Antibody data
- Antibody Data
- Antigen structure
- References [46]
- Comments [0]
- Validations [0]
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- Product number
- 17333-1-AP - Provider product page

- Provider
- Proteintech Group
- Product name
- HSL antibody
- Antibody type
- Polyclonal
- Description
- HSL antibody (Cat. #17333-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, pig, mouse and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Porcine
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Effect of Cordyceps militaris Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents.
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
African swine fever virus hijacks lipolysis induced by chaperone-mediated autophagy to upregulate fatty acid β-oxidation and promote viral replication.
NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis.
A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.
TRIM59 deficiency aggravates HFD-induced obesity in mice associated with increased adipose tissue inflammation, lipid accumulation, and apoptosis.
1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity.
Ox-LDL-stimulated macrophage-derived exosomes regulate adipose tissue remodeling and promote the progression of atherosclerosis.
TMEM132C and LIPE protein molecules drive synovial hyperplasia via the PPARγ signaling axis: Mechanistic insights into core pathogenic proteins in rheumatoid arthritis.
Influence of fatty acid distribution on lipid metabolism and cognitive development in first-weaned mice.
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Mechanism of Myh3 gene regulation of intramuscular fat content in Beijing black pigs via the MAPK signaling pathway.
Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes.
Cold-Induced DHRS4 Promotes Thermogenesis via Enhanced Fatty Acid β-Oxidation in Porcine Subcutaneous Adipocytes.
Loss of lipid droplet-mitochondria contacts confers protection against ethanol-induced cardiotoxicity.
Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis.
Dahuang Huanglian Xiexin Decoction ameliorates obesity via modulating adipocyte differentiation and lipid degradation through inhibiting endoplasmic reticulum stress.
Pea Albumin Alleviates Oleic Acid-Induced Lipid Accumulation in LO2 Cells Through Modulating Lipid Metabolism and Fatty Acid Oxidation Pathways.
Sestrin2 in POMC neurons modulates energy balance and obesity related metabolic disorders via mTOR signaling.
HuR promotes triglyceride synthesis and intestinal fat absorption.
Calmodulin Contributes to Lipolysis and Inflammatory Responses in Clinical Ketosis Cows through the TLR4/IKK/NF-κB Pathway.
Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation.
Lipid droplets synthesized during luteinization are degraded after pregnancy.
Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
Identification of Adipogenesis Subgroups and Immune Infiltration Characteristics in Diabetic Peripheral Neuropathy.
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Combined exposure to deoxynivalenol facilitates lipid metabolism disorder in high-fat-diet-induced obesity mice.
CircRNA-mediated regulation of brown adipose tissue adipogenesis.
The involvement of hormone-sensitive lipase in all-trans retinoic acid induced cleft palate.
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats.
Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.
DECR1 directly activates HSL to promote lipolysis in cervical cancer cells.
Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.
Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging.
PLK1 promotes cholesterol efflux and alleviates atherosclerosis by up-regulating ABCA1 and ABCG1 expression via the AMPK/PPARγ/LXRα pathway.
Differential regulatory roles of microRNAs during intramuscular adipogenesis in Chinese Guizhou Congjiang Xiang pigs.
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Kusama K, Fujii C, Yoshida K, Yoshie M, Adachi Y, Miyaoka H, Tamura K
International journal of endocrinology 2026;2026:6699051
International journal of endocrinology 2026;2026:6699051
Monascus pilosus SWM-008-Fermented Red Mold Rice and Its Monascinol Ameliorate Non-Alcoholic Fatty Liver Disease via Activation of the AMPK-ATGL Pathway and Enrichment of Butyrate-Producing Bacteria.
Hsieh CP, Hsu YW, Pan TM, Lee CL
Molecular nutrition & food research 2026 Jan;70(1):e70342
Molecular nutrition & food research 2026 Jan;70(1):e70342
Isomeranzin activates Gnas-AMPK signaling to drive white adipose browning and curb obesity in mice.
Shi M, Ye Y, Hu L, Yan Y, Jiang S, Wang P, Li F, Ai M, Huang J, Yang L, Huang K, Liang M
EMBO molecular medicine 2026 Jan;18(1):55-90
EMBO molecular medicine 2026 Jan;18(1):55-90
PRMT3-mediated post-translational adaptation to fasting regulates metabolic flexibility.
Huang Z, Liu X, Chen X, Zhou Y, Chen Q, Liu Y, Zhu H, Cheng K, Feng Y, Dong M, Song L, Wang L, Liu S, Shan T, Kuang S, Dong Y, Vidal-Puig A, Zhang Y, Jia Z
Nature communications 2026 Feb 2;17(1)
Nature communications 2026 Feb 2;17(1)
Annexin A1 exacerbates islet stellate cell activation by regulating triglyceride catabolism via the PPARα/ACOX1/CYP4a pathway.
Li Q, Zhang Y, Yu T, Shi L, Qiu Q, Wang B, Sang Y, Li R, Lv Q, Wang J, Liu X, Geng H, Jones PM, Liang J, Xu W
Islets 2026 Dec 31;18(1):2633793
Islets 2026 Dec 31;18(1):2633793
African swine fever virus hijacks lipolysis induced by chaperone-mediated autophagy to upregulate fatty acid β-oxidation and promote viral replication.
Yang X, Xiong X, Liu H, Wen X, Shi X, Ma H, Wang R, Cao W, Yang F, Ru Y, Tian H, He J, Guo J, Han S, Zhu Z, Zheng H
mBio 2026 Apr 8;17(4):e0336825
mBio 2026 Apr 8;17(4):e0336825
NAT10-mediated N4-acetylcytidine modification in KLF9 mRNA promotes adipogenesis.
Wan X, Wang L, Khan MA, Peng L, Sun X, Yi X, Wang Z, Chen K
Cell death and differentiation 2025 Sep;32(9):1613-1629
Cell death and differentiation 2025 Sep;32(9):1613-1629
A galacturonan from sea buckthorn (Hippophae rhamnoides L.) berry modulates dyslipidemia by promoting hepatic lipolysis and mitochondrial oxidation.
Sun Y, Ni W, Wang D, Ren J, Zhao D, Yu S, Liu S, Zhang S, Wang S, Wang W, Liu M
Carbohydrate polymers 2025 Sep 1;363:123708
Carbohydrate polymers 2025 Sep 1;363:123708
TRIM59 deficiency aggravates HFD-induced obesity in mice associated with increased adipose tissue inflammation, lipid accumulation, and apoptosis.
Chen Y, Han X, Liu T, Ni Y, Deng X, Wei W, Jiang M
Cellular signalling 2025 Oct;134:111954
Cellular signalling 2025 Oct;134:111954
1-Linoleoylglycerophosphocholine stimulates UCP1-dependent thermogenesis and mitochondrial respiration to combat obesity.
Wang R, Zhu T, Lu J, Cheng M, Wang X, Guo X, Huang S, Gao J
Journal of lipid research 2025 Nov;66(11):100914
Journal of lipid research 2025 Nov;66(11):100914
Ox-LDL-stimulated macrophage-derived exosomes regulate adipose tissue remodeling and promote the progression of atherosclerosis.
Liu X, Xu G, Xu Y, Xu Y
Molecular and cellular endocrinology 2025 Nov 1;609:112660
Molecular and cellular endocrinology 2025 Nov 1;609:112660
TMEM132C and LIPE protein molecules drive synovial hyperplasia via the PPARγ signaling axis: Mechanistic insights into core pathogenic proteins in rheumatoid arthritis.
Cheng F, Dai Z, Zhang J
International journal of biological macromolecules 2025 May;309(Pt 3):143027
International journal of biological macromolecules 2025 May;309(Pt 3):143027
Influence of fatty acid distribution on lipid metabolism and cognitive development in first-weaned mice.
Ni X, Li J, Xiong H, Deng Z, Sun Y
Food research international (Ottawa, Ont.) 2025 May;209:116292
Food research international (Ottawa, Ont.) 2025 May;209:116292
PRRSV Nsp4 induces ATGL protein degradation to promote viral replication and lipid droplet accumulation.
Xie E, Wang Q, Yi H, Wang J, Liu X, Ye R, Lu L, Tian T, Chen A, Zheng G, Zhang G, Wang H
International journal of biological macromolecules 2025 Jun;312:144097
International journal of biological macromolecules 2025 Jun;312:144097
Mechanism of Myh3 gene regulation of intramuscular fat content in Beijing black pigs via the MAPK signaling pathway.
Luo Y, Xu G, Zhang C, Wen Z, Chu H, Dai Y, Hong L, Zhang J, Vignon AS, Sun C, Zhang L, Pu L
BMC genomics 2025 Jul 7;26(1):642
BMC genomics 2025 Jul 7;26(1):642
Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes.
Kusama K, Oka K, Yashiro Y, Yoshida K, Miyaoka H, Tamura K
FEBS open bio 2025 Feb;15(2):335-345
FEBS open bio 2025 Feb;15(2):335-345
Cold-Induced DHRS4 Promotes Thermogenesis via Enhanced Fatty Acid β-Oxidation in Porcine Subcutaneous Adipocytes.
Ma X, Ye Z, Li M, Wei W, Chen J, Zhang L
Animals : an open access journal from MDPI 2025 Apr 22;15(9)
Animals : an open access journal from MDPI 2025 Apr 22;15(9)
Loss of lipid droplet-mitochondria contacts confers protection against ethanol-induced cardiotoxicity.
He W, He W, Zeng L, Zhao R, Qiu K, He P, Sun Z, Tan N
Experimental cell research 2025 Apr 15;447(2):114517
Experimental cell research 2025 Apr 15;447(2):114517
Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis.
Zhu JY, Chen M, Mu WJ, Luo HY, Li Y, Li S, Yan LJ, Li RY, Yin MT, Li X, Chen HM, Guo L
Nature communications 2025 Apr 1;16(1):3111
Nature communications 2025 Apr 1;16(1):3111
Dahuang Huanglian Xiexin Decoction ameliorates obesity via modulating adipocyte differentiation and lipid degradation through inhibiting endoplasmic reticulum stress.
Hao L, Li M, Gu H, Li J
Prostaglandins & other lipid mediators 2024 Oct;174:106874
Prostaglandins & other lipid mediators 2024 Oct;174:106874
Pea Albumin Alleviates Oleic Acid-Induced Lipid Accumulation in LO2 Cells Through Modulating Lipid Metabolism and Fatty Acid Oxidation Pathways.
Fang B, Luo J, Cui Z, Liu R, Wang P, Zhang J
Foods (Basel, Switzerland) 2024 Oct 30;13(21)
Foods (Basel, Switzerland) 2024 Oct 30;13(21)
Sestrin2 in POMC neurons modulates energy balance and obesity related metabolic disorders via mTOR signaling.
Hu H, Lu X, He Y, Li J, Wang S, Luo Z, Wang Y, Wei J, Huang H, Duan C, Sun N
The Journal of nutritional biochemistry 2024 Nov;133:109703
The Journal of nutritional biochemistry 2024 Nov;133:109703
HuR promotes triglyceride synthesis and intestinal fat absorption.
Liu C, Lin Y, Wang Y, Lin S, Zhou J, Tang H, Yi X, Ma Z, Xia T, Jiang B, Tian F, Ju Z, Liu B, Gu X, Yang Z, Wang W
Cell reports 2024 May 28;43(5):114238
Cell reports 2024 May 28;43(5):114238
Calmodulin Contributes to Lipolysis and Inflammatory Responses in Clinical Ketosis Cows through the TLR4/IKK/NF-κB Pathway.
Chang J, Wang Z, Hao Y, Song Y, Xia C
Animals : an open access journal from MDPI 2024 Jun 4;14(11)
Animals : an open access journal from MDPI 2024 Jun 4;14(11)
Sleep deprivation induced fat accumulation in the visceral white adipose tissue by suppressing SIRT1/FOXO1/ATGL pathway activation.
Wang W, Liu K, Xu H, Zhang C, Zhang Y, Ding M, Xing C, Huang X, Wen Q, Lu C, Song L
Journal of physiology and biochemistry 2024 Aug;80(3):561-572
Journal of physiology and biochemistry 2024 Aug;80(3):561-572
Lipid droplets synthesized during luteinization are degraded after pregnancy.
Mitsui J, Ibayashi M, Aizawa R, Ishikawa T, Miyasaka N, Tsukamoto S
The Journal of reproduction and development 2024 Apr 4;70(2):72-81
The Journal of reproduction and development 2024 Apr 4;70(2):72-81
Lipopolysaccharide binding protein resists hepatic oxidative stress by regulating lipid droplet homeostasis.
Zhang Q, Shen X, Yuan X, Huang J, Zhu Y, Zhu T, Zhang T, Wu H, Wu Q, Fan Y, Ni J, Meng L, He A, Shi C, Li H, Hu Q, Wang J, Chang C, Huang F, Li F, Chen M, Liu A, Ye S, Zheng M, Fang H
Nature communications 2024 Apr 13;15(1):3213
Nature communications 2024 Apr 13;15(1):3213
In Vitro Comparative Analysis of the Effect and Structure-Based Influencing Factors of Flavonols on Lipid Accumulation.
Ang B, Yang T, Wang Z, Cheng Y, Chen Q, Wang Z, Zeng M, Chen J, He Z
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
Journal of agricultural and food chemistry 2024 Apr 10;72(14):8237-8246
Identification of Adipogenesis Subgroups and Immune Infiltration Characteristics in Diabetic Peripheral Neuropathy.
Lin Y, Qu L, Wu J, Pu M, Huang Y, Cao Y
Journal of immunology research 2023;2023:3673094
Journal of immunology research 2023;2023:3673094
Paternal cadmium exposure affects estradiol synthesis by impairing intracellular cholesterol homeostasis and mitochondrial function in offspring female mice.
Zhang Y, Zhou J, Zeng L, Xiong Y, Wang X, Xiang W, Su P
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
Ecotoxicology and environmental safety 2023 Sep 15;263:115280
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Combined exposure to deoxynivalenol facilitates lipid metabolism disorder in high-fat-diet-induced obesity mice.
Jin J, Huangfu B, Xing F, Xu W, He X
Environment international 2023 Dec;182:108345
Environment international 2023 Dec;182:108345
CircRNA-mediated regulation of brown adipose tissue adipogenesis.
Liu K, Liu X, Deng Y, Li Z, Tang A
Frontiers in nutrition 2022;9:926024
Frontiers in nutrition 2022;9:926024
The involvement of hormone-sensitive lipase in all-trans retinoic acid induced cleft palate.
Zheng K, Ye QN
The International journal of developmental biology 2022;66(7-8-9):383-389
The International journal of developmental biology 2022;66(7-8-9):383-389
LAMC1-mediated preadipocytes differentiation promoted peritoneum pre-metastatic niche formation and gastric cancer metastasis.
Fang Y, Dou R, Huang S, Han L, Fu H, Yang C, Song J, Zheng J, Zhang X, Liu K, Xiang Z, Zhang X, Wang S, Xiong B
International journal of biological sciences 2022;18(7):3082-3101
International journal of biological sciences 2022;18(7):3082-3101
Paternal cadmium exposure affects testosterone synthesis by reducing the testicular cholesterol pool in offspring mice.
Zhou J, Zhang Y, Zeng L, Wang X, Mu H, Wang M, Pan H, Su P
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
Ecotoxicology and environmental safety 2022 Sep 1;242:113947
Human gingival mesenchymal stem cells improve movement disorders and tyrosine hydroxylase neuronal damage in Parkinson disease rats.
Lei T, Xiao Z, Zhang X, Cai S, Bi W, Yang Y, Wang D, Li Q, Du H
Cytotherapy 2022 Nov;24(11):1105-1120
Cytotherapy 2022 Nov;24(11):1105-1120
Rhodiola activates macrophage migration inhibitory factor to alleviate non-alcoholic fatty liver disease.
Liu J, Li D, Dun Y, Li H, Ripley-Gonzalez JW, Zhang J, Qiu L, You B, Liu S
Life sciences 2022 Nov 1;308:120949
Life sciences 2022 Nov 1;308:120949
DECR1 directly activates HSL to promote lipolysis in cervical cancer cells.
Zhou H, Zhang J, Yan Z, Qu M, Zhang G, Han J, Wang F, Sun K, Wang L, Yang X
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Mar;1867(3):159090
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Mar;1867(3):159090
Lactoferrin Prevents Chronic Alcoholic Injury by Regulating Redox Balance and Lipid Metabolism in Female C57BL/6J Mice.
Li DM, Wu YX, Hu ZQ, Wang TC, Zhang LL, Zhou Y, Tong X, Xu JY, Qin LQ
Antioxidants (Basel, Switzerland) 2022 Jul 31;11(8)
Antioxidants (Basel, Switzerland) 2022 Jul 31;11(8)
Phenotypic and genotypic changes in obesity and type 2 diabetes of male KK mice with aging.
Iizuka Y, Kim H, Nakasatomi M, Matsumoto A, Shimizu J
Experimental animals 2022 Feb 9;71(1):71-81
Experimental animals 2022 Feb 9;71(1):71-81
PLK1 promotes cholesterol efflux and alleviates atherosclerosis by up-regulating ABCA1 and ABCG1 expression via the AMPK/PPARγ/LXRα pathway.
Hu HJ, Wang XH, Zhang TQ, Liu Y, Chen ZR, Zhang ZZ, Huang H, Tang HF, Jiang ZS
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Dec;1867(12):159221
Biochimica et biophysica acta. Molecular and cell biology of lipids 2022 Dec;1867(12):159221
Differential regulatory roles of microRNAs during intramuscular adipogenesis in Chinese Guizhou Congjiang Xiang pigs.
Tan L, Chen Z, Ruan Y, Xu H
Epigenetics 2022 Dec;17(12):1800-1819
Epigenetics 2022 Dec;17(12):1800-1819
Gentisic acid prevents diet-induced obesity in mice by accelerating the thermogenesis of brown adipose tissue.
Han X, Guo J, Gao Y, Zhan J, You Y, Huang W
Food & function 2021 Feb 15;12(3):1262-1270
Food & function 2021 Feb 15;12(3):1262-1270
Cancer‑associated adipocytes exhibit distinct phenotypes and facilitate tumor progression in pancreatic cancer.
Cai Z, Liang Y, Xing C, Wang H, Hu P, Li J, Huang H, Wang W, Jiang C
Oncology reports 2019 Dec;42(6):2537-2549
Oncology reports 2019 Dec;42(6):2537-2549
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