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Learn16554-1-AP
antibody from Proteintech Group
Targeting: CYP19A1
ARO, ARO1, aromatase, CPV1, CYAR, CYP19, P-450AROM
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [33]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 16554-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16554-1-AP, RRID:AB_2088670
- Product name
- CYP19A1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated CYP19A1 antibody (Cat. #16554-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Metabolomic changes following PMSG-induced estrus synchronization in Qianbei Ma goats.
Circadian rhythm disruption induces PCOS-like phenotypes by interfering with ovarian steroid hormone synthesis pathways.
Macrophage Membrane-Cloaked, ROS-Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome.
Effects of dietary protein level on reproductive performance, transcriptomics and metabolomics of ovaries of female northern snakehead (Channa argus) broodstock.
Alpha-ketoglutarate enhances the proliferation and steroidogenic capacities of Tan sheep granulosa cells through autophagy pathway regulation.
An insulin receptor activity surge in follicle cells drives vitellogenesis by upregulating CrebA.
Propofol-mediated inhibition of ovarian function by mitophagy over-activation via TGF-β1/SMAD2/3 signaling pathway.
Integrating serum pharmacochemistry, network pharmacology, and metabolomics to explore the protective mechanism of Hua-Feng-Dan in ischemic stroke.
Up-regulated WNT5A in PCOS affects steroidogenesis, proliferation and apoptosis of granulosa cells through the PI3K/AKT pathway.
A novel nuclear receptor NR1D1 suppresses HSD17B12 transcription to regulate granulosa cell apoptosis and autophagy via the AMPK pathway in sheep.
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis.
High-Calorie Diet Exacerbates the Crosstalk Between Gestational Diabetes and Youth-Onset Diabetes in Female Offspring Through Disrupted Estrogen Signaling.
Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells.
Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development.
Gut-ovary axis and multiomic insights into PCOS in a DHEA-induced rat model.
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Circulating Interleukin-6 Mediates PM(2.5)-Induced Ovarian Injury by Suppressing the PPARγ Pathway.
The therapeutic effect of anti-CD19 antibody on DHEA-induced PCOS mice.
mTORC1 accelerates osteosarcoma progression via m(6)A-dependent stabilization of USP7 mRNA.
Integrated analysis of single-cell and bulk RNA-sequencing reveals a novel signature based on NK cell marker genes to predict prognosis and immunotherapy response in gastric cancer.
BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose and NaNO(2).
T(reg) deficiency-mediated T(H) 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells.
Effects of the FABP4 gene on steroid hormone secretion in goose ovarian granulosa cells.
The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress.
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.
CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.
Hormonal changes and folliculogenesis in female offspring of rats exposed to cadmium during gestation and lactation.
The relationship of bone-tumor-induced spinal cord astrocyte activation and aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice.
Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure.
Estrogen Secreted by Mesenchymal Stem Cells Necessarily Determines Their Feasibility of Therapeutical Application.
Colocalization of aromatase in spinal cord astrocytes: differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor.
Qiao FX, Ju YH, Wang XD, An PC, Ji Q, Li RY, Zeng TJ, Liu Q, Zhang DY, Feng ZH, Cao MS, Chen X
Animal reproduction science 2026 May;288:108145
Animal reproduction science 2026 May;288:108145
Circadian rhythm disruption induces PCOS-like phenotypes by interfering with ovarian steroid hormone synthesis pathways.
Feng C, Guo L, Gao X, Ji X, Liu Y, Liu J, Liu S, Liu Y, Ma L, He X
The Journal of steroid biochemistry and molecular biology 2026 May;259:106980
The Journal of steroid biochemistry and molecular biology 2026 May;259:106980
Macrophage Membrane-Cloaked, ROS-Triggered Quercetin Nanocarriers Target Ovarian Lesions to Treat Polycystic Ovary Syndrome.
Li W, Guan Y, Song N, Zhang F, Deng Z, Yin T, Yang Y, Conde J, Jin W, Yin Z
Advanced healthcare materials 2026 May;15(17):e05171
Advanced healthcare materials 2026 May;15(17):e05171
Effects of dietary protein level on reproductive performance, transcriptomics and metabolomics of ovaries of female northern snakehead (Channa argus) broodstock.
Fei S, Zhang J, Liu H, Luo Q, Zhao J, Ou M
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2026 Mar;24:164-176
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2026 Mar;24:164-176
Alpha-ketoglutarate enhances the proliferation and steroidogenic capacities of Tan sheep granulosa cells through autophagy pathway regulation.
Wang J, Wang L, Zhao M, Min S, Yan Y, He J, Song H, Liu X, Chen Q
The Journal of steroid biochemistry and molecular biology 2026 Jun;260:106991
The Journal of steroid biochemistry and molecular biology 2026 Jun;260:106991
An insulin receptor activity surge in follicle cells drives vitellogenesis by upregulating CrebA.
Wang X, Liu H, Yin Z, Shao T, Li L, Ma J, He F
EMBO reports 2026 Feb;27(3):748-773
EMBO reports 2026 Feb;27(3):748-773
Propofol-mediated inhibition of ovarian function by mitophagy over-activation via TGF-β1/SMAD2/3 signaling pathway.
Miao L, Chen M, Zhou Y, Pan S, Li X, Wang Y, Zhang J, Zhu X
Cellular signalling 2025 Oct;134:111916
Cellular signalling 2025 Oct;134:111916
Integrating serum pharmacochemistry, network pharmacology, and metabolomics to explore the protective mechanism of Hua-Feng-Dan in ischemic stroke.
Yuan X, He X, Shu Q, Gao Y, Chen Y, Xu J, Zhang Y, Cao G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157251
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157251
Up-regulated WNT5A in PCOS affects steroidogenesis, proliferation and apoptosis of granulosa cells through the PI3K/AKT pathway.
Li Y, Liu Z, Tan Y, Chen Y, Huang Z, Chen Y
Journal of ovarian research 2025 Nov 14;18(1):262
Journal of ovarian research 2025 Nov 14;18(1):262
A novel nuclear receptor NR1D1 suppresses HSD17B12 transcription to regulate granulosa cell apoptosis and autophagy via the AMPK pathway in sheep.
Cai Y, Xu H, Deng K, Yang H, Zhao B, Zhang C, Li S, Wei Z, Wang Z, Wang F, Zhang Y
International journal of biological macromolecules 2025 May;306(Pt 1):141271
International journal of biological macromolecules 2025 May;306(Pt 1):141271
AMH regulates granulosa cell function via ESR2/ p38-MAPK signaling pathway in sheep.
Xu H, Cai Y, Yang H, Zhang C, Liu W, Zhao B, Wang F, Zhang Y
Communications biology 2025 May 29;8(1):824
Communications biology 2025 May 29;8(1):824
LncRNA NEAT1 participates in diminished ovarian reserve by affecting granulosa cell apoptosis and estradiol synthesis via the miR-204-5p/ESR1 axis.
Dong L, Wu H, Qi F, Chen W, Xu Y, Li M, Wang Y, Yan R, Cai P
Journal of ovarian research 2025 May 16;18(1):102
Journal of ovarian research 2025 May 16;18(1):102
High-Calorie Diet Exacerbates the Crosstalk Between Gestational Diabetes and Youth-Onset Diabetes in Female Offspring Through Disrupted Estrogen Signaling.
Jia X, Cao X, Wang Y, Yang S, Ji L
Nutrients 2025 Jun 26;17(13)
Nutrients 2025 Jun 26;17(13)
Effects of PPARG on the proliferation, apoptosis, and estrogen secretion in goat granulosa cells.
Zhao J, Xu Y, Yu H, Li X, Wang W, Mao D
Theriogenology 2025 Jan 1;231:62-72
Theriogenology 2025 Jan 1;231:62-72
Genetic loss of Uchl1 leads to female infertility by affecting oocyte quality and follicular development.
Luo J, Zhang J, Zhang Y, Li M, Yu L, Song D, Sun Z
Molecular and cellular endocrinology 2025 Feb 1;597:112440
Molecular and cellular endocrinology 2025 Feb 1;597:112440
Gut-ovary axis and multiomic insights into PCOS in a DHEA-induced rat model.
Chen Z, Lu Q, Lin A, Tan M, Li W, Tang S, Feng J, Hou C, Zhu Y, Xu M, Liu T, Xia M
Scientific reports 2025 Dec 8;16(1):1191
Scientific reports 2025 Dec 8;16(1):1191
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L
Journal of ovarian research 2025 Apr 26;18(1):85
Journal of ovarian research 2025 Apr 26;18(1):85
Circulating Interleukin-6 Mediates PM(2.5)-Induced Ovarian Injury by Suppressing the PPARγ Pathway.
Chen Y, Zhang J, Zhang T, Wu Y, Xi Y, Wu T, Li M, Li Y, Zhou S, Wu M, Wang S
Research (Washington, D.C.) 2024;7:0538
Research (Washington, D.C.) 2024;7:0538
The therapeutic effect of anti-CD19 antibody on DHEA-induced PCOS mice.
Wang T, Xiong X, Xiao N, Yan Y, Liu X, Xie Q, Su X, Chen M, Peng J, Wang S, Mei H, Lin G, Gong F, Cheng L
International immunopharmacology 2024 Mar 30;130:111711
International immunopharmacology 2024 Mar 30;130:111711
mTORC1 accelerates osteosarcoma progression via m(6)A-dependent stabilization of USP7 mRNA.
Yang Z, Yu W, Xu A, Liu B, Jin L, Tao H, Wang D
Cell death discovery 2024 Mar 11;10(1):127
Cell death discovery 2024 Mar 11;10(1):127
Integrated analysis of single-cell and bulk RNA-sequencing reveals a novel signature based on NK cell marker genes to predict prognosis and immunotherapy response in gastric cancer.
Sun JR, Kong CF, Ye YX, Wang Q, Qu XK, Jia LQ, Wu S
Scientific reports 2024 Apr 1;14(1):7648
Scientific reports 2024 Apr 1;14(1):7648
BaZiBuShen alleviates altered testicular morphology and spermatogenesis and modulates Sirt6/P53 and Sirt6/NF-κB pathways in aging mice induced by D-galactose and NaNO(2).
Li L, Chen B, An T, Zhang H, Xia B, Li R, Zhu R, Tian Y, Wang L, Zhao D, Mo F, Li Y, Yang G, Orekhov AN, Prentki M, Zhang D, Jiang G, Zhu X
Journal of ethnopharmacology 2021 May 10;271:113810
Journal of ethnopharmacology 2021 May 10;271:113810
T(reg) deficiency-mediated T(H) 1 response causes human premature ovarian insufficiency through apoptosis and steroidogenesis dysfunction of granulosa cells.
Jiao X, Zhang X, Li N, Zhang D, Zhao S, Dang Y, Zanvit P, Jin W, Chen ZJ, Chen W, Qin Y
Clinical and translational medicine 2021 Jun;11(6):e448
Clinical and translational medicine 2021 Jun;11(6):e448
Effects of the FABP4 gene on steroid hormone secretion in goose ovarian granulosa cells.
Fan R, Cao Z, Chen M, Wang H, Liu M, Gao M, Luan X
British poultry science 2021 Feb;62(1):81-91
British poultry science 2021 Feb;62(1):81-91
The Immp2l Mutation Causes Ovarian Aging Through ROS-Wnt/β-Catenin-Estrogen Pathway: Preventive Effect of Melatonin.
He Q, Gu L, Lin Q, Ma Y, Liu C, Pei X, Li PA, Yang Y
Endocrinology 2020 Sep 1;161(9)
Endocrinology 2020 Sep 1;161(9)
Novel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress.
Peng Y, Yang X, Luo X, Liu C, Cao X, Wang H, Guo L
Biological research 2020 Oct 27;53(1):50
Biological research 2020 Oct 27;53(1):50
Elevated maternal androgen is associated with dysfunctional placenta and lipid disorder in newborns of mothers with polycystic ovary syndrome.
Sun M, Sun B, Qiao S, Feng X, Li Y, Zhang S, Lin Y, Hou L
Fertility and sterility 2020 Jun;113(6):1275-1285.e2
Fertility and sterility 2020 Jun;113(6):1275-1285.e2
CYP enzymes, expressed within live human suspension cells, are superior to widely-used microsomal enzymes in identifying potent CYP1A1/CYP1B1 inhibitors: Identification of quinazolinones as CYP1A1/CYP1B1 inhibitors that efficiently reverse B[a]P toxicity and cisplatin resistance.
Sonawane VR, Siddique MUM, Gatchie L, Williams IS, Bharate SB, Jayaprakash V, Sinha BN, Chaudhuri B
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Apr 1;131:177-194
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2019 Apr 1;131:177-194
Hormonal changes and folliculogenesis in female offspring of rats exposed to cadmium during gestation and lactation.
Li Z, Li T, Leng Y, Chen S, Liu Q, Feng J, Chen H, Huang Y, Zhang Q
Environmental pollution (Barking, Essex : 1987) 2018 Jul;238:336-347
Environmental pollution (Barking, Essex : 1987) 2018 Jul;238:336-347
The relationship of bone-tumor-induced spinal cord astrocyte activation and aromatase expression to mechanical hyperalgesia and cold hypersensitivity in intact female and ovariectomized mice.
Smeester BA, O'Brien EE, Michlitsch KS, Lee JH, Beitz AJ
Neuroscience 2016 Jun 2;324:344-54
Neuroscience 2016 Jun 2;324:344-54
Novel WT1 Missense Mutations in Han Chinese Women with Premature Ovarian Failure.
Wang H, Li G, Zhang J, Gao F, Li W, Qin Y, Chen ZJ
Scientific reports 2015 Sep 11;5:13983
Scientific reports 2015 Sep 11;5:13983
Estrogen Secreted by Mesenchymal Stem Cells Necessarily Determines Their Feasibility of Therapeutical Application.
Li J, Peng X, Zeng X, Liu B, Hao Q, Yu X, Zhu L, Hu Q
Scientific reports 2015 Oct 19;5:15286
Scientific reports 2015 Oct 19;5:15286
Colocalization of aromatase in spinal cord astrocytes: differences in expression and relationship to mechanical and thermal hyperalgesia in murine models of a painful and a non-painful bone tumor.
O'Brien EE, Smeester BA, Michlitsch KS, Lee JH, Beitz AJ
Neuroscience 2015 Aug 20;301:235-45
Neuroscience 2015 Aug 20;301:235-45
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- A2780 cells were subjected to SDS PAGE followed by western blot with 16554-1-AP(CYP19A1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human placenta using 16554-1-AP(CYP19A1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The CYP19A1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human CYP19A1. This antibody recognizes human, mouse antigen. The CYP19A1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
