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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [2]
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- Product number
- 602201 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#602201, RRID:AB_2141956
- Product name
- Purified anti-MCM2
- Antibody type
- Polyclonal
- Antigen
- Recombinant (partial), C-terminal
- Description
- The MCM2 protein (minichromosome maintenance protein 2) is a 120 kD member of the MCM family that forms a heterotetramer with other family members. This nuclear protein functions in eukaryotic genome replication. MCM2 forms a complex with MCM4, MCM6, and MCM7. MCM2 regulates the helicase activity of the pre-replication complex and is involved in the formation of replication forks. MCM2 is regulated by protein kinases Cdc2 and Cdc7 and can be modified by phosphorylation. The Poly6022 antibody recognizes the C-terminal region of both human and mouse MCM2 and has been shown to be useful for Western blotting.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Vial size
- 50 µl
- Storage
- Upon receipt, store frozen at -20° C.
Submitted references Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress.
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.
Song B, Liu XS, Davis K, Liu X
Molecular and cellular biology 2011 Dec;31(23):4844-56
Molecular and cellular biology 2011 Dec;31(23):4844-56
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing.
Wu ZQ, Liu X
Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 12;105(6):1919-24
Proceedings of the National Academy of Sciences of the United States of America 2008 Feb 12;105(6):1919-24
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