11204-1-AP

antibody from Proteintech Group

Targeting: ENO1 ENO1L1, MBP-1, MPB1, PPH

Provider product page for 11204-1-AP

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Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [115]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunoprecipitation [1]
Immunohistochemistry [1]

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Product number: 11204-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11204-1-AP, RRID:AB_2099064
Product name: ENO1 antibody
Antibody type: Polyclonal
Description: KD/KO validated ENO1 antibody (Cat. #11204-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

ENO1 protein structure - 11204-1-AP shown in red.

Submitted references ENO1 inhibition synergizes with chidamide to induce ferroptosis in PTCL-NOS through metabolic remodeling.

Zhu F, Tian M, Lu K, Wang C, Liu J, Li X, Gu X, Lv B, Huang Z, Zeng L, Li Z, Lu H, Xu K
Blood science (Baltimore, Md.) 2026 Mar;8(1):e00272

USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.

Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916

A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.

Thayer JA, Petersen JD, Huang X, Gruel Budet LM, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
The EMBO journal 2026 Jan;45(1):64-105

Neuronal Subtype-Specific Expression of γ-Enolase: Its Role in Neuronal Differentiation.

Horvat S, Pečar Fonović U, Zidar N, Doljak B, Kos J, Pišlar A
Neuromolecular medicine 2026 Jan 30;28(1):4

Enolase 1 suppresses influenza A virus replication by blocking the nuclear import of the viral ribonucleoprotein complex.

Kong X, Liu J, Zhu Q, Xu S
Cellular and molecular life sciences : CMLS 2026 Feb 25;83(1)

In vitro study: HIF-1α-dependent glycolysis enhances NETosis in hypoxic conditions.

Ye Y, Wang Y, Xu Q, Liu J, Yang Z, Wuren T, Ge RL
Frontiers in immunology 2025;16:1583587

Alpha-enolase promotes progression of acute myeloid leukemia via MAPK/ERK signaling pathway.

Zhang S, Wang H, Zhang X, Kui X, Huang D, Qin M, Liu S, Sun MZ, Yan J
Blood science (Baltimore, Md.) 2025 Sep;7(3):e00246

LncPRESS1 promotes the progression and cisplatin resistance of breast cancer through upregulation of ENO1 and activation of glycolysis.

Ke L, Gao W, Leng Y, Chen J, Chen H, Li S, Zhang Y, Luo L
Cell division 2025 Oct 4;20(1):23

Exosomal Proteome from Hepatocellular Carcinoma Patient-Derived Xenograft Mice Serves as Identity of Liver Cancer.

Zuo T, Chen P, Zhang Z, Mao M, Li Y, Li Z, Feng X, Wang Y, Sun Z, Jiao F, Gao F, Zhang T, Li Y, Zhang Y, Liu F, Zhang Y, Ruan Y, Chang L, Hu L, Zhang Y, Xu P
Journal of proteome research 2025 Oct 3;24(10):4977-4987

Integrative analysis identifies radiotherapy resistance-associated CAF subtypes shaping the tumor immune landscape in breast cancer.

Li Y, Zhang Z, Liu X, Cheng Y, Li K, Zheng W, He Z
BMC cancer 2025 Oct 17;25(1):1603

Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production.

Chen Z, Liao J, Zhu C, Chang R, Liang H, Ding Z, Huang Z, Chen X, Liang J, Zhang B
Cancer research 2025 Oct 15;85(20):3930-3948

Dexmedetomidine alleviates sepsis-induced acute lung injury by inhibiting M1 macrophage polarization via inhibition of PKM2-mediated Warburg effect.

He Y, Xie W, Zhou H, Wang Y, Chen L, Xu Z, Feng Y, Liu G, Liu J, Li X, Lv Y, Bai Y, Hu D, Wu Q
Biochemical pharmacology 2025 Nov;241:117130

Prognostic evaluation of glycolysis markers in hepatocellular carcinoma: insights from meta-analysis and multi-omics approaches.

Li G, Li Y, Zhou J, Tang S, Guo H, Lin J
BMC medical genomics 2025 Nov 8;18(1):179

SIRT5-mediated desuccinylation of PPA2 enhances HIF-1alpha-dependent adaptation to hypoxic stress and colorectal cancer metastasis.

Zhang X, Di Y, Wang Y, Qin J, Ye L, Wen X, Ke Z, Wang Z, He W
The EMBO journal 2025 May;44(9):2514-2540

A Ratiometric Catalog of Protein Isoform Shifts in the Cardiac Fetal Gene Program.

Han Y, Binti S, Wennersten SA, Pandi B, Ng DCM, Lau E, Lam MPY
bioRxiv : the preprint server for biology 2025 May 31;

Integrative Single-Cell and Bulk RNA Sequencing Identifies a Glycolysis-Related Prognostic Signature for Predicting Prognosis in Pancreatic Cancer.

Wu N, Zhou C, Yan X, Liu Z, Jiang R, Luo Y, Jiang P, Mu Y, Xiao S, Huang X, Zhou Y, Sun D, Jin Y
International journal of molecular sciences 2025 May 26;26(11)

Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer.

Huo R, Li W, Wu H, He K, Wang H, Zhang S, Jiang SH, Li R, Xue J
Cell death & disease 2025 Mar 3;16(1):149

Deletion of ENO1 sensitizes pancreatic cancer cells to gemcitabine via MYC/RRM1-mediated glycolysis.

Lu Y, Ma H, Xiong X, Du Y, Liu L, Wang J, Zhao W
Scientific reports 2025 Mar 22;15(1):9941

The DCDC2/ENO1 axis promotes tumor progression and immune evasion in intrahepatic cholangiocarcinoma via activating FGL1-LAG3 checkpoint.

Wan W, Li Y, Sun W, Cheng Z, Ma F, Shen S, Liu H, Zhang J
Journal of experimental & clinical cancer research : CR 2025 Jun 18;44(1):177

Citrullinated ENO1 Vaccine Enhances PD-1 Blockade in Mice Implanted with Murine Triple-Negative Breast Cancer Cells.

León-Letelier RA, Sevillano-Mantas AM, Chen Y, Park S, Vykoukal J, Fahrmann JF, Ostrin EJ, Garrett C, Dou R, Cai Y, Hsiao FC, Dennison JB, Vilar E, Arun BK, Hanash S, Katayama H
Vaccines 2025 Jun 11;13(6)

Lactate production by tumor-resident Staphylococcus promotes metastatic colonization in lung adenocarcinoma.

Yu H, Du Y, He Y, Sun Y, Li J, Jia B, Chen J, Peng X, An T, Li J, Chi Y, Wang M, Cao L, Tai Y, Zhai X, Nuersulitan R, Li S, Wu N, Wang J, Xiong H, Wan S, Liu J, Yang X, Hu X, Lin D, Sun W, Wang Y, An G, Ji X, Kong L, Ding L, Ma Y, Tian Z, Dong B, Bi Y, Wu J, Wang Z
Cell host & microbe 2025 Jul 9;33(7):1089-1105.e7

Gut microbiota-bile acid crosstalk contributes to calcium oxalate nephropathy through Hsp90α-mediated ferroptosis.

Liu L, Ma Y, Jian Z, Liao B, Li Y, Lin L, Wang M, Chen J, Wei J, Yang M, Liu Y, Yuan Y, Wen J, Xiang L, Qi S, Jin X, Wang K
Cell reports 2025 Jul 22;44(7):115936

Tumor-intrinsic ENO1 inhibition promotes antitumor immune response and facilitates the efficacy of anti-PD-L1 immunotherapy in bladder cancer.

Shen C, Liu J, Hu D, Liu C, Xie F, Wang Y
Journal of experimental & clinical cancer research : CR 2025 Jul 15;44(1):207

ARID1A deficiency promotes malignant proliferation of hepatocellular carcinoma by activating HDAC7/ENO1 signaling pathway.

Zhang S, Wu G, Shi L, Ding P, Liu G, Chang W, Dai Y, Han X, Ma X
Hepatology communications 2025 Jul 1;9(7)

Self-organizing glycolytic waves tune cellular metabolic states and fuel cancer progression.

Zhan H, Pal DS, Borleis J, Deng Y, Long Y, Janetopoulos C, Huang CH, Devreotes PN
Nature communications 2025 Jul 1;16(1):5563

TRIM2 promotes metabolic adaptation to glutamine deprivation via enhancement of CPT1A activity.

Liao K, Liu K, Wang Z, Zhao K, Mei Y
The FEBS journal 2025 Jan;292(2):275-293

Natural product mediated mesenchymal-epithelial remodeling by covalently binding ENO1 to degrade m6A modified β-catenin mRNA.

Chen T, Liu G, Chen S, Zhang F, Ma S, Bai Y, Zhang Q, Ding Y
Acta pharmaceutica Sinica. B 2025 Jan;15(1):467-483

Osteoblast-Derived ECM1 Promotes Anti-Androgen Resistance in Bone Metastatic Prostate Cancer.

Wang X, Wang M, Lin Q, He L, Zhang B, Chen X, Chen G, Du H, Lang C, Peng X, Dai Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jan;12(2):e2407662

CASC8 activates the pentose phosphate pathway to inhibit disulfidptosis in pancreatic ductal adenocarcinoma though the c-Myc-GLUT1 axis.

Yao HF, Ge J, Chen J, Tang X, Li C, Hu X, Ahmed AA, Pu Y, Zhou G, Zhang T, Cai Z, Jiang C
Journal of experimental & clinical cancer research : CR 2025 Jan 27;44(1):26

FOSL1 transcriptionally dictates the Warburg effect and enhances chemoresistance in triple-negative breast cancer.

Zhao G, Liu Y, Yin S, Cao R, Zhao Q, Fu Y, Du Y
Journal of translational medicine 2025 Jan 2;23(1):1

LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.

Bin Y, Liu M, He R, Tang P, Qu W, Wu D, Tan L, Wang Q, Jiang P, Hu H
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244

ITGA3 promotes pancreatic cancer progression through HIF1α- and c-Myc-driven glycolysis in a collagen I-dependent autocrine manner.

Li R, Ji Q, Fu S, Gu J, Liu D, Wang L, Yuan X, Wen Y, Dai C, Li H
Cancer gene therapy 2025 Feb;32(2):240-253

Novel reporter of the PINK1-Parkin mitophagy pathway identifies its damage sensor in the import gate.

Thayer JA, Petersen JD, Huang X, Hawrot J, Ramos DM, Sekine S, Li Y, Ward ME, Narendra DP
bioRxiv : the preprint server for biology 2025 Feb 20;

Fucosyltransferase 8-Derived Circular RNA Drives M2 Polarization of Macrophages Through ENO1-TNF Signaling Axis to Promote Lung Cancer Progression.

Ren Y, Shen Y, Wu Q, Zhang P, Wang L, Li F, Shen Y
Thoracic cancer 2025 Dec;16(23):e70194

Autophagy-dependent secretion of ENO1 mediates chemoresistance of glioblastoma and tumor microenvironment remodeling.

Xie Q, Chen L, Huang Y, Yu Z, Zhu R, Li J, Zhao J, Song Y, Li H, Lu Y
Cell death & disease 2025 Dec 6;17(1):79

α-Enolase and γ-Enolase Expression in Enriched S- and N-Type SH-SY5Y Cells: Regulatory Role of Cathepsin X.

Horvat S, Zidar N, Kos J, Pišlar A
Molecular neurobiology 2025 Aug;62(8):10006-10019

Silencing PIM1 inhibits ENO1-induced AKT activation and attenuates fibrillogenesis during spinal cord injury-induced skeletal muscle atrophy.

Yu X, Cao J, Wang B, Fu J, Liu J, Sui T, Wang Z, Wu C, Chang J, Cao X, Zhang S
The Journal of biological chemistry 2025 Aug;301(8):110398

Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation.

Zhang S, Wang YS, Li Y, To KI, Zhang ET, Jin YH
Cellular signalling 2025 Aug;132:111781

Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.

Liang Z, Liu J, Gou Y, Wang H, Li Z, Cao Y, Zhang H, Bai R, Zhang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e08220

The α- to γ-enolase switch: The role and regulation of γ-enolase during oligodendrocyte differentiation.

Horvat S, Fonović UP, Mitrović A, Zidar N, Kos J, Pišlar A
International journal of biological macromolecules 2025 Apr;301:140464

Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice.

He X, Wang C, Zhang Q, Yang T, Guo Q, Wang Y, Guo J, Wang P, Zhang J, Tang H, Zhu Y, Wang J
Aging cell 2025 Apr;24(4):e14433

Proteomic Analysis of Human Follicular Fluid-Derived Exosomes Reveals That Insufficient Folliculogenesis in Aging Women is Associated With Infertility.

Liu Z, Zhou Q, Zan J, Tian J, Zhang Y, Wu F, Zhao H, Peng Q, Liu S, Chen Q, Liu E, Liao Z, Zou P, Mei L, Wang W, Dong S, Niu L, Wu S, He L, Zhou X, Jin Y, Li P, Yang S
Molecular & cellular proteomics : MCP 2025 Apr;24(4):100930

Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.

Li WJ, Chen YC, Lin YA, Zou YQ, Hu GS, Yang JJ, Nie XY, Li MY, Wang YR, He YH, Zhao Y, Tan YH, Deng X, He WL, Cheng Y, Fu FM, Liu W
Cell reports 2025 Apr 22;44(4):115487

Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism.

Zhao Y, Han S, Zeng Z, Zheng H, Li Y, Wang F, Huang Y, Zhao Y, Zhuo W, Lv G, Wang H, Zhao G, Zhao E, Hu Y, Hu P, Zhao G
Theranostics 2024;14(18):7088-7110

PRKDC Induces Chemoresistance in Osteosarcoma by Recruiting GDE2 to Stabilize GNAS and Activate AKT.

Zhang W, Li W, Yin C, Feng C, Liu B, Xu H, Jin X, Tu C, Li Z
Cancer research 2024 Sep 4;84(17):2873-2887

Single-cell dissection reveals promotive role of ENO1 in leukemia stem cell self-renewal and chemoresistance in acute myeloid leukemia.

Tian Y, Guo J, Mao L, Chen Z, Zhang X, Li Y, Zhang Y, Zha X, Luo OJ
Stem cell research & therapy 2024 Oct 8;15(1):347

Identification of TPI1 As a potential therapeutic target in pancreatic cancer with dependency of TP53 mutation using multi-omics analysis.

Toyoda T, Miura N, Kato S, Masuda T, Ohashi R, Matsushita A, Matsuda F, Ohtsuki S, Katakura A, Honda K
Cancer science 2024 Nov;115(11):3622-3635

Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.

Luo J, Yang Y, Zhang G, Fang D, Liu K, Mei Y, Wang F
Cell death & disease 2024 May 21;15(5):354

Proximal telomeric decompaction due to telomere shortening drives FOXC1-dependent myocardial senescence.

Li B, Xiong W, Zuo W, Shi Y, Wang T, Chang L, Wu Y, Ma H, Bian Q, Chang ACY
Nucleic acids research 2024 Jun 24;52(11):6269-6284

N6-Methyladenosine enhances the translation of ENO1 to promote the progression of bladder cancer by inhibiting PCNA ubiquitination.

Shen C, Liu J, Xie F, Yu Y, Ma X, Hu D, Liu C, Wang Y
Cancer letters 2024 Jul 28;595:217002

Multi-omics reveals the role of ENO1 in bladder cancer and constructs an epithelial-related prognostic model to predict prognosis and efficacy.

Su Z, You L, He Y, Chen J, Zhang G, Liu Z
Scientific reports 2024 Jan 25;14(1):2189

Integrative plasma and fecal metabolomics identify functional metabolites in adenoma-colorectal cancer progression and as early diagnostic biomarkers.

Sun Y, Zhang X, Hang D, Lau HC, Du J, Liu C, Xie M, Pan Y, Wang L, Liang C, Zhou X, Chen D, Rong J, Zhao Z, Cheung AH, Wu Y, Gou H, Wong CC, Du L, Deng J, Hu Z, Shen H, Miao Y, Yu J
Cancer cell 2024 Aug 12;42(8):1386-1400.e8

METTL3-mediated N6-methyladenosine exacerbates ferroptosis via m6A-IGF2BP2-dependent mitochondrial metabolic reprogramming in sepsis-induced acute lung injury.

Zhang H, Wu D, Wang Y, Guo K, Spencer CB, Ortoga L, Qu M, Shi Y, Shao Y, Wang Z, Cata JP, Miao C
Clinical and translational medicine 2023 Sep;13(9):e1389

HOXA1 promotes aerobic glycolysis and cancer progression in cervical cancer.

Zhang Z, Peng J, Li B, Wang Z, Wang H, Wang Y, Hong L
Cellular signalling 2023 Sep;109:110747

The diapause-like colorectal cancer cells induced by SMC4 attenuation are characterized by low proliferation and chemotherapy insensitivity.

Sun X, He L, Liu H, Thorne RF, Zeng T, Liu L, Zhang B, He M, Huang Y, Li M, Gao E, Ma M, Cheng C, Meng F, Lang C, Li H, Xiong W, Pan S, Ren D, Dang B, Yang Y, Wu M, Liu L
Cell metabolism 2023 Sep 5;35(9):1563-1579.e8

Depressed Proximal Glycolysis in Myocardium Of Human Heart Failure with Preserved Ejection Fraction.

Koleini N, Meddeb M, Keykhaei M, Kwon S, Zhao L, Hahn V, Sharma K, Pearce EL, Kass DA
medRxiv : the preprint server for health sciences 2023 Oct 2;

Glioblastoma glycolytic signature predicts unfavorable prognosis, immunological heterogeneity, and ENO1 promotes microglia M2 polarization and cancer cell malignancy.

Liang X, Wang Z, Dai Z, Zhang H, Zhang J, Luo P, Liu Z, Liu Z, Yang K, Cheng Q, Zhang M
Cancer gene therapy 2023 Mar;30(3):481-496

Zhou Z, Tang J, Lu Y, Jia J, Luo T, Su K, Dai X, Zhang H, Liu O
Cancer cell international 2023 Feb 25;23(1):37

ENO1 promotes liver carcinogenesis through YAP1-dependent arachidonic acid metabolism.

Sun L, Suo C, Zhang T, Shen S, Gu X, Qiu S, Zhang P, Wei H, Ma W, Yan R, Chen R, Jia W, Cao J, Zhang H, Gao P
Nature chemical biology 2023 Dec;19(12):1492-1503

Seven oxidative stress-related genes predict the prognosis of hepatocellular carcinoma.

Miao C, He X, Chen G, Kahlert UD, Yao C, Shi W, Su D, Hu L, Zhang Z
Aging 2023 Dec 14;15(24):15050-15063

Circ_0000235 targets MCT4 to promote glycolysis and progression of bladder cancer by sponging miR-330-5p.

Zhong J, Xu A, Xu P, Su M, Wang P, Liu Z, Li B, Liu C, Jiang N
Cell death discovery 2023 Aug 2;9(1):283

RNA-binding protein ENO1 promotes the tumor progression of gastric cancer by binding to and regulating gastric cancer-related genes.

Wang N, Qiao H, Hao J, Deng C, Zhou N, Yang L, Zeng M, Guan Q
Journal of gastrointestinal oncology 2023 Apr 29;14(2):585-598

Enhanced E6AP-mediated ubiquitination of ENO1 via LINC00663 contributes to radiosensitivity of breast cancer by regulating mitochondrial homeostasis.

Ma J, Zhu J, Li J, Liu J, Kang X, Yu J
Cancer letters 2023 Apr 28;560:216118

The RNA-binding protein landscapes differ between mammalian organs and cultured cells.

Perez-Perri JI, Ferring-Appel D, Huppertz I, Schwarzl T, Sahadevan S, Stein F, Rettel M, Galy B, Hentze MW
Nature communications 2023 Apr 12;14(1):2074

CCDC65, a Gene Knockout that leads to Early Death of Mice, acts as a potentially Novel Tumor Suppressor in Lung Adenocarcinoma.

Zhang Z, Xu P, Hu Z, Fu Z, Deng T, Deng X, Peng L, Xie Y, Long L, Zheng D, Shen P, Zhang M, Gong B, Zhu Z, Lin J, Chen R, Liu Z, Yang H, Li R, Fang W
International journal of biological sciences 2022;18(10):4171-4186

Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity.

Wang R, Li J, Zhang C, Guan X, Qin B, Jin R, Qin L, Xu S, Zhang X, Liu R, Ye Q, Cheng L
Frontiers in oncology 2022;12:821620

FAM126A interacted with ENO1 mediates proliferation and metastasis in pancreatic cancer via PI3K/AKT signaling pathway.

Li Y, Li Y, Luo J, Fu X, Liu P, Liu S, Pan Y
Cell death discovery 2022 May 5;8(1):248

POU6F1 cooperates with RORA to suppress the proliferation of lung adenocarcinoma by downregulation HIF1A signaling pathway.

Xiao W, Geng W, Zhou M, Xu J, Wang S, Huang Q, Sun Y, Li Y, Yang G, Jin Y
Cell death & disease 2022 May 3;13(5):427

Metabolic lactate production coordinates vasculature development and progenitor behavior in the developing mouse neocortex.

Dong X, Zhang Q, Yu X, Wang D, Ma J, Ma J, Shi SH
Nature neuroscience 2022 Jul;25(7):865-875

Riboregulation of Enolase 1 activity controls glycolysis and embryonic stem cell differentiation.

Huppertz I, Perez-Perri JI, Mantas P, Sekaran T, Schwarzl T, Russo F, Ferring-Appel D, Koskova Z, Dimitrova-Paternoga L, Kafkia E, Hennig J, Neveu PA, Patil K, Hentze MW
Molecular cell 2022 Jul 21;82(14):2666-2680.e11

Identification of ENO1 as a prognostic biomarker and molecular target among ENOs in bladder cancer.

Huang Z, Yan Y, Wang T, Wang Z, Cai J, Cao X, Yang C, Zhang F, Wu G, Shen B
Journal of translational medicine 2022 Jul 14;20(1):315

ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1.

Zhang T, Sun L, Hao Y, Suo C, Shen S, Wei H, Ma W, Zhang P, Wang T, Gu X, Li ST, Chen Z, Yan R, Zhang Y, Cai Y, Zhou R, Jia W, Huang F, Gao P, Zhang H
Nature cancer 2022 Jan;3(1):75-89

The long noncoding RNA glycoLINC assembles a lower glycolytic metabolon to promote glycolysis.

Zhu Y, Jin L, Shi R, Li J, Wang Y, Zhang L, Liang CZ, Narayana VK, De Souza DP, Thorne RF, Zhang LR, Zhang XD, Wu M
Molecular cell 2022 Feb 3;82(3):542-554.e6

Long non-coding RNA CTSLP8 mediates ovarian cancer progression and chemotherapy resistance by modulating cellular glycolysis and regulating c-Myc expression through PKM2.

Li X, Zhang Y, Wang X, Lin F, Cheng X, Wang Z, Wang X
Cell biology and toxicology 2022 Dec;38(6):1027-1045

Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-κB signaling.

Tang S, Nie X, Ruan J, Cao Y, Kang J, Ding C
Cell death & disease 2022 Aug 9;13(8):695

α-Enolase reduces cerebrovascular Aβ deposits by protecting Aβ amyloid formation.

Inoue Y, Tasaki M, Masuda T, Misumi Y, Nomura T, Ando Y, Ueda M
Cellular and molecular life sciences : CMLS 2022 Aug 2;79(8):462

KMT5A downregulation participated in High Glucose-mediated EndMT via Upregulation of ENO1 Expression in Diabetic Nephropathy.

Lu L, Li X, Zhong Z, Zhou W, Zhou D, Zhu M, Miao C
International journal of biological sciences 2021;17(15):4093-4107

lncRNA GAS6-AS1 inhibits progression and glucose metabolism reprogramming in LUAD via repressing E2F1-mediated transcription of GLUT1.

Luo J, Wang H, Wang L, Wang G, Yao Y, Xie K, Li X, Xu L, Shen Y, Ren B
Molecular therapy. Nucleic acids 2021 Sep 3;25:11-24

Reciprocal regulation of LOXL2 and HIF1α drives the Warburg effect to support pancreatic cancer aggressiveness.

Li R, Li H, Zhu L, Zhang X, Liu D, Li Q, Ni B, Hu L, Zhang Z, Zhang Y, Wang X, Jiang SH
Cell death & disease 2021 Nov 26;12(12):1106

Knockdown of GTF2E2 inhibits the growth and progression of lung adenocarcinoma via RPS4X in vitro and in vivo.

Bi G, Zhu D, Bian Y, Huang Y, Zhan C, Yang Y, Wang Q
Cancer cell international 2021 Mar 23;21(1):181

FAX-RIC enables robust profiling of dynamic RNP complex formation in multicellular organisms in vivo.

Na Y, Kim H, Choi Y, Shin S, Jung JH, Kwon SC, Kim VN, Kim JS
Nucleic acids research 2021 Mar 18;49(5):e28

Low chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk.

Wang XH, Xu S, Zhou XY, Zhao R, Lin Y, Cao J, Zang WD, Tao H, Xu W, Li MQ, Zhao SM, Jin LP, Zhao JY
Nature communications 2021 Jun 8;12(1):3428

Proteomic and mechanistic study of Qingxuan Tongluo formula and curcumin in the treatment of Mycoplasma pneumoniae pneumonia.

Wei L, Zhong W, Sun T, Li H, Sun T, Han Y, Sun D, Li X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jan;133:110998

Valproic acid Suppresses Breast Cancer Cell Growth Through Triggering Pyruvate Kinase M2 Isoform Mediated Warburg Effect.

Li Z, Yang L, Zhang S, Song J, Sun H, Shan C, Wang D, Liu S
Cell transplantation 2021 Jan-Dec;30:9636897211027524

Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma.

Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K
Cell reports 2020 Oct 20;33(3):108293

Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis.

Li ST, Huang D, Shen S, Cai Y, Xing S, Wu G, Jiang Z, Hao Y, Yuan M, Wang N, Zhu L, Yan R, Yang D, Wang L, Liu Z, Hu X, Zhou R, Qu K, Li A, Duan X, Zhang H, Gao P
Nature metabolism 2020 Mar;2(3):256-269

Fast and unbiased purification of RNA-protein complexes after UV cross-linking.

Urdaneta EC, Beckmann BM
Methods (San Diego, Calif.) 2020 Jun 1;178:72-82

Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1.

Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S, Shan C
Biochemical pharmacology 2020 Aug;178:114092

Accelerated Metabolite Levels of Aerobic Glycolysis and the Pentose Phosphate Pathway Are Required for Efficient Replication of Infectious Spleen and Kidney Necrosis Virus in Chinese Perch Brain Cells.

Guo X, Wu S, Li N, Lin Q, Liu L, Liang H, Niu Y, Huang Z, Fu X
Biomolecules 2019 Sep 2;9(9)

Purification of cross-linked RNA-protein complexes by phenol-toluol extraction.

Urdaneta EC, Vieira-Vieira CH, Hick T, Wessels HH, Figini D, Moschall R, Medenbach J, Ohler U, Granneman S, Selbach M, Beckmann BM
Nature communications 2019 Mar 1;10(1):990

Enolase-1 serves as a biomarker of diagnosis and prognosis in hepatocellular carcinoma patients.

Zhu W, Li H, Yu Y, Chen J, Chen X, Ren F, Ren Z, Cui G
Cancer management and research 2018;10:5735-5745

Gamma-enolase predicts lung damage in severe acute pancreatitis-induced acute lung injury.

Owusu L, Xu C, Chen H, Liu G, Zhang G, Zhang J, Tang Z, Sun Z, Yi X
Journal of molecular histology 2018 Aug;49(4):347-356

Upregulation of α-enolase protects cardiomyocytes from phenylephrine-induced hypertrophy.

Gao S, Liu XP, Wei LH, Lu J, Liu P
Canadian journal of physiology and pharmacology 2018 Apr;96(4):352-358

Functional Effects of Cigarette Smoke-Induced Changes in Airway Smooth Muscle Mitochondrial Morphology.

Aravamudan B, Thompson M, Sieck GC, Vassallo R, Pabelick CM, Prakash YS
Journal of cellular physiology 2017 May;232(5):1053-1068

CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.

Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825

Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with 11204-1-AP(ENO1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using ENO1 antibody 11204-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: IP Result of anti-ENO1 (IP:11204-1-AP, 3ug; Detection:11204-1-AP 1:500) with mouse skeletal muscle tissue lysate 3500ug.
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 11204-1-AP(ENO1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue