10967-1-AP

antibody from Proteintech Group

Targeting: COIL CLN80, p80-coilin

Provider product page for 10967-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [24]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 10967-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#10967-1-AP, RRID:AB_2276345
Product name: Coilin antibody
Antibody type: Polyclonal
Description: Coilin antibody (Cat. #10967-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

COIL protein structure - 10967-1-AP shown in red.

Submitted references Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles.

Liu S, Chen Z, Shen X, Gao J, Guo J, Rong Y, Li T, Zhou F, Si Y, Zhao H, Cheng T, Shi L, Yu J, Ma Y
Molecular cell 2026 May 7;86(9):1723-1741.e11

Modulating p53 condensation rewires transcriptional programs to enhance tumor suppression.

Liu Y, Jia H, Guan X, Guo J, Wang J, Xiang S, Chen J, Liu Y, Li Y, Wang G
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Mar 25;

RNase MRP subunit composition and role in 40S ribosome biogenesis.

Smith EM, Ly J, Haug S, Cheeseman IM
Nature structural & molecular biology 2026 Jan;33(1):20-33

YTHDC1 Orchestrates Telomerase Assembly via Scaffold-Mediated TERT-TERC Interaction.

Cheng X, Wang S, Yu Y, Xu J, Wang Q, Wei Y, Jin Z, Qi X, Jian D, Shi Y, Li Z, Ma Z, Wang W, Xia T, Xing J, Gu X, Tang H
Aging cell 2026 Jan;25(1):e70332

Coiled-coil-domain-mediated TRIM E3 protein condensation modulates enzymatic activity and functional specificity.

Chen Q, Yang P
Cell reports 2025 Jun 24;44(6):115766

Abnormal regulation of membrane-less organelles contributes to profilin1-associated ALS.

Ma G, Ruan X, Yang B, Li N, Su D, Sun S, Chen S, Xu K, Ying Z, Wang H
The Journal of biological chemistry 2025 Jul;301(7):110259

Dissecting the role of SMN multimerization in its dissociation from the Cajal body using harmine as a tool compound.

Ohazama S, Fujimoto A, Konda D, Yokoyama R, Nakagawa S, Maita H
Journal of cell science 2024 Sep 15;137(18)

Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence.

Han X, Xing L, Hong Y, Zhang X, Hao B, Lu JY, Huang M, Wang Z, Ma S, Zhan G, Li T, Hao X, Tao Y, Li G, Zhou S, Zheng Z, Shao W, Zeng Y, Ma D, Zhang W, Xie Z, Deng H, Yan J, Deng W, Shen X
Cell stem cell 2024 May 2;31(5):694-716.e11

Mutations of Key Functional Residues in CRM1/XPO1 Differently Alter Its Intranuclear Localization and the Nuclear Export of Endogenous Cargos.

Omaetxebarria MJ, Sendino M, Arrizabalaga L, Mota I, Zubiaga AM, Rodríguez JA
Biomolecules 2024 Dec 10;14(12)

HSF4/COIL complex-dependent R-loop mediates ultraviolet-induced inflammatory skin injury.

Feng YQ, Zhang H, Han JX, Cui BJ, Qin LN, Zhang L, Li QQ, Wu XY, Xiao NN, Zhang Y, Lin TT, Liu HJ, Sun T
Clinical and translational medicine 2023 Jul;13(7):e1336

Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.

Xu B, Yang R, Yang B, Li L, Chen J, Fu J, Qu X, Huo D, Tan C, Chen H, Peng Z, Wang X
Molecular brain 2022 Jan 3;15(1):4

UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells.

Niu H, Zhao M, Huang J, Wang J, Si Y, Cheng S, Ding W
Cell communication and signaling : CCS 2022 Feb 12;20(1):18

A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules.

Pourpre R, Lakisic G, Desgranges E, Cossart P, Pagliuso A, Bierne H
Scientific reports 2022 Dec 19;12(1):21961

Transcriptomic Analysis of Gene Networks Regulated by U11 Small Nuclear RNA in Bladder Cancer.

Wang Z, Wang X, Wang Y, Tang S, Feng C, Pan L, Lu Q, Tao Y, Xie Y, Wang Q, Tang Z
Frontiers in genetics 2021;12:695597

Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.

Zhang Y, Chen X, Wang Q, Du C, Lu W, Yuan H, Zhang Z, Li D, Ling X, Ren X, Zhao Y, Su Q, Xing Z, Qin Y, Yang X, Shen Y, Wu H, Qi Y
Journal of molecular medicine (Berlin, Germany) 2021 Dec;99(12):1797-1813

UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins.

Rossi S, Rompietti V, Antonucci Y, Giovannini D, Scopa C, Scaricamazza S, Scardigli R, Cestra G, Serafino A, Carrì MT, D'Ambrosi N, Cozzolino M
Neurobiology of disease 2020 May;138:104792

mRNAs are sorted for export or degradation before passing through nuclear speckles.

Fan J, Kuai B, Wang K, Wang L, Wang Y, Wu X, Chi B, Li G, Cheng H
Nucleic acids research 2018 Sep 19;46(16):8404-8416

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.

Pawellek A, Ryder U, Tammsalu T, King LJ, Kreinin H, Ly T, Hay RT, Hartley RC, Lamond AI
eLife 2017 Sep 8;6

Identification of small molecule inhibitors of pre-mRNA splicing.

Pawallek A, McElroy S, Samatov T, Mitchell L, Woodland A, Ryder U, Gray D, Lührmann R, Lamond AI
The Journal of biological chemistry 2015 Mar 6;290(10):6005

EphB4 localises to the nucleus of prostate cancer cells.

Mertens-Walker I, Lisle JE, Nyberg WA, Stephens CR, Burke L, Rutkowski R, Herington AC, Stephenson SA
Experimental cell research 2015 Apr 10;333(1):105-15

Identification of small molecule inhibitors of pre-mRNA splicing.

Pawellek A, McElroy S, Samatov T, Mitchell L, Woodland A, Ryder U, Gray D, Lührmann R, Lamond AI
The Journal of biological chemistry 2014 Dec 12;289(50):34683-98

Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.

Dury AY, El Fatimy R, Tremblay S, Rose TM, Côté J, De Koninck P, Khandjian EW
PLoS genetics 2013 Oct;9(10):e1003890

Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells.

Gu Z, Li Y, Lee P, Liu T, Wan C, Wang Z
PloS one 2012;7(8):e44033

FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short.

Chen S, Evans HG, Evans DR
PloS one 2012;7(3):e32971

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 10967-1-AP(COIL antibody) at dilution of 1:800
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using COIL antibody 10967-1-AP at 1:50 and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 10967-1-AP(COIL antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue