Explore
Validate
LearnTissue expression
Cell line expression
Protein structure
TNNI2
Troponin I2, fast skeletal typeAMCD2B, DA2B, FSSV
This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
Top validated antibodies |
|||||
| antibodies-online |  ABIN1107195 |
2 references | Monoclonal |
WB
EL
IHC
FC
|
|
| Proteintech Group | 22130-1-AP |
4 references | Polyclonal |
WB
EL
IP
IHC
|
|
| LSBio | LS-C169427 |
Monoclonal |
WB
EL
IHC
|
||
| OriGene | AM06710PU-N |
Monoclonal |
WB
EL
ICC
IHC
FC
|
||
| Acris Antibodies GmbH | AM06710PU-N |
Monoclonal |
WB
EL
ICC
IHC
FC
|
||
All Antibodies
Filters
Enhanced validation Supportive data in Antibodypedia Data presented on provider website
Data in Antibodypedia (inconclusive) Recommended by provider