24613-1-AP

antibody from Proteintech Group

Targeting: ANGPT2 Ang2

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

24613-1-AP

Provider

Proteintech Group

Product name

Angiopoietin 2 antibody

Antibody type

Polyclonal

Description

Angiopoietin 2 antibody (Cat. #24613-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Ubiquitin ligase CHFR impairs Tie2 signaling via K (48) -linked ubiquitylation and degradation of Akt1 in endothelial cells.

Ansari MO, Mo GCH, Jayathilaka L, Chen H, Malik AB, Tiruppathi C
bioRxiv : the preprint server for biology 2026 Mar 31;

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Frontiers in pharmacology 2025;16:1548122

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Targeted Anti-Inflammatory Nanozymes with Pro-Angiogenic Activity for Myocardial Infarction Therapy.

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Advanced healthcare materials 2025 May;14(14):e2404979

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Tie2-expressing monocytes/macrophages promote angiogenesis in chronically ischaemic brain tissue.

Tai C, Ling C, Yang Y, Zhang B, Sun J, Mo N, Sun T, Huang L, Yao C, Wang H, Chen C
Cell & bioscience 2025 May 21;15(1):62

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RalB uncoupling from exocyst is required for endothelial Weibel-Palade body exocytosis.

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Molecular biology of the cell 2025 May 1;36(5):ar62

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RBMS3-loss impedes TRIM21-induced ubiquitination of ANGPT2 in an RNA-independent manner and drives sorafenib resistance in hepatocellular carcinoma.

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Oncogene 2025 Jun;44(21):1620-1633

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FSTL3 promotes colorectal cancer by activating the HIF1 pathway.

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Gene 2025 Jun 20;954:149435

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Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma.

Li C, Wu P, Xie X, Chen X, Chen L, Zhu L, Xuan Z, Liu T, Tan W, Zhang S, Lin D, Wu C
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Synthesis and anti-tumor activity of menthylamine derivatives: Focusing on the potent inhibitory effect of compound W8 on glioma growth.

Wu X, Zhuo Y, Liu J, He Z, Wang M, Lei W, Liang Q, Wang A, Shen Z, Chen S, Zheng S, Huang H
Bioorganic & medicinal chemistry 2025 Jan 1;117:118024

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Doxorubicin-loaded PEGylated liposome modified with ANGPT2-specific peptide for integrative glioma-targeted imaging and therapy.

Li H, Gan R, Liu J, Xu D, Zhang Q, Tian H, Guo H, Wang H, Wang Z, Zeng X
Materials today. Bio 2025 Feb;30:101455

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Transcriptional subtypes on immune microenvironment and predicting postoperative recurrence and metastasis in human pheochromocytoma and paraganglioma.

Liu Y, Yan X, Zhang Y, Gao Z, Nan F, Shi S, Chen J, Li L
eLife 2025 Dec 16;14

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Impaired decidualization and angiogenesis in eutopic endometrium of endometriosis: insights from in vitro models†.

Qin R, Zhong X, Lin J, Li C, Liu X, Qin A, Zheng F
Biology of reproduction 2025 Dec 16;113(6):1539-1548

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Tanshinone IIA improved psychological stress-induced embryo implantation disorders by inhibiting GC/GR signaling and promoting angiogenesis.

Li F, Zhao S, Fang Q, Qiao Z, Meng Y, Jin Q, Zong L, Shui L, Chen S, Han H, Wang J, Wu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156946

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Single-cell and spatial transcriptomics reveal apelin/APJ pathway's role in microvessel formation and tumour progression in hepatocellular carcinoma.

Zhu Y, Zhang P, Huo X, Ling Y, Lv X, Lin S, Song H
Journal of cellular and molecular medicine 2024 Oct;28(20):e70152

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HIF-1α knockdown attenuates phenotypic transformation and oxidative stress induced by high salt in human aortic vascular smooth muscle cells.

Deng W, Huang S, Yu L, Gao B, Pan Y, Wang X, Li L
Scientific reports 2024 Nov 15;14(1):28100

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Phosphodiesterase inhibitor ameliorates senescent changes of renal interstitial pericytes in aging kidney.

Kim HD, Kim EN, Lim JH, Kim Y, Ban TH, Lee H, Kim YS, Park CW, Choi BS
Aging cell 2024 Mar;23(3):e14075

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Ubiquitin ligase CHFR mediated degradation of VE-cadherin through ubiquitylation disrupts endothelial adherens junctions.

Tiruppathi C, Wang DM, Ansari MO, Bano S, Tsukasaki Y, Mukhopadhyay A, Joshi JC, Loch C, Niessen HWM, Malik AB
Nature communications 2023 Oct 18;14(1):6582

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Human placenta-based genome-wide mRNA sequencing to identify TEK/IGF1/CSF1/ANGPT2 as crucial segments in the pathogenesis of pre-eclampsia.

Wang L, Zhang L, Fan Y, Peng Y, Song D, Fu J, Wang X
Frontiers in genetics 2022;13:944932

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Extracellular Vesicles Secreted by Mouse Decidual Cells Carry Critical Information for the Establishment of Pregnancy.

Ma Q, Beal JR, Song X, Bhurke A, Bagchi IC, Bagchi MK
Endocrinology 2022 Oct 23;163(12)

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Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension.

Mprah R, Ma Y, Adzika GK, Ndzie Noah ML, Adekunle AO, Duah M, Adu-Amankwaah J, Wowui PI, Okwuma JD, Qiao W, Wang C
Clinical and experimental pharmacology & physiology 2022 May;49(5):558-566

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Single-cell sequencing reveals microglia induced angiogenesis by specific subsets of endothelial cells following spinal cord injury.

Yao C, Cao Y, Wang D, Lv Y, Liu Y, Gu X, Wang Y, Wang X, Yu B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 Jul;36(7):e22393

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Matrine inhibits synovial angiogenesis in collagen-induced arthritis rats by regulating HIF-VEGF-Ang and inhibiting the PI3K/Akt signaling pathway.

Ao L, Gao H, Jia L, Liu S, Guo J, Liu B, Dong Q
Molecular immunology 2022 Jan;141:13-20

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MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of HIF-1α and ANGPT2.

Huang YH, Lian WS, Wang FS, Wang PW, Lin HY, Tsai MC, Yang YL
International journal of molecular sciences 2022 Jan 31;23(3)

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Lycium barbarum polysaccharides attenuates high glucose-induced diabetic retinal angiogenesis by rescuing the expression of miR-15a-5p in RF/6A cells.

Zhu Y, Zhao Q, Jiang Y
Journal of ethnopharmacology 2022 Jan 30;283:114652

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Akt1-dependent expression of angiopoietin 1 and 2 in vascular smooth muscle cells leads to vascular stabilization.

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Experimental & molecular medicine 2022 Aug;54(8):1133-1145

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A study of the effects of hydroxyapatite bioceramic extract on Ang/Tie2 system of umbilical vein endothelial cells.

Zhang X, Liu Y, Su Y, Fan X, Hu F
Technology and health care : official journal of the European Society for Engineering and Medicine 2021;29(S1):531-538

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MAPK-RAP1A Signaling Enriched in Hepatocellular Carcinoma Is Associated With Favorable Tumor-Infiltrating Immune Cells and Clinical Prognosis.

Li H, Han G, Li X, Li B, Wu B, Jin H, Wu L, Wang W
Frontiers in oncology 2021;11:649980

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Discovery of Novel Small-Molecule Antiangiogenesis Agents to Treat Diabetic Retinopathy.

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The Changes of Twist1 Pathway in Pulmonary Microvascular Permeability in a Newborn Rat Model of Hyperoxia-Induced Acute Lung Injury.

Ruan Y, Dong W, Kang L, Lei X, Zhang R, Wang F, Zhu X
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Distinct Roles of VEGFA and ANGPT2 in Lung Adenocarcinoma and Squamous Cell Carcinoma.

Qin S, Yi M, Jiao D, Li A, Wu K
Journal of Cancer 2020;11(1):153-167

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Targeting the ERβ/Angiopoietin-2/Tie-2 signaling-mediated angiogenesis with the FDA-approved anti-estrogen Faslodex to increase the Sunitinib sensitivity in RCC.

Gu J, Zhang Y, Han Z, Gao L, Cui J, Sun Y, Niu Y, You B, Huang CP, Chang C, Wang X, Yeh S
Cell death & disease 2020 May 14;11(5):367

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Tumor-Derived EV-Encapsulated miR-181b-5p Induces Angiogenesis to Foster Tumorigenesis and Metastasis of ESCC.

Wang Y, Lu J, Chen L, Bian H, Hu J, Li D, Xia C, Xu H
Molecular therapy. Nucleic acids 2020 Jun 5;20:421-437

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Angiopoietin-2 regulated by progesterone induces uterine vascular remodeling during pregnancy.

Park YG, Choi J, Seol JW
Molecular medicine reports 2020 Aug;22(2):1235-1242

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Decreased ZNF750 promotes angiogenesis in a paracrine manner via activating DANCR/miR-4707-3p/FOXC2 axis in esophageal squamous cell carcinoma.

Bi Y, Guo S, Xu X, Kong P, Cui H, Yan T, Ma Y, Cheng Y, Chen Y, Liu X, Zhang L, Cheng C, Xu E, Qian Y, Yang J, Song B, Li H, Wang F, Hu X, Liu X, Niu X, Zhai Y, Liu J, Li Y, Cheng X, Cui Y
Cell death & disease 2020 Apr 27;11(4):296

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Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer.

Choi J, Lee DH, Park SY, Seol JW
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Sep;117:109091

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Dl-3-N-butylphthalide promotes angiogenesis and upregulates sonic hedgehog expression after cerebral ischemia in rats.

Zhou PT, Wang LP, Qu MJ, Shen H, Zheng HR, Deng LD, Ma YY, Wang YY, Wang YT, Tang YH, Tian HL, Zhang ZJ, Yang GY
CNS neuroscience & therapeutics 2019 Jun;25(6):748-758

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Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion.

Li Q, Yuan DM, Ma LH, Ma CH, Liu YF, Lv TF, Song Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016 Dec;37:16249–16258

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

K-562 cells were subjected to SDS PAGE followed by western blot with 24613-1-AP( ANGPT2 Antibody) at dilution of 1:600

Other comments

WB

Appendix

24613-1-AP.pdf

Show more

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using 24613-1-AP( ANGPT2 Antibody) at dilution of 1:50 (under 40x lens)

Other comments

IHC

Appendix

24613-1-AP.pdf

Show more