CABT-B1909

antibody from Creative Diagnostics

Targeting: ERG erg-3, p55

Western blot (Recommended by provider)

Immunocytochemistry (Recommended by provider)

Antibody Data

Product number

CABT-B1909

Provider

Creative Diagnostics

Product name

Anti-ERG (C-terminal) polyclonal antibody

Antibody type

Polyclonal

Description

Erg-3 (also known as p55, ets-related, TMPRSS2/ERG fusion, Transcriptional regulator ERG, Transcriptional protein ERG, v-ets avian erythroblastosis virus E26 oncogene related, v-ets erythroblastosis virus E26 oncogene homolog, v-ets erythroblastosis virus E26 oncogene like) is encoded by the ERG gene in human. ERG is a member of the erythroblast transformation-specific (ETS) family of transcriptions factors involved in embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. ERG contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. In addition to the nucleus, ERG is also found associated with cytoplasmic mRNP granules containing untranslated mRNAs. Fusion gene products as a result of chromosomal translocations are found in prostate cancer (TMPSSR2-ERG and NDRG1-ERG), Ewings sarcoma (EWS-ERG), and acute myeloid leukemia (FUS-ERG).

Reactivity

Human, Mouse

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

100 _L

Concentration

Please refer to lot specific datasheet.

Storage

Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.