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- Antibody Data
- Antigen structure
- References [11]
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- Validations
- Immunohistochemistry [1]
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- Product number
- AF-252-PB - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal Pleiotrophin/PTN Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human Pleiotrophin/PTN in direct ELISAs and Western blots. In direct ELISAs, less than 50% cross-reactivity with recombinant mouse PTN is observed, and less than 1% cross-reactivity with recombinant human Midkine is observed.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 250 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Chronic myeloid leukemia stem cells require cell-autonomous pleiotrophin signaling.
A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo.
Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis.
The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity.
Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth.
Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways.
Gene expression changes in the course of neural progenitor cell differentiation.
The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor.
Himburg HA, Roos M, Fang T, Zhang Y, Termini CM, Schlussel L, Kim M, Pang A, Kan J, Zhao L, Suh H, Sasine JP, Sapparapu G, Bowers PM, Schiller G, Chute JP
The Journal of clinical investigation 2020 Jan 2;130(1):315-328
The Journal of clinical investigation 2020 Jan 2;130(1):315-328
A glucocorticoid- and diet-responsive pathway toggles adipocyte precursor cell activity in vivo.
Wong JC, Krueger KC, Costa MJ, Aggarwal A, Du H, McLaughlin TL, Feldman BJ
Science signaling 2016 Oct 25;9(451):ra103
Science signaling 2016 Oct 25;9(451):ra103
Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
Chen AC, Donovan A, Ned-Sykes R, Andrews NC
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 15;112(37):11714-9
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 15;112(37):11714-9
Pleiotrophin gene therapy for peripheral ischemia: evaluation of full-length and truncated gene variants.
Fang Q, Mok PY, Thomas AE, Haddad DJ, Saini SA, Clifford BT, Kapasi NK, Danforth OM, Usui M, Ye W, Luu E, Sharma R, Bartel MJ, Pathmanabhan JA, Ang AA, Sievers RE, Lee RJ, Springer ML
PloS one 2013;8(4):e61413
PloS one 2013;8(4):e61413
Pleiotrophin produced by multiple myeloma induces transdifferentiation of monocytes into vascular endothelial cells: a novel mechanism of tumor-induced vasculogenesis.
Chen H, Campbell RA, Chang Y, Li M, Wang CS, Li J, Sanchez E, Share M, Steinberg J, Berenson A, Shalitin D, Zeng Z, Gui D, Perez-Pinera P, Berenson RJ, Said J, Bonavida B, Deuel TF, Berenson JR
Blood 2009 Feb 26;113(9):1992-2002
Blood 2009 Feb 26;113(9):1992-2002
The pro-angiogenic cytokine pleiotrophin potentiates cardiomyocyte apoptosis through inhibition of endogenous AKT/PKB activity.
Li J, Wei H, Chesley A, Moon C, Krawczyk M, Volkova M, Ziman B, Margulies KB, Talan M, Crow MT, Boheler KR
The Journal of biological chemistry 2007 Nov 30;282(48):34984-93
The Journal of biological chemistry 2007 Nov 30;282(48):34984-93
Role of heparin binding growth factors in nigrostriatal dopamine system development and Parkinson's disease.
Marchionini DM, Lehrmann E, Chu Y, He B, Sortwell CE, Becker KG, Freed WJ, Kordower JH, Collier TJ
Brain research 2007 May 25;1147:77-88
Brain research 2007 May 25;1147:77-88
Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth.
Chen H, Gordon MS, Campbell RA, Li M, Wang CS, Lee HJ, Sanchez E, Manyak SJ, Gui D, Shalitin D, Said J, Chang Y, Deuel TF, Baritaki S, Bonavida B, Berenson JR
Blood 2007 Jul 1;110(1):287-95
Blood 2007 Jul 1;110(1):287-95
Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways.
Li F, Shetty AK, Sugahara K
The Journal of biological chemistry 2007 Feb 2;282(5):2956-66
The Journal of biological chemistry 2007 Feb 2;282(5):2956-66
Gene expression changes in the course of neural progenitor cell differentiation.
Gurok U, Steinhoff C, Lipkowitz B, Ropers HH, Scharff C, Nuber UA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Jun 30;24(26):5982-6002
The Journal of neuroscience : the official journal of the Society for Neuroscience 2004 Jun 30;24(26):5982-6002
The anti-HIV cytokine midkine binds the cell surface-expressed nucleolin as a low affinity receptor.
Said EA, Krust B, Nisole S, Svab J, Briand JP, Hovanessian AG
The Journal of biological chemistry 2002 Oct 4;277(40):37492-502
The Journal of biological chemistry 2002 Oct 4;277(40):37492-502
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Pleiotrophin/PTN in Human Pituitary. Pleiotrophin/PTN in Human Pituitary.
