Antibody data
- Antibody Data
- Antigen structure
- References [16]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 10967-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10967-1-AP, RRID:AB_2276345
- Product name
- Coilin antibody
- Antibody type
- Polyclonal
- Description
- Coilin antibody (Cat. #10967-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Nuclear RNA homeostasis promotes systems-level coordination of cell fate and senescence.
HSF4/COIL complex-dependent R-loop mediates ultraviolet-induced inflammatory skin injury.
Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.
UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells.
A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules.
Transcriptomic Analysis of Gene Networks Regulated by U11 Small Nuclear RNA in Bladder Cancer.
Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.
UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins.
mRNAs are sorted for export or degradation before passing through nuclear speckles.
Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.
Identification of small molecule inhibitors of pre-mRNA splicing.
EphB4 localises to the nucleus of prostate cancer cells.
Identification of small molecule inhibitors of pre-mRNA splicing.
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.
Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells.
FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short.
Han X, Xing L, Hong Y, Zhang X, Hao B, Lu JY, Huang M, Wang Z, Ma S, Zhan G, Li T, Hao X, Tao Y, Li G, Zhou S, Zheng Z, Shao W, Zeng Y, Ma D, Zhang W, Xie Z, Deng H, Yan J, Deng W, Shen X
Cell stem cell 2024 May 2;31(5):694-716.e11
Cell stem cell 2024 May 2;31(5):694-716.e11
HSF4/COIL complex-dependent R-loop mediates ultraviolet-induced inflammatory skin injury.
Feng YQ, Zhang H, Han JX, Cui BJ, Qin LN, Zhang L, Li QQ, Wu XY, Xiao NN, Zhang Y, Lin TT, Liu HJ, Sun T
Clinical and translational medicine 2023 Jul;13(7):e1336
Clinical and translational medicine 2023 Jul;13(7):e1336
Long non-coding RNA lncC11orf54-1 modulates neuroinflammatory responses by activating NF-κB signaling during meningitic Escherichia coli infection.
Xu B, Yang R, Yang B, Li L, Chen J, Fu J, Qu X, Huo D, Tan C, Chen H, Peng Z, Wang X
Molecular brain 2022 Jan 3;15(1):4
Molecular brain 2022 Jan 3;15(1):4
UHMK1-dependent phosphorylation of Cajal body protein coilin alters 5-FU sensitivity in colon cancer cells.
Niu H, Zhao M, Huang J, Wang J, Si Y, Cheng S, Ding W
Cell communication and signaling : CCS 2022 Feb 12;20(1):18
Cell communication and signaling : CCS 2022 Feb 12;20(1):18
A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules.
Pourpre R, Lakisic G, Desgranges E, Cossart P, Pagliuso A, Bierne H
Scientific reports 2022 Dec 19;12(1):21961
Scientific reports 2022 Dec 19;12(1):21961
Transcriptomic Analysis of Gene Networks Regulated by U11 Small Nuclear RNA in Bladder Cancer.
Wang Z, Wang X, Wang Y, Tang S, Feng C, Pan L, Lu Q, Tao Y, Xie Y, Wang Q, Tang Z
Frontiers in genetics 2021;12:695597
Frontiers in genetics 2021;12:695597
Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.
Zhang Y, Chen X, Wang Q, Du C, Lu W, Yuan H, Zhang Z, Li D, Ling X, Ren X, Zhao Y, Su Q, Xing Z, Qin Y, Yang X, Shen Y, Wu H, Qi Y
Journal of molecular medicine (Berlin, Germany) 2021 Dec;99(12):1797-1813
Journal of molecular medicine (Berlin, Germany) 2021 Dec;99(12):1797-1813
UsnRNP trafficking is regulated by stress granules and compromised by mutant ALS proteins.
Rossi S, Rompietti V, Antonucci Y, Giovannini D, Scopa C, Scaricamazza S, Scardigli R, Cestra G, Serafino A, Carrì MT, D'Ambrosi N, Cozzolino M
Neurobiology of disease 2020 May;138:104792
Neurobiology of disease 2020 May;138:104792
mRNAs are sorted for export or degradation before passing through nuclear speckles.
Fan J, Kuai B, Wang K, Wang L, Wang Y, Wu X, Chi B, Li G, Cheng H
Nucleic acids research 2018 Sep 19;46(16):8404-8416
Nucleic acids research 2018 Sep 19;46(16):8404-8416
Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP.
Pawellek A, Ryder U, Tammsalu T, King LJ, Kreinin H, Ly T, Hay RT, Hartley RC, Lamond AI
eLife 2017 Sep 8;6
eLife 2017 Sep 8;6
Identification of small molecule inhibitors of pre-mRNA splicing.
Pawallek A, McElroy S, Samatov T, Mitchell L, Woodland A, Ryder U, Gray D, Lührmann R, Lamond AI
The Journal of biological chemistry 2015 Mar 6;290(10):6005
The Journal of biological chemistry 2015 Mar 6;290(10):6005
EphB4 localises to the nucleus of prostate cancer cells.
Mertens-Walker I, Lisle JE, Nyberg WA, Stephens CR, Burke L, Rutkowski R, Herington AC, Stephenson SA
Experimental cell research 2015 Apr 10;333(1):105-15
Experimental cell research 2015 Apr 10;333(1):105-15
Identification of small molecule inhibitors of pre-mRNA splicing.
Pawellek A, McElroy S, Samatov T, Mitchell L, Woodland A, Ryder U, Gray D, Lührmann R, Lamond AI
The Journal of biological chemistry 2014 Dec 12;289(50):34683-98
The Journal of biological chemistry 2014 Dec 12;289(50):34683-98
Nuclear Fragile X Mental Retardation Protein is localized to Cajal bodies.
Dury AY, El Fatimy R, Tremblay S, Rose TM, Côté J, De Koninck P, Khandjian EW
PLoS genetics 2013 Oct;9(10):e1003890
PLoS genetics 2013 Oct;9(10):e1003890
Protein arginine methyltransferase 5 functions in opposite ways in the cytoplasm and nucleus of prostate cancer cells.
Gu Z, Li Y, Lee P, Liu T, Wan C, Wang Z
PloS one 2012;7(8):e44033
PloS one 2012;7(8):e44033
FLASH knockdown sensitizes cells to Fas-mediated apoptosis via down-regulation of the anti-apoptotic proteins, MCL-1 and Cflip short.
Chen S, Evans HG, Evans DR
PloS one 2012;7(3):e32971
PloS one 2012;7(3):e32971
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 10967-1-AP(COIL antibody) at dilution of 1:800
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using COIL antibody 10967-1-AP at 1:50 and FITC-labeled donkey anti-rabbit IgG(green). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human prostate cancer using 10967-1-AP(COIL antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue