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LearnMAB310
antibody from R&D Systems
Targeting: CXCL12
PBSF, SCYB12, SDF-1a, SDF-1b, SDF1, SDF1A, SDF1B, TLSF-a, TLSF-b, TPAR1
Blocking/NeutralizingAntibody data
- Antibody Data
- Antigen structure
- References [38]
- Comments [0]
- Validations [0]
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- Product number
- MAB310 - Provider product page
- Provider
- R&D Systems
- Product name
- Anti-Human/Mouse CXCL12/SDF-1 Monoclonal Antibody (Clone 79014)
- Antibody type
- Monoclonal
- Antigen
- E. coli-derived recombinant human CXCL12/SDF‑1α, Lys22-Lys89
- Description
- Protein A or G purified from hybridoma culture supernatant
- Reactivity
- Human, Mouse
- Host
- Mouse
- Antigen sequence
Q6ICW0- Isotype
- IgG
- Vial size
- 500 µg
Submitted references Indian Hedgehog Suppresses a Stromal Cell-Driven Intestinal Immune Response.
Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins.
Cathepsin K cleavage of SDF-1α inhibits its chemotactic activity towards glioblastoma stem-like cells.
Physiologically activated mammary fibroblasts promote postpartum mammary cancer.
Stromal Cell-Derived Factor 1 Mediates Immune Cell Attraction upon Urinary Tract Infection.
Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration.
Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells.
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo.
CXCR4+ CD45- Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow.
Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation.
Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell.
Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function.
Platelet expression of stromal cell-derived factor-1 is associated with the degree of valvular aortic stenosis.
An important role of the SDF-1/CXCR4 axis in chronic skin inflammation.
SDF1-a facilitates Lin-/Sca1+ cell homing following murine experimental cerebral ischemia.
Vitamin D promotes vascular regeneration.
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs.
Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
CXCL12-CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells.
Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070.
Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment.
Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation.
CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1.
CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice.
Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.
CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis.
Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration.
Cloning and expression pattern of dog SDF-1 and the implications of altered expression of SDF-1 in ischemic myocardium.
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
SDF-1 is both necessary and sufficient to promote proliferative retinopathy.
The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
Westendorp BF, Büller NVJA, Karpus ON, van Dop WA, Koster J, Versteeg R, Koelink PJ, Snel CY, Meisner S, Roelofs JJTH, Uhmann A, Ver Loren van Themaat E, Heijmans J, Hahn H, Muncan V, Wildenberg ME, van den Brink GR
Cellular and molecular gastroenterology and hepatology 2018;5(1):67-82.e1
Cellular and molecular gastroenterology and hepatology 2018;5(1):67-82.e1
Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins.
Hira VVV, Wormer JR, Kakar H, Breznik B, van der Swaan B, Hulsbos R, Tigchelaar W, Tonar Z, Khurshed M, Molenaar RJ, Van Noorden CJF
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2018 Mar;66(3):155-173
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2018 Mar;66(3):155-173
Cathepsin K cleavage of SDF-1α inhibits its chemotactic activity towards glioblastoma stem-like cells.
Hira VV, Verbovšek U, Breznik B, Srdič M, Novinec M, Kakar H, Wormer J, der Swaan BV, Lenarčič B, Juliano L, Mehta S, Van Noorden CJ, Lah TT
Biochimica et biophysica acta. Molecular cell research 2017 Mar;1864(3):594-603
Biochimica et biophysica acta. Molecular cell research 2017 Mar;1864(3):594-603
Physiologically activated mammary fibroblasts promote postpartum mammary cancer.
Guo Q, Minnier J, Burchard J, Chiotti K, Spellman P, Schedin P
JCI insight 2017 Mar 23;2(6):e89206
JCI insight 2017 Mar 23;2(6):e89206
Stromal Cell-Derived Factor 1 Mediates Immune Cell Attraction upon Urinary Tract Infection.
Isaacson B, Hadad T, Glasner A, Gur C, Granot Z, Bachrach G, Mandelboim O
Cell reports 2017 Jul 5;20(1):40-47
Cell reports 2017 Jul 5;20(1):40-47
Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration.
Sun JL, Jiao K, Niu LN, Jiao Y, Song Q, Shen LJ, Tay FR, Chen JH
Biomaterials 2017 Jan;113:203-216
Biomaterials 2017 Jan;113:203-216
Hepatic carcinoma-associated fibroblasts enhance immune suppression by facilitating the generation of myeloid-derived suppressor cells.
Deng Y, Cheng J, Fu B, Liu W, Chen G, Zhang Q, Yang Y
Oncogene 2017 Feb 23;36(8):1090-1101
Oncogene 2017 Feb 23;36(8):1090-1101
CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis.
Chen XW, Yu TJ, Zhang J, Li Y, Chen HL, Yang GF, Yu W, Liu YZ, Liu XX, Duan CF, Tang HL, Qiu M, Wang CL, Zheng H, Yue J, Guo AM, Yang J
Oncogene 2017 Aug 31;36(35):5045-5057
Oncogene 2017 Aug 31;36(35):5045-5057
Natural nitration of CXCL12 reduces its signaling capacity and chemotactic activity in vitro and abrogates intra-articular lymphocyte recruitment in vivo.
Janssens R, Mortier A, Boff D, Vanheule V, Gouwy M, Franck C, Larsen O, Rosenkilde MM, Van Damme J, Amaral FA, Teixeira MM, Struyf S, Proost P
Oncotarget 2016 Sep 20;7(38):62439-62459
Oncotarget 2016 Sep 20;7(38):62439-62459
CXCR4+ CD45- Cells are Niche Forming for Osteoclastogenesis via the SDF-1, CXCL7, and CX3CL1 Signaling Pathways in Bone Marrow.
Goto Y, Aoyama M, Sekiya T, Kakita H, Waguri-Nagaya Y, Miyazawa K, Asai K, Goto S
Stem cells (Dayton, Ohio) 2016 Nov;34(11):2733-2743
Stem cells (Dayton, Ohio) 2016 Nov;34(11):2733-2743
Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation.
Kasagi Y, Harada Y, Morodomi Y, Iwai T, Saito S, Yoshida K, Oki E, Saeki H, Ohgaki K, Sugiyama M, Onimaru M, Maehara Y, Yonemitsu Y
Cancer research 2016 Jan 15;76(2):347-57
Cancer research 2016 Jan 15;76(2):347-57
Lipopolysaccharide Promotes Choroidal Neovascularization by Up-Regulation of CXCR4 and CXCR7 Expression in Choroid Endothelial Cell.
Feng YF, Guo H, Yuan F, Shen MQ
PloS one 2015;10(8):e0136175
PloS one 2015;10(8):e0136175
Mesenchymal Stem Cells Ameliorate Atherosclerotic Lesions via Restoring Endothelial Function.
Lin YL, Yet SF, Hsu YT, Wang GJ, Hung SC
Stem cells translational medicine 2015 Jan;4(1):44-55
Stem cells translational medicine 2015 Jan;4(1):44-55
Platelet expression of stromal cell-derived factor-1 is associated with the degree of valvular aortic stenosis.
Wurster T, Tegtmeyer R, Borst O, Rath D, Geisler T, Gawaz M, Bigalke B
PloS one 2014;9(5):e97405
PloS one 2014;9(5):e97405
An important role of the SDF-1/CXCR4 axis in chronic skin inflammation.
Zgraggen S, Huggenberger R, Kerl K, Detmar M
PloS one 2014;9(4):e93665
PloS one 2014;9(4):e93665
SDF1-a facilitates Lin-/Sca1+ cell homing following murine experimental cerebral ischemia.
Mocco J, Afzal A, Ansari S, Wolfe A, Caldwell K, Connolly ES, Scott EW
PloS one 2014;9(1):e85615
PloS one 2014;9(1):e85615
Vitamin D promotes vascular regeneration.
Wong MS, Leisegang MS, Kruse C, Vogel J, Schürmann C, Dehne N, Weigert A, Herrmann E, Brüne B, Shah AM, Steinhilber D, Offermanns S, Carmeliet G, Badenhoop K, Schröder K, Brandes RP
Circulation 2014 Sep 16;130(12):976-86
Circulation 2014 Sep 16;130(12):976-86
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow.
Beck TC, Gomes AC, Cyster JG, Pereira JP
The Journal of experimental medicine 2014 Dec 15;211(13):2567-81
The Journal of experimental medicine 2014 Dec 15;211(13):2567-81
IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs.
Fleige H, Ravens S, Moschovakis GL, Bölter J, Willenzon S, Sutter G, Häussler S, Kalinke U, Prinz I, Förster R
The Journal of experimental medicine 2014 Apr 7;211(4):643-51
The Journal of experimental medicine 2014 Apr 7;211(4):643-51
Hematopoietic stem cell cytokines and fibroblast growth factor-2 stimulate human endothelial cell-pericyte tube co-assembly in 3D fibrin matrices under serum-free defined conditions.
Smith AO, Bowers SL, Stratman AN, Davis GE
PloS one 2013;8(12):e85147
PloS one 2013;8(12):e85147
CXCL12-CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells.
Yang QE, Kim D, Kaucher A, Oatley MJ, Oatley JM
Journal of cell science 2013 Feb 15;126(Pt 4):1009-20
Journal of cell science 2013 Feb 15;126(Pt 4):1009-20
Inhibition of CXCR4-CXCL12 chemotaxis in melanoma by AMD11070.
O'Boyle G, Swidenbank I, Marshall H, Barker CE, Armstrong J, White SA, Fricker SP, Plummer R, Wright M, Lovat PE
British journal of cancer 2013 Apr 30;108(8):1634-40
British journal of cancer 2013 Apr 30;108(8):1634-40
Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment.
Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T
The American journal of pathology 2010 Nov;177(5):2268-77
The American journal of pathology 2010 Nov;177(5):2268-77
Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation.
Wei L, Kanbe K, Lee M, Wei X, Pei M, Sun X, Terek R, Chen Q
Developmental biology 2010 May 1;341(1):236-45
Developmental biology 2010 May 1;341(1):236-45
CXCR4 and CXCR7 regulate angiogenesis and CT26.WT tumor growth independent from SDF-1.
Kollmar O, Rupertus K, Scheuer C, Nickels RM, Haberl GC, Tilton B, Menger MD, Schilling MK
International journal of cancer 2010 Mar 15;126(6):1302-15
International journal of cancer 2010 Mar 15;126(6):1302-15
CXCL12 enhances exogenous CD4+CD25+ T cell migration and prevents embryo loss in non-obese diabetic mice.
Lin Y, Xu L, Jin H, Zhong Y, Di J, Lin QD
Fertility and sterility 2009 Jun;91(6):2687-96
Fertility and sterility 2009 Jun;91(6):2687-96
Rapid chemotherapy-induced acute endothelial progenitor cell mobilization: implications for antiangiogenic drugs as chemosensitizing agents.
Shaked Y, Henke E, Roodhart JM, Mancuso P, Langenberg MH, Colleoni M, Daenen LG, Man S, Xu P, Emmenegger U, Tang T, Zhu Z, Witte L, Strieter RM, Bertolini F, Voest EE, Benezra R, Kerbel RS
Cancer cell 2008 Sep 9;14(3):263-73
Cancer cell 2008 Sep 9;14(3):263-73
CXCL12 (SDF-1alpha) suppresses ongoing experimental autoimmune encephalomyelitis by selecting antigen-specific regulatory T cells.
Meiron M, Zohar Y, Anunu R, Wildbaum G, Karin N
The Journal of experimental medicine 2008 Oct 27;205(11):2643-55
The Journal of experimental medicine 2008 Oct 27;205(11):2643-55
CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis.
Ouwehand K, Santegoets SJ, Bruynzeel DP, Scheper RJ, de Gruijl TD, Gibbs S
European journal of immunology 2008 Nov;38(11):3050-9
European journal of immunology 2008 Nov;38(11):3050-9
Activation of bone marrow-derived microglia promotes photoreceptor survival in inherited retinal degeneration.
Sasahara M, Otani A, Oishi A, Kojima H, Yodoi Y, Kameda T, Nakamura H, Yoshimura N
The American journal of pathology 2008 Jun;172(6):1693-703
The American journal of pathology 2008 Jun;172(6):1693-703
Cloning and expression pattern of dog SDF-1 and the implications of altered expression of SDF-1 in ischemic myocardium.
Wei YJ, Tang Y, Li J, Cui CJ, Zhang H, Zhang XL, Zhang H, Hu SS
Cytokine 2007 Oct;40(1):52-9
Cytokine 2007 Oct;40(1):52-9
Osteoblasts support B-lymphocyte commitment and differentiation from hematopoietic stem cells.
Zhu J, Garrett R, Jung Y, Zhang Y, Kim N, Wang J, Joe GJ, Hexner E, Choi Y, Taichman RS, Emerson SG
Blood 2007 May 1;109(9):3706-12
Blood 2007 May 1;109(9):3706-12
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 15;178(12):8148-57
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 15;178(12):8148-57
Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury.
Petty JM, Sueblinvong V, Lenox CC, Jones CC, Cosgrove GP, Cool CD, Rai PR, Brown KK, Weiss DJ, Poynter ME, Suratt BT
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 15;178(12):8148-57
Journal of immunology (Baltimore, Md. : 1950) 2007 Jun 15;178(12):8148-57
SDF-1 is both necessary and sufficient to promote proliferative retinopathy.
Butler JM, Guthrie SM, Koc M, Afzal A, Caballero S, Brooks HL, Mames RN, Segal MS, Grant MB, Scott EW
The Journal of clinical investigation 2005 Jan;115(1):86-93
The Journal of clinical investigation 2005 Jan;115(1):86-93
The role of CCL21 in recruitment of T-precursor cells to fetal thymi.
Liu C, Ueno T, Kuse S, Saito F, Nitta T, Piali L, Nakano H, Kakiuchi T, Lipp M, Hollander GA, Takahama Y
Blood 2005 Jan 1;105(1):31-9
Blood 2005 Jan 1;105(1):31-9
CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin.
Cardones AR, Murakami T, Hwang ST
Cancer research 2003 Oct 15;63(20):6751-7
Cancer research 2003 Oct 15;63(20):6751-7
Serum inactivation contributes to the failure of stromal-derived factor-1 to block HIV-I infection in vivo.
Villalba S, Salvucci O, Aoki Y, De La Luz Sierra M, Gupta G, Davis D, Wyvill K, Little R, Yarchoan R, Tosato G
Journal of leukocyte biology 2003 Nov;74(5):880-8
Journal of leukocyte biology 2003 Nov;74(5):880-8
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