Antibody data
- Antibody Data
- Antigen structure
- References [17]
- Comments [0]
- Validations
- Western blot [2]
- Blocking/Neutralizing [1]
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Validation data
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- Product number
- AF-246-NA - Provider product page
- Provider
- Novus Biologicals
- Product name
- Goat Polyclonal LAP (TGF-beta 1) Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified. Detects human LAP TGF-beta 1 in direct ELISAs and Western blots.
- Reactivity
- Human
- Host
- Goat
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.
Submitted references Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis.
Immune cell expression of TGFβ1 in cancer with lymphoid stroma: dendritic cell and regulatory T cell contact.
Multicolor quantitative confocal imaging cytometry.
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration.
MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells.
Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating Cells.
Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells.
Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation.
TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells.
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.
Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31.
Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.
Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1.
Transforming growth factor-beta signaling in hypertensive remodeling of porcine aorta.
Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils.
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells.
van de Vlekkert D, Demmers J, Nguyen XX, Campos Y, Machado E, Annunziata I, Hu H, Gomero E, Qiu X, Bongiovanni A, Feghali-Bostwick CA, d'Azzo A
Science advances 2019 Jul;5(7):eaav3270
Science advances 2019 Jul;5(7):eaav3270
Immune cell expression of TGFβ1 in cancer with lymphoid stroma: dendritic cell and regulatory T cell contact.
Ohtani H, Terashima T, Sato E
Virchows Archiv : an international journal of pathology 2018 Jun;472(6):1021-1028
Virchows Archiv : an international journal of pathology 2018 Jun;472(6):1021-1028
Multicolor quantitative confocal imaging cytometry.
Coutu DL, Kokkaliaris KD, Kunz L, Schroeder T
Nature methods 2018 Jan;15(1):39-46
Nature methods 2018 Jan;15(1):39-46
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration.
Miroshnychenko O, Chang WT, Dragoo JL
The American journal of sports medicine 2017 Mar;45(4):945-953
The American journal of sports medicine 2017 Mar;45(4):945-953
MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells.
Li CX, Talele NP, Boo S, Koehler A, Knee-Walden E, Balestrini JL, Speight P, Kapus A, Hinz B
Nature materials 2017 Mar;16(3):379-389
Nature materials 2017 Mar;16(3):379-389
Cutting Edge: ERK1 Mediates the Autocrine Positive Feedback Loop of TGF-β and Furin in Glioma-Initiating Cells.
Ventura E, Weller M, Burghardt I
Journal of immunology (Baltimore, Md. : 1950) 2017 Jun 15;198(12):4569-4574
Journal of immunology (Baltimore, Md. : 1950) 2017 Jun 15;198(12):4569-4574
Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells.
Shahinian H, Loessner D, Biniossek ML, Kizhakkedathu JN, Clements JA, Magdolen V, Schilling O
Molecular oncology 2014 Feb;8(1):68-82
Molecular oncology 2014 Feb;8(1):68-82
Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation.
Yasmin N, Bauer T, Modak M, Wagner K, Schuster C, Köffel R, Seyerl M, Stöckl J, Elbe-Bürger A, Graf D, Strobl H
The Journal of experimental medicine 2013 Nov 18;210(12):2597-610
The Journal of experimental medicine 2013 Nov 18;210(12):2597-610
TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells.
Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M, Kuratsu J, Lang FF
Cancer research 2013 Apr 1;73(7):2333-44
Cancer research 2013 Apr 1;73(7):2333-44
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche.
Yamazaki S, Ema H, Karlsson G, Yamaguchi T, Miyoshi H, Shioda S, Taketo MM, Karlsson S, Iwama A, Nakauchi H
Cell 2011 Nov 23;147(5):1146-58
Cell 2011 Nov 23;147(5):1146-58
Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31.
Shen M, Siu S, Byrd S, Edelmann KH, Patel N, Ketchem RR, Mehlin C, Arnett HA, Hasegawa H
Experimental cell research 2011 Apr 15;317(7):976-93
Experimental cell research 2011 Apr 15;317(7):976-93
Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis.
Ha CT, Wu JA, Irmak S, Lisboa FA, Dizon AM, Warren JW, Ergun S, Dveksler GS
Biology of reproduction 2010 Jul;83(1):27-35
Biology of reproduction 2010 Jul;83(1):27-35
Induction of epithelial-mesenchymal transition in primary airway epithelial cells from patients with asthma by transforming growth factor-beta1.
Hackett TL, Warner SM, Stefanowicz D, Shaheen F, Pechkovsky DV, Murray LA, Argentieri R, Kicic A, Stick SM, Bai TR, Knight DA
American journal of respiratory and critical care medicine 2009 Jul 15;180(2):122-33
American journal of respiratory and critical care medicine 2009 Jul 15;180(2):122-33
Transforming growth factor-beta signaling in hypertensive remodeling of porcine aorta.
Popovic N, Bridenbaugh EA, Neiger JD, Hu JJ, Vannucci M, Mo Q, Trzeciakowski J, Miller MW, Fossum TW, Humphrey JD, Wilson E
American journal of physiology. Heart and circulatory physiology 2009 Dec;297(6):H2044-53
American journal of physiology. Heart and circulatory physiology 2009 Dec;297(6):H2044-53
Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils.
Rose DM, Sydlaske AD, Agha-Babakhani A, Johnson K, Terkeltaub R
Arthritis and rheumatism 2006 Oct;54(10):3363-71
Arthritis and rheumatism 2006 Oct;54(10):3363-71
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB
Blood 2005 Jan 15;105(2):750-8
Blood 2005 Jan 15;105(2):750-8
Compromised lymphocytes infiltrate hepatocellular carcinoma: the role of T-regulatory cells.
Unitt E, Rushbrook SM, Marshall A, Davies S, Gibbs P, Morris LS, Coleman N, Alexander GJ
Hepatology (Baltimore, Md.) 2005 Apr;41(4):722-30
Hepatology (Baltimore, Md.) 2005 Apr;41(4):722-30
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human LAP (TGF-ß1) by Simple Western<sup abp="263">TM. Detection of Human LAP (TGF-ß1) by Simple Western<sup abp="263">TM.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Detection of Human LAP (TGF-ß1) by Western Blot. Detection of Human LAP (TGF-ß1) by Western Blot.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- LAP TGF-ß1 Inhibition of TGF-ß1 Activity and Neutralization by Human LAP TGF-ß1 Antibody. LAP TGF-ß1 Inhibition of TGF-ß1 Activity and Neutralization by Human LAP TGF-ß1 Antibody.