17402-1-AP

antibody from Proteintech Group

Targeting: CXCL12 PBSF, SCYB12, SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, TLSF-a, TLSF-b, TPAR1

Provider product page for 17402-1-AP

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [52]
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Validations
Immunohistochemistry [1]

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Product number: 17402-1-AP - Provider product page
Provider: Proteintech Group
Product name: CXCL12/SDF-1 antibody
Antibody type: Polyclonal
Description: CXCL12/SDF-1 antibody (Cat. #17402-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CXCL12 protein structure - 17402-1-AP shown in red.

Submitted references Intratumoral CXCR4(hi) neutrophils display ferroptotic and immunosuppressive signatures in hepatoblastoma.

Lu Z, Wang X, Feng J, Chai W, Wang W, Wang Q, Yang S, Yang W, Su Y, Mou W, Peng Y, Wang H, Gui J
Frontiers in immunology 2024;15:1363454

Tumor-associated macrophages promoting PD-L1 expression in infiltrating B cells through the CXCL12/CXCR4 axis in human hepatocellular carcinoma.

Lian SL, Lu YT, Lu YJ, Yao YL, Wang XL, Jiang RQ
American journal of cancer research 2024;14(2):832-853

Activation of CaMKII/HDAC4 by SDF1 contributes to pulmonary arterial hypertension via stabilization Runx2.

Chen Y, Liu J, Zhang Q, Chai L, Chen H, Li D, Wang Y, Qiu Y, Shen N, Zhang J, Wang Q, Wang J, Xie X, Li S, Li M
European journal of pharmacology 2024 May 5;970:176483

Tibial cortex transverse transport promotes ischemic diabetic foot ulcer healing via enhanced angiogenesis and inflammation modulation in a novel rat model.

Qin W, Liu K, Su H, Hou J, Yang S, Pan K, Yang S, Liu J, Zhou P, Lin Z, Zhen P, Mo Y, Fan B, Li Z, Kuang X, Nie X, Hua Q
European journal of medical research 2024 Mar 6;29(1):155

Modulating Th1/Th2 drift in asthma-related immune inflammation by enhancing bone mesenchymal stem cell homing through targeted inhibition of the Notch1/Jagged1 signaling pathway.

Kun W, Xiaomei C, Lei Y, Huizhi Z
International immunopharmacology 2024 Mar 30;130:111713

Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma.

Sun BY, Wang ZT, Chen KZ, Song Y, Wu JF, Zhang D, Sun GQ, Zhou J, Fan J, Hu B, Yi Y, Qiu SJ
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Photo-metallo-immunotherapy: Fabricating Chromium-Based Nanocomposites to Enhance CAR-T Cell Infiltration and Cytotoxicity against Solid Tumors.

Zou Q, Liao K, Li G, Huang X, Zheng Y, Yang G, Luo M, Xue EY, Lan C, Wang S, Shen Y, Luo D, Ng DKP, Liu Q
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68Ga-FAPI PET imaging monitors response to combined TGF-βR inhibition and immunotherapy in metastatic colorectal cancer.

Li K, Liu W, Yu H, Chen J, Tang W, Wang J, Qi M, Sun Y, Xu X, Zhang J, Li X, Guo W, Li X, Song S, Tang S
The Journal of clinical investigation 2024 Jan 4;134(4)

3D-printed PCL@BG scaffold integrated with SDF-1α-loaded hydrogel for enhancing local treatment of bone defects.

Wang C, Dong J, Liu F, Liu N, Li L
Journal of biological engineering 2024 Jan 2;18(1):1

High-mobility group box 1 fragment ameliorates chronic pancreatitis induced by caerulein in mice.

Hokkoku D, Sasaki K, Kobayashi S, Shimbo T, Kitayama T, Yamazaki S, Yamamoto Y, Ouchi Y, Imamura H, Kado T, Toya K, Fujii W, Iwagami Y, Yamada D, Tomimaru Y, Noda T, Takahashi H, Tamai K, Doki Y, Eguchi H
Journal of gastroenterology 2024 Aug;59(8):744-757

Matrix vesicles promote bone repair after a femoral bone defect in mice.

Mizukami Y, Kawao N, Takafuji Y, Ohira T, Okada K, Jo JI, Tabata Y, Kaji H
PloS one 2023;18(4):e0284258

Co-Delivery Nanomicelles for Potentiating TNBC Immunotherapy by Synergetically Reshaping CAFs-Mediated Tumor Stroma and Reprogramming Immunosuppressive Microenvironment.

Zhang Y, Han X, Wang K, Liu D, Ding X, Hu Z, Wang J
International journal of nanomedicine 2023;18:4329-4346

Multi-omics reveals Dengzhan Shengmai formulation ameliorates cognitive impairments in D-galactose-induced aging mouse model by regulating CXCL12/CXCR4 and gut microbiota.

Hou JY, Xu H, Cao GZ, Tian LL, Wang LH, Zhu NQ, Zhang JJ, Yang HJ
Frontiers in pharmacology 2023;14:1175970

Tibial cortex transverse transport potentiates diabetic wound healing via activation of SDF-1/CXCR4 signaling.

Ou S, Wu X, Yang Y, Xia C, Zhang W, Qu Y, Li J, Chen B, Zhu L, Xu C, Qi Y
PeerJ 2023;11:e15894

CREB1-driven CXCR4(hi) neutrophils promote skin inflammation in mouse models and human patients.

Chen J, Bai Y, Xue K, Li Z, Zhu Z, Li Q, Yu C, Li B, Shen S, Qiao P, Li C, Luo Y, Qiao H, Dang E, Yin W, Gudjonsson JE, Wang G, Shao S
Nature communications 2023 Sep 22;14(1):5894

Single-cell analysis reveals immune cellular components in odontogenic keratocysts.

Man QW, Li RF, Liu JF, Zhao Y, Liu B
Oral diseases 2023 Nov;29(8):3420-3432

Angelica sinensis polysaccharides ameliorated 5-Fluorouracil-induced damage of early B cell progenitors by alleviating oxidative stress of IL-7 producing mesenchymal stem and progenitor cells.

Xiao H, Wang Y, Wang Z, Wang B, Hu L, Hou J, Du K, Sun N, Wang L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Nov;167:115599

Herpetin Promotes Bone Marrow Mesenchymal Stem Cells to Alleviate Carbon Tetrachloride-Induced Acute Liver Injury in Mice.

Ding Y, Tan R, Gu J, Gong P
Molecules (Basel, Switzerland) 2023 May 1;28(9)

Duan JL, Liu JJ, Ruan B, Ding J, Fang ZQ, Xu H, Song P, Xu C, Li ZW, Du W, Xu M, Ling YW, He F, Wang L
Nature aging 2023 Mar;3(3):258-274

3D bioprinted autologous bone particle scaffolds for cranioplasty promote bone regeneration with both implanted and native BMSCs.

Huan Y, Zhou D, Wu X, He X, Chen H, Li S, Jia B, Dou Y, Fei X, Wu S, Wei J, Fei Z, Xu T, Fei F
Biofabrication 2023 Mar 14;15(2)

[MiR-30e-5p overexpression promotes proliferation and migration of colorectal cancer cells by activating the CXCL12 axis via downregulating PTEN].

Wei K, Shi J, Xiao Y, Wang W, Yang Q, Chen C
Nan fang yi ke da xue xue bao = Journal of Southern Medical University 2023 Jul 20;43(7):1081-1092

Saxagliptin alleviates erectile dysfunction through increasing stromal cell-derived factor-1 in diabetes mellitus.

Sun T, Xu W, Wang J, Wang T, Wang S, Liu K, Liu J
Andrology 2023 Feb;11(2):295-306

Prognostic Value of CXCL12 in Non-Small Cell Lung Cancer Patients Undergoing Tumor Resection.

Kogue Y, Kobayashi H, Nakamura Y, Takano T, Furuta C, Kawano O, Yasuma T, Nishimura T, D'Alessandro-Gabazza CN, Fujimoto H, Gabazza EC, Kobayashi T, Fukai I
Pharmaceuticals (Basel, Switzerland) 2023 Feb 7;16(2)

Zoledronic acid generates a spatiotemporal effect to attenuate osteoarthritis by inhibiting potential Wnt5a-associated abnormal subchondral bone resorption.

Ding D, Wang L, Yan J, Zhou Y, Feng G, Ma L, Yang Y, Pei X, Jin Q
PloS one 2022;17(7):e0271485

miR-1273h-5p suppresses CXCL12 expression and inhibits gastric cancer cell invasion and metastasis.

Wang YC, Lu S, Zhou XJ, Yang L, Liu P, Zhang L, Hu Y, Dong XZ
Open medicine (Warsaw, Poland) 2022;17(1):930-946

C-X-C-Chemokine-Receptor-Type-4 Inhibitor AMD3100 Attenuates Pulmonary Inflammation and Fibrosis in Silicotic Mice.

Sun Q, Tao X, Li B, Cao H, Chen H, Zou Y, Tao H, Mu M, Wang W, Xu K
Journal of inflammation research 2022;15:5827-5843

NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats.

Luo C, Peng Y, Zhou X, Fan J, Chen W, Zhang H, Wei A
Frontiers in endocrinology 2022;13:913296

Growth arrest-specific protein 2 (GAS2) interacts with CXCR4 to promote T-cell leukemogenesis partially via c-MYC.

Ma W, Wan Y, Zhang J, Yao J, Wang Y, Lu J, Liu H, Huang X, Zhang X, Zhou H, He Y, Wu D, Wang J, Zhao Y
Molecular oncology 2022 Oct;16(20):3720-3734

miR-126 downregulates CXCL12 expression in intestinal epithelial cells to suppress the recruitment and function of macrophages and tumorigenesis in a murine model of colitis-associated colorectal cancer.

Wu S, Yuan W, Luo W, Nie K, Wu X, Meng X, Shen Z, Wang X
Molecular oncology 2022 Oct;16(19):3465-3489

Tumor promoting effect of circ_002172 associates with induced immune escape in breast cancer via the miR-296-5p/CXCL12 axis.

Li P, Ren X, Zheng Y, Sun J, Ye G
International immunopharmacology 2022 May;106:108530

Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis.

Ding D, Yan J, Feng G, Zhou Y, Ma L, Jin Q
International journal of molecular medicine 2022 Jan;49(1)

SDF-1 inhibits the dedifferentiation of islet β cells in hyperglycaemia by up-regulating FoxO1 via binding to CXCR4.

Chen XY, Shi YX, Huang YP, Ding M, Shen QL, Li CJ, Lin JN
Journal of cellular and molecular medicine 2022 Feb;26(3):750-763

Single-Cell RNA Sequencing Reveals CXCLs Enriched Fibroblasts Within Odontogenic Keratocysts.

Man QW, Li RF, Li SR, Wang J, Bu LL, Zhao Y, Liu B
Journal of inflammation research 2021;14:7359-7369

VISTA Blockade Aggravates Bone Loss in Experimental Murine Apical Periodontitis.

Yang F, Zhang Y, Chen Z, Zhang L
Frontiers in immunology 2021;12:738586

Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.

Ma S, Zhou J, Huang T, Zhang Z, Xing Q, Zhou X, Zhang K, Yao M, Cheng T, Wang X, Wen X, Guan F
Acta biomaterialia 2021 Sep 1;131:185-197

N2-Polarized Neutrophils Guide Bone Mesenchymal Stem Cell Recruitment and Initiate Bone Regeneration: A Missing Piece of the Bone Regeneration Puzzle.

Cai B, Lin D, Li Y, Wang L, Xie J, Dai T, Liu F, Tang M, Tian L, Yuan Y, Kong L, Shen SGF
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2021 Oct;8(19):e2100584

AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose.

Zhang Z, Wu H, Huang S, Chen L, Chen X, Zhang W, Liao L, Zhang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111476

The protective mechanism of Klotho gene-modified bone marrow mesenchymal stem cells on acute kidney injury induced by rhabdomyolysis.

Ni W, Zhang Y, Yin Z
Regenerative therapy 2021 Dec;18:255-267

Tumoural activation of TLR3-SLIT2 axis in endothelium drives metastasis.

Tavora B, Mederer T, Wessel KJ, Ruffing S, Sadjadi M, Missmahl M, Ostendorf BN, Liu X, Kim JY, Olsen O, Welm AL, Goodarzi H, Tavazoie SF
Nature 2020 Oct;586(7828):299-304

Cancer-associated fibroblasts induce epithelial-mesenchymal transition and cisplatin resistance in ovarian cancer via CXCL12/CXCR4 axis.

Zhang F, Cui JY, Gao HF, Yu H, Gao FF, Chen JL, Chen L
Future oncology (London, England) 2020 Nov;16(32):2619-2633

Protein kinase CK2 participates in estrogen-mediated endothelial progenitor cell homing to endometriotic lesions through stromal cells in a stromal cell-derived factor-1- CXCR4-dependent manner.

Zhao R, Feng D, Zhuang G, Liu Y, Chi S, Zhang J, Zhou X, Zhang W, Wang H
Fertility and sterility 2020 May;113(5):1067-1079.e5

Bioinformatic analysis reveals the importance of epithelial-mesenchymal transition in the development of endometriosis.

Chen M, Zhou Y, Xu H, Hill C, Ewing RM, He D, Zhang X, Wang Y
Scientific reports 2020 May 21;10(1):8442

M2 macrophages promote vasculogenesis during retinal neovascularization by regulating bone marrow-derived cells via SDF-1/VEGF.

Wang Y, Chang T, Wu T, Xu W, Dou G, Wang Y, Guo C
Cell and tissue research 2020 Jun;380(3):469-486

The protective effects of umbilical cord-derived endothelial colony forming cells on hepatic veno-occlusive disease.

Chen L, Zhang J, Liu X, Yao M, Zhang H
Cell biology international 2020 Dec;44(12):2541-2552

Magnetic targeting enhances the cutaneous wound healing effects of human mesenchymal stem cell-derived iron oxide exosomes.

Li X, Wang Y, Shi L, Li B, Li J, Wei Z, Lv H, Wu L, Zhang H, Yang B, Xu X, Jiang J
Journal of nanobiotechnology 2020 Aug 14;18(1):113

Effect of chronic methylphenidate treatment on hippocampal neurovascular unit and memory performance in late adolescent rats.

Coelho-Santos V, Cardoso FL, Magalhães A, Ferreira-Teixeira M, Leitão RA, Gomes C, Rito M, Barbosa M, Fontes-Ribeiro CA, Silva AP
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 2019 Dec;29(2):195-210

MACC1 overexpression in carcinoma‑associated fibroblasts induces the invasion of lung adenocarcinoma cells via paracrine signaling.

Li Z, Guo T, Fang L, Li N, Wang X, Wang P, Zhao S, Li F, Cui Y, Shu X, Zhao L, Li J, Gu C
International journal of oncology 2019 Apr;54(4):1367-1375

Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1β Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes.

Liang S, Lv ZT, Zhang JM, Wang YT, Dong YH, Wang ZG, Chen K, Cheng P, Yang Q, Guo FJ, Lu WW, Zhu WT, Chen AM
Frontiers in pharmacology 2018;9:1378

The cryo-thermal therapy-induced IL-6-rich acute pro-inflammatory response promoted DCs phenotypic maturation as the prerequisite to CD4(+) T cell differentiation.

Liu K, He K, Xue T, Liu P, Xu LX
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 2018 May;34(3):261-272

Effects of crenolanib, a nonselective inhibitor of PDGFR, in a mouse model of transient middle cerebral artery occlusion.

Wang J, Fu X, Zhang D, Yu L, Lu Z, Gao Y, Liu X, Man J, Li S, Li N, Wang M, Liu X, Chen X, Zang W, Yang Q, Wang J
Neuroscience 2017 Nov 19;364:202-211

Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.

Cho KI, Yoon D, Qiu S, Danziger Z, Grill WM, Wetsel WC, Ferreira PA
Disease models & mechanisms 2017 May 1;10(5):559-579

High-mobility group box-1-Toll-Like receptor 4 axis mediates the recruitment of endothelial progenitor cells in alkali-induced corneal neovascularization.

Yang S, Yang TS, Wang F, Su SB
International immunopharmacology 2015 Sep;28(1):450-8

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 17402-1-AP( CXCL12 Antibody) at dilution of 1:50 (under 10x lens)
Other comments: IHC
Appendix: 17402-1-AP.pdf

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