PA1-24327

antibody from Invitrogen Antibodies
Targeting: ERG erg-3, p55
Provider product page for PA1-24327

Antibody data

Product number
PA1-24327 - Provider product page
Provider
Invitrogen Antibodies
Product name
ERG Polyclonal Antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide
Description
Description: The eBioSN4 monoclonal antibody reacts with human CD9. CD9 is a 24 kDa member of the tetraspanin family, whose members are characterized by the presence of 4 hydrophobic transmembrane domains. CD9 is expressed in platelets, eosinophils, basophils, pre-B cells, activated T cells and neural cell lines. Furthermore, CD9 expression has been associated with a malignant phenotype, including expression on 90% of non T cell acute lymphoblastic leukemia cells and on 50% of chronic lymphocytic and acute myeloblastic leukemias. In platelets, CD9 is expressed in alpha-granules and through association with the integrin alphaIIb/betaIII plays a role in platelet aggregation, as demonstrated by the use of anti-human CD9 antibodies. CD9 has also been shown to induce the aggregation of pre-B cell lines, and the adhesion and migration of pre-B cells and Schwann cells. Additionally, it has been demonstrated that CD9 is able to provide a co-stimulatory signal for T cells independently of CD28, in the absence of antigen-presenting cells. Binding of the eBioSN4 monoclonal antibody partially cross-blocks binding of another anti-human CD9 monoclonal antibody, MM2/57.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100 µg
Concentration
1 mg/mL
Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
ERG protein structure - PA1-24327 shown in red.