younis MR, Fu S, Wang X, Liu B, Li K, Lui S, Wu M
Advanced healthcare materials 2025 Apr;14(11):e2404907
Advanced healthcare materials 2025 Apr;14(11):e2404907
Regulation of nanoparticle exocytosis direction via receptors transfer: A novel strategy to enhance therapeutic efficacy of semaglutide.
Wang Y, Ni M, Huang M, Xing L, Liu X, Jia F, Huang Y
International journal of pharmaceutics 2025 Apr 15;674:125439
International journal of pharmaceutics 2025 Apr 15;674:125439
ACVR2A attenuation impacts lactate production and hyperglycolytic conditions attracting regulatory T cells in hepatocellular carcinoma.
Yasukawa K, Shimada S, Akiyama Y, Taniai T, Igarashi Y, Tsukihara S, Tanji Y, Umemura K, Kamachi A, Nara A, Yamane M, Akahoshi K, Shimizu A, Soejima Y, Tanabe M, Tanaka S
Cell reports. Medicine 2025 Apr 15;6(4):102038
Cell reports. Medicine 2025 Apr 15;6(4):102038
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Hu Y, Li Y, Xiong H, Zhang Y, Wang F, Zhuo W, Zeng Z, Zhao Y, Wang H, Hu P, Han S, Huang Y, Lv G, Zhao G
International journal of biological sciences 2024;20(11):4341-4363
International journal of biological sciences 2024;20(11):4341-4363
Exploring SLC16A1 as an Oncogenic Regulator and Therapeutic Target in Cholangiocarcinoma.
Huang J, Liu F, Liu D, Tang S, Shen D
Journal of Cancer 2024;15(12):3794-3808
Journal of Cancer 2024;15(12):3794-3808
MCT1-mediated endothelial cell lactate shuttle as a target for promoting axon regeneration after spinal cord injury.
Shi C, Xu J, Ding Y, Chen X, Yuan F, Zhu F, Duan C, Hu J, Lu H, Wu T, Jiang L
Theranostics 2024;14(14):5662-5681
Theranostics 2024;14(14):5662-5681
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma.
Galvan C, Flores AA, Cerrilos V, Avila I, Murphy C, Zheng W, Christofk HR, Lowry WE
Science advances 2024 Sep 20;10(38):eadn2806
Science advances 2024 Sep 20;10(38):eadn2806
Lactate promotes fatty acid oxidation by the tricarboxylic acid cycle and mitochondrial respiration in muscles of obese mice.
Park SY, Jung SR, Kim JY, Kim YW, Sung HK, Park SY, Doh KO, Koh JH
American journal of physiology. Cell physiology 2024 Sep 1;327(3):C619-C633
American journal of physiology. Cell physiology 2024 Sep 1;327(3):C619-C633
ITCH inhibits alkaliptosis in human pancreatic cancer cells through YAP1-dependent SLC16A1 activation.
Cai X, Chen F, Tang H, Chao D, Kang R, Tang D, Liu J
The international journal of biochemistry & cell biology 2024 Oct;175:106646
The international journal of biochemistry & cell biology 2024 Oct;175:106646
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.
Cluntun AA, Visker JR, Velasco-Silva JN, Lang MJ, Cedeño-Rosario L, Shankar TS, Hamouche R, Ling J, Kim JE, Toshniwal AG, Low HK, Cunningham CN, Carrington J, Catrow JL, Pearce Q, Jeong MY, Bott AJ, Narbona-Pérez ÁJ, Stanley CE, Li Q, Eberhardt DR, Morgan JT, Yadav T, Wells CE, Ramadurai DKA, Swiatek WI, Chaudhuri D, Rothstein JD, Muoio DM, Paulo JA, Gygi SP, Baker SA, Navankasattusas S, Cox JE, Funai K, Drakos SG, Rutter J, Ducker GS
bioRxiv : the preprint server for biology 2024 Oct 8;
bioRxiv : the preprint server for biology 2024 Oct 8;
Enhanced glycolysis causes extracellular acidification and activates acid-sensing ion channel 1a in hypoxic pulmonary hypertension.
Tuineau MN, Herbert LM, Garcia SM, Resta TC, Jernigan NL
American journal of physiology. Lung cellular and molecular physiology 2024 Oct 1;327(4):L439-L451
American journal of physiology. Lung cellular and molecular physiology 2024 Oct 1;327(4):L439-L451
Deregulation of lactate permeability using a small-molecule transporter (Lactrans-1) disturbs intracellular pH and triggers cancer cell death.
Arias-Betancur A, Fontova P, Alonso-Carrillo D, Carreira-Barral I, Duis J, García-Valverde M, Soto-Cerrato V, Quesada R, Pérez-Tomás R
Biochemical pharmacology 2024 Nov;229:116469
Biochemical pharmacology 2024 Nov;229:116469
Endo-Lysosomal Network Disorder Reprograms Energy Metabolism in SorL1-Null Rat Hippocampus.
Wang Y, Yang Y, Cai Y, Aobulikasimu A, Wang Y, Hu C, Miao Z, Shao Y, Zhao M, Hu Y, Xu C, Chen X, Li Z, Chen J, Wang L, Chen S
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Nov;11(41):e2407709
Astragaloside IV promotes cerebral tissue restoration through activating AMPK- mediated microglia polarization in ischemic stroke rats.
Li MC, Jia JT, Wang YX, Zhuang YM, Wang HY, Lin ZY, Lu Y, Li MZ, Wang ZJ, Zhao H
Journal of ethnopharmacology 2024 Nov 15;334:118532
Journal of ethnopharmacology 2024 Nov 15;334:118532
Identification of feature genes in intestinal epithelial cell types.
Lou R, Song W, Yu S, Wang X, Liu Y, Chen YG, Wang Y
Cell regeneration (London, England) 2024 Nov 15;13(1):24
Cell regeneration (London, England) 2024 Nov 15;13(1):24
Knockdown of SLC16A3 decreases extracellular lactate concentration in hepatocellular carcinoma, alleviates hypoxia and induces ferroptosis.
Shen J, Wu Z, Zhou Y, Yang D, Wang X, Yu B, Zhao K, Ding Y
Biochemical and biophysical research communications 2024 Nov 12;733:150709
Biochemical and biophysical research communications 2024 Nov 12;733:150709
Autophagy mediates the impact of Porphyromonas gingivalis on short-chain fatty acids metabolism in periodontitis-induced gut dysbiosis.
Sun J, Wang X, Xiao J, Yang Q, Huang X, Yang Z, Liu H, Liu Y, Wang H, Huang Z, Ma L, Cao Z
Scientific reports 2024 Nov 1;14(1):26291
Scientific reports 2024 Nov 1;14(1):26291
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc.
Wang J, Yang Y, Shao F, Meng Y, Guo D, He J, Lu Z
Nature metabolism 2024 May;6(5):914-932
Nature metabolism 2024 May;6(5):914-932
Role of monocarboxylate transporters in AMPK-mediated protection against excitotoxic injury in the rat retina.
Yamagishi H, Kirai N, Morita A, Kashihara T, Nakahara T
European journal of pharmacology 2024 May 5;970:176510
European journal of pharmacology 2024 May 5;970:176510
Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
Zhang Y, Jiang H, Dong M, Min J, He X, Tan Y, Liu F, Chen M, Chen X, Yin Q, Zheng L, Shao Y, Li X, Chen H
Cell reports 2024 May 28;43(5):114180
Cell reports 2024 May 28;43(5):114180
Deciphering metabolic heterogeneity in retinoblastoma unravels the role of monocarboxylate transporter 1 in tumor progression.
Tang J, Liu Y, Wang Y, Zhang Z, Nie J, Wang X, Ai S, Li J, Gao Y, Li C, Cheng C, Su S, Chen S, Zhang P, Lu R
Biomarker research 2024 May 11;12(1):48
Biomarker research 2024 May 11;12(1):48
NBS1 lactylation is required for efficient DNA repair and chemotherapy resistance.
Chen H, Li Y, Li H, Chen X, Fu H, Mao D, Chen W, Lan L, Wang C, Hu K, Li J, Zhu C, Evans I, Cheung E, Lu D, He Y, Behrens A, Yin D, Zhang C
Nature 2024 Jul;631(8021):663-669
Nature 2024 Jul;631(8021):663-669
Astrocytic metabolic control of orexinergic activity in the lateral hypothalamus regulates sleep and wake architecture.
Braga A, Chiacchiaretta M, Pellerin L, Kong D, Haydon PG
Nature communications 2024 Jul 16;15(1):5979
Nature communications 2024 Jul 16;15(1):5979
CHCHD4-TRIAP1 regulation of innate immune signaling mediates skeletal muscle adaptation to exercise.
Ma J, Wang PY, Zhuang J, Son AY, Karius AK, Syed AM, Nishi M, Wu Z, Mori MP, Kim YC, Hwang PM
Cell reports 2024 Jan 23;43(1):113626
Cell reports 2024 Jan 23;43(1):113626
Epigenetic drug screening for trophoblast syncytialization reveals a novel role for MLL1 in regulating fetoplacental growth.
Wu J, Qin C, Tian F, Liu X, Hu J, Wu F, Chen C, Lin Y
BMC medicine 2024 Feb 5;22(1):57
BMC medicine 2024 Feb 5;22(1):57
Colorectal cancer cells establish metabolic reprogramming with cancer-associated fibroblasts (CAFs) through lactate shuttle to enhance invasion, migration, and angiogenesis.
Wang X, Qu Y, Ji J, Liu H, Luo H, Li J, Han X
International immunopharmacology 2024 Dec 25;143(Pt 2):113470
International immunopharmacology 2024 Dec 25;143(Pt 2):113470
Optimization of protocols for immunohistochemical assessment of enteric nervous system in formalin fixed human tissue.
Hong SM, Qian X, Deshpande V, Kulkarni S
bioRxiv : the preprint server for biology 2024 Dec 17;
bioRxiv : the preprint server for biology 2024 Dec 17;
Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis.
Liu S, Wang H, Li J, Gao J, Yu L, Wei X, Cui M, Zhao Y, Liang Y, Wang H
Immunology and cell biology 2024 Aug;102(7):605-617
Immunology and cell biology 2024 Aug;102(7):605-617
Hepcidin depending on astrocytic NEO1 ameliorates blood-brain barrier dysfunction after subarachnoid hemorrhage.
Wei B, Liu W, Jin L, Huang Y, Cheng W, Fan H, Su S, Jin F, Zhang X, Yang Z, Liang S, Li L, Wu Y, Liu Y, Duan C, Li X
Cell death & disease 2024 Aug 7;15(8):569
Cell death & disease 2024 Aug 7;15(8):569
Sodium Acetate Enhances Neutrophil Extracellular Trap Formation via Histone Acetylation Pathway in Neutrophil-like HL-60 Cells.
Yasuda H, Takishita Y, Morita A, Tsutsumi T, Nakagawa N, Sato EF
International journal of molecular sciences 2024 Aug 11;25(16)
International journal of molecular sciences 2024 Aug 11;25(16)
Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
The Journal of physiology 2024 Apr;602(7):1313-1340
The Journal of physiology 2024 Apr;602(7):1313-1340
Solute carrier family 16 member 1 as a potential prognostic factor for pancreatic ductal adenocarcinoma and its influence on tumor immunity.
Wang M, Liu L, Li X, Jiang W, Xiao J, Hao Q, Wang J, Reddy AV, Talbot A, Ikuta S, Tian D, Ren L
Journal of gastrointestinal oncology 2024 Apr 30;15(2):730-746
Journal of gastrointestinal oncology 2024 Apr 30;15(2):730-746
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis.
Min K, Yenilmez B, Kelly M, Echeverria D, Elleby M, Lifshitz LM, Raymond N, Tsagkaraki E, Harney SM, DiMarzio C, Wang H, McHugh N, Bramato B, Morrison B, Rothstein JD, Khvorova A, Czech MP
eLife 2024 Apr 2;12
eLife 2024 Apr 2;12
Lactate-driven type I collagen deposition facilitates cancer stem cell-like phenotype of head and neck squamous cell carcinoma.
Sun Y, Chen Y, Zhao H, Wang J, Liu Y, Bai J, Hu C, Shang Z
iScience 2024 Apr 19;27(4):109340
iScience 2024 Apr 19;27(4):109340
Purinergic receptor P2Y12 boosts autoimmune hepatitis through hexokinase 2-dependent glycolysis in T cells.
Zhuang W, Liu X, Liu G, Lv J, Qin H, Wang C, Xie L, Saimaier K, Han S, Shi C, Hua Q, Zhang R, Du C
International journal of biological sciences 2023;19(11):3576-3594
International journal of biological sciences 2023;19(11):3576-3594
The reduced SCFA-producing gut microbes are involved in the inflammatory activation in Kawasaki disease.
Wang F, Qian F, Zhang Q, Zhao J, Cen J, Zhang J, Zhou J, Luo M, Jia C, Rong X, Chu M
Frontiers in immunology 2023;14:1124118
Frontiers in immunology 2023;14:1124118
Acidification of intracellular pH in MM tumor cells overcomes resistance to hypoxia-mediated apoptosis in vitro and in vivo.
Gastelum G, Kraut J, Veena M, Baibussinov A, Lamb C, Lyons K, Chang EY, Frost P
Frontiers in oncology 2023;13:1268421
Frontiers in oncology 2023;13:1268421
Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis.
Min K, Yenilmez B, Kelly M, Echeverria D, Elleby M, Lifshitz LM, Raymond N, Tsagkaraki E, Harney SM, DiMarzio C, Wang H, McHugh N, Bramato B, Morrision B, Rothstein JD, Khvorova A, Czech MP
bioRxiv : the preprint server for biology 2023 Oct 19;
bioRxiv : the preprint server for biology 2023 Oct 19;
Defining metabolic flexibility in hair follicle stem cell induced squamous cell carcinoma.
Galvan C, Flores A, Cerrillos V, Avila I, Murphy C, Zheng W, To TT, Christofk HR, Lowry WE
bioRxiv : the preprint server for biology 2023 Oct 19;
bioRxiv : the preprint server for biology 2023 Oct 19;
Aquaporin-4 Deficiency is Associated with Cognitive Impairment and Alterations in astrocyte-neuron Lactate Shuttle.
Cha H, Choi JH, Jeon H, Kim JH, Kim M, Kim SJ, Park W, Lim JS, Lee E, Ahn JS, Kim JH, Hong SH, Park JE, Jung JH, Yoo HJ, Lee S
Molecular neurobiology 2023 Nov;60(11):6212-6226
Molecular neurobiology 2023 Nov;60(11):6212-6226
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
Zhou P, Chang WY, Gong DA, Xia J, Chen W, Huang LY, Liu R, Liu Y, Chen C, Wang K, Tang N, Huang AL
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
SLC16a6, mTORC1, and Autophagy Regulate Ketone Body Excretion in the Intestinal Cells.
Uebanso T, Fukui M, Naito C, Shimohata T, Mawatari K, Takahashi A
Biology 2023 Nov 26;12(12)
Biology 2023 Nov 26;12(12)
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.
Zhang L, Liang J, Qin H, Lv Y, Liu X, Li Z, Chao Z, Jia C, Qin X, Zhang H
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296
Prognostic Value of Monocarboxylate Transporter 1 Overexpression in Cancer: A Systematic Review.
Silva A, Cerqueira MC, Rosa B, Sobral C, Pinto-Ribeiro F, Costa MF, Baltazar F, Afonso J
International journal of molecular sciences 2023 Mar 7;24(6)
International journal of molecular sciences 2023 Mar 7;24(6)
Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners.
Xu Y, Kusuyama J, Osana S, Matsuhashi S, Li L, Takada H, Inada H, Nagatomi R
The Journal of biological chemistry 2023 Jun;299(6):104802
The Journal of biological chemistry 2023 Jun;299(6):104802
Lactate metabolism is essential in early-onset mitochondrial myopathy.
Chen Z, Bordieanu B, Kesavan R, Lesner NP, Venigalla SSK, Shelton SD, DeBerardinis RJ, Mishra P
Science advances 2023 Jan 4;9(1):eadd3216
Science advances 2023 Jan 4;9(1):eadd3216
ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis.
Chen F, Zhu S, Kang R, Tang D, Liu J
Cell reports 2023 Jan 31;42(1):111911
Cell reports 2023 Jan 31;42(1):111911
Hyperpolarized (13)C-Pyruvate to Assess Response to Anti-PD1 Immune Checkpoint Inhibition in YUMMER 1.7 Melanoma Xenografts.
Farah C, Neveu MA, Bouzin C, Knezevic Z, Gallez B, Leucci E, Baurain JF, Mignion L, Jordan BF
International journal of molecular sciences 2023 Jan 28;24(3)
International journal of molecular sciences 2023 Jan 28;24(3)
Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
Zhao H, Chen Y, Liao YP, Chen HM, Yang QH, Xiao Y, Luo J, Chen ZZ, Yi L, Hu GY
Clinical and experimental medicine 2023 Feb;23(1):55-64
Clinical and experimental medicine 2023 Feb;23(1):55-64
Functional heterogeneity of MCT1 and MCT4 in metabolic reprogramming affects osteosarcoma growth and metastasis.
Sheng G, Gao Y, Wu H, Liu Y, Yang Y
Journal of orthopaedic surgery and research 2023 Feb 22;18(1):131
Journal of orthopaedic surgery and research 2023 Feb 22;18(1):131
Fibroblast growth factor 21 protects the liver from apoptosis in a type 1 diabetes mouse model via regulating L-lactate homeostasis.
Yan J, Xie J, Xu S, Guo Y, Ji K, Li C, Gao H, Zhao L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115737
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115737
Arteriolosclerosis differs from venular collagenosis in relation to cerebrovascular parenchymal damages: an autopsy-based study.
Cao Y, Huang MY, Mao CH, Wang X, Xu YY, Qian XJ, Ma C, Qiu WY, Zhu YC
Stroke and vascular neurology 2023 Aug;8(4):267-275
Stroke and vascular neurology 2023 Aug;8(4):267-275
Huangqin Decoction Exerts Beneficial Effects on Rotenone-Induced Rat Model of Parkinson's Disease by Improving Mitochondrial Dysfunction and Alleviating Metabolic Abnormality of Mitochondria.
Gao L, Cao M, Du GH, Qin XM
Frontiers in aging neuroscience 2022;14:911924
Frontiers in aging neuroscience 2022;14:911924
Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.
Sun W, Wen M, Liu M, Wang Q, Liu Q, Li L, Siebert HC, Loers G, Zhang R, Zhang N
Frontiers in aging neuroscience 2022;14:1075161
Frontiers in aging neuroscience 2022;14:1075161
Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline.
Zhao L, Jiang H, Xie J, Shen D, Yi Q, Yan J, Li C, Zheng H, Gao H
Molecular neurobiology 2022 Sep;59(9):5656-5672
Molecular neurobiology 2022 Sep;59(9):5656-5672
Simultaneous targeting of glycolysis and oxidative phosphorylation as a therapeutic strategy to treat diffuse large B-cell lymphoma.
Noble RA, Thomas H, Zhao Y, Herendi L, Howarth R, Dragoni I, Keun HC, Vellano CP, Marszalek JR, Wedge SR
British journal of cancer 2022 Sep;127(5):937-947
British journal of cancer 2022 Sep;127(5):937-947
Spatial dynamic metabolomics identifies metabolic cell fate trajectories in human kidney differentiation.
Wang G, Heijs B, Kostidis S, Rietjens RGJ, Koning M, Yuan L, Tiemeier GL, Mahfouz A, Dumas SJ, Giera M, Kers J, Chuva de Sousa Lopes SM, van den Berg CW, van den Berg BM, Rabelink TJ
Cell stem cell 2022 Nov 3;29(11):1580-1593.e7
Cell stem cell 2022 Nov 3;29(11):1580-1593.e7
Lactate Activates AMPK Remodeling of the Cellular Metabolic Profile and Promotes the Proliferation and Differentiation of C2C12 Myoblasts.
Zhou Y, Liu X, Huang C, Lin D
International journal of molecular sciences 2022 Nov 13;23(22)
International journal of molecular sciences 2022 Nov 13;23(22)
Combined HP (13)C Pyruvate and (13)C-Glucose Fluxomic as a Potential Marker of Response to Targeted Therapies in YUMM1.7 Melanoma Xenografts.
Farah C, Neveu MA, Yelek C, Bouzin C, Gallez B, Baurain JF, Mignion L, Jordan BF
Biomedicines 2022 Mar 19;10(3)
Biomedicines 2022 Mar 19;10(3)
Focal adhesion kinase-related non-kinase ameliorates liver fibrosis by inhibiting aerobic glycolysis via the FAK/Ras/c-myc/ENO1 pathway.
Huang T, Li YQ, Zhou MY, Hu RH, Zou GL, Li JC, Feng S, Liu YM, Xin CQ, Zhao XK
World journal of gastroenterology 2022 Jan 7;28(1):123-139
World journal of gastroenterology 2022 Jan 7;28(1):123-139
Tumor Metabolism Is Affected by Obesity in Preclinical Models of Triple-Negative Breast Cancer.
Yelek C, Mignion L, Paquot A, Bouzin C, Corbet C, Muccioli GG, Cani PD, Jordan BF
Cancers 2022 Jan 23;14(3)
Cancers 2022 Jan 23;14(3)
Prolonged culturing of iPSC-derived brain endothelial-like cells is associated with quiescence, downregulation of glycolysis, and resistance to disruption by an Alzheimer's brain milieu.
Williams LM, Fujimoto T, Weaver RR, Logsdon AF, Evitts KM, Young JE, Banks WA, Erickson MA
Fluids and barriers of the CNS 2022 Feb 5;19(1):10
Fluids and barriers of the CNS 2022 Feb 5;19(1):10
Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer.
Cappellesso F, Orban MP, Shirgaonkar N, Berardi E, Serneels J, Neveu MA, Di Molfetta D, Piccapane F, Caroppo R, Debellis L, Ostyn T, Joudiou N, Mignion L, Richiardone E, Jordan BF, Gallez B, Corbet C, Roskams T, DasGupta R, Tejpar S, Di Matteo M, Taverna D, Reshkin SJ, Topal B, Virga F, Mazzone M
Nature cancer 2022 Dec;3(12):1464-1483
Nature cancer 2022 Dec;3(12):1464-1483
1,25(OH)(2)D(3) alleviates LPS-induced preeclampsia-like rats impairment in the protective effect by TLR4/NF-kB pathway.
Ma Y, Yang Y, Lv M, Zhang Y, He Q, Zhang Y, Su H, Deng X, Qian Y
Placenta 2022 Dec;130:34-41
Placenta 2022 Dec;130:34-41
Limosilactobacillus reuteri and caffeoylquinic acid synergistically promote adipose browning and ameliorate obesity-associated disorders.
Liu Y, Zhong X, Lin S, Xu H, Liang X, Wang Y, Xu J, Wang K, Guo X, Wang J, Yu M, Li C, Xie C
Microbiome 2022 Dec 15;10(1):226
Microbiome 2022 Dec 15;10(1):226
Voglibose Regulates the Secretion of GLP-1 Accompanied by Amelioration of Ileal Inflammatory Damage and Endoplasmic Reticulum Stress in Diabetic KKAy Mice.
Fu Y, Ji W, Liu Q, Zhang L, Li C, Huan Y, Lei L, Gao X, Chen L, Feng C, Lei L, Zhai J, Li P, Cao H, Liu S, Shen Z
International journal of molecular sciences 2022 Dec 14;23(24)
International journal of molecular sciences 2022 Dec 14;23(24)
Monocarboxylate transporter 1 is a novel target for breast cancer stem like-cell inhibition by diallyl trisulfide.
Kim SH, Singh SV
Molecular carcinogenesis 2022 Aug;61(8):752-763
Molecular carcinogenesis 2022 Aug;61(8):752-763
A Novel Role for DNA-PK in Metabolism by Regulating Glycolysis in Castration-Resistant Prostate Cancer.
Dylgjeri E, Kothari V, Shafi AA, Semenova G, Gallagher PT, Guan YF, Pang A, Goodwin JF, Irani S, McCann JJ, Mandigo AC, Chand S, McNair CM, Vasilevskaya I, Schiewer MJ, Lallas CD, McCue PA, Gomella LG, Seifert EL, Carroll JS, Butler LM, Holst J, Kelly WK, Knudsen KE
Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Apr 1;28(7):1446-1459
Clinical cancer research : an official journal of the American Association for Cancer Research 2022 Apr 1;28(7):1446-1459
Combination of Exercise and Intake of Amino Acid Mixture Synergistically Induces Beige Adipocyte Formation in Mice.
Kojima T, Esaki N, Tsuda T
Journal of nutritional science and vitaminology 2021;67(4):225-233
Journal of nutritional science and vitaminology 2021;67(4):225-233
MCT2 overexpression promotes recovery of cognitive function by increasing mitochondrial biogenesis in a rat model of stroke.
Yu X, Zhang R, Wei C, Gao Y, Yu Y, Wang L, Jiang J, Zhang X, Li J, Chen X
Animal cells and systems 2021;25(2):93-101
Animal cells and systems 2021;25(2):93-101
Conditional Knockout of Pdha1 in Mouse Hippocampus Impairs Cognitive Function: The Possible Involvement of Lactate.
Chen W, Sun X, Zhan L, Zhou W, Bi T
Frontiers in neuroscience 2021;15:767560
Frontiers in neuroscience 2021;15:767560
Ramulus Mori (Sangzhi) Alkaloids (SZ-A) Ameliorate Glucose Metabolism Accompanied by the Modulation of Gut Microbiota and Ileal Inflammatory Damage in Type 2 Diabetic KKAy Mice.
Liu Q, Liu S, Cao H, Ji W, Li C, Huan Y, Lei L, Fu Y, Gao X, Liu Y, Shen Z
Frontiers in pharmacology 2021;12:642400
Frontiers in pharmacology 2021;12:642400
Effects of endurance training on the expression of host proteins involved in SARS-CoV-2 cell entry in C57BL/6J mouse.
Tamura Y, Jee E, Kouzaki K, Kotani T, Nakazato K
Physiological reports 2021 Sep;9(17):e15014
Physiological reports 2021 Sep;9(17):e15014
Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis.
Ryuge A, Kosugi T, Maeda K, Banno R, Gou Y, Zaitsu K, Ito T, Sato Y, Hirayama A, Tsubota S, Honda T, Nakajima K, Ozaki T, Kondoh K, Takahashi K, Kato N, Ishimoto T, Soga T, Nakagawa T, Koike T, Arima H, Yuzawa Y, Minokoshi Y, Maruyama S, Kadomatsu K
JCI insight 2021 Oct 22;6(20)
JCI insight 2021 Oct 22;6(20)
Immunoreactivity and a new staining method of monocarboxylate transporter 1 located in endothelial cells of cerebral vessels of human brain in distinguishing cerebral venules from arterioles.
Cao Y, Ao DH, Ma C, Qiu WY, Zhu YC
European journal of histochemistry : EJH 2021 Oct 1;65(s1)
European journal of histochemistry : EJH 2021 Oct 1;65(s1)
Monocarboxylate transporter 1 promotes proliferation and invasion of renal cancer cells by mediating acetate transport.
Li M, Long X, Wan H, Yin M, Yang B, Zhang F, Guo X
Cell biology international 2021 Jun;45(6):1278-1287
Cell biology international 2021 Jun;45(6):1278-1287
hCINAP serves a critical role in hypoxia‑induced cardiomyocyte apoptosis via modulating lactate production and mitochondrial‑mediated apoptosis signaling.
Xie H, Xu G, Gao Y, Yuan Z
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
In Vitro and In Vivo Characterization of MCT1 Inhibitor AZD3965 Confirms Preclinical Safety Compatible with Breast Cancer Treatment.
Benyahia Z, Blackman MCNM, Hamelin L, Zampieri LX, Capeloa T, Bedin ML, Vazeille T, Schakman O, Sonveaux P
Cancers 2021 Feb 2;13(3)
Cancers 2021 Feb 2;13(3)
Wogonin inhibits the growth of HT144 melanoma via regulating hedgehog signaling-mediated inflammation and glycolysis.
Li L, Ji Y, Zhang L, Cai H, Ji Z, Gu L, Yang S
International immunopharmacology 2021 Dec;101(Pt B):108222
International immunopharmacology 2021 Dec;101(Pt B):108222
Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites.
Kong LL, Gao L, Wang KX, Liu NN, Liu CD, Ma GD, Yang HG, Qin XM, Du GH
Acta pharmacologica Sinica 2021 Aug;42(8):1223-1234
Acta pharmacologica Sinica 2021 Aug;42(8):1223-1234
ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.
Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059
Theranostics 2020;10(26):12044-12059
Lowering the increased intracellular pH of human-induced pluripotent stem cell-derived endothelial cells induces formation of mature Weibel-Palade bodies.
Tiemeier GL, de Koning R, Wang G, Kostidis S, Rietjens RGJ, Sol WMPJ, Dumas SJ, Giera M, van den Berg CW, Eikenboom JCJ, van den Berg BM, Carmeliet P, Rabelink TJ
Stem cells translational medicine 2020 Jul;9(7):758-772
Stem cells translational medicine 2020 Jul;9(7):758-772
Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming.
Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, Zhang H, Ma H
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
Journal of cellular and molecular medicine 2020 Jul;24(14):7789-7801
HCAR1/MCT1 Regulates Tumor Ferroptosis through the Lactate-Mediated AMPK-SCD1 Activity and Its Therapeutic Implications.
Zhao Y, Li M, Yao X, Fei Y, Lin Z, Li Z, Cai K, Zhao Y, Luo Z
Cell reports 2020 Dec 8;33(10):108487
Cell reports 2020 Dec 8;33(10):108487
Acidic Stress Triggers Sodium-Coupled Bicarbonate Transport and Promotes Survival in A375 Human Melanoma Cells.
Yang OCY, Loh SH
Scientific reports 2019 May 2;9(1):6858
Scientific reports 2019 May 2;9(1):6858
Subacute ruminal acidosis suppressed the expression of MCT1 in rumen of cows.
Zhao C, Wang Y, Peng Z, Sun X, Sun G, Yuan X, Li X, Liu G
Journal of cellular physiology 2019 Jul;234(7):11734-11745
Journal of cellular physiology 2019 Jul;234(7):11734-11745
Rno-miR-425-5p targets the DLST and SLC16A1 genes to reduce liver damage caused by excessive energy mobilization under cold stress.
Lang L, Xu B, Li SZ, Guo W, Yuan J, Zang S, Chen Y, Yang HM, Lian S
Journal of animal physiology and animal nutrition 2019 Jul;103(4):1251-1262
Journal of animal physiology and animal nutrition 2019 Jul;103(4):1251-1262
Monocarboxylate transporter 1 is an independent prognostic factor in esophageal squamous cell carcinoma.
Chen X, Chen X, Liu F, Yuan Q, Zhang K, Zhou W, Guan S, Wang Y, Mi S, Cheng Y
Oncology reports 2019 Apr;41(4):2529-2539
Oncology reports 2019 Apr;41(4):2529-2539
Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.
Jiang E, Xu Z, Wang M, Yan T, Huang C, Zhou X, Liu Q, Wang L, Chen Y, Wang H, Liu K, Shao Z, Shang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5690-5703
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5690-5703
Autophagy promotes metastasis and glycolysis by upregulating MCT1 expression and Wnt/β-catenin signaling pathway activation in hepatocellular carcinoma cells.
Fan Q, Yang L, Zhang X, Ma Y, Li Y, Dong L, Zong Z, Hua X, Su D, Li H, Liu J
Journal of experimental & clinical cancer research : CR 2018 Jan 19;37(1):9
Journal of experimental & clinical cancer research : CR 2018 Jan 19;37(1):9
Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma.
Noble RA, Bell N, Blair H, Sikka A, Thomas H, Phillips N, Nakjang S, Miwa S, Crossland R, Rand V, Televantou D, Long A, Keun HC, Bacon CM, Bomken S, Critchlow SE, Wedge SR
Haematologica 2017 Jul;102(7):1247-1257
Haematologica 2017 Jul;102(7):1247-1257
Lanthanum damages learning and memory and suppresses astrocyte-neuron lactate shuttle in rat hippocampus.
Jin C, Gao L, Li Y, Wu S, Lu X, Yang J, Cai Y
Experimental brain research 2017 Dec;235(12):3817-3832
Experimental brain research 2017 Dec;235(12):3817-3832
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