Antibody data
- Antibody Data
- Antigen structure
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- Product number
- abx000705 - Provider product page
- Provider
- Abbexa
- Product name
- Neural Cell Adhesion Molecule 1 / CD56 (NCAM1) Antibody
- Antibody type
- Polyclonal
- Description
- NCAM1 Antibody is a Rabbit Polyclonal antibody against NCAM1. Neural cell adhesion molecule 1 (NCAM1, also known as CD56) is a cell adhesion glycoprotein of the immunoglobulin (Ig) superfamily. It is a multifunction protein involved in synaptic plasticity, neurodevelopment, and neurogenesis. NCAM1 is expressed on human neurones, glial cells, skeletal muscle cells, NK cells and a subset of T cells, and the expression is observed in a wide variety human tumors, including myeloma, myeloid leukemia, neuroendocrine tumors, Wilms' tumor, neuroblastoma, and NK/T cell lymphomas. Three major isoforms of NCAM1, with molecular masses of 120, 140, and 180 kDa, are generated by alternative splicing of mRNA (PMID: 9696812). The glycosylphosphatidylinositol (GPI)-anchored NCAM120 and the transmembrane NCAM140 and NCAM180 consist of five Ig-like domains and two fibronectin-type III repeats (FNIII). All three forms can be posttranslationally modiļ¬ed by addition of polysialic acid (PSA) (PMID: 14976519). Several other isofroms have also been described.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µl
- Concentration
- > 1 mg/ml
- Storage
- Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
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