DCABH-20080

antibody from Creative Diagnostics

Targeting: SERPINB3 HsT1196, SCC, SCCA1, T4-A

ELISA (Recommended by provider)

Antibody Data

Product number

DCABH-20080

Provider

Creative Diagnostics

Proper citation

Creative Diagnostics Cat#DCABH-20080, RRID:AB_2489696

Product name

Mouse Anti-Human SERPINB3 monoclonal antibody, clone 3

Antibody type

Monoclonal

Description

Serpin B3, also known as Squamous Cell Carcinoma Antigen-1 (SCCA1), is a member of the serpin superfamily of serine protease inhibitors. Serpins primarily inhibit serine proteases and some are known to inhibit caspases and papain-like cysteine proteases. Serpin B3 belongs to the subgroup ovalbumin-related serpins which are involved in the regulation of apoptosis, inflammation, angiogenesis and embryogenesis. Serpin B3 was initially isolated from human cervical squamous cell tissue. It is a tumor marker for squamous cell carcinomas in various areas including the cervix, head, neck and lung. Unlike typical serpins, Serpin B3 shows inhibitory activity against papain-like lysosomal cysteine proteases Cathepsin K, L, and S, while lacking inhibitory activity against serine proteases.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3

Concentration

Lot specific

Storage

Store at 4 °C for short term storage. Aliquot and store at -20 °C for long term storage. Avoid repeated freeze/thaw cycles.