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- Antigen structure
- References [12]
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- Validations
- Western blot [2]
- Immunohistochemistry [2]
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- Product number
- 15420-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15420-1-AP, RRID:AB_2176874
- Product name
- RAB2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated RAB2 antibody (Cat. #15420-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references C9orf72-catalyzed GTP loading of Rab39A enables HOPS-mediated membrane tethering and fusion in mammalian autophagy.
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.
Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells.
Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the Brucella Intracellular Cycle.
Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication.
Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2.
Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Zhang S, Tong M, Zheng D, Huang H, Li L, Ungermann C, Pan Y, Luo H, Lei M, Tang Z, Fu W, Chen S, Liu X, Zhong Q
Nature communications 2023 Oct 11;14(1):6360
Nature communications 2023 Oct 11;14(1):6360
Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes.
Schleinitz A, Pöttgen LA, Keren-Kaplan T, Pu J, Saftig P, Bonifacino JS, Haas A, Jeschke A
Cell reports 2023 Jan 31;42(1):111969
Cell reports 2023 Jan 31;42(1):111969
Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells.
Xiang C, Chen P, Zhang Q, Li Y, Pan Y, Xie W, Sun J, Liu Z
iScience 2021 Aug 20;24(8):102849
iScience 2021 Aug 20;24(8):102849
Epistatic Interplay between Type IV Secretion Effectors Engages the Small GTPase Rab2 in the Brucella Intracellular Cycle.
Smith EP, Cotto-Rosario A, Borghesan E, Held K, Miller CN, Celli J
mBio 2020 Mar 31;11(2)
mBio 2020 Mar 31;11(2)
Pin1 inhibition exerts potent activity against acute myeloid leukemia through blocking multiple cancer-driving pathways.
Lian X, Lin YM, Kozono S, Herbert MK, Li X, Yuan X, Guo J, Guo Y, Tang M, Lin J, Huang Y, Wang B, Qiu C, Tsai CY, Xie J, Gao ZJ, Wu Y, Liu H, Zhou XZ, Lu KP, Chen Y
Journal of hematology & oncology 2018 May 30;11(1):73
Journal of hematology & oncology 2018 May 30;11(1):73
Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
Kozono S, Lin YM, Seo HS, Pinch B, Lian X, Qiu C, Herbert MK, Chen CH, Tan L, Gao ZJ, Massefski W, Doctor ZM, Jackson BP, Chen Y, Dhe-Paganon S, Lu KP, Zhou XZ
Nature communications 2018 Aug 9;9(1):3069
Nature communications 2018 Aug 9;9(1):3069
A Brucella Type IV Effector Targets the COG Tethering Complex to Remodel Host Secretory Traffic and Promote Intracellular Replication.
Miller CN, Smith EP, Cundiff JA, Knodler LA, Bailey Blackburn J, Lupashin V, Celli J
Cell host & microbe 2017 Sep 13;22(3):317-329.e7
Cell host & microbe 2017 Sep 13;22(3):317-329.e7
Rab2a and Rab27a cooperatively regulate the transition from granule maturation to exocytosis through the dual effector Noc2.
Matsunaga K, Taoka M, Isobe T, Izumi T
Journal of cell science 2017 Feb 1;130(3):541-550
Journal of cell science 2017 Feb 1;130(3):541-550
Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance.
Ueda N, Tomita T, Yanagisawa K, Kimura N
Journal of neurochemistry 2016 May;137(4):647-58
Journal of neurochemistry 2016 May;137(4):647-58
Disruption of the AMPK-TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion.
Chen L, Chen Q, Xie B, Quan C, Sheng Y, Zhu S, Rong P, Zhou S, Sakamoto K, MacKintosh C, Wang HY, Chen S
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7219-24
Proceedings of the National Academy of Sciences of the United States of America 2016 Jun 28;113(26):7219-24
RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.
Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G
EMBO reports 2016 Jul;17(7):1061-80
EMBO reports 2016 Jul;17(7):1061-80
The Rab2A GTPase promotes breast cancer stem cells and tumorigenesis via Erk signaling activation.
Luo ML, Gong C, Chen CH, Hu H, Huang P, Zheng M, Yao Y, Wei S, Wulf G, Lieberman J, Zhou XZ, Song E, Lu KP
Cell reports 2015 Apr 7;11(1):111-24
Cell reports 2015 Apr 7;11(1):111-24
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- mouse brain tissue were subjected to SDS PAGE followed by western blot with 15420-1-AP(RAB2A antibody) at dilution of 1:1000
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- rat brain tissue were subjected to SDS PAGE followed by western blot with 15420-1-AP( RAB2A Antibody) at dilution of 1:1000
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human brain using 15420-1-AP(RAB2A antibody) at dilution of 1:100 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The RAB2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human RAB2. This antibody recognizes human,mouse,rat antigen. The RAB2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
