Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B11979 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Human anti-Human IRF-7 recombinant monoclonal antibody, clone SFB420 [PE]
- Antibody type
- Monoclonal
- Description
- It recognozes the interferon regulatory factor 7 (IRF-7) phosphorylated at serines 477 and 479 (pS477/pS479). IRF-7 is a member of the IRF family of transcription factors and a key player in the innate immune response against viral infections. Constitutive expression of IRF-7 is limited to peripheral blood lymphocytes and dendritic cells while in most cell types its expression can be induced by type I interferon. IRF-7 is sequestered in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, it becomes phosphorylated by TBK and IKK-i kinases. Phosphorylated IRF-7 migrates in the nucleus where it can activate interferon type I genes and other interferon-stimulated genes. Additional information: It displays negligible binding to Fc receptors.
- Reactivity
- Human
- Host
- Human
- Conjugate
- Yellow dye
- Isotype
- IgG
- Antibody clone number
- SFB420
- Vial size
- for 100 tests
- Storage
- Store protected from light at 2ÿ8 °C. Do not freeze.
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