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- Antibody Data
- Antigen structure
- References [63]
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- Immunocytochemistry [1]
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- Product number
- MAB240-100 - Provider product page
- Provider
- R&D Systems
- Product name
- TGF-beta 1 Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects TGF-beta 1 from human, mouse, rat, and other species in direct ELISAs and Western blots. In sandwich ELISAs, less than 2% cross-reactivity with recombinant human (rh) TGF-beta 3 and recombinant amphibian TGF-beta 5 and no cross-reactivity with recombinant porcine TGF-beta 2 or rhTGF-beta 2 is observed.
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 9016
- Vial size
- 100 ug
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references Cryptotanshinone Ameliorates Radiation-Induced Lung Injury in Rats.
A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction.
Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts.
Spatio-temporal overview of neuroinflammation in an experimental mouse stroke model.
Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.
Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.
Specific Inhibitor of Smad3 (SIS3) Attenuates Fibrosis, Apoptosis, and Inflammation in Unilateral Ureteral Obstruction Kidneys by Inhibition of Transforming Growth Factor β (TGF-β)/Smad3 Signaling.
CD8α+CD11c+ Extracellular Vesicles in the Lungs Control Immune Homeostasis of the Respiratory Tract via TGF-β1 and IL-10.
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration.
Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.
FOXO1 expression in keratinocytes promotes connective tissue healing.
Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGFβ/Smad and MAPK-JNK Signaling Pathways.
Platelet-Derived Ectosomes Reduce NK Cell Function.
A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro.
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood.
Macrophage TGF-β1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions.
Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury.
Role of urotensin II in advanced glycation end product-induced extracellular matrix synthesis in rat proximal tubular epithelial cells.
Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells.
Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1.
Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1.
TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β.
CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism.
Mesenchymal stem cells cancel azoxymethane-induced tumor initiation.
Regulation of renal fibrosis by Smad3 Thr388 phosphorylation.
Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-β signaling.
Reduction of methylglyoxal-induced glycation by pyridoxamine improves adipose tissue microvascular lesions.
Exosomes with membrane-associated TGF-β1 from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction.
TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
HIV-1 promotes intake of Leishmania parasites by enhancing phosphatidylserine-mediated, CD91/LRP-1-dependent phagocytosis in human macrophages.
Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis.
C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.
Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity.
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß.
AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
Activation of Toll-like receptor 3 augments myofibroblast differentiation.
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Intrastromal keratotomy with femtosecond laser avoids profibrotic TGF-beta1 induction.
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
Bystander central memory but not effector memory CD8+ T cells suppress allograft rejection.
Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms.
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells.
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-beta1/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy.
Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression.
Increased frequency of CD4+ cells expressing CD161 in cancer patients.
Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma.
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis.
trans fatty acids and systemic inflammation in heart failure.
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription.
Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4.
Isoform specificity of commercially-available anti-TGF-beta antibodies.
Jiang Y, You F, Zhu J, Zheng C, Yan R, Zeng J
Evidence-based complementary and alternative medicine : eCAM 2019;2019:1908416
Evidence-based complementary and alternative medicine : eCAM 2019;2019:1908416
A KDM6A-KLF10 reinforcing feedback mechanism aggravates diabetic podocyte dysfunction.
Lin CL, Hsu YC, Huang YT, Shih YH, Wang CJ, Chiang WC, Chang PJ
EMBO molecular medicine 2019 May;11(5)
EMBO molecular medicine 2019 May;11(5)
Association between FOXP3+ regulatory T-cells and occurrence of peritoneal lesions in women with ovarian endometrioma and dermoid cysts.
Khan KN, Yamamoto K, Fujishita A, Koshiba A, Kuroboshi H, Sakabayashi S, Teramukai S, Nakashima M, Kitawaki J
Reproductive biomedicine online 2019 Jun;38(6):857-869
Reproductive biomedicine online 2019 Jun;38(6):857-869
Spatio-temporal overview of neuroinflammation in an experimental mouse stroke model.
Buscemi L, Price M, Bezzi P, Hirt L
Scientific reports 2019 Jan 24;9(1):507
Scientific reports 2019 Jan 24;9(1):507
Elevated circulating TGFβ1 during acute liver failure activates TGFβR2 on cortical neurons and exacerbates neuroinflammation and hepatic encephalopathy in mice.
McMillin M, Grant S, Frampton G, Petrescu AD, Williams E, Jefferson B, Thomas A, Brahmaroutu A, DeMorrow S
Journal of neuroinflammation 2019 Apr 2;16(1):69
Journal of neuroinflammation 2019 Apr 2;16(1):69
Eosinophil recruitment is dynamically regulated by interplay among lung dendritic cell subsets after allergen challenge.
Yi S, Zhai J, Niu R, Zhu G, Wang M, Liu J, Huang H, Wang Y, Jing X, Kang L, Song W, Shi Y, Tang H
Nature communications 2018 Sep 24;9(1):3879
Nature communications 2018 Sep 24;9(1):3879
Specific Inhibitor of Smad3 (SIS3) Attenuates Fibrosis, Apoptosis, and Inflammation in Unilateral Ureteral Obstruction Kidneys by Inhibition of Transforming Growth Factor β (TGF-β)/Smad3 Signaling.
Ji X, Wang H, Wu Z, Zhong X, Zhu M, Zhang Y, Tan R, Liu Y, Li J, Wang L
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 20;24:1633-1641
Medical science monitor : international medical journal of experimental and clinical research 2018 Mar 20;24:1633-1641
CD8α+CD11c+ Extracellular Vesicles in the Lungs Control Immune Homeostasis of the Respiratory Tract via TGF-β1 and IL-10.
Wan S, Wang S, Weng L, Zhang G, Lin Z, Fei X, Zhang F, Yang F, Wang J, Cai Z
Journal of immunology (Baltimore, Md. : 1950) 2018 Mar 1;200(5):1651-1660
Journal of immunology (Baltimore, Md. : 1950) 2018 Mar 1;200(5):1651-1660
The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration.
Miroshnychenko O, Chang WT, Dragoo JL
The American journal of sports medicine 2017 Mar;45(4):945-953
The American journal of sports medicine 2017 Mar;45(4):945-953
Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction.
Shimizu T, Narang N, Chen P, Yu B, Knapp M, Janardanan J, Blair J, Liao JK
JCI insight 2017 Jul 6;2(13)
JCI insight 2017 Jul 6;2(13)
FOXO1 expression in keratinocytes promotes connective tissue healing.
Zhang C, Lim J, Liu J, Ponugoti B, Alsadun S, Tian C, Vafa R, Graves DT
Scientific reports 2017 Feb 21;7:42834
Scientific reports 2017 Feb 21;7:42834
Suppression of Hepatic Epithelial-to-Mesenchymal Transition by Melittin via Blocking of TGFβ/Smad and MAPK-JNK Signaling Pathways.
Park JH, Park B, Park KK
Toxins 2017 Apr 13;9(4)
Toxins 2017 Apr 13;9(4)
Platelet-Derived Ectosomes Reduce NK Cell Function.
Sadallah S, Schmied L, Eken C, Charoudeh HN, Amicarella F, Schifferli JA
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 1;197(5):1663-71
Journal of immunology (Baltimore, Md. : 1950) 2016 Sep 1;197(5):1663-71
A novel immunomodulatory function of neutrophils on rhinovirus-activated monocytes in vitro.
Tang FS, Hansbro PM, Burgess JK, Ammit AJ, Baines KJ, Oliver BG
Thorax 2016 Nov;71(11):1039-1049
Thorax 2016 Nov;71(11):1039-1049
A single heterochronic blood exchange reveals rapid inhibition of multiple tissues by old blood.
Rebo J, Mehdipour M, Gathwala R, Causey K, Liu Y, Conboy MJ, Conboy IM
Nature communications 2016 Nov 22;7:13363
Nature communications 2016 Nov 22;7:13363
Macrophage TGF-β1 and the Proapoptotic Extracellular Matrix Protein BIGH3 Induce Renal Cell Apoptosis in Prediabetic and Diabetic Conditions.
Moritz RJ, LeBaron RG, Phelix CF, Rupaimoole R, Kim HS, Tsin A, Asmis R
International journal of clinical medicine 2016 Jul;7(7):496-510
International journal of clinical medicine 2016 Jul;7(7):496-510
Manual therapy as an effective treatment for fibrosis in a rat model of upper extremity overuse injury.
Bove GM, Harris MY, Zhao H, Barbe MF
Journal of the neurological sciences 2016 Feb 15;361:168-80
Journal of the neurological sciences 2016 Feb 15;361:168-80
Role of urotensin II in advanced glycation end product-induced extracellular matrix synthesis in rat proximal tubular epithelial cells.
Tian L, Fu P, Zhou M, Gu Y, Li Y, Qi J
International journal of molecular medicine 2016 Dec;38(6):1831-1838
International journal of molecular medicine 2016 Dec;38(6):1831-1838
Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells.
Sommer A, Fabri M
PloS one 2015;10(6):e0130395
PloS one 2015;10(6):e0130395
Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
Spallanzani RG, Torres NI, Avila DE, Ziblat A, Iraolagoitia XL, Rossi LE, Domaica CI, Fuertes MB, Rabinovich GA, Zwirner NW
Journal of immunology (Baltimore, Md. : 1950) 2015 Sep 1;195(5):2141-8
Journal of immunology (Baltimore, Md. : 1950) 2015 Sep 1;195(5):2141-8
Hypoxia down-regulates expression of secretory leukocyte protease inhibitor in bronchial epithelial cells via TGF-β1.
Påhlman LI, Jögi A, Gram M, Mori M, Egesten A
BMC pulmonary medicine 2015 Mar 7;15:19
BMC pulmonary medicine 2015 Mar 7;15:19
Dendritic cell SIRT1-HIF1α axis programs the differentiation of CD4+ T cells through IL-12 and TGF-β1.
Liu G, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang R, Chu Y, Yang R
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 3;112(9):E957-65
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar 3;112(9):E957-65
TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses.
Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K
Nature communications 2015 Feb 19;6:6329
Nature communications 2015 Feb 19;6:6329
Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β.
Wiener Z, Band AM, Kallio P, Högström J, Hyvönen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K
Proceedings of the National Academy of Sciences of the United States of America 2014 May 27;111(21):E2229-36
Proceedings of the National Academy of Sciences of the United States of America 2014 May 27;111(21):E2229-36
CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFβ / GARP-mediated mechanism.
Miller MM, Petty CS, Tompkins MB, Fogle JE
Virology journal 2014 Jan 18;11:7
Virology journal 2014 Jan 18;11:7
Mesenchymal stem cells cancel azoxymethane-induced tumor initiation.
Nasuno M, Arimura Y, Nagaishi K, Isshiki H, Onodera K, Nakagaki S, Watanabe S, Idogawa M, Yamashita K, Naishiro Y, Adachi Y, Suzuki H, Fujimiya M, Imai K, Shinomura Y
Stem cells (Dayton, Ohio) 2014 Apr;32(4):913-25
Stem cells (Dayton, Ohio) 2014 Apr;32(4):913-25
Regulation of renal fibrosis by Smad3 Thr388 phosphorylation.
Qu X, Li X, Zheng Y, Ren Y, Puelles VG, Caruana G, Nikolic-Paterson DJ, Li J
The American journal of pathology 2014 Apr;184(4):944-952
The American journal of pathology 2014 Apr;184(4):944-952
Cancer-associated fibroblasts might sustain the stemness of scirrhous gastric cancer cells via transforming growth factor-β signaling.
Hasegawa T, Yashiro M, Nishii T, Matsuoka J, Fuyuhiro Y, Morisaki T, Fukuoka T, Shimizu K, Shimizu T, Miwa A, Hirakawa K
International journal of cancer 2014 Apr 15;134(8):1785-95
International journal of cancer 2014 Apr 15;134(8):1785-95
Reduction of methylglyoxal-induced glycation by pyridoxamine improves adipose tissue microvascular lesions.
Rodrigues T, Matafome P, Santos-Silva D, Sena C, Seiça R
Journal of diabetes research 2013;2013:690650
Journal of diabetes research 2013;2013:690650
Exosomes with membrane-associated TGF-β1 from gene-modified dendritic cells inhibit murine EAE independently of MHC restriction.
Yu L, Yang F, Jiang L, Chen Y, Wang K, Xu F, Wei Y, Cao X, Wang J, Cai Z
European journal of immunology 2013 Sep;43(9):2461-72
European journal of immunology 2013 Sep;43(9):2461-72
TGF-β signaling regulates neuronal C1q expression and developmental synaptic refinement.
Bialas AR, Stevens B
Nature neuroscience 2013 Dec;16(12):1773-82
Nature neuroscience 2013 Dec;16(12):1773-82
A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
Guo Z, Khattar M, Schroder PM, Miyahara Y, Wang G, He X, Chen W, Stepkowski SM
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3153-62
Journal of immunology (Baltimore, Md. : 1950) 2013 Apr 1;190(7):3153-62
HIV-1 promotes intake of Leishmania parasites by enhancing phosphatidylserine-mediated, CD91/LRP-1-dependent phagocytosis in human macrophages.
Lodge R, Ouellet M, Barat C, Andreani G, Kumar P, Tremblay MJ
PloS one 2012;7(3):e32761
PloS one 2012;7(3):e32761
Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis.
Zhu Y, Colak T, Shenoy M, Liu L, Mehta K, Pai R, Zou B, Xie XS, Pasricha PJ
Molecular pain 2012 Sep 11;8:65
Molecular pain 2012 Sep 11;8:65
C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY
Diabetologia 2011 Oct;54(10):2713-23
Diabetologia 2011 Oct;54(10):2713-23
Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.
Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y
The Journal of clinical investigation 2011 Nov;121(11):4548-66
The Journal of clinical investigation 2011 Nov;121(11):4548-66
Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity.
Heise RL, Stober V, Cheluvaraju C, Hollingsworth JW, Garantziotis S
The Journal of biological chemistry 2011 May 20;286(20):17435-44
The Journal of biological chemistry 2011 May 20;286(20):17435-44
An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition.
Gregory PA, Bracken CP, Smith E, Bert AG, Wright JA, Roslan S, Morris M, Wyatt L, Farshid G, Lim YY, Lindeman GJ, Shannon MF, Drew PA, Khew-Goodall Y, Goodall GJ
Molecular biology of the cell 2011 May 15;22(10):1686-98
Molecular biology of the cell 2011 May 15;22(10):1686-98
Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß.
Oida T, Weiner HL
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3529-35
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3529-35
AIDS progression is associated with the emergence of IL-17-producing cells early after simian immunodeficiency virus infection.
Campillo-Gimenez L, Cumont MC, Fay M, Kared H, Monceaux V, Diop O, Müller-Trutwin M, Hurtrel B, Lévy Y, Zaunders J, Dy M, Leite-de-Moraes MC, Elbim C, Estaquier J
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 15;184(2):984-92
Journal of immunology (Baltimore, Md. : 1950) 2010 Jan 15;184(2):984-92
Activation of Toll-like receptor 3 augments myofibroblast differentiation.
Sugiura H, Ichikawa T, Koarai A, Yanagisawa S, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Ichinose M
American journal of respiratory cell and molecular biology 2009 Jun;40(6):654-62
American journal of respiratory cell and molecular biology 2009 Jun;40(6):654-62
Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells.
Pot C, Jin H, Awasthi A, Liu SM, Lai CY, Madan R, Sharpe AH, Karp CL, Miaw SC, Ho IC, Kuchroo VK
Journal of immunology (Baltimore, Md. : 1950) 2009 Jul 15;183(2):797-801
Journal of immunology (Baltimore, Md. : 1950) 2009 Jul 15;183(2):797-801
Intrastromal keratotomy with femtosecond laser avoids profibrotic TGF-beta1 induction.
Meltendorf C, Burbach GJ, Ohrloff C, Ghebremedhin E, Deller T
Investigative ophthalmology & visual science 2009 Aug;50(8):3688-95
Investigative ophthalmology & visual science 2009 Aug;50(8):3688-95
Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.
Hosui A, Kimura A, Yamaji D, Zhu BM, Na R, Hennighausen L
The Journal of experimental medicine 2009 Apr 13;206(4):819-31
The Journal of experimental medicine 2009 Apr 13;206(4):819-31
Bystander central memory but not effector memory CD8+ T cells suppress allograft rejection.
Wan N, Dai H, Wang T, Moore Y, Zheng XX, Dai Z
Journal of immunology (Baltimore, Md. : 1950) 2008 Jan 1;180(1):113-21
Journal of immunology (Baltimore, Md. : 1950) 2008 Jan 1;180(1):113-21
Transforming growth factor-beta stimulates intestinal epithelial focal adhesion kinase synthesis via Smad- and p38-dependent mechanisms.
Walsh MF, Ampasala DR, Hatfield J, Vander Heide R, Suer S, Rishi AK, Basson MD
The American journal of pathology 2008 Aug;173(2):385-99
The American journal of pathology 2008 Aug;173(2):385-99
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells.
Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F
Nature immunology 2007 Sep;8(9):942-9
Nature immunology 2007 Sep;8(9):942-9
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Ball SG, Shuttleworth CA, Kielty CM
The Journal of cell biology 2007 May 7;177(3):489-500
The Journal of cell biology 2007 May 7;177(3):489-500
Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells.
Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ Jr, Yokota SJ, Bankert RB
Journal of immunology (Baltimore, Md. : 1950) 2007 May 1;178(9):5552-62
Journal of immunology (Baltimore, Md. : 1950) 2007 May 1;178(9):5552-62
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
Rafei M, Wu JH, Annabi B, Lejeune L, François M, Galipeau J
Blood 2007 Mar 1;109(5):2234-42
Blood 2007 Mar 1;109(5):2234-42
Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-beta1/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy.
Li J, Campanale NV, Liang RJ, Deane JA, Bertram JF, Ricardo SD
The American journal of pathology 2006 Nov;169(5):1527-40
The American journal of pathology 2006 Nov;169(5):1527-40
Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription.
Ebert EC, Mehta V
Cellular immunology 2006 May;241(1):7-13
Cellular immunology 2006 May;241(1):7-13
Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression.
Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY
Immunology letters 2006 Jun 15;105(2):159-66
Immunology letters 2006 Jun 15;105(2):159-66
Increased frequency of CD4+ cells expressing CD161 in cancer patients.
Iliopoulou EG, Karamouzis MV, Missitzis I, Ardavanis A, Sotiriadou NN, Baxevanis CN, Rigatos G, Papamichail M, Perez SA
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Dec 1;12(23):6901-9
Clinical cancer research : an official journal of the American Association for Cancer Research 2006 Dec 1;12(23):6901-9
Increase of CD4+ CD25+ regulatory T-cells in the liver of patients with hepatocellular carcinoma.
Yang XH, Yamagiwa S, Ichida T, Matsuda Y, Sugahara S, Watanabe H, Sato Y, Abo T, Horwitz DA, Aoyagi Y
Journal of hepatology 2006 Aug;45(2):254-62
Journal of hepatology 2006 Aug;45(2):254-62
Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function.
Godfrey WR, Spoden DJ, Ge YG, Baker SR, Liu B, Levine BL, June CH, Blazar BR, Porter SB
Blood 2005 Jan 15;105(2):750-8
Blood 2005 Jan 15;105(2):750-8
Rapid analysis of inflammatory cytokines in cerebrospinal fluid using chip-based immunoaffinity electrophoresis.
Phillips TM
Electrophoresis 2004 Jun;25(10-11):1652-9
Electrophoresis 2004 Jun;25(10-11):1652-9
trans fatty acids and systemic inflammation in heart failure.
Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
The American journal of clinical nutrition 2004 Dec;80(6):1521-5
The American journal of clinical nutrition 2004 Dec;80(6):1521-5
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
Lim HW, Hillsamer P, Kim CH
The Journal of clinical investigation 2004 Dec;114(11):1640-9
The Journal of clinical investigation 2004 Dec;114(11):1640-9
Transforming growth factor-beta -Smad signaling pathway cooperates with NF-kappa B to mediate nontypeable Haemophilus influenzae-induced MUC2 mucin transcription.
Jono H, Shuto T, Xu H, Kai H, Lim DJ, Gum JR Jr, Kim YS, Yamaoka S, Feng XH, Li JD
The Journal of biological chemistry 2002 Nov 22;277(47):45547-57
The Journal of biological chemistry 2002 Nov 22;277(47):45547-57
Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
American journal of physiology. Lung cellular and molecular physiology 2002 May;282(5):L1049-56
American journal of physiology. Lung cellular and molecular physiology 2002 May;282(5):L1049-56
Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4.
Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL
Journal of immunology (Baltimore, Md. : 1950) 2000 May 15;164(10):5337-43
Journal of immunology (Baltimore, Md. : 1950) 2000 May 15;164(10):5337-43
Isoform specificity of commercially-available anti-TGF-beta antibodies.
Mozes MM, Hodics T, Kopp JB
Journal of immunological methods 1999 May 27;225(1-2):87-93
Journal of immunological methods 1999 May 27;225(1-2):87-93
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Supportive validation
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- R&D Systems (provider)
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- TGF-beta 1 in HEK293 Human Cell Line. TGF-beta 1 was detected in immersion fixed HEK293 human embryonic kidney cell line using Mouse Anti-TGF-beta 1 Monoclonal Antibody (Catalog # MAB240) at 3 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 493-conjugated Anti-Mouse IgG Secondary Antibody (green; Catalog # NL009) and counterstained with DAPI (blue). Specific staining was localized to cytoplasm. View our protocol for Fluorescent ICC Staining of Cells on Coverslips.
Supportive validation
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- R&D Systems (provider)
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- Experimental details
- TGF-beta 1 in Human Prostate Cancer Tissue. TGF-beta 1 was detected in immersion fixed paraffin-embedded sections of human prostate cancer tissue using Mouse Anti- TGF-beta 1 Monoclonal Antibody (Catalog # MAB240) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). Specific labeling was localized to the cytoplasm of epithelial cells in the prostate gland. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Supportive validation
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- R&D Systems (provider)
- Main image
- Experimental details
- Detection of TGF-beta 1 in PC-3 Human Cell Line by Flow Cytometry. PC-3 human prostate cancer cell line was stained with Mouse Anti-TGF-beta 1 Monoclonal Antibody (Catalog # MAB240, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Allophycocyanin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0101B). To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin.
Supportive validation
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- R&D Systems (provider)
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- TGF-beta 1 Inhibition of IL-4-dependent Cell Proliferation and Neutralization by TGF-beta 1 Antibody. Recombinant Human TGF-beta 1 (Catalog # 240-B) inhibits Recombinant Mouse IL-4 (Catalog # 404-ML) induced proliferation in the HT-2 mouse T cell line in a dose-dependent manner (orange line). Inhibition of Recombinant Mouse IL-4 (7.5 ng/mL) activity elicited by Recombinant Human TGF-beta 1 (0.25 ng/mL) is neutralized (green line) by increasing concentrations of Mouse Anti-TGF-beta 1 Monoclonal Antibody (Catalog # MAB240). The ND50 is typically 0.3-1.0 µg/mL.
