NMB

This gene encodes a member of the bombesin-like family of neuropeptides, which negatively regulate eating behavior. The encoded protein may regulate colonic smooth muscle contraction through binding to its cognate receptor, the neuromedin B receptor (NMBR). Polymorphisms of this gene may be associated with hunger, weight gain and obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Description

Neuromedin B

Tissue specificity

Tissue enhanced (adipose tissue, brain)

Subcell location

Nucleoplasm, Vesicles, Plasma membrane

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

15 (84655129 - 84658563)

Ensembl ID

ENSG00000197696  (ver. 103.38)

Orthologs

Mouse Nmb: ENSMUSG00000025723

UniProt

P08949

neXtProt

NX_P08949

Human splice variants
Mouse splice variants

Protein structure