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- References [118]
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- Product number
- 10449-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10449-1-AP, RRID:AB_2168724
- Product name
- GADD34 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated GADD34 antibody (Cat. #10449-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway.
Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells.
The Involvement of Unfolded Protein Response in the Mechanism of Nitrogen Mustard-Induced Ocular Toxicity.
Stress response silencing by an E3 ligase mutated in neurodegeneration.
The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation.
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis.
Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress.
Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression.
GADD34 activates p53 and may have utility as a marker of atherosclerosis.
Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.
PKR-mediated stress response enhances dengue and Zika virus replication.
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases.
Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3.
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2.
Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response.
Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model.
Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer.
PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability.
Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction.
The crosstalk between MYC and mTORC1 during osteoclastogenesis.
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.
Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.
Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition.
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
Host 5'-3' Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication by Downregulating the dsRNA-Activated Kinase PKR.
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal.
Temporal control of the integrated stress response by a stochastic molecular switch.
Salubrinal-mediated activation of eIF2α signaling improves oxidative stress-induced BMSCs senescence and senile osteoporosis.
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response.
Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering.
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury.
GCN2 kinase activation by ATP-competitive kinase inhibitors.
Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation.
Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway.
Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Activation of the Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor.
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases.
The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids.
Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis.
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
eIF2B-capturing viral protein NSs suppresses the integrated stress response.
GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis.
GADD34 is a modulator of autophagy during starvation.
The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes.
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
CReP mediates selective translation initiation at the endoplasmic reticulum.
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
GADD34 attenuates HIV-1 replication by viral 5'-UTR TAR RNA-mediated translational inhibition.
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.
Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Pseudorabies virus infection inhibits stress granules formation via dephosphorylating eIF2α.
The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus.
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma.
Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress.
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.
Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation.
Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.
Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats.
ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes.
Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Activating Transcription Factor-6α Deletion Modulates the Endoplasmic Reticulum Stress Response after Spinal Cord Injury but Does Not Affect Locomotor Recovery.
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.
Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells.
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.
Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.
Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.
Oral proteasome inhibitor with strong preclinical efficacy in myeloma models.
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.
The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.
Failure of amino acid homeostasis causes cell death following proteasome inhibition.
Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Avelar RA, Gupta R, Carvette G, da Veiga Leprevost F, Colina J, Teitel J, Nesvizhskii AI, O'Connor CM, Hatzoglou M, Shenolikar S, Arvan P, Narla G, DiFeo A
Research square 2024 Mar 28;
Research square 2024 Mar 28;
Human Betacoronavirus OC43 Interferes with the Integrated Stress Response Pathway in Infected Cells.
Dolliver SM, Galbraith C, Khaperskyy DA
Viruses 2024 Jan 31;16(2)
Viruses 2024 Jan 31;16(2)
The Involvement of Unfolded Protein Response in the Mechanism of Nitrogen Mustard-Induced Ocular Toxicity.
Zhylkibayev A, Ung TT, Mobley J, Athar M, Gorbatyuk M
The Journal of pharmacology and experimental therapeutics 2024 Jan 17;388(2):518-525
The Journal of pharmacology and experimental therapeutics 2024 Jan 17;388(2):518-525
Stress response silencing by an E3 ligase mutated in neurodegeneration.
Haakonsen DL, Heider M, Ingersoll AJ, Vodehnal K, Witus SR, Uenaka T, Wernig M, Rapé M
Nature 2024 Feb;626(8000):874-880
Nature 2024 Feb;626(8000):874-880
The integrated stress response effector GADD34 is repurposed by neurons to promote stimulus-induced translation.
Oliveira MM, Mohamed M, Elder MK, Banegas-Morales K, Mamcarz M, Lu EH, Golhan EAN, Navrange N, Chatterjee S, Abel T, Klann E
Cell reports 2024 Feb 27;43(2):113670
Cell reports 2024 Feb 27;43(2):113670
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Liu C, Chen L, Cong Y, Cheng L, Shuai Y, Lv F, Chen K, Song Y, Xing Y
Cell death & disease 2024 Feb 16;15(2):149
Cell death & disease 2024 Feb 16;15(2):149
Inhibition of PPP1R15A alleviates osteoporosis via suppressing RANKL-induced osteoclastogenesis.
Ding ZB, Chen Y, Zheng YR, Wang YY, Deng WD, Zheng JH, Yang Q, Chen ZY, Li LH, Jiang H, Li XJ
Acta pharmacologica Sinica 2024 Apr;45(4):790-802
Acta pharmacologica Sinica 2024 Apr;45(4):790-802
Turnover of PPP1R15A mRNA encoding GADD34 controls responsiveness and adaptation to cellular stress.
Magg V, Manetto A, Kopp K, Wu CC, Naghizadeh M, Lindner D, Eke L, Welsch J, Kallenberger SM, Schott J, Haucke V, Locker N, Stoecklin G, Ruggieri A
Cell reports 2024 Apr 23;43(4):114069
Cell reports 2024 Apr 23;43(4):114069
Single-cell protein activity analysis reveals a novel subpopulation of chondrocytes and the corresponding key master regulator proteins associated with anti-senescence and OA progression.
Guang Z, Min Z, Jun-Tan L, Tian-Xu D, Xiang G
Frontiers in immunology 2023;14:1077003
Frontiers in immunology 2023;14:1077003
GADD34 activates p53 and may have utility as a marker of atherosclerosis.
Tomiyoshi G, Nakamura R, Shinmen N, Yoshida Y, Mine S, Machida T, Iwase K, Iwadate Y, Hiwasa T, Kuroda H
Frontiers in medicine 2023;10:1128921
Frontiers in medicine 2023;10:1128921
Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.
Chen Y, Quan S, Patil V, Kunjamma RB, Tokars HM, Leisten ED, Joy G, Wills S, Chan JR, Wong YC, Popko B
Glia 2023 Sep;71(9):2180-2195
Glia 2023 Sep;71(9):2180-2195
Triiodothyronine positively regulates endoplasmic reticulum-associated degradation (ERAD) and promotes androgenic signaling in androgen-dependent prostate cancer cells.
Erzurumlu Y, Muhammed MT
Cellular signalling 2023 Sep;109:110745
Cellular signalling 2023 Sep;109:110745
Activation of endoplasmic reticulum stress by harmine suppresses the growth of esophageal squamous cell carcinoma.
Fan R, Wang S, Wu Y, Feng Y, Gao M, Cao Y, Ma X, Xie S, Wang C, Gao L, Wang Y, Dai F
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Phytotherapy research : PTR 2023 Oct;37(10):4655-4673
Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome.
Hooshmandi M, Sharma V, Thörn Perez C, Sood R, Krimbacher K, Wong C, Lister KC, Ureña Guzmán A, Bartley TD, Rocha C, Maussion G, Nadler E, Roque PM, Gantois I, Popic J, Lévesque M, Kaufman RJ, Avoli M, Sanz E, Nader K, Hagerman RJ, Durcan TM, Costa-Mattioli M, Prager-Khoutorsky M, Lacaille JC, Martinez-Cerdeno V, Gibson JR, Huber KM, Sonenberg N, Gkogkas CG, Khoutorsky A
Neuron 2023 Oct 4;111(19):3028-3040.e6
Neuron 2023 Oct 4;111(19):3028-3040.e6
PKR-mediated stress response enhances dengue and Zika virus replication.
Ricciardi-Jorge T, da Rocha EL, Gonzalez-Kozlova E, Rodrigues-Luiz GF, Ferguson BJ, Sweeney T, Irigoyen N, Mansur DS
mBio 2023 Oct 31;14(5):e0093423
mBio 2023 Oct 31;14(5):e0093423
Sirtuin 6 is required for the integrated stress response and resistance to inhibition of transcriptional cyclin-dependent kinases.
Kartha N, Gianopulos JE, Schrank Z, Cavender SM, Dobersch S, Kynnap BD, Wallace-Povirk A, Wladyka CL, Santana JF, Kim JC, Yu A, Bridgwater CM, Fuchs K, Dysinger S, Lampano AE, Notta F, Price DH, Hsieh AC, Hingorani SR, Kugel S
Science translational medicine 2023 May 3;15(694):eabn9674
Science translational medicine 2023 May 3;15(694):eabn9674
Endoplasmic reticulum stress promotes sepsis-induced muscle atrophy via activation of STAT3 and Smad3.
Zheng Y, Dai H, Chen R, Zhong Y, Zhou C, Wang Y, Zhan C, Luo J
Journal of cellular physiology 2023 Mar;238(3):582-596
Journal of cellular physiology 2023 Mar;238(3):582-596
1,25(OH)(2) D(3) induced vitamin D receptor signaling negatively regulates endoplasmic reticulum-associated degradation (ERAD) and androgen receptor signaling in human prostate cancer cells.
Erzurumlu Y, Aydogdu E, Dogan HK, Catakli D, Muhammed MT, Buyuksandic B
Cellular signalling 2023 Mar;103:110577
Cellular signalling 2023 Mar;103:110577
Dexamethasone-stimulated glucocorticoid receptor signaling positively regulates the endoplasmic reticulum-associated degradation (ERAD) mechanism in hepatocellular carcinoma cells.
Erzurumlu Y, Dogan HK, Cataklı D
Steroids 2023 Jul;195:109238
Steroids 2023 Jul;195:109238
Enhanced SARS-CoV-2 entry via UPR-dependent AMPK-related kinase NUAK2.
Prasad V, Cerikan B, Stahl Y, Kopp K, Magg V, Acosta-Rivero N, Kim H, Klein K, Funaya C, Haselmann U, Cortese M, Heigwer F, Bageritz J, Bitto D, Jargalsaikhan S, Neufeldt C, Pahmeier F, Boutros M, Yamauchi Y, Ruggieri A, Bartenschlager R
Molecular cell 2023 Jul 20;83(14):2559-2577.e8
Molecular cell 2023 Jul 20;83(14):2559-2577.e8
Insights into the mechanism of oligodendrocyte protection and remyelination enhancement by the integrated stress response.
Chen Y, Quan S, Patil V, Kunjamma RB, Tokars HM, Leisten ED, Chan J, Wong Y, Popko B
bioRxiv : the preprint server for biology 2023 Jan 23;
bioRxiv : the preprint server for biology 2023 Jan 23;
Progesterone regulates the endoplasmic reticulum-associated degradation and Unfolded Protein Response axis by mimicking the androgenic stimulation in prostate cancer cells.
Erzurumlu Y, Dogan HK, Catakli D
Molecular biology reports 2023 Feb;50(2):1253-1265
Molecular biology reports 2023 Feb;50(2):1253-1265
An RNA stem-loop functions in conjunction with an upstream open reading frame to direct preferential translation in the integrated stress response.
Amin PH, Carlson KR, Wek RC
The Journal of biological chemistry 2023 Feb;299(2):102864
The Journal of biological chemistry 2023 Feb;299(2):102864
Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model.
Kidwell A, Yadav SPS, Maier B, Zollman A, Ni K, Halim A, Janosevic D, Myslinski J, Syed F, Zeng L, Waffo AB, Banno K, Xuei X, Doud EH, Dagher PC, Hato T
Journal of the American Society of Nephrology : JASN 2023 Feb 1;34(2):220-240
Journal of the American Society of Nephrology : JASN 2023 Feb 1;34(2):220-240
Lithium chloride induces apoptosis by activating endoplasmic reticulum stress in pancreatic cancer.
Wu H, Zhang Y, Liang J, Wu J, Zhang Y, Su H, Zhang Q, Shen Y, Shen S, Wang L, Zou X, Hang C, Zhang S, Lv Y
Translational oncology 2023 Dec;38:101792
Translational oncology 2023 Dec;38:101792
PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability.
Fevga C, Tesson C, Carreras Mascaro A, Courtin T, van Coller R, Sakka S, Ferraro F, Farhat N, Bardien S, Damak M, Carr J, Ferrien M, Boumeester V, Hundscheid J, Grillenzoni N, Kessissoglou IA, Kuipers DJS, Quadri M, French and Mediterranean Parkinson disease Genetics Study Group, International Parkinsonism Genetics Network, Corvol JC, Mhiri C, Hassan BA, Breedveld GJ, Lesage S, Mandemakers W, Brice A, Bonifati V
Brain : a journal of neurology 2023 Apr 19;146(4):1496-1510
Brain : a journal of neurology 2023 Apr 19;146(4):1496-1510
Inhibition of the integrated stress response reverses oxidative stress damage-induced postoperative cognitive dysfunction.
Jiang L, Dong R, Xu M, Liu Y, Xu J, Ma Z, Xia T, Gu X
Frontiers in cellular neuroscience 2022;16:992869
Frontiers in cellular neuroscience 2022;16:992869
The crosstalk between MYC and mTORC1 during osteoclastogenesis.
Bae S, Oh B, Tsai J, Park PSU, Greenblatt MB, Giannopoulou EG, Park-Min KH
Frontiers in cell and developmental biology 2022;10:920683
Frontiers in cell and developmental biology 2022;10:920683
GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis.
Cordova RA, Misra J, Amin PH, Klunk AJ, Damayanti NP, Carlson KR, Elmendorf AJ, Kim HG, Mirek ET, Elzey BD, Miller MJ, Dong XC, Cheng L, Anthony TG, Pili R, Wek RC, Staschke KA
eLife 2022 Sep 15;11
eLife 2022 Sep 15;11
Ribosome changes reprogram translation for chemosurvival in G0 leukemic cells.
Datta C, Truesdell SS, Wu KQ, Bukhari SIA, Ngue H, Buchanan B, Le Tonqueze O, Lee S, Kollu S, Granovetter MA, Boukhali M, Kreuzer J, Batool MS, Balaj L, Haas W, Vasudevan S
Science advances 2022 Oct 28;8(43):eabo1304
Science advances 2022 Oct 28;8(43):eabo1304
Salidroside attenuates sepsis-associated acute lung injury through PPP1R15A mediated endoplasmic reticulum stress inhibition.
Jiang L, Xu L, Zheng L, Wang Y, Zhuang M, Yang D
Bioorganic & medicinal chemistry 2022 Oct 1;71:116865
Bioorganic & medicinal chemistry 2022 Oct 1;71:116865
Impaired Restoration of Global Protein Synthesis Contributes to Increased Vulnerability to Acute ER Stress Recovery in Huntington's Disease.
Xu H, Bensalel J, Capobianco E, Lu ML, Wei J
Cellular and molecular neurobiology 2022 Nov;42(8):2757-2771
Cellular and molecular neurobiology 2022 Nov;42(8):2757-2771
A systems biological analysis of the ATF4-GADD34-CHOP regulatory triangle upon endoplasmic reticulum stress.
Márton M, Bánhegyi G, Gyöngyösi N, Kálmán EÉ, Pettkó-Szandtner A, Káldi K, Kapuy O
FEBS open bio 2022 Nov;12(11):2065-2082
FEBS open bio 2022 Nov;12(11):2065-2082
Host 5'-3' Exoribonuclease XRN1 Acts as a Proviral Factor for Measles Virus Replication by Downregulating the dsRNA-Activated Kinase PKR.
BenDavid E, Pfaller CK, Pan Y, Samuel CE, Ma D
Journal of virology 2022 Nov 23;96(22):e0131922
Journal of virology 2022 Nov 23;96(22):e0131922
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Chang L, Liu X, Chen J, Liu H, Wang G, Wang G, Liao X, Shen X
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal.
Adachi Y, Masuda M, Sakakibara I, Uchida T, Niida Y, Mori Y, Kamei Y, Okumura Y, Ohminami H, Ohnishi K, Yamanaka-Okumura H, Nikawa T, Taketani Y
Life science alliance 2022 Mar;5(7)
Life science alliance 2022 Mar;5(7)
Temporal control of the integrated stress response by a stochastic molecular switch.
Klein P, Kallenberger SM, Roth H, Roth K, Ly-Hartig TBN, Magg V, Aleš J, Talemi SR, Qiang Y, Wolf S, Oleksiuk O, Kurilov R, Di Ventura B, Bartenschlager R, Eils R, Rohr K, Hamprecht FA, Höfer T, Fackler OT, Stoecklin G, Ruggieri A
Science advances 2022 Mar 25;8(12):eabk2022
Science advances 2022 Mar 25;8(12):eabk2022
Salubrinal-mediated activation of eIF2α signaling improves oxidative stress-induced BMSCs senescence and senile osteoporosis.
Li L, Hu G, Xie R, Yang J, Shi X, Jia Z, Qu X, Wang M, Wu Y
Biochemical and biophysical research communications 2022 Jun 25;610:70-76
Biochemical and biophysical research communications 2022 Jun 25;610:70-76
Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response.
Pitera AP, Szaruga M, Peak-Chew SY, Wingett SW, Bertolotti A
The EMBO journal 2022 Jun 1;41(11):e109985
The EMBO journal 2022 Jun 1;41(11):e109985
Signaling by the integrated stress response kinase PKR is fine-tuned by dynamic clustering.
Zappa F, Muniozguren NL, Wilson MZ, Costello MS, Ponce-Rojas JC, Acosta-Alvear D
The Journal of cell biology 2022 Jul 4;221(7)
The Journal of cell biology 2022 Jul 4;221(7)
Stress-induced perturbations in intracellular amino acids reprogram mRNA translation in osmoadaptation independently of the ISR.
Krokowski D, Jobava R, Szkop KJ, Chen CW, Fu X, Venus S, Guan BJ, Wu J, Gao Z, Banaszuk W, Tchorzewski M, Mu T, Ropelewski P, Merrick WC, Mao Y, Sevval AI, Miranda H, Qian SB, Manifava M, Ktistakis NT, Vourekas A, Jankowsky E, Topisirovic I, Larsson O, Hatzoglou M
Cell reports 2022 Jul 19;40(3):111092
Cell reports 2022 Jul 19;40(3):111092
Selective activation of cannabinoid receptor-2 reduces white matter injury via PERK signaling in a rat model of traumatic brain injury.
Li L, Luo Q, Shang B, Yang X, Zhang Y, Pan Q, Wu N, Tang W, Du D, Sun X, Jiang L
Experimental neurology 2022 Jan;347:113899
Experimental neurology 2022 Jan;347:113899
GCN2 kinase activation by ATP-competitive kinase inhibitors.
Tang CP, Clark O, Ferrarone JR, Campos C, Lalani AS, Chodera JD, Intlekofer AM, Elemento O, Mellinghoff IK
Nature chemical biology 2022 Feb;18(2):207-215
Nature chemical biology 2022 Feb;18(2):207-215
Enterovirus 71 Activates GADD34 via Precursor 3CD to Promote IRES-Mediated Viral Translation.
Li H, Li W, Zhang S, Qiu M, Li Z, Lin Y, Tan J, Qiao W
Microbiology spectrum 2022 Feb 23;10(1):e0138821
Microbiology spectrum 2022 Feb 23;10(1):e0138821
Tetrandrine alleviates inflammation and neuron apoptosis in experimental traumatic brain injury by regulating the IRE1α/JNK/CHOP signal pathway.
Liu H, He S, Li C, Wang J, Zou Q, Liao Y, Chen R
Brain and behavior 2022 Dec;12(12):e2786
Brain and behavior 2022 Dec;12(12):e2786
Cysteine dioxygenase 1 attenuates the proliferation via inducing oxidative stress and integrated stress response in gastric cancer cells.
Ma G, Zhao Z, Qu Y, Cai F, Liu S, Liang H, Zhang R, Deng J
Cell death discovery 2022 Dec 16;8(1):493
Cell death discovery 2022 Dec 16;8(1):493
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
Alfred N, Qian B, Qin X, Yin X, Prajapati M, Dou Y, Li Y, Zhang Z
Frontiers in veterinary science 2021;8:645571
Frontiers in veterinary science 2021;8:645571
Activation of the Protein Kinase R-Like Endoplasmic Reticulum Kinase (PERK) Pathway of the Unfolded Protein Response after Experimental Traumatic Brain Injury and Treatment with a PERK Inhibitor.
Brady RD, Bird S, Sun M, Yamakawa GR, Major BP, Mychasiuk R, O'Brien TJ, McDonald SJ, Shultz SR
Neurotrauma reports 2021;2(1):330-342
Neurotrauma reports 2021;2(1):330-342
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases.
Gan G, Shi Z, Shangguan C, Zhang J, Yuan Y, Chen L, Liu W, Li B, Meng S, Xiong W, Mi J
Theranostics 2021;11(12):6006-6018
Theranostics 2021;11(12):6006-6018
The eIF2 kinase GCN2 directs keratinocyte collective cell migration during wound healing via coordination of reactive oxygen species and amino acids.
Miles RR, Amin PH, Diaz MB, Misra J, Aukerman E, Das A, Ghosh N, Guith T, Knierman MD, Roy S, Spandau DF, Wek RC
The Journal of biological chemistry 2021 Nov;297(5):101257
The Journal of biological chemistry 2021 Nov;297(5):101257
Sensitization of the UPR by loss of PPP1R15A promotes fibrosis and senescence in IPF.
Monkley S, Overed-Sayer C, Parfrey H, Rassl D, Crowther D, Escudero-Ibarz L, Davis N, Carruthers A, Berks R, Coetzee M, Kolosionek E, Karlsson M, Griffin LR, Clausen M, Belfield G, Hogaboam CM, Murray LA
Scientific reports 2021 Nov 3;11(1):21584
Scientific reports 2021 Nov 3;11(1):21584
Mutation in FBXO32 causes dilated cardiomyopathy through up-regulation of ER-stress mediated apoptosis.
Al-Yacoub N, Colak D, Mahmoud SA, Hammonds M, Muhammed K, Al-Harazi O, Assiri AM, Al-Buraiki J, Al-Habeeb W, Poizat C
Communications biology 2021 Jul 16;4(1):884
Communications biology 2021 Jul 16;4(1):884
Chromosome 22q11.2 deletion causes PERK-dependent vulnerability in dopaminergic neurons.
Arioka Y, Shishido E, Kushima I, Suzuki T, Saito R, Aiba A, Mori D, Ozaki N
EBioMedicine 2021 Jan;63:103138
EBioMedicine 2021 Jan;63:103138
LXRα activation and Raf inhibition trigger lethal lipotoxicity in liver cancer.
Rudalska R, Harbig J, Snaebjornsson MT, Klotz S, Zwirner S, Taranets L, Heinzmann F, Kronenberger T, Forster M, Cui W, D'Artista L, Einig E, Hinterleitner M, Schmitz W, Dylawerska A, Kang TW, Poso A, Rosenfeldt MT, Malek NP, Bitzer M, Laufer S, Pichler BJ, Popov N, Schulze A, Zender L, Dauch D
Nature cancer 2021 Feb;2(2):201-217
Nature cancer 2021 Feb;2(2):201-217
eIF2B-capturing viral protein NSs suppresses the integrated stress response.
Kashiwagi K, Shichino Y, Osaki T, Sakamoto A, Nishimoto M, Takahashi M, Mito M, Weber F, Ikeuchi Y, Iwasaki S, Ito T
Nature communications 2021 Dec 7;12(1):7102
Nature communications 2021 Dec 7;12(1):7102
GADD34-mediated dephosphorylation of eIF2α facilitates pseudorabies virus replication by maintaining de novo protein synthesis.
Zhu T, Jiang X, Xin H, Zheng X, Xue X, Chen JL, Qi B
Veterinary research 2021 Dec 20;52(1):148
Veterinary research 2021 Dec 20;52(1):148
GADD34 is a modulator of autophagy during starvation.
Gambardella G, Staiano L, Moretti MN, De Cegli R, Fagnocchi L, Di Tullio G, Polletti S, Braccia C, Armirotti A, Zippo A, Ballabio A, De Matteis MA, di Bernardo D
Science advances 2020 Sep;6(39)
Science advances 2020 Sep;6(39)
The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes.
Wu H, Meng Z, Jiao Y, Ren Y, Yang X, Liu H, Wang R, Cui Y, Pan L, Cao Y
Journal of clinical laboratory analysis 2020 Oct;34(10):e23437
Journal of clinical laboratory analysis 2020 Oct;34(10):e23437
Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress.
Wang F, Liu L, Tong Y, Li L, Liu Y, Gao WQ
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550
Cell cycle (Georgetown, Tex.) 2020 Mar;19(5):541-550
Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration.
Smith HL, Freeman OJ, Butcher AJ, Holmqvist S, Humoud I, Schätzl T, Hughes DT, Verity NC, Swinden DP, Hayes J, de Weerd L, Rowitch DH, Franklin RJM, Mallucci GR
Neuron 2020 Mar 4;105(5):855-866.e5
Neuron 2020 Mar 4;105(5):855-866.e5
CReP mediates selective translation initiation at the endoplasmic reticulum.
Kastan JP, Dobrikova EY, Bryant JD, Gromeier M
Science advances 2020 Jun;6(23):eaba0745
Science advances 2020 Jun;6(23):eaba0745
Post-Transcriptional Regulation of Alpha One Antitrypsin by a Proteasome Inhibitor.
Rao L, Xu Y, Reineke LC, Bhattacharya A, Tyryshkin A, Shin JN, Eissa NT
International journal of molecular sciences 2020 Jun 17;21(12)
International journal of molecular sciences 2020 Jun 17;21(12)
Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease.
Lu Y, Sun Y, Liu Z, Lu Y, Zhu X, Lan B, Mi Z, Dang L, Li N, Zhan W, Tan L, Pi J, Xiong H, Zhang L, Chen Y
Science translational medicine 2020 Jul 29;12(554)
Science translational medicine 2020 Jul 29;12(554)
Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis.
Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, Du G
Cell proliferation 2020 Jan;53(1):e12706
Cell proliferation 2020 Jan;53(1):e12706
A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems.
Sicari D, Delaunay-Moisan A, Combettes L, Chevet E, Igbaria A
The FEBS journal 2020 Jan;287(1):27-42
The FEBS journal 2020 Jan;287(1):27-42
GADD34 attenuates HIV-1 replication by viral 5'-UTR TAR RNA-mediated translational inhibition.
Ishaq M, Marshall H, Natarajan V
Virology 2020 Jan 15;540:119-131
Virology 2020 Jan 15;540:119-131
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation.
Shrestha P, Ayata P, Herrero-Vidal P, Longo F, Gastone A, LeDoux JE, Heintz N, Klann E
Nature neuroscience 2020 Feb;23(2):281-292
Nature neuroscience 2020 Feb;23(2):281-292
Altered m(6)A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection.
Gokhale NS, McIntyre ABR, Mattocks MD, Holley CL, Lazear HM, Mason CE, Horner SM
Molecular cell 2020 Feb 6;77(3):542-555.e8
Molecular cell 2020 Feb 6;77(3):542-555.e8
Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB.
Young-Baird SK, Lourenço MB, Elder MK, Klann E, Liebau S, Dever TE
Molecular cell 2020 Feb 20;77(4):875-886.e7
Molecular cell 2020 Feb 20;77(4):875-886.e7
Pseudorabies virus infection inhibits stress granules formation via dephosphorylating eIF2α.
Xu S, Chen D, Chen D, Hu Q, Zhou L, Ge X, Han J, Guo X, Yang H
Veterinary microbiology 2020 Aug;247:108786
Veterinary microbiology 2020 Aug;247:108786
The FDA-Approved Oral Drug Nitazoxanide Amplifies Host Antiviral Responses and Inhibits Ebola Virus.
Jasenosky LD, Cadena C, Mire CE, Borisevich V, Haridas V, Ranjbar S, Nambu A, Bavari S, Soloveva V, Sadukhan S, Cassell GH, Geisbert TW, Hur S, Goldfeld AE
iScience 2019 Sep 27;19:1279-1290
iScience 2019 Sep 27;19:1279-1290
Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus.
Gao P, Chai Y, Song J, Liu T, Chen P, Zhou L, Ge X, Guo X, Han J, Yang H
PLoS pathogens 2019 Nov;15(11):e1008169
PLoS pathogens 2019 Nov;15(11):e1008169
Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma.
Cao X, Dang L, Zheng X, Lu Y, Lu Y, Ji R, Zhang T, Ruan X, Zhi J, Hou X, Yi X, Li MJ, Gu T, Gao M, Zhang L, Chen Y
Thyroid : official journal of the American Thyroid Association 2019 Jun;29(6):809-823
Thyroid : official journal of the American Thyroid Association 2019 Jun;29(6):809-823
Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress.
Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim MJ, Machnicka K, Liszewska E, Jaworski J, Chacinska A
Molecular biology of the cell 2019 Jul 15;30(15):1864-1877
Molecular biology of the cell 2019 Jul 15;30(15):1864-1877
Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice.
Patel V, Bidault G, Chambers JE, Carobbio S, Everden AJT, Garcés C, Dalton LE, Gribble FM, Vidal-Puig A, Marciniak SJ
Scientific reports 2019 Feb 27;9(1):2903
Scientific reports 2019 Feb 27;9(1):2903
Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation.
Peng X, Yang T, He L, Chen X, Jiang Y, Zhang H, Liu H, Peng Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2203-2215
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(6):2203-2215
Loss of tuberous sclerosis complex 2 sensitizes tumors to nelfinavir-bortezomib therapy to intensify endoplasmic reticulum stress-induced cell death.
Johnson CE, Dunlop EA, Seifan S, McCann HD, Hay T, Parfitt GJ, Jones AT, Giles PJ, Shen MH, Sampson JR, Errington RJ, Davies DM, Tee AR
Oncogene 2018 Nov;37(45):5913-5925
Oncogene 2018 Nov;37(45):5913-5925
Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease.
Sun X, Aimé P, Dai D, Ramalingam N, Crary JF, Burke RE, Greene LA, Levy OA
Experimental neurology 2018 May;303:95-107
Experimental neurology 2018 May;303:95-107
Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats.
Melas PA, Qvist JS, Deidda M, Upreti C, Wei YB, Sanna F, Fratta W, Scherma M, Fadda P, Kandel DB, Kandel ER
Cell reports 2018 Mar 13;22(11):2909-2923
Cell reports 2018 Mar 13;22(11):2909-2923
ICE1 promotes the link between splicing and nonsense-mediated mRNA decay.
Baird TD, Cheng KC, Chen YC, Buehler E, Martin SE, Inglese J, Hogg JR
eLife 2018 Mar 12;7
eLife 2018 Mar 12;7
EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response.
Moon SL, Parker R
RNA (New York, N.Y.) 2018 Jun;24(6):841-852
RNA (New York, N.Y.) 2018 Jun;24(6):841-852
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes.
Collier AE, Spandau DF, Wek RC
Molecular biology of the cell 2018 Jan 1;29(1):29-41
Molecular biology of the cell 2018 Jan 1;29(1):29-41
Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
Lee IC, Ho XY, George SE, Goh CW, Sundaram JR, Pang KKL, Luo W, Yusoff P, Sze NSK, Shenolikar S
Cell death and differentiation 2018 Feb;25(2):255-267
Cell death and differentiation 2018 Feb;25(2):255-267
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment.
Hyer ML, Milhollen MA, Ciavarri J, Fleming P, Traore T, Sappal D, Huck J, Shi J, Gavin J, Brownell J, Yang Y, Stringer B, Griffin R, Bruzzese F, Soucy T, Duffy J, Rabino C, Riceberg J, Hoar K, Lublinsky A, Menon S, Sintchak M, Bump N, Pulukuri SM, Langston S, Tirrell S, Kuranda M, Veiby P, Newcomb J, Li P, Wu JT, Powe J, Dick LR, Greenspan P, Galvin K, Manfredi M, Claiborne C, Amidon BS, Bence NF
Nature medicine 2018 Feb;24(2):186-193
Nature medicine 2018 Feb;24(2):186-193
Activating Transcription Factor-6α Deletion Modulates the Endoplasmic Reticulum Stress Response after Spinal Cord Injury but Does Not Affect Locomotor Recovery.
Saraswat Ohri S, Mullins A, Hetman M, Whittemore SR
Journal of neurotrauma 2018 Feb 1;35(3):486-491
Journal of neurotrauma 2018 Feb 1;35(3):486-491
Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B.
Krzyzosiak A, Sigurdardottir A, Luh L, Carrara M, Das I, Schneider K, Bertolotti A
Cell 2018 Aug 23;174(5):1216-1228.e19
Cell 2018 Aug 23;174(5):1216-1228.e19
Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury.
Dolinay T, Aonbangkhen C, Zacharias W, Cantu E, Pogoriler J, Stablow A, Lawrence GG, Suzuki Y, Chenoweth DM, Morrisey E, Christie JD, Beers MF, Margulies SS
Respiratory research 2018 Aug 22;19(1):157
Respiratory research 2018 Aug 22;19(1):157
Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate.
Chang TK, Lawrence DA, Lu M, Tan J, Harnoss JM, Marsters SA, Liu P, Sandoval W, Martin SE, Ashkenazi A
Molecular cell 2018 Aug 16;71(4):629-636.e5
Molecular cell 2018 Aug 16;71(4):629-636.e5
Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly.
Shelkovnikova TA, Dimasi P, Kukharsky MS, An H, Quintiero A, Schirmer C, Buée L, Galas MC, Buchman VL
Cell death & disease 2017 May 11;8(5):e2788
Cell death & disease 2017 May 11;8(5):e2788
Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.
Dalet A, Argüello RJ, Combes A, Spinelli L, Jaeger S, Fallet M, Vu Manh TP, Mendes A, Perego J, Reverendo M, Camosseto V, Dalod M, Weil T, Santos MA, Gatti E, Pierre P
The EMBO journal 2017 Mar 15;36(6):761-782
The EMBO journal 2017 Mar 15;36(6):761-782
Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells.
Dunlop EA, Johnson CE, Wiltshire M, Errington RJ, Tee AR
Oncotarget 2017 Jul 25;8(30):48711-48724
Oncotarget 2017 Jul 25;8(30):48711-48724
PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz.
Crespillo-Casado A, Chambers JE, Fischer PM, Marciniak SJ, Ron D
eLife 2017 Apr 27;6
eLife 2017 Apr 27;6
Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse.
Sidoli M, Musner N, Silvestri N, Ungaro D, D'Antonio M, Cavener DR, Feltri ML, Wrabetz L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Nov 2;36(44):11350-11361
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 Nov 2;36(44):11350-11361
Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy.
Musner N, Sidoli M, Zambroni D, Del Carro U, Ungaro D, D'Antonio M, Feltri ML, Wrabetz L
ASN neuro 2016 Mar-Apr;8(2)
ASN neuro 2016 Mar-Apr;8(2)
Oral proteasome inhibitor with strong preclinical efficacy in myeloma models.
Park J, Park E, Jung CK, Kang SW, Kim BG, Jung Y, Kim TH, Lim JY, Lee SE, Min CK, Won KA
BMC cancer 2016 Mar 24;16:247
BMC cancer 2016 Mar 24;16:247
Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression.
Young SK, Shao Y, Bidwell JP, Wek RC
The Journal of biological chemistry 2016 Jun 24;291(26):13780-8
The Journal of biological chemistry 2016 Jun 24;291(26):13780-8
An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response.
De Gassart A, Bujisic B, Zaffalon L, Decosterd LA, Di Micco A, Frera G, Tallant R, Martinon F
Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 12;113(2):E117-26
Proceedings of the National Academy of Sciences of the United States of America 2016 Jan 12;113(2):E117-26
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia.
Radford H, Moreno JA, Verity N, Halliday M, Mallucci GR
Acta neuropathologica 2015 Nov;130(5):633-42
Acta neuropathologica 2015 Nov;130(5):633-42
Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response.
Young SK, Willy JA, Wu C, Sachs MS, Wek RC
The Journal of biological chemistry 2015 Nov 20;290(47):28257-28271
The Journal of biological chemistry 2015 Nov 20;290(47):28257-28271
Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation.
Chambers JE, Dalton LE, Clarke HJ, Malzer E, Dominicus CS, Patel V, Moorhead G, Ron D, Marciniak SJ
eLife 2015 Mar 16;4
eLife 2015 Mar 16;4
DNA Damage Regulates Translation through β-TRCP Targeting of CReP.
Loveless TB, Topacio BR, Vashisht AA, Galaang S, Ulrich KM, Young BD, Wohlschlegel JA, Toczyski DP
PLoS genetics 2015 Jun;11(6):e1005292
PLoS genetics 2015 Jun;11(6):e1005292
Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells.
van 't Wout EF, van Schadewijk A, van Boxtel R, Dalton LE, Clarke HJ, Tommassen J, Marciniak SJ, Hiemstra PS
PLoS pathogens 2015 Jun;11(6):e1004946
PLoS pathogens 2015 Jun;11(6):e1004946
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.
Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, Hong L, Fan X, Chen Q, Tian J, Jiang M, Sun X, Jin C, Yin ZY, Liu Q, Zhang J, Qin F, Lin KH, Yu JS, Deng X, Wang HR, Zhao B, Johnson RL, Chen L, Zhou D
Nature communications 2015 Feb 19;6:6239
Nature communications 2015 Feb 19;6:6239
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Das I, Krzyzosiak A, Schneider K, Wrabetz L, D'Antonio M, Barry N, Sigurdardottir A, Bertolotti A
Science (New York, N.Y.) 2015 Apr 10;348(6231):239-42
Science (New York, N.Y.) 2015 Apr 10;348(6231):239-42
Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease.
Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R
PloS one 2014;9(7):e101643
PloS one 2014;9(7):e101643
The heat-shock response co-inducer arimoclomol protects against retinal degeneration in rhodopsin retinitis pigmentosa.
Parfitt DA, Aguila M, McCulley CH, Bevilacqua D, Mendes HF, Athanasiou D, Novoselov SS, Kanuga N, Munro PM, Coffey PJ, Kalmar B, Greensmith L, Cheetham ME
Cell death & disease 2014 May 22;5(5):e1236
Cell death & disease 2014 May 22;5(5):e1236
Autoubiquitination of the 26S proteasome on Rpn13 regulates breakdown of ubiquitin conjugates.
Besche HC, Sha Z, Kukushkin NV, Peth A, Hock EM, Kim W, Gygi S, Gutierrez JA, Liao H, Dick L, Goldberg AL
The EMBO journal 2014 May 16;33(10):1159-76
The EMBO journal 2014 May 16;33(10):1159-76
The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic β cells by blocking PERK-mediated translational attenuation.
Ozasa R, Okada T, Nadanaka S, Nagamine T, Zyryanova A, Harding H, Ron D, Mori K
Cell structure and function 2013;38(2):183-95
Cell structure and function 2013;38(2):183-95
The PERK/ATF4/LAMP3-arm of the unfolded protein response affects radioresistance by interfering with the DNA damage response.
Nagelkerke A, Bussink J, van der Kogel AJ, Sweep FC, Span PN
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):415-21
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2013 Sep;108(3):415-21
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress.
Thomas SE, Malzer E, Ordóñez A, Dalton LE, van T Wout EFA, Liniker E, Crowther DC, Lomas DA, Marciniak SJ
The Journal of biological chemistry 2013 Mar 15;288(11):7606-7617
The Journal of biological chemistry 2013 Mar 15;288(11):7606-7617
Eukaryotic initiation factor 2α phosphorylation mediates fetal hemoglobin induction through a post-transcriptional mechanism.
Hahn CK, Lowrey CH
Blood 2013 Jul 25;122(4):477-85
Blood 2013 Jul 25;122(4):477-85
The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma.
Dalton LE, Clarke HJ, Knight J, Lawson MH, Wason J, Lomas DA, Howat WJ, Rintoul RC, Rassl DM, Marciniak SJ
British journal of cancer 2013 Apr 2;108(6):1340-7
British journal of cancer 2013 Apr 2;108(6):1340-7
Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.
Clavarino G, Cláudio N, Couderc T, Dalet A, Judith D, Camosseto V, Schmidt EK, Wenger T, Lecuit M, Gatti E, Pierre P
PLoS pathogens 2012;8(5):e1002708
PLoS pathogens 2012;8(5):e1002708
Failure of amino acid homeostasis causes cell death following proteasome inhibition.
Suraweera A, Münch C, Hanssum A, Bertolotti A
Molecular cell 2012 Oct 26;48(2):242-53
Molecular cell 2012 Oct 26;48(2):242-53
Sustained translational repression by eIF2α-P mediates prion neurodegeneration.
Moreno JA, Radford H, Peretti D, Steinert JR, Verity N, Martin MG, Halliday M, Morgan J, Dinsdale D, Ortori CA, Barrett DA, Tsaytler P, Bertolotti A, Willis AE, Bushell M, Mallucci GR
Nature 2012 May 6;485(7399):507-11
Nature 2012 May 6;485(7399):507-11
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasis.
Tsaytler P, Harding HP, Ron D, Bertolotti A
Science (New York, N.Y.) 2011 Apr 1;332(6025):91-4
Science (New York, N.Y.) 2011 Apr 1;332(6025):91-4
Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer.
Kupperman E, Lee EC, Cao Y, Bannerman B, Fitzgerald M, Berger A, Yu J, Yang Y, Hales P, Bruzzese F, Liu J, Blank J, Garcia K, Tsu C, Dick L, Fleming P, Yu L, Manfredi M, Rolfe M, Bolen J
Cancer research 2010 Mar 1;70(5):1970-80
Cancer research 2010 Mar 1;70(5):1970-80
An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer.
Soucy TA, Smith PG, Milhollen MA, Berger AJ, Gavin JM, Adhikari S, Brownell JE, Burke KE, Cardin DP, Critchley S, Cullis CA, Doucette A, Garnsey JJ, Gaulin JL, Gershman RE, Lublinsky AR, McDonald A, Mizutani H, Narayanan U, Olhava EJ, Peluso S, Rezaei M, Sintchak MD, Talreja T, Thomas MP, Traore T, Vyskocil S, Weatherhead GS, Yu J, Zhang J, Dick LR, Claiborne CF, Rolfe M, Bolen JB, Langston SP
Nature 2009 Apr 9;458(7239):732-6
Nature 2009 Apr 9;458(7239):732-6
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 10449-1-AP(GADD34 antibody) at dilution of 1:600
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 10449-1-AP(GADD34 antibody) at dilution of 1:100 (under 40x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The GADD34 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human GADD34. This antibody recognizes human antigen. The GADD34 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
