18262-1-AP

antibody from Proteintech Group

Targeting: PDK1

Provider product page for 18262-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [68]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 18262-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#18262-1-AP, RRID:AB_10598310
Product name: PDK1 antibody
Antibody type: Polyclonal
Description: PDK1 antibody (Cat. #18262-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PDK1 protein structure - 18262-1-AP shown in red.

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RSC medicinal chemistry 2026 Mar 2;

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Cell reports 2026 Mar 17;45(4):117123

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Liu Y, Yang X, Qin M, Chen W, Liu C, Jiang W, Wang Y, Tan S, Sun H, Chen J, Sun H, He S
Journal of ethnopharmacology 2026 Jun 28;365:121554

Shaoyao Gancao Decoction alleviates ulcerative colitis-associated secondary liver injury by inhibiting the phosphorylation of pyruvate dehydrogenase in macrophages.

Tang F, Tang Y, Li L, Zhou F, Sun C, Ouyang B, Huang D, Li M, He W, Pei G, Tan Y
Journal of ethnopharmacology 2026 Jul 15;366:121652

Druggable target ATAD2 enhances the malignant progression and cooperates with E2F1 to up-regulate PDK1 expression in glioma.

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iScience 2026 Apr 17;29(4):115183

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PDK1, associated with glycolytic metabolism, is a potential prognostic biomarker in osteosarcoma.

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Gáll T, Pethő D, Nagy A, Póliska S, Balla G, Balla J
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LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.

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Derepressing nuclear pyruvate dehydrogenase induces therapeutic cancer cell reprogramming.

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International journal of molecular sciences 2025 Apr 2;26(7)

USP7 promotes endothelial activation to aggravate sepsis-induced acute lung injury through PDK1/AKT/NF-κB signaling pathway.

Liu Z, Shi X, Ke T, Yan Z, Xiong L, Tang F
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Quercetin Limits Tumor Immune Escape through PDK1/CD47 Axis in Melanoma.

Li X, He X, Lin B, Li L, Deng Q, Wang C, Zhang J, Chen Y, Zhao J, Li X, Li Y, Xi Q, Zhang R
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Frontiers of medicine 2024 Oct;18(5):878-895

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Qin F, Tan H, Yang Y, Xu L, Yang X
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NUPR1 modulates pulmonary embolism progression via smooth muscle cells phenotypic transformation.

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Heliyon 2024 Nov 15;10(21):e38918

Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1.

Zhu G, Guan F, Li S, Zhang Q, Zhang X, Qin Y, Sun Z, Peng S, Cheng J, Li Y, Ren R, Fan T, Liu H
Molecular carcinogenesis 2024 May;63(5):897-911

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The Journal of clinical investigation 2024 Aug 15;134(18)

Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle.

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Yao Y, Shi J, Zhang C, Gao W, Huang N, Liu Y, Yan W, Han Y, Zhou W, Kong L
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PDK1 inhibition reduces autophagy and cell senescence through the PI3K/AKT signalling pathway in a cigarette smoke mouse emphysema model.

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PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.

Ma Y, Zhang X, Han X, Hao Z, Ji R, Li J, Guo W, Zhang Y, Guan F, Ma S
Molecular carcinogenesis 2023 Jun;62(6):866-881

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PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: mouse liver tissue were subjected to SDS PAGE followed by western blot with 18262-1-AP(PDK1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PDK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDK1. This antibody recognizes human,mouse,rat antigen. The PDK1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 18262-1-AP.pdf

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