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- Product number
- 18262-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#18262-1-AP, RRID:AB_10598310
- Product name
- PDK1 antibody
- Antibody type
- Polyclonal
- Description
- PDK1 antibody (Cat. #18262-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Glutaminase potentiates the glycolysis in esophageal squamous cell carcinoma by interacting with PDK1.
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Targeting ONECUT3 blocks glycolytic metabolism and potentiates anti-PD-1 therapy in pancreatic cancer.
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo.
Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes.
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Inhibition of phosphoglycerate kinase 1 attenuates autoimmune myocarditis by reprogramming CD4+ T cell metabolism.
PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway.
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
P-coumaric acid ameliorates Aβ(25-35)-induced brain damage in mice by modulating gut microbiota and serum metabolites.
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth.
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
RNA-seq transcriptome profiling of liver regeneration in mice identifies the miR-34b-5p/phosphoinositide-dependent protein kinase 1 axis as a potential target for hepatocyte proliferation.
RETRACTED: PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages.
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1.
HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance.
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes.
The anti-rotavirus effect of baicalin via the gluconeogenesis-related p-JNK-PDK1-AKT-SIK2 signaling pathway.
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.
Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome.
Zhu G, Guan F, Li S, Zhang Q, Zhang X, Qin Y, Sun Z, Peng S, Cheng J, Li Y, Ren R, Fan T, Liu H
Molecular carcinogenesis 2024 May;63(5):897-911
Molecular carcinogenesis 2024 May;63(5):897-911
Lactate accumulation induced by Akt2-PDK1 signaling promotes pulmonary fibrosis.
Sun Z, Ji Z, He W, Duan R, Qu J, Yu G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23426
Targeting ONECUT3 blocks glycolytic metabolism and potentiates anti-PD-1 therapy in pancreatic cancer.
Chen PC, Ning Y, Li H, Su JG, Shen JB, Feng QC, Jiang SH, Shi PD, Guo RS
Cellular oncology (Dordrecht, Netherlands) 2024 Feb;47(1):81-96
Cellular oncology (Dordrecht, Netherlands) 2024 Feb;47(1):81-96
Total Astragalus saponins can reverse type 2 diabetes mellitus-related intestinal dysbiosis and hepatic insulin resistance in vivo.
Ma L, La X, Zhang B, Xu W, Tian C, Fu Q, Wang M, Wu C, Chen Z, Chang H, Li JA
Frontiers in endocrinology 2023;14:1190827
Frontiers in endocrinology 2023;14:1190827
Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes.
Yao Y, Shi J, Zhang C, Gao W, Huang N, Liu Y, Yan W, Han Y, Zhou W, Kong L
Cell death & disease 2023 Nov 7;14(11):722
Cell death & disease 2023 Nov 7;14(11):722
PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming.
Ma Y, Zhang X, Han X, Hao Z, Ji R, Li J, Guo W, Zhang Y, Guan F, Ma S
Molecular carcinogenesis 2023 Jun;62(6):866-881
Molecular carcinogenesis 2023 Jun;62(6):866-881
Inhibition of phosphoglycerate kinase 1 attenuates autoimmune myocarditis by reprogramming CD4+ T cell metabolism.
Lu Y, Zhao N, Wu Y, Yang S, Wu Q, Dong Q, Du Y
Cardiovascular research 2023 Jun 13;119(6):1377-1389
Cardiovascular research 2023 Jun 13;119(6):1377-1389
PDK1-stabilized LncRNA SPRY4-IT1 promotes breast cancer progression via activating NF-κB signaling pathway.
Zhang Y, Chen H, Yuan R, Wang Y, Zhang D, Zeng Q, Jiang W, Zhang R, Chen T, Chai C, Guo B
Molecular carcinogenesis 2023 Jul;62(7):1009-1024
Molecular carcinogenesis 2023 Jul;62(7):1009-1024
A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.
Song R, Ma S, Xu J, Ren X, Guo P, Liu H, Li P, Yin F, Liu M, Wang Q, Yu L, Liu J, Duan B, Rahman NA, Wołczyński S, Li G, Li X
Molecular cancer 2023 Jan 23;22(1):16
Molecular cancer 2023 Jan 23;22(1):16
P-coumaric acid ameliorates Aβ(25-35)-induced brain damage in mice by modulating gut microbiota and serum metabolites.
Cao B, Zeng MN, Hao FX, Hao ZY, Zhang ZK, Liang XW, Wu YY, Zhang YH, Feng WS, Zheng XK
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115825
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115825
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth.
Yi X, Qi M, Huang M, Zhou S, Xiong J
Frontiers in pharmacology 2022;13:796763
Frontiers in pharmacology 2022;13:796763
CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.
Wang X, Jian W, Luo Q, Fang L
Cell death & disease 2022 Sep 17;13(9):794
Cell death & disease 2022 Sep 17;13(9):794
RNA-seq transcriptome profiling of liver regeneration in mice identifies the miR-34b-5p/phosphoinositide-dependent protein kinase 1 axis as a potential target for hepatocyte proliferation.
Lei X, Dai X, Wang Q, Long R, Xiang Z, Li H, Long Z, Zhang C, Zhu Z
Biochemical and biophysical research communications 2022 Oct 30;627:111-121
Biochemical and biophysical research communications 2022 Oct 30;627:111-121
RETRACTED: PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages.
Xu Y, Lu J, Tang Y, Xie W, Zhang H, Wang B, Zhang S, Hou W, Zou C, Jiang P, Zhang W
Cancer letters 2022 Mar 31;529:19-36
Cancer letters 2022 Mar 31;529:19-36
FOXM1 regulates glycolysis in nasopharyngeal carcinoma cells through PDK1.
Yang Q, Wu F, Zhang Y, Wang R
Journal of cellular and molecular medicine 2022 Jul;26(13):3783-3796
Journal of cellular and molecular medicine 2022 Jul;26(13):3783-3796
HDAC2- and EZH2-Mediated Histone Modifications Induce PDK1 Expression through miR-148a Downregulation in Breast Cancer Progression and Adriamycin Resistance.
Xie Y, Shi Z, Qian Y, Jiang C, Liu W, Liu B, Jiang B
Cancers 2022 Jul 23;14(15)
Cancers 2022 Jul 23;14(15)
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes.
Li Y, Yang L, Hou Y, Zhang Z, Chen M, Wang M, Liu J, Wang J, Zhao Z, Xie C, Lu X
Bioactive materials 2022 Dec;18:213-227
Bioactive materials 2022 Dec;18:213-227
The anti-rotavirus effect of baicalin via the gluconeogenesis-related p-JNK-PDK1-AKT-SIK2 signaling pathway.
Song L, Zhong P, Zhu X, Zhou R, Gao M, Lan Q, Chen J, Chen Y, Zhao W
European journal of pharmacology 2021 Apr 15;897:173927
European journal of pharmacology 2021 Apr 15;897:173927
The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.
Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q
Nature communications 2019 Mar 4;10(1):1034
Nature communications 2019 Mar 4;10(1):1034
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Zhang X, Liu Z, Xiao Q, Zeng C, Lai CH, Fan X, Ye Q, Wang Y, Xiong Y
Artificial organs 2018 Mar;42(3):280-289
Artificial organs 2018 Mar;42(3):280-289
Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver.
Zeng T, Zhang CL, Zhao N, Guan MJ, Xiao M, Yang R, Zhao XL, Yu LH, Zhu ZP, Xie KQ
Redox biology 2018 Apr;14:295-304
Redox biology 2018 Apr;14:295-304
Defective insulin signaling and the protective effects of dimethyldiguanide during follicular development in the ovaries of polycystic ovary syndrome.
Wang F, Wang S, Zhang Z, Lin Q, Liu Y, Xiao Y, Xiao K, Wang Z
Molecular medicine reports 2017 Dec;16(6):8164-8170
Molecular medicine reports 2017 Dec;16(6):8164-8170
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse liver tissue were subjected to SDS PAGE followed by western blot with 18262-1-AP(PDK1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PDK1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDK1. This antibody recognizes human,mouse,rat antigen. The PDK1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
