Antibody data
- Antibody Data
- Antigen structure
- References [37]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
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- Product number
- 22392-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- IRF7 antibody
- Antibody type
- Polyclonal
- Description
- IRF7 antibody (Cat. #22392-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PIN1 suppresses bladder cancer progression by inducing cellular senescence and activating the interferon response pathway.
Targeting SUMOylation Triggers IFN-β-dependent Activation of Patient and Allogenic NK Cells in Preclinical Models of Acute Myeloid Leukemia.
Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation.
Athero-oncology perspective: identifying hub genes for atherosclerosis diagnosis using machine learning.
EcSnx27 facilitates in vitro release of Singapore grouper iridovirus and interacts with its major capsid protein.
Ultrasound Visualization of Spatiotemporal Autophagy-Regulated Nanodroplets for Amplifying ICB in Melanoma via Remodeling Tumor Inflammatory Microenvironment.
Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus.
SARS-CoV-2-Derived RNA Fragment Induces Myocardial Dysfunction via siRNA-like Suppression of Mitochondrial ATP Synthase.
The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein.
Potentiating microglial efferocytosis by MFG-E8 improves survival and neurological outcome after successful cardiopulmonary resuscitation in mice.
Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.
Ginsenoside Rh2-Liposome Potentiate Vaccine Immunity through Enhanced MHC‑I Presentation.
Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation.
Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy.
Global MicroRNA Profiling of HSV-1 Infected Cornea Identifies miR-329 as a Novel Regulator of Virus Infection.
IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis.
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway.
BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity.
Transcription Factor IRF7 is Involved in Psoriasis Development and Response to Guselkumab Treatment.
Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer.
Etelcalcetide ameliorates bone loss in chronic kidney disease-mineral and bone disorder by activation of IRF7 and necroptosis pathways.
Single-cell transcriptomics reveals IRF7 regulation of the tumor microenvironment in isocitrate dehydrogenase wild-type glioma.
NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis.
Structure elucidation and molecular mechanism of an immunomodulatory polysaccharide from Nostoc commune.
Fish Snx27 promotes viral products by modulating the innate immune response and exosomal machinery.
Construction of an interferon regulatory factors-related risk model for predicting prognosis, immune microenvironment and immunotherapy in clear cell renal cell carcinoma.
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling.
NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization.
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses.
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation.
TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes.
pol-miR-194a of Japanese flounder (Paralichthys olivaceus) suppresses type I interferon response and facilitates Edwardsiella tarda infection.
A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Genetic characterization of bovine viral diarrhea virus strains in Beijing, China and innate immune responses of peripheral blood mononuclear cells in persistently infected dairy cattle.
Zhang L, Chen C, Huang W, Dong L, Zhang J, Liu B, He W
Cellular signalling 2026 Jul;143:112476
Cellular signalling 2026 Jul;143:112476
Targeting SUMOylation Triggers IFN-β-dependent Activation of Patient and Allogenic NK Cells in Preclinical Models of Acute Myeloid Leukemia.
Hallal R, de Toledo M, Tempé D, Berrahouane R, Zemiti S, Coënon L, Gitenay D, George S, Schüssler M, Laguette N, Bonnet S, Gabellier L, Cartron G, Pelegrin M, Villalba M, Bossis G
Molecular cancer therapeutics 2026 Jan 2;25(1):125-139
Molecular cancer therapeutics 2026 Jan 2;25(1):125-139
Sustained STING-IRF7 signaling aggravates LPS-induced endometrial inflammation via excessive neutrophil extracellular traps generation.
Chu M, Ma D, Song Z, Liang L, Xing F, Bao H
Frontiers in immunology 2025;16:1671848
Frontiers in immunology 2025;16:1671848
Athero-oncology perspective: identifying hub genes for atherosclerosis diagnosis using machine learning.
Zhao L, Lv X, Chen W, Li X, Zhou J, Ai Q, Tuo Q
Frontiers in immunology 2025;16:1616096
Frontiers in immunology 2025;16:1616096
EcSnx27 facilitates in vitro release of Singapore grouper iridovirus and interacts with its major capsid protein.
Zhao Z, Cai J, Wang S, Liang Y, Qin C, Wu C, Li L, Zang YA, Yu Y, Chen J
Developmental and comparative immunology 2025 Sep;170:105455
Developmental and comparative immunology 2025 Sep;170:105455
Ultrasound Visualization of Spatiotemporal Autophagy-Regulated Nanodroplets for Amplifying ICB in Melanoma via Remodeling Tumor Inflammatory Microenvironment.
Wu N, Zhang Q, Tang R, Deng L, Cao Y, Fu B, Dong H, Huang Z, Wan L, He H, Lin Y, Liu J, Xia C, Li P
ACS applied materials & interfaces 2025 May 21;17(20):29364-29378
ACS applied materials & interfaces 2025 May 21;17(20):29364-29378
Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus.
Zhang S, Zhong R, Zhou M, Li K, Lv H, Wang H, Xu Y, Liu D, Ma Q, Chen L, Zhang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415948
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jun;12(21):e2415948
SARS-CoV-2-Derived RNA Fragment Induces Myocardial Dysfunction via siRNA-like Suppression of Mitochondrial ATP Synthase.
Nukaga S, Fujiwara-Tani R, Mori T, Kawahara I, Nishida R, Miyagawa Y, Goto K, Ohmori H, Fujii K, Sasaki T, Nakashima C, Luo Y, Mori S, Kishi S, Ogata R, Kuniyasu H
International journal of molecular sciences 2025 Jun 4;26(11)
International journal of molecular sciences 2025 Jun 4;26(11)
The puzzling regulation of the interferon signaling system by the p53 tumor suppressor protein.
Będzińska A, Łasut-Szyszka B, Krześniak M, Gdowicz-Kłosok A, Rusin M
Cellular and molecular life sciences : CMLS 2025 Jun 13;82(1):233
Cellular and molecular life sciences : CMLS 2025 Jun 13;82(1):233
Potentiating microglial efferocytosis by MFG-E8 improves survival and neurological outcome after successful cardiopulmonary resuscitation in mice.
Zhang K, Zhang Y, Li Z, Chen J, Chang Y, Li Y, Zeng S, Pan S, Pan S, Huang K
Brain pathology (Zurich, Switzerland) 2025 Jul;35(4):e13327
Brain pathology (Zurich, Switzerland) 2025 Jul;35(4):e13327
Cancer cell type-specific derepression of transposable elements by inhibition of chromatin modifier enzymes.
Patel D, Tiusanen V, Karttunen K, Pihlajamaa P, Sahu B
Communications biology 2025 Jul 3;8(1):992
Communications biology 2025 Jul 3;8(1):992
Ginsenoside Rh2-Liposome Potentiate Vaccine Immunity through Enhanced MHC‑I Presentation.
Nie Q, Chen Z, Gong W, Cao W, Wang X, Liu Y, Zhang S, Yang Y, Meng Z
ACS omega 2025 Jul 29;10(29):31940-31953
ACS omega 2025 Jul 29;10(29):31940-31953
Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation.
Sakiyama H, Baba K, Kimura Y, Ogawa K, Nishiike U, Hayakawa H, Yoshida M, Aguirre C, Ikenaka K, Nagano S, Mochizuki H
Neurochemistry international 2025 Jan;182:105906
Neurochemistry international 2025 Jan;182:105906
Matrine relieved DHAV-1-induced hepatocyte excessive interferon and pyroptosis by activating mitophagy.
Wang W, Fu X, Gu B, Hu M, Liu J
Poultry science 2025 Jan;104(1):104601
Poultry science 2025 Jan;104(1):104601
Global MicroRNA Profiling of HSV-1 Infected Cornea Identifies miR-329 as a Novel Regulator of Virus Infection.
Sharma P, Naqvi RA, Borase H, Kapoor D, Valverde A, Capistrano K, Yadavalli T, Naqvi AR, Shukla D
Investigative ophthalmology & visual science 2025 Feb 3;66(2):61
Investigative ophthalmology & visual science 2025 Feb 3;66(2):61
IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis.
Liu H, Wu C, Li G, Peng X, Zhang Z, Su Z, Lin J, Wang X, Shen H, Wu Y, Liu W, Wang P, Zheng G
Arthritis research & therapy 2025 Dec 8;28(1):10
Arthritis research & therapy 2025 Dec 8;28(1):10
Cilostazol attenuates vascular inflammation via the regulation of TICAM1/IRF3 signaling pathway.
Chiu HW, Shih CC, Huang HJ, Huang TH, Sung LC
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2025 Aug;189:118275
BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity.
Lai Y, Yang X, Wei D, Wang X, Sun R, Li Y, Ji P, Bao Y, Chu T, Zhang C, Liang Q, Xu J, Zhang X, Chen Y, Wang Y
Cell reports 2025 Apr 22;44(4):115493
Cell reports 2025 Apr 22;44(4):115493
Transcription Factor IRF7 is Involved in Psoriasis Development and Response to Guselkumab Treatment.
Yuan X, Xin T, Yu H, Huang J, Xu Y, Ou C, Chen Y
Journal of inflammation research 2024;17:1039-1055
Journal of inflammation research 2024;17:1039-1055
Genome-wide analysis reveals the MORC3-mediated repression of PD-L1 expression in head and neck cancer.
Fu W, Chang X, Ye K, Zheng Z, Lai Q, Ge M, Shi Y
Frontiers in cell and developmental biology 2024;12:1410130
Frontiers in cell and developmental biology 2024;12:1410130
Etelcalcetide ameliorates bone loss in chronic kidney disease-mineral and bone disorder by activation of IRF7 and necroptosis pathways.
Chiu HW, Lu KC, Lin YC, Hou YC, Liao MT, Chen YJ, Chiu YJ, Zheng CM
International journal of biological macromolecules 2024 Sep 24;280(Pt 3):135978
International journal of biological macromolecules 2024 Sep 24;280(Pt 3):135978
Single-cell transcriptomics reveals IRF7 regulation of the tumor microenvironment in isocitrate dehydrogenase wild-type glioma.
Li J, Long S, Yang Z, Wei W, Yu S, Liu Q, Hui X, Li X, Wang Y
MedComm 2024 Nov;5(11):e754
MedComm 2024 Nov;5(11):e754
NR4A1 depletion inhibits colorectal cancer progression by promoting necroptosis via the RIG-I-like receptor pathway.
Zhu J, Li J, Yang K, Chen Y, Wang J, He Y, Shen K, Wang K, Shi T, Chen W
Cancer letters 2024 Mar 31;585:216693
Cancer letters 2024 Mar 31;585:216693
Histone lysine demethylase KDM5B facilitates proliferation and suppresses apoptosis in human acute myeloid leukemia cells through the miR-140-3p/BCL2 axis.
Huang J, Jin S, Guo R, Wu W, Yang C, Qin Y, Chen Q, He X, Qu J, Yang Z
RNA (New York, N.Y.) 2024 Mar 18;30(4):435-447
RNA (New York, N.Y.) 2024 Mar 18;30(4):435-447
Structure elucidation and molecular mechanism of an immunomodulatory polysaccharide from Nostoc commune.
Yang Y, Ren P, Sun Y, Li J, Zhou X, Zhang H, He C, Dai H, Guan L
International journal of biological macromolecules 2024 Dec;283(Pt 1):137435
International journal of biological macromolecules 2024 Dec;283(Pt 1):137435
Fish Snx27 promotes viral products by modulating the innate immune response and exosomal machinery.
Yu Y, Liu J, Zhao Z, Lan X, Li L, Hu J, Zang Y-a, Zhang X, Chen J
Journal of virology 2024 Dec 17;98(12):e0097424
Journal of virology 2024 Dec 17;98(12):e0097424
Construction of an interferon regulatory factors-related risk model for predicting prognosis, immune microenvironment and immunotherapy in clear cell renal cell carcinoma.
Pan H, Lu W, Zhang M, Liu C
Frontiers in oncology 2023;13:1131191
Frontiers in oncology 2023;13:1131191
STAT3 regulates antiviral immunity by suppressing excessive interferon signaling.
Liu S, Liu S, Yu Z, Zhou W, Zheng M, Gu R, Hong J, Yang Z, Chi X, Guo G, Li X, Chen N, Huang S, Wang S, Chen JL
Cell reports 2023 Jul 25;42(7):112806
Cell reports 2023 Jul 25;42(7):112806
NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization.
Chen L, Dai M, Zuo W, Dai Y, Yang Q, Yu S, Huang M, Liu H
International immunopharmacology 2023 Feb;115:109554
International immunopharmacology 2023 Feb;115:109554
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses.
Maarifi G, Martin MF, Zebboudj A, Boulay A, Nouaux P, Fernandez J, Lagisquet J, Garcin D, Gaudin R, Arhel NJ, Nisole S
Cell chemical biology 2022 Jul 21;29(7):1113-1125.e6
Cell chemical biology 2022 Jul 21;29(7):1113-1125.e6
Inducible ATP1B1 Upregulates Antiviral Innate Immune Responses by the Ubiquitination of TRAF3 and TRAF6.
Cao W, Guo Y, Cheng Z, Xu G, Zuo Q, Nie L, Huang Y, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Journal of immunology (Baltimore, Md. : 1950) 2021 Jun 1;206(11):2668-2681
Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated inflammation.
Cai Y, Xu B, Zhou F, Wu J, Li S, Zheng Q, Li Y, Li X, Gao F, Dong S, Liu R
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Apr;84:153495
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Apr;84:153495
TET2 is involved in DNA hydroxymethylation, cell proliferation and inflammatory response in keratinocytes.
Liu X, Wang X, Liu N, Zhu K, Zhang S, Duan X, Huang Y, Jin Z, Jaypaul H, Wu Y, Chen H
Molecular medicine reports 2020 Apr;21(4):1941-1949
Molecular medicine reports 2020 Apr;21(4):1941-1949
pol-miR-194a of Japanese flounder (Paralichthys olivaceus) suppresses type I interferon response and facilitates Edwardsiella tarda infection.
Guan XL, Zhang BC, Sun L
Fish & shellfish immunology 2019 Apr;87:220-225
Fish & shellfish immunology 2019 Apr;87:220-225
A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response.
Lyu XM, Zhu XW, Zhao M, Zuo XB, Huang ZX, Liu X, Jiang T, Yang XX, Li X, Long XB, Wang JG, Li JB, Han MY, Wang S, Liu TF, Zhang B, Sun T, Cheng Z, Qiu MC, Dong L, Zheng L, Zhang LC, Wang JH, Wei GG, Yao K, Wang Q, Zheng HF, Li X
Cancer medicine 2018 Aug;7(8):3848-3861
Cancer medicine 2018 Aug;7(8):3848-3861
Inducible TAP1 Negatively Regulates the Antiviral Innate Immune Response by Targeting the TAK1 Complex.
Xia Z, Xu G, Yang X, Peng N, Zuo Q, Zhu S, Hao H, Liu S, Zhu Y
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Journal of immunology (Baltimore, Md. : 1950) 2017 May 1;198(9):3690-3704
Genetic characterization of bovine viral diarrhea virus strains in Beijing, China and innate immune responses of peripheral blood mononuclear cells in persistently infected dairy cattle.
Weng XG, Song QJ, Wu Q, Liu MC, Wang ML, Wang JF
Journal of veterinary science 2015;16(4):491-500
Journal of veterinary science 2015;16(4):491-500
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- HEK-293 cells were subjected to SDS PAGE followed by western blot with 22392-1-AP( IRF7 Antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The IRF7 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human IRF7. This antibody recognizes human antigen. The IRF7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.