21652-1-AP

antibody from Proteintech Group

Targeting: TNNI3 CMD2A, CMH7, TNNC1

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Data presented on provider website)

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Supportive data in Antibodypedia)

Antibody Data

Product number

21652-1-AP

Provider

Proteintech Group

Product name

Cardiac Troponin I antibody

Antibody type

Polyclonal

Description

Cardiac Troponin I antibody (Cat. #21652-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

SIRT3 regulates cardiolipin biosynthesis in pressure overload-induced cardiac remodeling by PPARγ-mediated mechanism.

Liu LX, Zheng XH, Hai JH, Zhang CM, Ti Y, Chen TS, Bu PL
PloS one 2024;19(4):e0301990

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Abundant Neutrophil-Initiated Acute Myocardial Injury Following Coxsackievirus A6 Infection.

Zhang Y, Chen S, Sun T, Duan G, Yang H, Feng H, Jiang W, Li D, Ji W, Zhu P, Jin Y
The Journal of infectious diseases 2024 May 15;229(5):1440-1450

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Ion cocktail therapy for myocardial infarction by synergistic regulation of both structural and electrical remodeling.

Que Y, Shi J, Zhang Z, Sun L, Li H, Qin X, Zeng Z, Yang X, Chen Y, Liu C, Liu C, Sun S, Jin Q, Zhang Y, Li X, Lei M, Yang C, Tian H, Tian J, Chang J
Exploration (Beijing, China) 2024 Jun;4(3):20230067

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Gene correction and overexpression of TNNI3 improve impaired relaxation in engineered heart tissue model of pediatric restrictive cardiomyopathy.

Hasegawa M, Miki K, Kawamura T, Takei Sasozaki I, Higashiyama Y, Tsuchida M, Kashino K, Taira M, Ito E, Takeda M, Ishida H, Higo S, Sakata Y, Miyagawa S
Development, growth & differentiation 2024 Feb;66(2):119-132

---

An Alternating Current Electroosmotic Flow-Based Ultrasensitive Electrochemiluminescence Microfluidic System for Ultrafast Monitoring, Detection of Proteins/miRNAs in Unprocessed Samples.

Xiong H, Zhu C, Dai C, Ye X, Li Y, Li P, Yang S, Ashraf G, Wei D, Chen H, Shen H, Kong J, Fang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Feb;11(6):e2307840

---

USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice.

Yan M, Mei Y, Zhang T, Liu Z, Su L, Xiao Y, Zhong X, Lu Y
International journal of cardiology 2024 Aug 1;408:132149

---

Thiamine-modified metabolic reprogramming of human pluripotent stem cell-derived cardiomyocyte under space microgravity.

Han X, Qu L, Yu M, Ye L, Shi L, Ye G, Yang J, Wang Y, Fan H, Wang Y, Tan Y, Wang C, Li Q, Lei W, Chen J, Liu Z, Shen Z, Li Y, Hu S
Signal transduction and targeted therapy 2024 Apr 8;9(1):86

---

Low-noise fluorescent detection of cardiac troponin I in human serum based on surface acoustic wave separation.

Chen X, Zhang C, Liu X, Dong Y, Meng H, Qin X, Jiang Z, Wei X
Microsystems & nanoengineering 2023;9:141

---

DNA methylation cooperates with H3K9me2 at HCN4 promoter to regulate the differentiation of bone marrow mesenchymal stem cells into pacemaker-like cells.

Sun X, Jin K, Ding X, Ruan Z, Xu P
PloS one 2023;18(8):e0289510

---

RBM25 regulates hypoxic cardiomyocyte apoptosis through CHOP-associated endoplasmic reticulum stress.

Zhu Z, Pu J, Li Y, Chen J, Ding H, Zhou A, Zhang X
Cell stress & chaperones 2023 Nov;28(6):861-876

---

Pathological implication of CaMKII in NF-κB pathway and SASP during cardiomyocytes senescence.

Li T, Meng Y, Ding P, Wang H, Liu J, Xia C, Chen Y, Li J
Mechanisms of ageing and development 2023 Jan;209:111758

---

Nrf2 attenuates methamphetamine-induced myocardial injury by regulating oxidative stress and apoptosis in mice.

Yu H, Peng Y, Dong W, Shen B, Yang G, Nie Q, Tian Y, Qin L, Song C, Chen B, Zhao Y, Li L, Hong S
Human & experimental toxicology 2023 Jan-Dec;42:9603271231219488

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Platelet Internalization Mediates Ferroptosis in Myocardial Infarction.

Miao S, Zhang Q, Ding W, Hou B, Su Z, Li M, Yang L, Zhang J, Chang W, Wang J
Arteriosclerosis, thrombosis, and vascular biology 2023 Feb;43(2):218-230

---

G9a inhibition promotes the formation of pacemaker-like cells by reducing the enrichment of H3K9me2 in the HCN4 promoter region.

Xu P, Jin K, Zhou J, Gu J, Gu X, Dong L, Sun X
Molecular medicine reports 2023 Feb;27(2)

---

Hydroxyurea protects against diabetic cardiomyopathy by inhibiting inflammation and apoptosis.

Zhou Y, Lu Q
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113291

---

Cannabidiol attenuates methamphetamine-induced cardiac inflammatory response through the PKA/CREB pathway in rats.

Nie Q, Dong W, Shen B, Yang G, Yu H, Zhang R, Peng Y, Yu Y, Hong S, Li L
Annals of translational medicine 2022 Sep;10(18):985

---

Exploration of the amino acid metabolic signature in anthracycline-induced cardiotoxicity using an optimized targeted metabolomics approach based on UPLC-MS/MS.

Li W, Li S, Cao Z, Sun Y, Qiu W, Jia M, Su M
Naunyn-Schmiedeberg's archives of pharmacology 2022 Oct;395(10):1209-1224

---

Epididymal white adipose tissue promotes angiotensin II-induced cardiac fibrosis in an exosome-dependent manner.

Su M, Li W, Yuan Y, Liu S, Liang C, Liu HE, Zhang R, Liu Y, Sun LI, Wei Y, Li C, Han X, Hao H, Zhao X, Luo Y, Yan S, Pan Z, Li Y
Translational research : the journal of laboratory and clinical medicine 2022 Oct;248:51-67

---

Engineering of thick human functional myocardium via static stretching and electrical stimulation.

Pretorius D, Kahn-Krell AM, LaBarge WC, Lou X, Zhang J
iScience 2022 Mar 18;25(3):103824

---

Pharmacological activation of estrogenic receptor G protein-coupled receptor 30 attenuates angiotensin II-induced atrial fibrosis in ovariectomized mice by modulating TGF-β1/smad pathway.

Liu D, Zhan Y, Ono K, Yin Y, Wang L, Wei M, Ji L, Liu M, Liu G, Zhou X, Zheng M
Molecular biology reports 2022 Jul;49(7):6341-6355

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The interaction protein of SORBS2 in myocardial tissue to find out the pathogenic mechanism of LVNC disease.

Li C, Zheng Y, Liu Y, Jin GH, Pan H, Yin F, Wu J
Aging 2022 Jan 20;14(2):800-810

---

Triggering receptor expressed on myeloid cells-2 promotes survival of cardiomyocytes after myocardial ischemic injury through PI3K/AKT pathway.

Fu C, Xu Q, Liu J, Tang S, Liu C, Cao Y
Cardiovascular diagnosis and therapy 2022 Feb;12(1):24-36

---

Indoxyl sulfate reduces Ito,f by activating ROS/MAPK and NF-κB signaling pathways.

Yang J, Li H, Zhang C, Zhou Y
JCI insight 2022 Feb 8;7(3)

---

A Modified Surgical Ventricular Reconstruction in Post-infarction Mice Persistently Alleviates Heart Failure and Improves Cardiac Regeneration.

Ma S, Yan J, Yang D, Liao W, Bin J, Lin H, Liao Y
Frontiers in cardiovascular medicine 2021;8:789493

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A Neonatal Mouse Model for Pressure Overload: Myocardial Response Corresponds to Severity.

Gu J, Chen X, Jin Y, Liu M, Xu Q, Liu X, Luo Z, Ling S, Liu N, Liu S
Frontiers in cardiovascular medicine 2021;8:660246

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Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model.

Ji W, Zhu P, Liang R, Zhang L, Zhang Y, Wang Y, Zhang W, Tao L, Chen S, Yang H, Jin Y, Duan G
Viruses 2021 Aug 11;13(8)

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CD38 Causes Autophagic Flux Inhibition and Cardiac Dysfunction Through a Transcriptional Inhibition Pathway Under Hypoxia/Ischemia Conditions.

Zhang X, Li L, Zhang Q, Wei Q, Lin J, Jia J, Zhang J, Yan T, Lv Y, Jiang X, Zhang P, Song H, Zhang D, Huang Y
Frontiers in cell and developmental biology 2020;8:191

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Improving the reproducibility, accuracy, and stability of an electrochemical biosensor platform for point-of-care use.

Chen LC, Wang E, Tai CS, Chiu YC, Li CW, Lin YR, Lee TH, Huang CW, Chen JC, Chen WL
Biosensors & bioelectronics 2020 May 1;155:112111

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Elevated myocardial SORBS2 and the underlying implications in left ventricular noncompaction cardiomyopathy.

Li C, Liu F, Liu S, Pan H, Du H, Huang J, Xie Y, Li Y, Zhao R, Wei Y
EBioMedicine 2020 Mar;53:102695

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Localized injection of miRNA-21-enriched extracellular vesicles effectively restores cardiac function after myocardial infarction.

Song Y, Zhang C, Zhang J, Jiao Z, Dong N, Wang G, Wang Z, Wang L
Theranostics 2019;9(8):2346-2360

---

Exosomes derived from cardiac progenitor cells attenuate CVB3-induced apoptosis via abrogating the proliferation of CVB3 and modulating the mTOR signaling pathways.

Li X, Yang Z, Nie W, Jiang J, Li S, Li Z, Tian L, Ma X
Cell death & disease 2019 Sep 18;10(10):691

---

PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.

Gu S, Hua H, Guo X, Jia Z, Zhang Y, Maslov LN, Zhang X, Ma H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902

---

Microtubule associated protein 4 phosphorylation leads to pathological cardiac remodeling in mice.

Li L, Zhang Q, Zhang X, Zhang J, Wang X, Ren J, Jia J, Zhang D, Jiang X, Zhang J, Mei H, Chen B, Hu J, Huang Y
EBioMedicine 2018 Nov;37:221-235

---

miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury.

Shi J, Bei Y, Kong X, Liu X, Lei Z, Xu T, Wang H, Xuan Q, Chen P, Xu J, Che L, Liu H, Zhong J, Sluijter JP, Li X, Rosenzweig A, Xiao J
Theranostics 2017;7(3):664-676

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

mouse heart tissue were subjected to SDS PAGE followed by western blot with 21652-1-AP(TNNI3 antibody) at dilution of 1:1000

Sample type

tissue

Immunohistochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunohistochemical of paraffin-embedded human heart using 21652-1-AP(TNNI3 antibody) at dilution of 1:50 (under 10x lens)

Sample type

tissue

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

The TNNI3 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human TNNI3. This antibody recognizes human, mouse, rat antigen. The TNNI3 antibody has been validated for the following applications: ELISA, WB, IHC analysis.

Appendix

21652-1-AP.pdf

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