10513-1-AP
antibody from Proteintech Group
Targeting: MCM2
BM28, CCNL1, cdc19, CDCL1, D3S3194, DFNA70, KIAA0030
Antibody data
- Antibody Data
- Antigen structure
- References [37]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
Comment
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- Product number
- 10513-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#10513-1-AP, RRID:AB_2142131
- Product name
- MCM2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated MCM2 antibody (Cat. #10513-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.
YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis.
RNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liver hepatocellular carcinoma cells.
MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer.
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.
Calcyclin-binding protein contributes to cholangiocarcinoma progression by inhibiting ubiquitination of MCM2.
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
circHECTD1 Promotes the Proliferation and Migration of Human Brain Vascular Smooth Muscle Cells via Interacting with KHDRBS3 to Stabilize EZH2 mRNA Expression.
Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma.
LncRNA AGPG Confers Endocrine Resistance in Breast Cancer by Promoting E2F1 Activity.
Molecular subtypes identified by multiomics analysis based on cuproptosis-related genes precisely predict response to immunotherapy and chemotherapy in colorectal cancer.
DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation.
Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening.
O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N(6)-methyladenosine-dependent manner.
Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis.
FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination.
Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation.
The Novel lncRNA RP9P Promotes Colorectal Cancer Progression by Modulating miR-133a-3p/FOXQ1 Axis.
Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.
Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes.
CDC7-independent G1/S transition revealed by targeted protein degradation.
LncRNA HAR1A Suppresses the Development of Non-Small Cell Lung Cancer by Inactivating the STAT3 Pathway.
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer.
Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function.
The influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis.
Dysregulation of phosphoproteins in hepatocellular carcinoma revealed via quantitative analysis of the phosphoproteome.
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation.
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
MCMs expression in lung cancer: implication of prognostic significance.
Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis.
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors.
Liu Y, Jiang H, Hu K, Zou H, Zhang W, Liu J, Jian X
PloS one 2024;19(4):e0298947
PloS one 2024;19(4):e0298947
YTHDF1 promotes gallbladder cancer progression via post-transcriptional regulation of the m6A/UHRF1 axis.
Chen J, Bai X, Zhang W, Yan Z, Liu Y, Zhou S, Wu X, He X, Yang A
Journal of cellular and molecular medicine 2024 May;28(9):e18328
Journal of cellular and molecular medicine 2024 May;28(9):e18328
RNF125‑mediated ubiquitination of MCM6 regulates the proliferation of human liver hepatocellular carcinoma cells.
Feng X, Song D, Liu X, Liang Y, Jiang P, Wu S, Liu F
Oncology letters 2024 Mar;27(3):105
Oncology letters 2024 Mar;27(3):105
MTCH2 stimulates cellular proliferation and cycles via PI3K/Akt pathway in breast cancer.
Jiang W, Miao Y, Xing X, Liu S, Xing W, Qian F
Heliyon 2024 Mar 30;10(6):e28172
Heliyon 2024 Mar 30;10(6):e28172
ACAT2 suppresses the ubiquitination of YAP1 to enhance the proliferation and metastasis ability of gastric cancer via the upregulation of SETD7.
Zhang M, Cai F, Guo J, Liu S, Ma G, Cai M, Zhang R, Deng J
Cell death & disease 2024 Apr 26;15(4):297
Cell death & disease 2024 Apr 26;15(4):297
Calcyclin-binding protein contributes to cholangiocarcinoma progression by inhibiting ubiquitination of MCM2.
Zhang Y, Liu L, Luo B, Tang H, Yu X, Bao S
Oncology research 2023;31(3):317-331
Oncology research 2023;31(3):317-331
ESRG is critical to maintain the cell survival and self-renewal/pluripotency of hPSCs by collaborating with MCM2 to suppress p53 pathway.
Li S, Liu H, Liu W, Shi N, Zhao M, Wanggou S, Luo W, Wang L, Zhu B, Zuo X, Xie W, Zhao C, Zhou Y, Luo L, Gao X, Jiang X, Ren C
International journal of biological sciences 2023;19(3):916-935
International journal of biological sciences 2023;19(3):916-935
circHECTD1 Promotes the Proliferation and Migration of Human Brain Vascular Smooth Muscle Cells via Interacting with KHDRBS3 to Stabilize EZH2 mRNA Expression.
Feng M, Tu W, Zhou Q, Du Y, Xu K, Wang Y
Journal of inflammation research 2023;16:1311-1323
Journal of inflammation research 2023;16:1311-1323
Significance of NotchScore and JAG1 in predicting prognosis and immune response of low-grade glioma.
Shi B, Ge F, Cai L, Yang Y, Guo X, Wu R, Fan Z, Cao B, Wang N, Si Y, Lin X, Dong W, Sun H
Frontiers in immunology 2023;14:1247288
Frontiers in immunology 2023;14:1247288
LncRNA AGPG Confers Endocrine Resistance in Breast Cancer by Promoting E2F1 Activity.
Yu S, Wang Y, Gong X, Fan Z, Wang Z, Liang Z, Wu R, Cao B, Wang N, Bi C, Lv D, Sun H
Cancer research 2023 Oct 2;83(19):3220-3236
Cancer research 2023 Oct 2;83(19):3220-3236
Molecular subtypes identified by multiomics analysis based on cuproptosis-related genes precisely predict response to immunotherapy and chemotherapy in colorectal cancer.
Li D, Gao W, Zhao W, Zhao Y, Zhang Y, Liu Y, Li Y, Ji S, Chen P, Li D
Molecular carcinogenesis 2023 Nov;62(11):1755-1769
Molecular carcinogenesis 2023 Nov;62(11):1755-1769
DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation.
Xu X, Chang CW, Li M, Omabe K, Le N, Chen YH, Liang F, Liu Y
Nature communications 2023 Mar 4;14(1):1233
Nature communications 2023 Mar 4;14(1):1233
Identifying CDC7 as a synergistic target of chemotherapy in resistant small-cell lung cancer via CRISPR/Cas9 screening.
Deng L, Yang L, Zhu S, Li M, Wang Y, Cao X, Wang Q, Guo L
Cell death discovery 2023 Feb 2;9(1):40
Cell death discovery 2023 Feb 2;9(1):40
O-GlcNAcylation of YTHDF2 promotes HBV-related hepatocellular carcinoma progression in an N(6)-methyladenosine-dependent manner.
Yang Y, Yan Y, Yin J, Tang N, Wang K, Huang L, Hu J, Feng Z, Gao Q, Huang A
Signal transduction and targeted therapy 2023 Feb 10;8(1):63
Signal transduction and targeted therapy 2023 Feb 10;8(1):63
Hypoxia Inhibits Cell Cycle Progression and Cell Proliferation in Brain Microvascular Endothelial Cells via the miR-212-3p/MCM2 Axis.
Shi Q, Li S, Lyu Q, Zhang S, Bai Y, Ma J
International journal of molecular sciences 2023 Feb 1;24(3)
International journal of molecular sciences 2023 Feb 1;24(3)
FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination.
Leung W, Baxley RM, Traband E, Chang YC, Rogers CB, Wang L, Durrett W, Bromley KS, Fiedorowicz L, Thakar T, Tella A, Sobeck A, Hendrickson EA, Moldovan GL, Shima N, Bielinsky AK
Cell reports 2023 Dec 26;42(12):113523
Cell reports 2023 Dec 26;42(12):113523
Overlaid Transcriptional and Proteome Analyses Identify Mitotic Kinesins as Important Targets of Arylsulfonamide-Mediated RBM39 Degradation.
Coomar S, Mota P, Penson A, Schwaller J, Abdel-Wahab O, Gillingham D
Molecular cancer research : MCR 2023 Aug 1;21(8):768-778
Molecular cancer research : MCR 2023 Aug 1;21(8):768-778
The Novel lncRNA RP9P Promotes Colorectal Cancer Progression by Modulating miR-133a-3p/FOXQ1 Axis.
Jin Z, Liu B, Lin B, Yang R, Wu C, Xue W, Zou X, Qian J
Frontiers in oncology 2022;12:843064
Frontiers in oncology 2022;12:843064
Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Pan C, Qin H, Jin H, Chen W, Guo H, Han X
Toxicology 2022 Oct;480:153326
Toxicology 2022 Oct;480:153326
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.
Zhou X, Luo J, Xie H, Wei Z, Li T, Liu J, Liao X, Zhu G, Peng T
Cell death discovery 2022 Oct 15;8(1):418
Cell death discovery 2022 Oct 15;8(1):418
Solving the MCM paradox by visualizing the scaffold of CMG helicase at active replisomes.
Polasek-Sedlackova H, Miller TCR, Krejci J, Rask MB, Lukas J
Nature communications 2022 Oct 14;13(1):6090
Nature communications 2022 Oct 14;13(1):6090
CDC7-independent G1/S transition revealed by targeted protein degradation.
Suski JM, Ratnayeke N, Braun M, Zhang T, Strmiska V, Michowski W, Can G, Simoneau A, Snioch K, Cup M, Sullivan CM, Wu X, Nowacka J, Branigan TB, Pack LR, DeCaprio JA, Geng Y, Zou L, Gygi SP, Walter JC, Meyer T, Sicinski P
Nature 2022 May;605(7909):357-365
Nature 2022 May;605(7909):357-365
LncRNA HAR1A Suppresses the Development of Non-Small Cell Lung Cancer by Inactivating the STAT3 Pathway.
Ma J, Cao K, Ling X, Zhang P, Zhu J
Cancers 2022 Jun 8;14(12)
Cancers 2022 Jun 8;14(12)
In Situ Peroxidase Labeling Followed by Mass-Spectrometry Reveals TIA1 Interactome.
Gourdomichali O, Zonke K, Kattan FG, Makridakis M, Kontostathi G, Vlahou A, Doxakis E
Biology 2022 Feb 11;11(2)
Biology 2022 Feb 11;11(2)
Potential Role of SWI/SNF Complex Subunit Actin-Like Protein 6A in Cervical Cancer.
Wang Q, Cao Z, Wei Y, Zhang J, Cheng Z
Frontiers in oncology 2021;11:724832
Frontiers in oncology 2021;11:724832
Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function.
Vazquez-Villasenor I, Garwood CJ, Simpson JE, Heath PR, Mortiboys H, Wharton SB
The European journal of neuroscience 2021 Nov;54(9):6987-7005
The European journal of neuroscience 2021 Nov;54(9):6987-7005
The influence of phenolic environmental estrogen on the transcriptome of uterine leiomyoma cells: A whole transcriptome profiling-based analysis.
Li Z, Yin H, Shen Y, Ren M, Xu X
Ecotoxicology and environmental safety 2021 Mar 15;211:111945
Ecotoxicology and environmental safety 2021 Mar 15;211:111945
Dysregulation of phosphoproteins in hepatocellular carcinoma revealed via quantitative analysis of the phosphoproteome.
Liu Y, Zhao Q, Xu F, Wang K, Zhao Y, Chen H, He W, Wang W, Zhang J, Zhang J
Oncology letters 2021 Feb;21(2):117
Oncology letters 2021 Feb;21(2):117
TRIM21-mediated proteasomal degradation of SAMHD1 regulates its antiviral activity.
Li Z, Huan C, Wang H, Liu Y, Liu X, Su X, Yu J, Zhao Z, Yu XF, Zheng B, Zhang W
EMBO reports 2020 Jan 7;21(1):e47528
EMBO reports 2020 Jan 7;21(1):e47528
Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation.
Chai N, Zhang H, Li L, Yu X, Liu Y, Lin Y, Wang L, Yan J, Nikolaevna SE, Zhao Y
Oxidative medicine and cellular longevity 2019;2019:5406468
Oxidative medicine and cellular longevity 2019;2019:5406468
Tmub1 negatively regulates liver regeneration via inhibiting STAT3 phosphorylation.
Fu H, Dong R, Zhang Y, Xu J, Liu M, Chen P
Cellular signalling 2019 Mar;55:65-72
Cellular signalling 2019 Mar;55:65-72
Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis.
Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, Zhang R, Zhong M, Chen C, Su J, Shen W
Biomaterials 2018 Sep;178:23-35
Biomaterials 2018 Sep;178:23-35
MCMs expression in lung cancer: implication of prognostic significance.
Liu YZ, Wang BS, Jiang YY, Cao J, Hao JJ, Zhang Y, Xu X, Cai Y, Wang MR
Journal of Cancer 2017;8(18):3641-3647
Journal of Cancer 2017;8(18):3641-3647
Lamin B2 binding to minichromosome maintenance complex component 7 promotes non-small cell lung carcinogenesis.
Ma Y, Fei L, Zhang M, Zhang W, Liu X, Wang C, Luo Y, Zhang H, Han Y
Oncotarget 2017 Dec 1;8(62):104813-104830
Oncotarget 2017 Dec 1;8(62):104813-104830
A panel of protein markers for the early detection of lung cancer with bronchial brushing specimens.
Liu YZ, Jiang YY, Wang BS, Hao JJ, Shang L, Zhang TT, Cao J, Xu X, Zhan QM, Wang MR
Cancer cytopathology 2014 Nov;122(11):833-41
Cancer cytopathology 2014 Nov;122(11):833-41
Non-steroidal anti-inflammatory drugs decrease E2F1 expression and inhibit cell growth in ovarian cancer cells.
Valle BL, D'Souza T, Becker KG, Wood WH 3rd, Zhang Y, Wersto RP, Morin PJ
PloS one 2013;8(4):e61836
PloS one 2013;8(4):e61836
Identification of genes associated with local aggressiveness and metastatic behavior in soft tissue tumors.
Cunha IW, Carvalho KC, Martins WK, Marques SM, Muto NH, Falzoni R, Rocha RM, Aguiar S, Simoes AC, Fahham L, Neves EJ, Soares FA, Reis LF
Translational oncology 2010 Feb;3(1):23-32
Translational oncology 2010 Feb;3(1):23-32
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 10513-1-AP(MCM2 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The MCM2 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human MCM2. This antibody recognizes human,mouse,rat antigen. The MCM2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.