22787-1-AP

antibody from Proteintech Group

Targeting: SLC16A3 MCT3, MCT4

Provider product page for 22787-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [21]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 22787-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#22787-1-AP, RRID:AB_11182479
Product name: MCT4 antibody
Antibody type: Polyclonal
Description: KD/KO validated MCT4 antibody (Cat. #22787-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

SLC16A3 protein structure - 22787-1-AP shown in red.

Submitted references Combination of Exercise and Intake of Amino Acid Mixture Synergistically Induces Beige Adipocyte Formation in Mice.

Kojima T, Esaki N, Tsuda T
Journal of nutritional science and vitaminology 2021;67(4):225-233

Pharmacological Inhibition of MCT4 Reduces 4-Hydroxytamoxifen Sensitivity by Increasing HIF-1α Protein Expression in ER-Positive MCF-7 Breast Cancer Cells.

Nadai T, Narumi K, Furugen A, Saito Y, Iseki K, Kobayashi M
Biological & pharmaceutical bulletin 2021;44(9):1247-1253

Activation of Hippocampal IR/IRS-1 Signaling Contributes to the Treatment with Zuogui Jiangtang Jieyu Decoction on the Diabetes-Related Depression.

Yang H, Ling J, Meng P, Liu J, Lin X, Li W, Wang Y
Evidence-based complementary and alternative medicine : eCAM 2021;2021:6688723

Comprehensive Analysis of the Relationship Between Metabolic Reprogramming and Immune Function in Prostate Cancer.

Xie W, Guo H, Zhang J, Hu L, Wu Y, Wang X
OncoTargets and therapy 2021;14:3251-3266

Elevated Lactate by High-Intensity Interval Training Regulates the Hippocampal BDNF Expression and the Mitochondrial Quality Control System.

Hu J, Cai M, Shang Q, Li Z, Feng Y, Liu B, Xue X, Lou S
Frontiers in physiology 2021;12:629914

Activated Pancreatic Stellate Cells Enhance the Warburg Effect to Cause the Malignant Development in Chronic Pancreatitis.

Tao Y, Shao F, Cai M, Liu Z, Peng Y, Huang Q, Meng F
Frontiers in oncology 2021;11:714598

Basigin deficiency prevents anaplerosis and ameliorates insulin resistance and hepatosteatosis.

Ryuge A, Kosugi T, Maeda K, Banno R, Gou Y, Zaitsu K, Ito T, Sato Y, Hirayama A, Tsubota S, Honda T, Nakajima K, Ozaki T, Kondoh K, Takahashi K, Kato N, Ishimoto T, Soga T, Nakagawa T, Koike T, Arima H, Yuzawa Y, Minokoshi Y, Maruyama S, Kadomatsu K
JCI insight 2021 Oct 22;6(20)

In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3.

Abdali A, Baci D, Damiani I, Belloni F, De Dominicis C, Gelmi ML, Corsini A, Bellosta S
Pharmacological research 2021 Jun;168:105592

Lactate sensing mechanisms in arterial chemoreceptor cells.

Torres-Torrelo H, Ortega-Sáenz P, Gao L, López-Barneo J
Nature communications 2021 Jul 6;12(1):4166

Overexpression of monocarboxylate transporter 4 promotes the migration and invasion of non-carcinogenic L929 fibroblast cells.

Li X, Zhou X, Liu Y, Fan J, Huo H, Yao J, Wang L, Ma N
Oncology letters 2021 Jan;21(1):44

Glycolysis is suppressed by DCZ0801-induced inactivation of the Akt/mTOR pathway in Multiple Myeloma.

Feng Q, Yao Q, Li B, Xie Y, Zhang H, Xu Z, Lu K, Hu K, Cheng Y, Shi B, Huang C, Li L, Wu X, You S, Shi J, Zhu W
Journal of Cancer 2020;11(16):4907-4916

ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system.

Zhang X, Dong Y, Zhao M, Ding L, Yang X, Jing Y, Song Y, Chen S, Hu Q, Ni Y
Theranostics 2020;10(26):12044-12059

Identification of the essential extracellular aspartic acids conserved in human monocarboxylate transporters 1, 2, and 4.

Yamaguchi A, Narumi K, Furugen A, Iseki K, Kobayashi M
Biochemical and biophysical research communications 2020 Sep 3;529(4):1061-1065

Metabolic reprogramming of normal oral fibroblasts correlated with increased glycolytic metabolism of oral squamous cell carcinoma and precedes their activation into carcinoma associated fibroblasts.

Zhang Z, Gao Z, Rajthala S, Sapkota D, Dongre H, Parajuli H, Suliman S, Das R, Li L, Bindoff LA, Costea DE, Liang X
Cellular and molecular life sciences : CMLS 2020 Mar;77(6):1115-1133

Jet-Lagged Nanoparticles Enhanced Immunotherapy Efficiency through Synergistic Reconstruction of Tumor Microenvironment and Normalized Tumor Vasculature.

Jiang Z, Xiong H, Yang S, Lu Y, Deng Y, Yao J, Yao J
Advanced healthcare materials 2020 Jun;9(12):e2000075

Breaking Glucose Transporter 1/Pyruvate Kinase M2 Glycolytic Loop Is Required for Cantharidin Inhibition of Metastasis in Highly Metastatic Breast Cancer.

Pan Y, Zheng Q, Ni W, Wei Z, Yu S, Jia Q, Wang M, Wang A, Chen W, Lu Y
Frontiers in pharmacology 2019;10:590

Acidic Stress Triggers Sodium-Coupled Bicarbonate Transport and Promotes Survival in A375 Human Melanoma Cells.

Yang OCY, Loh SH
Scientific reports 2019 May 2;9(1):6858

Homology modeling and site-directed mutagenesis identify amino acid residues underlying the substrate selection mechanism of human monocarboxylate transporters 1 (hMCT1) and 4 (hMCT4).

Futagi Y, Kobayashi M, Narumi K, Furugen A, Iseki K
Cellular and molecular life sciences : CMLS 2019 Dec;76(24):4905-4921

Tumoral microvesicle-activated glycometabolic reprogramming in fibroblasts promotes the progression of oral squamous cell carcinoma.

Jiang E, Xu Z, Wang M, Yan T, Huang C, Zhou X, Liu Q, Wang L, Chen Y, Wang H, Liu K, Shao Z, Shang Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5690-5703

Prognostic value of monocarboxylate transporter 4 in patients with esophageal squamous cell carcinoma.

Cheng B, Chen X, Li Y, Huang X, Yu J
Oncology reports 2018 Nov;40(5):2906-2915

Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device.

Shi H, Jiang H, Wang L, Cao Y, Liu P, Xu X, Wang Y, Sun L, Niu H
Cell cycle (Georgetown, Tex.) 2015;14(19):3058-65

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 22787-1-AP(SLC16A3 antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The SLC16A3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human SLC16A3. This antibody recognizes human antigen. The SLC16A3 antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 22787-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 22787-1-AP(SLC16A3 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 22787-1-AP(SLC16A3 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue