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- Antigen structure
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- Product number
- 21898-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- TGF Beta 1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated TGF Beta 1 antibody (Cat. #21898-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Huanggan decoction ameliorates cholestatic hepatic fibrosis in rats via TGF-β1/Smad3 signaling pathway.
TAPI-1 Combined With Silicone Stents Alleviated Severe Traumatic Tracheal Stenosis via the ADAM17/TGF-β1 Pathway.
LncRNA RMST knockout inhibits fibrosis by down-regulating Smad3 during mouse skin wound healing.
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis.
Gut microbiota dysbiosis and metabolic abnormalities promote oxidative stress and fibrosis in idiopathic pulmonary fibrosis.
The chitosan collagen salvianolic membrane mitigates intervertebral disc degeneration through suppression of the Wnt/β-catenin signaling.
Suppression of LTBP1 enhances the sensitivity of bladder cancer to cisplatin.
Far Infrared Radiation Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Modulation of the p53/TGF-β Signaling Pathway.
Class Effect of SGLT2 Inhibitors Against Doxorubicin-Induced Cardiotoxicity via Regulating Adenosine Kinase Mediated-Cardiac Oxidative Stress.
Integrating WGCNA and network pharmacology to unravel the multi-target mechanisms of Ludangshen Oral liquid against nephrotic syndrome: Involvement of TGF-β1/Smad3 and gut microbiota.
S100A8/A9 promotes renal fibrosis by driving macrophage-to-myofibroblast transition via the TLR4/NF-κB pathway.
CACNB2 overexpression suppresses atrial fibroblast activation and atrial fibrosis to mitigate atrial fibrillation.
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
HNRNPC Promotes Keloid Progression by Modulating the Stability of N(6)-Methyladenosine-Modified WDR77 mRNA and Expression of TGF-β and SMAD3.
Calhm6 Governs Macrophage Polarization Through Chp1-Camk4-Creb1 Axis and Ectosomal Delivery in Inflammatory Responses.
Recombinant BMP9 Reinforces Gut Vascular Barrier in Experimental Colitis.
A New Histology-Based Prognostic Index for Acute Lymphoblastic Leukemia: Preliminary Results of the "ALL Urayasu Classification".
MARCHF1-mediated SULF1 degradation blocks THBS2/TGF-β/SMAD2/3 signaling to reverse colon cancer metastasis and 5-FU resistance.
Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut-liver axis.
Combined strategy of dual-module cerium nanosystem composite extracellular vesicles regulate ROS in the tissue microenvironment to promote periodontitis recovery.
Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF-κB and TGF-β Signaling Pathways.
Interleukin-7 induces EMT to promote tumor growth and metastasis in NSCLC via Notch1/TGF-β pathway.
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
KLF7 as a biomarker for the pre-metastatic state promotes colorectal cancer liver metastasis via TGFβ autocrine signaling.
Succinate Mediates Immune-Angiogenic Response by Activating Macrophage M2 Polarization in Oxygen-Induced Retinopathy.
Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease.
IGFBP-5/TGF-β1 mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis.
CD44 is associated with papillary thyroid carcinoma metastasis via potential modulation of the immunosuppressive tumor microenvironment.
Dose-Dependent Hepatotoxicity of Diethyl Phthalate in Female Wistar Rats.
Hypoxia-preconditioned mesenchymal stromal cell-derived exosomes attenuate LPS-induced acute lung injury and early epithelial remodeling in mice: evidence for a miR-486a-5p-Skp2-GATA4 axis.
Xijiaqi Formula attenuates myocardial infarction-induced chronic heart failure by inhibiting TGF-β1/Smads-mediated fibroblast activation.
PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF-β/Smad Signalling Pathway.
Macrophage CBX4 Potentiates Atherosclerosis by its SUMO E3 Ligase Activity.
Angiopoietin-like protein 6 protects against methionine-choline deficient diet induced liver fibrosis by suppressing hepatic stellate cells activation via TGF-β1/Smad3 pathway.
Role and mechanism of tetrahedral DNA nanostructures in the repair of urethral injury in rats.
Zinc Attenuates Cadmium and High-Fat Diet-Induced Cardiomyopathy by Enhancing Metallothionein-Mediated Cardiac Protection.
The FOXC2-LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma.
Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis.
1-O-acetylbritannilactone alleviates high-fat diet-induced fatty liver by covalently targeting NLRP3.
Overexpression of Decorin Optimizes the Treatment Efficacy of Umbilical Cord Mesenchymal Stem Cells in Bleomycin-Induced Pulmonary Fibrosis in Rats.
TGF-β-Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization.
Tetrahedral Framework Nucleic Acids Inhibit Oxidative Stress and Cardiomyocyte Apoptosis in Doxorubicin-Induced Cardiotoxicity.
ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity.
Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway.
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway.
SPHK1-mediated M2 macrophage polarization drives TGF-β1-dependent thrombus fibrosis.
Lactobacillus rhamnosus GG attenuates MASLD/MASH progression by modulating gut microbiota and metabolic pathways.
The miR-941/FOXN4/TGF-β feedback loop induces N2 polarization of neutrophils and enhances tumor progression of lung adenocarcinoma.
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
TSP-1-CD47-integrin α4β1 axis drives T cell infiltration and synovial inflammation in rheumatoid arthritis.
Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice.
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.
Exosomes of human adipose stem cells mitigate irradiation injury to salivary glands by inhibiting epithelial-mesenchymal transition through miR-199a-3p targeting Twist1 and regulating TGFβ1/Smad3 pathway.
Curcumin-primed milk-derived extracellular vesicles remodel hair follicle microenvironment for the treatment of androgenetic alopecia.
Development and functional evaluation of recombinant type III collagen intrauterine implant gel.
Identify of blood glucose metabolism regulation pathways and related proteins in the db/db mouse model through iTRAQ quantitative mass spectrometry.
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Reduced FGF9 Leads to Kidney Injury Through Regulating Renal Tubular Epithelial Cell EMT in Diabetes.
Resveratrol ameliorates streptozotocin induced renal inflammation and promotes autophagy by mediating the SphK1 pathway via Sirt1 in Wistar rats.
Transglutaminase 2 in human peritoneal dialysis-related peritoneal injury.
FGL1-mediated lymph node metastasis in stage T1 non-small cell lung cancer: therapeutic targeting.
LCN2-positive alveolar type II cells promote silica-induced pulmonary fibrosis via STAT3-TGF-β1-Smad3-mediated signaling.
Yishen Qufeng formula mediates ferroptosis to improve renal fibrosis in unilateral ureteral obstruction rats.
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
The protective role of Agrin and CAF22 in hypertensive nephropathy.
Pancreatic stellate cells promote pancreatic regeneration in chronic pancreatitis via exosomal lncRNA MALAT1-Induced acinar-ductal metaplasia.
Attenuation of Pulmonary Fibrosis by the MyD88 Inhibitor TJ-M2010-5 Through Autophagy Induction in Mice.
Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.
PSG1 in Regulating Proliferation and Migration of Human Umbilical Vein Endothelial Cells Through the TGF-β/Orai3 Signaling Pathway.
Vericiguat as a novel PPARα ligand alleviates pressure-overload-induced heart failure.
Dapagliflozin ameliorates high glucose-induced epithelial-mesenchymal transition via up-regulating ACE2 mediated by EZH2 in diabetic nephropathy.
Deciphering age‑related differences in wound healing: Insights from the interaction between endothelial cells and fibroblasts.
Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway.
Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease.
Wuhu decoction regulates ROS/AMPK/mTOR pathway-mediated dendritic cells autophagy and pyroptosis for the treatment of respiratory syncytial virus-induced asthma.
Anemoside B4 improves cardiac function after myocardial infarction by regulating HTR2A/ERK pathway.
TMEM16F phospholipid scramblase regulates tumorigenesis by modulating the tumor immune microenvironment.
Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor.
Transcription factor MEOX1 accelerates pulmonary fibrosis by regulating mitophagy and senescence.
Bacteroides vulgatus alleviates heart failure via butyric acid-TGF-β1/MAPK pathway.
TNAP-induced CD47 membrane expression enhances TGF-β1 conversion in liver fibrosis.
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.
MicroRNA-93-5p alleviates uric acid-induced fibrosis in renal tubular epithelial cells by regulating the SMAD5/Id2 signaling pathway.
LXR-β regulates microglial efferocytosis and neuroinflammation in CPSP via STAT6 activation.
Immunohistochemical Expression of TNFR1, IL-6, and TGF-β1 in the Synovial Tissue of Patients with Hip Osteoarthritis.
Shenqi compound ameliorates renal fibrosis in diabetic kidney disease by inhibiting LRG1/TGF-β/Smad signaling pathway.
HMGA1 drives EMT in obliterative bronchiolitis through epigenetic regulation of chromatin accessibility in pulmonary epithelial cells.
Nrf2 alleviates excessive deposition of extracellular matrix in mammary fibrosis through TGF/Smad and ROS signals.
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
Multifunctional quercetin-hordein-chitosan nanoparticles: A non-antibiotic strategy for accelerated wound healing.
Effects of Extracorporeal Shockwave Therapy on Wound Healing in Rats.
Subchondral injection of human umbilical cord mesenchymal stem cells ameliorates knee osteoarthritis by inhibiting osteoblast apoptosis and TGF-beta activity.
Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-β pathway.
Exploring the wound-healing mechanism of Cayratia japonica extract: A combined experimental and network pharmacology study.
Lentinan alleviates cadmium-induced kidney injury by reducing cadmium accumulation via promoting cadmium excretion and metallothionein synthesis and regulating silencing information regulator1/nuclear factor erythroid 2-related factor 2/nuclear factor kappa-B signaling pathway.
Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC.
Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF-β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology.
Decorin-mediated dermal papilla cell-derived exosomes regulate hair follicle growth and development through miR-129-2-3p/SMAD3/TGF-β axis.
Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β-Adrenergic Activation.
Apabetalone alleviates ligature-induced periodontitis by inhibiting M1 macrophage polarization via an immunometabolic shift.
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota.
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
A New Histology-Based Prognostic Index for Acute Myeloid Leukemia: Preliminary Results for the "AML Urayasu Classification".
Brown adipose tissue transplantation ameliorates hindlimb ischemic damage in diabetic mice.
Bronchopulmonary dysplasia demonstrates dysregulated autotaxin/lysophosphatidic acid signaling in a neonatal mouse model.
Macrophage Changes and High-Throughput Sequencing in Aging Mouse Intervertebral Disks.
Curcumin-loaded platelets with hydroxypropyl chitin hydrogel composite system through photo-activation for effective hemostasis management and wound healing.
Enhancing BMSC chondrogenesis with a dynamic viscoelastic hyaluronan hydrogel loaded with kartogenin for cartilage repair.
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
Prognostic value of protein expression, tumor morphology and location within the pancreas in pancreatic ductal adenocarcinoma.
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways.
Effect of COL11A1 on oral squamous cell carcinoma.
Intratracheal Administration of Polystyrene Micro(nano)plastics with a Mixed Particle Size Promote Pulmonary Fibrosis in Rats by Activating TGF-β1 Signaling and Destabilizing Mitochondrial Dynamics and Mitophagy in a Dose- and Time-Dependent Manner.
SiRNA-Targeting TGF-β1 Based on Nanoparticle-Coated Ureteral Stents to Inhibit Ureteral Stricture.
Aerobic Exercise Upregulates Renal-Derived ELABELA to Improve Myocardial Fibrosis by Activating APJ-AMPK-Sirt1 and Inhibiting TGFβ1-Smad2/3 Signaling Pathways in Myocardial Infarction Mice.
Scutellarin prevents obesity-induced renal fibrosis via reduced activation of AP-1.
METTL3 Modulates Radiation-Induced Cardiac Fibrosis via the Akt/mTOR Pathway.
Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, inhibits adrenal aldosterone synthesis and renal ERK/EGR1 pathway in the treatment of diabetic kidney disease.
Endoplasmic reticulum stress contributes to the development of ocular graft-vs-host disease in the eyelids and the ocular surface.
Quercetin protects against neuronal toxicity by activating the PI3K/Akt/GSK-3β pathway in vivo models of MPTP-induced Parkinson's disease.
M2 Macrophage-Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1(hi) Neutrophils to Enhance Inflamed Bone Regeneration.
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization.
Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein.
Activation of Hippocampal ACE2 Prevents the Dysbiosis-induced Depression-like Behavior in Mice by Enhanced Neurogenesis and Neuroprotection via Mas Receptor.
Liraglutide inhibits the development of colorectal cancer by regulating TGF-β/Smad3 signaling pathway and affecting epithelial-mesenchymal transition.
Secreted phosphoprotein 1 promotes the activation of keloid fibroblasts via the CD44/TGF-β1/Smad pathway.
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing.
TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy.
MST3 Regulates AMPK and YAP-Hippo Signaling in Cell Models Relevant to Renal Fibrosis.
THBS4 downregulation alters trophoblast function in preeclampsia via the TGF-β1/Smad signaling cascade.
Increased glucose concentration modifies TGF-β1 and NFκB signaling pathways in aniridia limbal fibroblasts, in vitro.
ACE2 Inhibits Dermal Regeneration Through Ang II in Tissue Expansion.
Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways.
Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis.
Xibining inhibition of the PI3K-AKT pathway reduces M1 macrophage polarization to ameliorate KOA synovial inflammation and nociceptive sensitization.
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma.
Therapeutic effects of Mudan granules on diabetic retinopathy: Mitigating fibrogenesis caused by FBN2 deficiency and inflammation associated with TNF-α elevation.
Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells.
Mitochondrial transfer of drug-loaded artificial mitochondria for enhanced anti-Glioma therapy through synergistic apoptosis/ferroptosis/immunogenic cell death.
SR9009 attenuates TGF-β1-induced renal fibrotic responses by inhibiting the NOX4/p38 signaling pathway in NRK-49F cells.
Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles.
Injectable agents for the induction of Peyronie's disease in model rats: a comparative study.
Ubiquitin-specific protease 25 improves myocardial ischemia-reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes.
Platelet-Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease.
Platelet-rich fibrin attenuates inflammation and fibrosis in vulvar lichen sclerosus via the TGF-β/SMAD3 pathway.
β-elemene inhibits tumor-promoting in small cell lung cancer by affecting M2 macrophages and TGF-β.
Molecular mechanism of Gancao Xiexin Decoction regulating EMT and suppressing hepatic metastasis of gastric cancer via the TGF-β1/SMAD pathway.
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction.
CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis.
Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity.
Differences in tumor angiogenesis and related factors between lung adenocarcinomas manifesting as pure ground glass opacity and solid nodules.
Long-term glucosamine supplementation aggravates atrial fibrillation susceptibility by impairing AMPK signaling.
IMUP promotes fatty acid metabolism and lung cancer progression by regulating TGF-β/SMAD3 signaling pathway.
Analysis of potential targets of 20S-protopanaxadiol on diabetic nephropathy based on network pharmacology, molecular docking, and experimental validation.
Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway.
Bosutinib alleviates peritoneal fibrosis by regulating mesothelial-to-mesenchymal transition through inhibition of the PI3K/AKT pathway.
Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR1) in lupus nephritis: A novel therapeutic target.
Viscoelastic Hydrogel with Mechanomodulatory Tension Shielding and Time-Dependent Immunomodulatory Effects for Scarless Healing.
Bmi-1 overexpression mitigates vitamin D deficiency-induced pulmonary fibrosis via TIME pathway.
NIR-II Responsive Multifunctional Scaffold Enabling "Kill-Modulation-Build" Synergistic Therapy for Infectious Bone Defects.
TGF-β1 promotes collagen synthesis in systemic sclerosis via upregulating P4HA3.
Pachymic Acid Suppresses Endometrial Cancer Cell Migration by Inhibiting the NR3C1/TGF-β/Smad Signaling Pathway.
HMGB1-enhanced autophagic degradation of E-cadherin facilitates mesothelial trans-differentiation and postoperative peritoneal adhesion.
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness.
Integrative analysis of non-small cell lung cancer identifies Jumonji domain-containing 6/ETS homologous factor axis as a target to overcome radioresistance.
Tanshinone IIA ameliorates septic immunosuppression by balancing the Th17/Treg cell ratio and modulating Treg function after induction of autophagy.
Concurrent inhibition of tumor growth and metastasis by a lipidated nanophotosensitizer tracing and disabling tumor extracellular vesicles.
Rehmannioside A alleviates renal inflammation and fibrosis in hypertensive nephropathy via AT1R/MAPK14/IL-17 signaling pathway.
Sanleng Wan inhibits endometriosis progression by regulating sphingolipid metabolism via the S1P/S1PR1-Akt axis based on serum metabolomics and network pharmacology.
Maimendong decoction and its active ingredient, ophiopogonin D, alleviate bleomycin-induced pulmonary fibrosis by regulating the behavior of lung fibroblasts.
ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice.
Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion.
The protective role of ureteral stents in reducing fibrosis and preventing stricture in ureteral injuries of different severities.
Taurine alleviated paraquat-induced oxidative stress and gut-liver axis damage in weaned piglets by regulating the Nrf2/Keap1 and TLR4/NF-κB signaling pathways.
Sorafenib inhibits ovarian inflammation and fibrosis in polycystic ovary syndrome by targeting the PDGFA/PDGFRα/NF-κB pathway in granulosa cells†.
Circadian clock gene BMAL1 is involved in transforming growth factor β1-induced fibrotic response in NRK-49F cells.
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways.
Uniform and controllable surface nano-structure on polyetheretherketone implants can regulate mechanical property to enhance soft tissue integration through Piezo1/TGF-β1 signaling axis.
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage.
MSC exosomes and MSC exosomes loaded with LncRNA H19 as nanotherapeutics regulate the neurogenetic potential of Müller Glial Cells in dry age-related macular degeneration.
Banxia Xiexin Decoction inhibits colitis-associated colorectal cancer development by modulating STAT3 signaling and gut microbiota.
CpG-Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2-Mediated Remodeling of Tumor-Associated Macrophages.
Alleviation of obesity cardiomyopathy by Fisetin through the inhibition of NF-κB/MAPK signaling.
Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy response.
Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids.
Cornua cervi degelatinatum inhibits breast cancer stem-like cell properties and metastasis via miR-148a-3p-mediated TGF-β/Smad2 pathway.
Thymidine Phosphorylase Promotes Abdominal Aortic Aneurysm via VSMC Modulation and Matrix Remodeling in Mice and Humans.
Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition.
Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway.
Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy.
Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β/Smad and p38MAPK signaling pathways.
Melatonin serves as a novel treatment in bladder fibrosis through TGF-β1/Smad and EMT.
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.
Pretreatment of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes with Quercetin Enhances the Healing of Diabetic Skin Wounds by Modulating Host-Microbiota Interactions.
RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis.
Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn's Disease: Network Pharmacology, Molecular Docking and Experiment Validation.
Huang Gan Formula Alleviates Systemic Inflammation and Uremia in Adenine-Induced Chronic Kidney Disease Rats May Associate with Modification of Gut Microbiota and Colonic Microenvironment.
Tiaogan Bushen Xiaoji Formula Enhances the Sensitivity of Estrogen Receptor- Positive Breast Cancer to Tamoxifen by Inhibiting the TGF-β/SMAD Pathway.
Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.
Profiling hypoxia signaling reveals a lncRNA signature contributing to immunosuppression in high-grade glioma.
Polygonatum cyrtonema polysaccharides reshape the gut microbiota to ameliorate dextran sodium sulfate-induced ulcerative colitis in mice.
Mingjing granule inhibits the subretinal fibrovascular membrane of two-stage laser-induced neovascular age-related macular degeneration in rats.
Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion.
Activating autophagy promotes skin regeneration induced by mechanical stretch during tissue expansion.
TNFSF15 variant predicts disease progression in Chinese patients with Crohn's disease.
Quercetin alleviates PM(2.5)-induced chronic lung injury in mice by targeting ferroptosis.
Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease.
Amorphous curcumin-based hydrogels to reduce the incidence of post-surgical intrauterine adhesions.
Melatonin Attenuates Diabetic Retinopathy by Regulating EndMT of Retinal Vascular Endothelial Cells via Inhibiting the HDAC7/FOXO1/ZEB1 Axis.
Cyy-272, an indazole derivative, effectively mitigates obese cardiomyopathy as a JNK inhibitor.
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Oxysophoridine inhibits oxidative stress and inflammation in hepatic fibrosis via regulating Nrf2 and NF-κB pathways.
Kindlin-2 mediates Peyronie's disease through activation of TGF-β/Smad signaling pathway under the presence of TGF-β1.
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Platelets promote primary hepatocellular carcinoma metastasis through TGF-β1-mediated cancer cell autophagy.
Gut commensal Alistipes as a potential pathogenic factor in colorectal cancer.
Syn-COM: A Multi-Level Predictive Synergy Framework for Innovative Drug Combinations.
S-Methyl-L-cysteine targeting MsrA attenuates Ang II-induced oxidative stress and atrial remodeling via the p38 MAPK signaling pathway.
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Blocking Sigmar1 exacerbates methamphetamine-induced hypertension.
Activation of SIRT3 by Tanshinone IIA ameliorates renal fibrosis by suppressing the TGF-β/TSP-1 pathway and attenuating oxidative stress.
The Effect of Metformin on Radiation-Induced Lung Fibrosis in Mice.
CircGNAO1 suppresses hepatocellular carcinoma progression and metastasis via sponging miR-182-5p and regulating FOXO1 expression.
Drugs targeting TGF-β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion.
Rapamycin alleviates irradiation-induced parotid injury by enhancing the whole gland homeostasis.
Targeting delivery of mifepristone to endometrial dysfunctional macrophages for endometriosis therapy.
Effect of Ritanserin and Duloxetine on the Gene Expression of Primary Aniridia and Healthy Human Limbal Stromal Cells, In Vitro.
Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation.
Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degeneration.
Up-regulation of IL-1β and sPLA2-III in the medial prefrontal cortex contributes to orofacial and somatic hyperalgesia induced by malocclusion via glial-neuron crosstalk.
Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis.
Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling.
Exosome-derived circ-001422 promotes tumor-associated macrophage M2 polarization to accelerate the progression of glioma.
Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing.
Long-term swimming exercise attenuates right ventricular hypertrophy via modulating meta-inflammation in monocrotaline-induced pulmonary hypertensive rats.
High relative humidity environment alleviates hypoxia-induced pulmonary arterial hypertension in mice.
CD8(+) tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis.
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.
Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways.
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.
The circadian clock gene, BMAL1, promotes radiosensitization in nasopharyngeal carcinoma by inhibiting the epithelial-to-mesenchymal transition via the TGF-β1/Smads/Snail1 axis.
Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways.
The extracellular matrix differentially directs myoblast motility and differentiation in distinct forms of muscular dystrophy: Dystrophic matrices alter myoblast motility.
Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition.
Cross-species single-cell analysis uncovers the immunopathological mechanisms associated with IgA nephropathy progression.
Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation.
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.
Fluorescent Chiral Quantum Dots to Unveil Origin-Dependent Exosome Uptake and Cargo Release.
MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy.
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis.
Inhibition of sugar-binding activity of Galectins-8 by thiogalactoside (TDG) attenuates secondary brain damage and improves long-term prognosis following intracerebral hemorrhage.
Glioma-derived exosome Lncrna Agap2-As1 promotes glioma proliferation and metastasis by mediating Tgf-β1 secretion of myeloid-derived suppressor cells.
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
Nicotinamide Mononucleotide Supplementation Alleviates Doxorubicin-Induced Multi-Organ Fibrosis.
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway.
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes.
Natural intestinal metabolite xylitol reduces BRD4 levels to mitigate renal fibrosis.
The XPO1 inhibitor selinexor ameliorates bleomycin-induced pulmonary fibrosis in mice via GBP5/NLRP3 inflammasome signaling.
The Effect of Salvianolic Acid A on Tumor-Associated Macrophage Polarization and Its Mechanisms in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation.
Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo.
BATF promotes extramedullary infiltration through TGF-β1/Smad/MMPs axis in acute myeloid leukemia.
Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress.
Engineered Surfaces That Promote Capture of Latent Proteins to Facilitate Integrin-Mediated Mechanical Activation of Growth Factors.
Dual-crosslinking gelatin-hyaluronic acid methacrylate based biomimetic PDAC desmoplastic niche enhances tumor-associated macrophages recruitment and M2-like polarization.
HUC-MSCs combined with platelet lysate treat diabetic chronic cutaneous ulcers in Bama miniature pig.
Cupric-polymeric nanoreactors integrate into copper metabolism to promote chronic diabetic wounds healing.
Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a.
Synergistic effects of photodynamic therapy and chemotherapy: Activating the intrinsic/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment.
A New Histology-Based Prognostic Index for Aggressive T-Cell lymphoma: Preliminary Results of the "TCL Urayasu Classification".
Potential Involvement of M1 Macrophage and VLA4/VCAM-1 Pathway in the Valvular Damage Due to Rheumatic Heart Disease.
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation.
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
CD34+ synovial fibroblasts exhibit high osteogenic potential in synovial chondromatosis.
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Honokiol Mitigates Metabolic-Associated Fatty Liver Disease by Regulating Nrf2 and RIPK3 Signaling Pathways.
miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39.
Estrogen inhibits TGF‑β1‑stimulated cardiac fibroblast differentiation and collagen synthesis by promoting Cdc42.
Chitosan-modified dihydromyricetin liposomes promote the repair of liver injury in mice suffering from diabetes mellitus.
Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
SH-Alb inhibits phenotype remodeling of pro-fibrotic macrophage to attenuate liver fibrosis through SIRT3-SOD2 axis.
Platelet-Derived TGF-β1 Promotes Deep Vein Thrombosis.
Neurosteroid [3α,5α]-3-Hydroxy-pregnan-20-one Enhances the CX3CL1-CX3CR1 Pathway in the Brain of Alcohol-Preferring Rats with Sex-Specificity.
ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8(+) T cells.
Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction-associated steatohepatitis.
Effect of luteolin on glioblastoma's immune microenvironment and tumor growth suppression.
Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts.
Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation.
Construction of the pulmonary bio-adhesive delivery system of nintedanib nanocrystalline for effective treatment of pulmonary fibrosis.
STAT4 Mediates IL-6 Trans-Signaling Arrhythmias in High Fat Diet Guinea Pig Heart.
FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease.
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways.
Targeting of G protein-coupled receptor 39 alleviates angiotensin II-induced renal damage by reducing ribonucleotide reductase M2.
17β-Estradiol mediates TGFBR3/Smad2/3 signaling to attenuate the fibrosis of TGF-β1-induced bovine endometrial epithelial cells via GPER.
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Multi-omic analysis revealed the therapeutic mechanisms of Alpinia oxyphylla fructus water extract against bladder overactivity in spontaneously hypertensive rats.
Platycodin D ameliorates ammonia-induced pulmonary fibrosis by repressing TGF-β1-mediated extracellular matrix remodeling.
Transcriptomics Reveals the Mechanism of Platycodin D Targeting TGFβ for Anti-Lung Cancer Activity.
The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix.
Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/AKT pathway.
Protein lysine acetylation played an important role in NH(3)-induced AEC2 damage and pulmonary fibrosis in piglets.
17β-Estradiol inhibits hydrogen peroxide-induced senescence and apoptosis in human umbilical vein endothelial cells by regulating the THBS1/TGF-β/Smad axis.
JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes.
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway.
Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway.
A dihydromyricetin-loaded phellinus igniarius polysaccharide/l-arginine modified chitosan-based hydrogel for promoting wound recovery in diabetic mice via JNK and TGF-β/Smad signaling pathway.
Chitosan-crosslinked polyvinyl alcohol anti-swelling hydrogel designed to prevent abdominal wall adhesion.
Gynostemma pentaphyllum Makino extract induces hair growth and exhibits an anti-graying effect via multiple mechanisms.
Transcription factor c-Maf drives macrophages to promote hypertrophic scar formation.
The novel antibody fusion protein rhNRG1-HER3i promotes heart regeneration by enhancing NRG1-ERBB4 signaling pathway.
Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation.
Multi-omics sequencing revealed endostar combined with cisplatin treated non small cell lung cancer via anti-angiogenesis.
Analysis of genetic variant associated with heart failure mortality implicates thymic stromal lymphopoietin as mediator of strain-induced myocardial fibroblast-mast cell crosstalk and fibrosis.
Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker.
Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin αvβ3-PI3K-Akt signaling pathway.
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Dual effect of vitamin D(3) on breast cancer-associated fibroblasts.
Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines.
The TGFβ1/SMADs/Snail1 signaling axis mediates pericyte-derived fibrous scar formation after spinal cord injury.
Icariin Regulates EMT and Stem Cell-Like Character in Breast Cancer through Modulating lncRNA NEAT1/TGFβ/SMAD2 Signaling Pathway.
Jingfang Granule mitigates Coxsackievirus B3-induced myocardial damage by modulating mucolipin 1 expression.
METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4.
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Alleviation of colitis by honeysuckle MIR2911 via direct regulation of gut microbiota.
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Simultaneous targeting of TGF-β1/PD-L1 via a hydrogel-nanoparticle system to remodel the ECM and immune microenvironment for limiting adhesion formation.
Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI.
Corrigendum to "Suppression of miR-143-3p contributes to the anti-fibrosis effect of atorvastatin on myocardial tissues via the modulation of Smad2 activity" [Experimental and Molecular Pathology 112 (2020) 104346].
Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression.
Aucubin ameliorates atherosclerosis by modulating tryptophan metabolism and inhibiting endothelial-mesenchymal transitions via gut microbiota regulation.
Isoastragaloside I attenuates cholestatic liver diseases by ameliorating liver injury, regulating bile acid metabolism and restoring intestinal barrier.
A multi-omics approach identifies the key role of disorders of sphingolipid metabolism in Ang II-induced hypertensive cardiomyopathy myocardial remodeling.
MS4A3 regulates hematopoietic myeloid differentiation through ROS/TGF-β/p38MAPK pathway.
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome.
Has_circ_0002360 facilitates immune evasion by enhancing heterogeneous nuclear ribonucleoprotein A1 stability, thereby promoting malignant progression in non-small cell lung cancer.
Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression.
Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells.
Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways.
A ROS-responsive and scavenging hydrogel for postoperative abdominal adhesion prevention.
Macrophage-Derived Nanosponges Adsorb Cytokines and Modulate Macrophage Polarization for Renal Cell Carcinoma Immunotherapy.
Exosomal miR-106a-5p derived from intermittently hypoxic non-small-cell lung cancer increases tumor malignancy.
EEPD1 attenuates radiation-induced cardiac hypertrophy and apoptosis by degrading FOXO3A in cardiomyocytes.
Activation of P2X7 Receptor Mediates the Abnormal Ovulation Induced by Chronic Restraint Stress and Chronic Cold Stress.
TRPV1 signaling of perirenal adipose tissue promotes DOCA-Salt-induced hypertension and kidney injury.
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway.
HBI-8000 improves heart failure with preserved ejection fraction via the TGF-β1/MAPK signalling pathway.
Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways.
Assessment of cellular senescence potential of PM2.5 using 3D human lung fibroblast spheroids in vitro model.
Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing.
Identification of a novel FOXO3 agonist that protects against alcohol induced liver injury.
B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding.
DNMT3A-mediated epigenetic silencing of SOX17 contributes to endothelial cell migration and fibroblast activation in wound healing.
Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder's lung.
Combined Verapamil-Polydopamine Nanoformulation Inhibits Adhesion Formation in Achilles Tendon Injury Using Rat Model.
Stimulation of Liver Fibrosis by N2 Neutrophils in Wilson's Disease.
Pathological granuloma fibrosis induced by agar-embedded Mycobacterium abscessus in C57BL/6JNarl mice.
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α.
Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.
FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis.
S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion.
Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds.
The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression.
TGF-β1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy.
Complement Regulatory Protein CD46 Manifests a Unique Role in Promoting the Migration of Bladder Cancer Cells.
Exosomal miR-21-5p derived from multiple myeloma cells promote renal epithelial-mesenchymal transition through targeting TGF-β/SMAD7 signalling pathway.
Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury.
Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach.
Glioma-derived small extracellular vesicles induce pericyte-phenotype transition of glioma stem cells under hypoxic conditions.
AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway.
Possible New Histological Prognostic Index for Large B-Cell Lymphoma.
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.
MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
CHI3L1 promotes myocardial fibrosis via regulating lncRNA TUG1/miR-495-3p/ETS1 axis.
LGR4 promotes tumorigenesis by activating TGF-β1/Smad signaling pathway in multiple myeloma.
Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue.
Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway.
A circular RNA activated by TGFβ promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability.
The Dual-Mode Transition of Myofibroblasts Derived from Hepatic Stellate Cells in Liver Fibrosis.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
IKVAV peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation.
C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension.
Alleviative effect of melatonin against the nephrotoxicity induced by cadmium exposure through regulating renal oxidative stress, inflammatory reaction, and fibrosis in a mouse model.
Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis.
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization.
Integrated network pharmacology to investigate the mechanism of Salvia miltiorrhiza Bunge in the treatment of myocardial infarction.
Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity.
Compound c17 alleviates inflammatory cardiomyopathy in streptozotocin-induced diabetic mice by targeting MyD88.
INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation.
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Activation of KrasG12D in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma.
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Metformin Attenuates TGF-β1-Induced Fibrosis in Salivary Gland: A Preliminary Study.
Establishment and application of the BRP prognosis model for idiopathic pulmonary fibrosis.
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Electroacupuncture alleviates intrauterine adhesion through regulating autophagy in rats.
Salidroside alleviates dexamethasone-induced inhibition of bone formation via transforming growth factor-beta/Smad2/3 signaling pathway.
Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice.
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.
USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
COL12A1 as a prognostic biomarker links immunotherapy response in breast cancer.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
A combination of umbilical cord mesenchymal stem cells and monosialotetrahexosy 1 ganglioside alleviates neuroinflammation in traumatic brain injury.
Chronic spinal cord compression associated with intervertebral disc degeneration in SPARC-null mice.
Chondroitin polymerizing factor predicts a poor prognosis and promotes breast cancer progression via the upstream TGF-β1/SMAD3 and JNK axis activation.
Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF-β/PTHrP/RANKL pathway.
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.
Chronic Exposure to TDI Induces Cell Migration and Invasion via TGF-β1 Signal Transduction.
Improvement of vaginal probiotics Lactobacillus crispatus on intrauterine adhesion in mice model and in clinical practice.
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps.
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.
Ultrasound-mediated mesoporous silica nanoparticles loaded with PDLIM5 siRNA inhibit gefitinib resistance in NSCLC cells by attenuating EMT.
Simultaneous neutralization of TGF-β and IL-6 attenuates Staphylococcus aureus-induced arthritic inflammation through differential modulation of splenic and synovial macrophages.
Luteolin reduces cardiac damage caused by hyperlipidemia in Sprague-Dawley rats.
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling.
Efficacy of Danggui Buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism.
Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3/PINK1 signaling axis to alleviate pulmonary fibrosis.
Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis.
AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice.
The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix.
Peptidomics Analysis Reveals the Buccal Gland of Jawless Vertebrate Lamprey as a Source of Multiple Bioactive Peptides.
Role of TGF-beta1 and TNF-alpha1 produced by neoplastic cells in the pathogenesis of fibrosis in patients with hematologic neoplasms.
Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions.
Sparganii Rhizoma alleviates pulmonary fibrosis by inhibiting fibroblasts differentiation and epithelial-mesenchymal transition mediated by TGF-β1/ Smad2/3 pathway.
Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6/JAK2/STAT3 signaling in vivo and in vitro.
Distinct cellular immune profiles in lung adenocarcinoma manifesting as pure ground glass opacity versus solid nodules.
Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.
Sacha inchi albumin delays skin-aging by alleviating inflammation, oxidative stress and regulating gut microbiota in d-galactose induced-aging mice.
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice.
Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis.
Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer.
Knockdown of ABCB7 inhibits esophageal cancer progression by inhibiting the TGF-β/Smad signaling.
Tartary buckwheat flavonoids alleviates high-fat diet induced kidney fibrosis in mice by inhibiting MAPK and TGF-β1/Smad signaling pathway.
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Ginsenoside Rg3 liposomes regulate tumor microenvironment for the treatment of triple negative breast cancer.
Dectin-1 plays a deleterious role in high fat diet-induced NAFLD of mice through enhancing macrophage activation.
Overexpression of LAG3, TIM3, and A2aR in adenoid cystic carcinoma and mucoepidermoid carcinoma.
Interference of ALOX5 alleviates inflammation and fibrosis in high glucose‑induced renal mesangial cells.
Formin protein DIAPH1 positively regulates PD-L1 expression and predicts the therapeutic response to anti-PD-1/PD-L1 immunotherapy.
Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1.
The effects of taraxasterol on liver fibrosis revealed by RNA sequencing.
Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.
Study on the treatment of postmenopausal osteoporosis with quercetin in Liuwei Dihuang Pill based on network pharmacology.
COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy.
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-β1/Smad3 signaling pathway.
Expression of transforming growth factor-β1 and autophagy markers in the bladder of rats with neurogenic lower urinary tract injury.
Mechanism of YY1 mediating autophagy dependent ferroptosis in PM2.5 induced cardiac fibrosis.
Pirfenidone suppressed triple-negative breast cancer metastasis by inhibiting the activity of the TGF-β/SMAD pathway.
Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.
A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice.
Hypoxia-Driven TGFβ Modulation of Side Population Cells in Breast Cancer: The Potential Role of ERα.
Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds with Endoplasmic Reticulum Stress-Relieving Properties for Promoted Scarless Wound Healing.
Study on the mechanism of aging-related erectile dysfunction based on bioinformatics and experimental verification.
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse.
Gut microbiota and bile acids partially mediate the improvement of fibroblast growth factor 21 on methionine-choline-deficient diet-induced non-alcoholic fatty liver disease mice.
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.
DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs.
Exosomes derived from human dermal fibroblasts protect against UVB‑induced skin photoaging.
Transforming Growth Factor β1 Ameliorates Microglial Activation in Perioperative Neurocognitive Disorders.
ABT-263 exerts a protective effect on upper urinary tract damage by alleviating neurogenic bladder fibrosis.
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis.
Autopsy analysis reveals increased macrophage infiltration and cell apoptosis in COVID-19 patients with severe pulmonary fibrosis.
Protocatechuic aldehyde increases pericyte coverage and mitigates pericyte damage to enhance the atherosclerotic plaque stability.
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway.
An injectable and light curable hyaluronic acid composite gel with anti-biofilm, anti-inflammatory and pro-healing characteristics for accelerating infected wound healing.
Proteomic analysis reveals the aging-related pathways contribute to pulmonary fibrogenesis.
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
Fluorescent Chiral Quantum Dots to Unveil Origin-Dependent Exosome Uptake and Cargo Release.
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14-3-3ζ.
Uncovering pharmacological mechanisms of Phellinus linteus on focal segmental glomeruloscleosis rats through tandem mass tag-based quantitative proteomic analysis, network pharmacology analysis and experimental validation.
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease.
Matrix stiffness-induced α-tubulin acetylation is required for skin fibrosis formation through activation of Yes-associated protein.
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response.
High SNRPA1 expression leads to poor prognosis in patients with lung adenocarcinoma.
MALAT1 binds to miR-188-3p to regulate ALOX5 activity in the lung inflammatory response of neonatal bronchopulmonary dysplasia.
Systemic Pharmacology Reveals the Potential Targets and Signaling Mechanisms in the Adjuvant Treatment of Brucellosis with Traditional Chinese Medicine.
Hypoxic Postconditioning Promotes Angiogenesis After Ischemic Stroke.
HOXA11 promotes lymphatic metastasis of gastric cancer via transcriptional activation of TGFβ1.
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload.
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis.
Relaxin-2 Prevents Erectile Dysfunction by Cavernous Nerve, Endothelial and Histopathological Protection Effects in Rats with Bilateral Cavernous Nerve Injury.
Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis.
Vagus nerve stimulation is a potential treatment for ischemic stroke.
Inhibition of Transglutaminase 2 Reduces Peritoneal Injury in a Chlorhexidine-Induced Peritoneal Fibrosis Model.
Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress.
AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling.
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway.
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.
Neuroprotection of cannabidiol in epileptic rats: Gut microbiome and metabolome sequencing.
CIDEC: A Potential Factor in Diabetic Vascular Inflammation.
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-β1/Smad Signaling.
Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway.
The Hair Growth-Promoting Effect of Gardenia florida Fruit Extract and Its Molecular Regulation.
PM2.5 Exposure Induces Lung Injury and Fibrosis by Regulating Ferroptosis via TGF-β Signaling.
Multifunctional Drug-Loaded Phase-Change Nanoparticles Inhibit the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Affecting the Activity of Activated Hepatic Stellate Cells.
The Traditional Chinese Medicine Formula FTZ Protects against Cardiac Fibrosis by Suppressing the TGFβ1-Smad2/3 Pathway.
Wound Healing Effects of Dracontomelon dao on Bacterial Infection Wounds in Rats and Its Potential Mechanisms under Simulated Space Environment.
Fufang Xueshuantong Improves Diabetic Cardiomyopathy by Regulating the Wnt/β-Catenin Pathway.
Pyrrosia petiolosa Extract Ameliorates Ethylene Glycol-Induced Urolithiasis in Rats by Inhibiting Oxidative Stress and Inflammatory Response.
HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis.
Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.
Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways.
Blockade of SK4 channels suppresses atrial fibrillation by attenuating atrial fibrosis in canines with prolonged atrial pacing.
GPC1 promotes the growth and migration of colorectal cancer cells through regulating the TGF-β1/SMAD2 signaling pathway.
Inhibition of Ureteral Stricture by Pirfenidone-Loaded Nanoparticle-Coated Ureteral Stents with Slow-Release Pirfenidone.
Exosome Derived from Mesenchymal Stem Cells Alleviates Pathological Scars by Inhibiting the Proliferation, Migration and Protein Expression of Fibroblasts via Delivering miR-138-5p to Target SIRT1.
Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Dexmedetomidine post-conditioning protects blood-brain barrier integrity by modulating microglia/macrophage polarization via inhibiting NF-κB signaling pathway in intracerebral hemorrhage.
MULT1-Encoding DNA Alleviates Schistosomiasis-Associated Hepatic Fibrosis via Modulating Cellular Immune Response.
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.
Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis.
TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.
ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model.
Kangfuxiaoyanshuan alleviates uterine inflammation and adhesion via inhibiting NF-κB p65 and TGF-β/MMP-2 signaling pathway in pelvic inflammatory disease rats.
Astragalus propinquus schischkin and Salvia miltiorrhiza bunge promote angiogenesis to treat myocardial ischemia via Ang-1/Tie-2/FAK pathway.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice.
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
High Expression of TGF-β1 Contributes to Hepatocellular Carcinoma Prognosis via Regulating Tumor Immunity.
Umbilical Cord Mesenchymal Stem Cells Ameliorate Kidney Injury in MRL/Ipr Mice Through the TGF-β1 Pathway.
A Case of Colonic Micropapillary Carcinoma with a High Frequency of Apoptosis.
Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections.
Sex-Dependent Effects of Chronic Microdrive Implantation on Acquisition of Trace Eyeblink Conditioning.
N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.
Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction.
β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function.
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Alamandine alleviated heart failure and fibrosis in myocardial infarction mice.
NR2F1 Regulates TGF-β1-Mediated Epithelial-Mesenchymal Transition Affecting Platinum Sensitivity and Immune Response in Ovarian Cancer.
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats and cell hypertrophy in HG-induced H9c2 cells by alleviating oxidative stress and restoring mitophagy.
Suppression of NADPH oxidase 4 inhibits PM(2.5)-induced cardiac fibrosis through ROS-P38 MAPK pathway.
Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis.
TGF-β1 peptide-based inhibitor P144 ameliorates renal fibrosis after ischemia-reperfusion injury by modulating alternatively activated macrophages.
Electroacupuncture attenuates chronic salpingitis transforming growth factor-β1/p38 mitogen-activated protein kinase signaling pathway.
Inhibition of Ubiquitin-specific Protease 4 Attenuates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Transforming Growth Factor Beta Receptor Type I.
Established new compound IMB16-4 self-emulsifying drug delivery systems for increasing oral bioavailability and enhancing anti-hepatic fibrosis effect.
Curcumin analog JM-2 alleviates diabetic cardiomyopathy inflammation and remodeling by inhibiting the NF-κB pathway.
The application of proteomics and metabolomics to reveal the molecular mechanism of Nutmeg-5 in ameliorating cardiac fibrosis following myocardial infarction.
Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals.
Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway.
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Celastrol attenuates renal injury in 5/6 nephrectomized rats via inhibiting epithelial-mesenchymal transition and transforming growth factor-β1/Smad3 pathway.
The silencing of lnc-NONHSAT071210 suppresses the proliferation, fibrosis, migration, and invasion of TGFβ1-treated lung epithelial cells.
The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment.
Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling.
Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway.
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury.
Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis.
Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling.
The miR-214-3p/c-Ski axis modulates endothelial-mesenchymal transition in human coronary artery endothelial cells in vitro and in mice model in vivo.
Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
MicroRNA-130a attenuates cardiac fibrosis after myocardial infarction through TGF-β/Smad signaling by directly targeting TGF-β receptor 1.
Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis.
The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis.
Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.
Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway.
Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.
Layer-by-Layer Pirfenidone/Cerium Oxide Nanocapsule Dressing Promotes Wound Repair and Prevents Scar Formation.
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts.
Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7.
Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis.
Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration.
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
The Chinese medicine Fufang Zhenzhu Tiaozhi capsule protects against atherosclerosis by suppressing EndMT via modulating Akt1/β-catenin signaling pathway.
Serum and glucocorticoid-regulated kinase 1 regulates transforming growth factor β1-connective tissue growth factor pathway in chronic rhinosinusitis.
Fucoidan-functionalized activated platelet-hitchhiking micelles simultaneously track tumor cells and remodel the immunosuppressive microenvironment for efficient metastatic cancer treatment.
Artesunate attenuates atherosclerosis by inhibiting macrophage M1-like polarization and improving metabolism.
The role of regulatory T cells on the activation of astrocytes in the brain of high-fat diet mice following lead exposure.
Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy.
A fragment of cell adhesion molecule L1 reduces amyloid-β plaques in a mouse model of Alzheimer's disease.
Decreased Monocyte Count Is Associated With Gestational Diabetes Mellitus Development, Macrosomia, and Inflammation.
Chronic exposure to biomass ambient particulate matter triggers alveolar macrophage polarization and activation in the rat lung.
Esomeprazole alleviates fibrosis in systemic sclerosis by modulating AhR/Smad2/3 signaling.
Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway.
Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.
Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial-mesenchymal transition in gastric cancer.
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
A comprehensive analysis on the relationship between BDE-209 exposure and erectile dysfunction.
A novel chemokine-based signature for prediction of prognosis and therapeutic response in glioma.
Phosphatidylserine liposome multilayers mediate the M1-to-M2 macrophage polarization to enhance bone tissue regeneration.
Endogenous neutralization of TGF-β and IL-6 ameliorates septic arthritis by altering RANKL/OPG interaction in lymphocytes.
A novel murine model of combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Paeoniflorin-free subfraction of Paeonia lactiflora Pall. shows the potential of anti-hepatic fibrosis: an integrated analysis of network pharmacology and experimental validation.
Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease.
Exercise-derived peptide protects against pathological cardiac remodeling.
Artificial Intelligence-Assisted Bioinformatics, Microneedle, and Diabetic Wound Healing: A "New Deal" of an Old Drug.
Adropin Carried by Reactive Oxygen Species-Responsive Nanocapsules Ameliorates Renal Lipid Toxicity in Diabetic Mice.
The compound losartan cream inhibits scar formation via TGF-β/Smad pathway.
Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
Expression of HHLA2, TMIGD2, and GITR in salivary gland adenoid cystic carcinoma and mucoepidermoid carcinoma.
Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Exogenous pancreatic kininogenase protects against tacrolimus-induced renal injury by inhibiting PI3K/AKT signaling: The role of bradykinin receptors.
Ginsenoside Rh4 Suppresses Metastasis of Gastric Cancer via SIX1-Dependent TGF-β/Smad2/3 Signaling Pathway.
Pinocembrin mediates antiarrhythmic effects in rats with isoproterenol-induced cardiac remodeling.
A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and progression.
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Blockade of Exosome Release Suppresses Atrial Fibrillation by Alleviating Atrial Fibrosis in Canines With Prolonged Atrial Pacing.
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Early Passive Leg Movement Prevents Against the Development of Heart Failure With Preserved Ejection Fraction in Rats.
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Ursolic Acid Regulates Intestinal Microbiota and Inflammatory Cell Infiltration to Prevent Ulcerative Colitis.
Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways.
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
FSTL3 is a Prognostic Biomarker in Gastric Cancer and is Correlated with M2 Macrophage Infiltration.
Pathologic role of peptidyl-prolyl isomerase Pin1 in pulmonary artery remodeling.
METTL3/METTL14 Transactivation and m(6)A-Dependent TGF-β1 Translation in Activated Kupffer Cells.
Targeting ADAR1 suppresses progression and peritoneal metastasis of gastric cancer through Wnt / β-catenin pathway.
Construction and Analysis of Immune Infiltration-Related ceRNA Network for Kidney Stones.
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Reynoutrin Improves Ischemic Heart Failure in Rats Via Targeting S100A1.
IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer.
TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway.
tRNA-Derived Fragment tRF-17-79MP9PP Attenuates Cell Invasion and Migration via THBS1/TGF-β1/Smad3 Axis in Breast Cancer.
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
IGF-1-Expressing Placenta-Derived Mesenchymal Stem Cells Promote Scalding Wound Healing.
Sustained-Release Hydrogel-Based Rhynchophylline Delivery System Improved Injured Tendon Repair.
A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells.
Costunolide Loaded in pH-Responsive Mesoporous Silica Nanoparticles for Increased Stability and an Enhanced Anti-Fibrotic Effect.
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.
Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.
Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice.
Effects of endurance exercise on serum inflammatory cytokine level and kidney structure in a rat diabetes model.
RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer.
Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism.
Long noncoding RNA SGO1-AS1 inactivates TGFβ signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis.
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation.
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.
Phenolic Compounds from Mori Cortex Ameliorate Sodium Oleate-Induced Epithelial-Mesenchymal Transition and Fibrosis in NRK-52e Cells through CD36.
Low-intensity pulsed ultrasound prevents prolonged hypoxia-induced cardiac fibrosis through HIF-1α/DNMT3a pathway via a TRAAK-dependent manner.
Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death.
Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.
Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration.
SPARC knockdown attenuated TGF-β1-induced fibrotic effects through Smad2/3 pathways in human pterygium fibroblasts.
Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGF-β1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction.
SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis.
Splicing factor SRSF6 mediates pleural fibrosis.
Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway.
CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis.
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Umbilical cord-derived mesenchymal stem cells exert anti-fibrotic action on hypertrophic scar-derived fibroblasts in co-culture by inhibiting the activation of the TGF β1/Smad3 pathway.
Relationship between podoplanin-expressing cancer-associated fibroblasts and the immune microenvironment of early lung squamous cell carcinoma.
Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-β/p38/MK2 signaling pathway.
Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity.
COL5A1 Variants Cause Aortic Dissection by Activating TGF-β-Signaling Pathway.
Pre-emptive pharmacological inhibition of fatty acid-binding protein 4 attenuates kidney fibrosis by reprogramming tubular lipid metabolism.
Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis.
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat.
MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme.
Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K/Akt/mTOR and NF-κB signalling pathways.
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.
PM2.5 inducing myocardial fibrosis mediated by Ang II/ERK1/2/TGF-β(1) signaling pathway in mice model.
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis.
Hepatic connective tissue growth factor expression and regulation differ between non-steatotic and non-alcoholic steatotic livers from brain-dead donor.
Phosphorylated nuclear factor erythroid 2-related factor 2 promotes the secretion of C-C motif chemokine ligand 2 and the recruitment of M2 macrophages.
Identifying the clinical presentations, progression, and sequela of pelvic inflammatory disease through physiological, histological and ultrastructural evaluation of a rat animal model.
The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats.
Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway.
Preparation of casein phosphopeptides calcium complex and the promotion in calcium cellular uptake through transcellular transport pathway.
Network pharmacology and experimental validation to explore the molecular mechanisms of Bushen Huoxue for the treatment of premature ovarian insufficiency.
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet.
Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses.
Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways.
Plasminogen Activator Urokinase Receptor Implies Immunosuppressive Features and Acts as an Unfavorable Prognostic Biomarker in Glioma.
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
CIDEC silencing attenuates diabetic nephropathy via inhibiting apoptosis and promoting autophagy.
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
FZD2 promotes TGF-β-induced epithelial-to-mesenchymal transition in breast cancer via activating notch signaling pathway.
Inhibitory effects of alkaline extract from the pericarp of Citrus reticulata Blanco on collagen behavior in bleomycin-induced pulmonary fibrosis.
High expression of COL5A2, a member of COL5 family, indicates the poor survival and facilitates cell migration in gastric cancer.
Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-β1 Promoter.
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Concentrated small extracellular vesicles from menstrual blood-derived stromal cells improve intrauterine adhesion, a pre-clinical study in a rat model.
Transient Receptor Potential Channel 6 Knockout Ameliorates Kidney Fibrosis by Inhibition of Epithelial-Mesenchymal Transition.
Gut Microbiota Modulates Intestinal Pathological Injury in Schistosoma japonicum-Infected Mice.
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Ginsenoside Rb1 Ameliorates Age-Related Myocardial Dysfunction by Regulating the NF-κB Signaling Pathway.
Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry.
Synergistic effect of Huyang Yangkun Formula and embryonic stem cells on 4-vinylcyclohexene diepoxide induced premature ovarian insufficiency in mice.
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Expression and Prognostic Value of Id-4 in Patients with Esophageal Squamous Cell Carcinoma.
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9.
Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence.
Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy.
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells.
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro.
Genome-wide pathogenesis interpretation using a heat diffusion-based systems genetics method and implications for gene function annotation.
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
The TGF-β1/COX-2-dependant pathway serves a key role in the generation of OKC-induced M2-polarized macrophage-like cells and angiogenesis.
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing.
A Histomorphological Study of the Divergent Corpus Spongiosum Surrounding the Urethral Plate in Hypospadias.
Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways.
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.
Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.
Chronic inflammation promotes proliferation in the prostatic stroma in rats with experimental autoimmune prostatitis: study for a novel method of inducing benign prostatic hyperplasia in a rat model.
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats.
Chitosan-calcium alginate dressing promotes wound healing: A preliminary study.
TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Protective effects and mechanisms of Rehmannia glutinosa leaves total glycoside on early kidney injury in db/db mice.
Inhibition of vascular calcification by microRNA-155-5p is accompanied by the inactivation of TGF-β1/Smad2/3 signaling pathway.
Small airway remodeling in diabetic and smoking chronic obstructive pulmonary disease patients.
Possible Roles of Periostin in the Formation of Hemodialysis Vascular Access Stenosis after Polytetrafluoroethylene Graft Implantation in Dogs.
Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.
The ancient Chinese formula Longdan Xiegan Tang improves antipsychotic-induced hyperprolactinemia by repairing the hypothalamic and pituitary TGF-β1 signaling in rats.
Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.
Thymosinβ4 alleviates cholestatic liver fibrosis in mice through downregulating PDGF/PDGFR and TGFβ/Smad pathways.
Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition.
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
microRNA-141 inhibits TGF-β1-induced epithelial-to-mesenchymal transition through inhibition of the TGF-β1/SMAD2 signalling pathway in endometriosis.
TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.
Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway.
Babao Dan inhibits the migration and invasion of gastric cancer cells by suppressing epithelial-mesenchymal transition through the TGF-β/Smad pathway.
Kidney targeted delivery of asiatic acid using a FITC labeled renal tubular-targeting peptide modified PLGA-PEG system.
Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway.
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.
Paeoniflorin ameliorates antipsychotic-induced hyperprolactinemia in rats by attenuating impairment of the dopamine D2 receptor and TGF-β1 signaling pathways in the hypothalamus and pituitary.
Retinoic acid attenuates cardiac injury induced by hyperglycemia in pre- and post-delivery mice.
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
N6-Methyladenosine Regulates the Expression and Secretion of TGFβ1 to Affect the Epithelial-Mesenchymal Transition of Cancer Cells.
Tumor Cell-Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA.
Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
β2-microglobulin as a biomarker of pulmonary fibrosis development in COPD patients.
LncRNA Gm16410 regulates PM(2.5)-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.
Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis.
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
Fangjihuangqi Decoction inhibits MDA-MB-231 cell invasion in vitro and decreases tumor growth and metastasis in triple-negative breast cancer xenografts tumor zebrafish model.
LncRNA MIAT/miR-133a-3p axis regulates atrial fibrillation and atrial fibrillation-induced myocardial fibrosis.
Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy.
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.
Effect of sarcolipin-mediated cell transdifferentiation in sarcopenia-associated skeletal muscle fibrosis.
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21.
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Disulfiram inhibits epithelial-mesenchymal transition through TGFβ-ERK-Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis.
Comparative Immunopathology of Cetacean morbillivirus Infection in Free-Ranging Dolphins From Western Mediterranean, Northeast-Central, and Southwestern Atlantic.
The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism.
Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation.
Effects of ubiquitin-proteasome inhibitor on the expression levels of TNF-α and TGF-β1 in mice with viral myocarditis.
Hyperoside protects against heart failure-induced liver fibrosis in rats.
The effect of topical ramipril and losartan cream in inhibiting scar formation.
CD36 promotes the epithelial-mesenchymal transition and metastasis in cervical cancer by interacting with TGF-β.
Biomimetic electrical stimulation induces rat bone marrow mesenchymal stem cells to differentiate into cardiomyocyte-like cells via TGF-beta 1 in vitro.
Distribution of platelets, transforming growth factor-β1, platelet-derived growth factor-BB, vascular endothelial growth factor and matrix metalloprotease-9 in advanced platelet-rich fibrin and concentrated growth factor matrices.
Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner.
Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia.
Anti-osteoporosis effects of osteoking via reducing reactive oxygen species.
Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis.
Rosiglitazone attenuates paraquat-induced lung fibrosis in rats in a PPAR gamma-dependent manner.
Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.
Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer.
miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.
TGFβi is involved in the chondrogenic differentiation of mesenchymal stem cells and is dysregulated in osteoarthritis.
Toxicity Effects of Methylene Blue on Rat Intervertebral Disc Annulus Fibrosus Cells.
Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII.
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Bronchial epithelial cell extracellular vesicles ameliorate epithelial-mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization.
Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice.
Role of PM(2.5) in the development and progression of COPD and its mechanisms.
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Protective effects of Rosavin on bleomycin-induced pulmonary fibrosis via suppressing fibrotic and inflammatory signaling pathways in mice.
The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma.
α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy.
Dynamics of elastin in liver fibrosis: Accumulates late during progression and degrades slowly in regression.
Identification of novel TGF-β regulated genes with pro-migratory roles.
Anti-inflammatory effects of hederagenin on diabetic cardiomyopathy via inhibiting NF-κB and Smads signaling pathways in a type-2 diabetic mice model.
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy.
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors.
Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance.
The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke.
Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy.
Gossypol Promotes Bone Formation in Ovariectomy-Induced Osteoporosis through Regulating Cell Apoptosis.
Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats.
Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway.
EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus.
Angiotensin II upregulates fibroblast-myofibroblast transition through Cx43-dependent CaMKII and TGF-β1 signaling in neonatal rat cardiac fibroblasts.
Antifibrotic Agent Pirfenidone Protects against Development of Radiation-Induced Pulmonary Fibrosis in a Murine Model.
Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway.
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-β1/Smad pathway in DN rats.
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.
Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy.
Study on Cardiotoxicity and Mechanism of "Fuzi" Extracts Based on Metabonomics.
Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma.
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway.
Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor.
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.
Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats.
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice.
microRNA-21 regulates astrocytic reaction post-acute phase of spinal cord injury through modulating TGF-β signaling.
Overexpression of YOD1 Promotes the Migration of Human Oral Keratinocytes by Enhancing TGF-β3 Signaling.
Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells.
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway.
HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer.
Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway.
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice.
Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.
NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice.
Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization.
Intrinsic renal cells induce lymphocytosis of Th22 cells from IgA nephropathy patients through B7-CTLA-4 and CCL-CCR pathways.
Inhibition of tumor-promoting stroma to enforce subsequently targeting AT(1)R on tumor cells by pathological inspired micelles.
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.
TGF-β1/Smad3 Signaling Pathway Mediates T-2 Toxin-Induced Decrease of Type II Collagen in Cultured Rat Chondrocytes.
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Gender differences in fibrosis remodeling in patients with long-standing persistent atrial fibrillation.
Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT.
Let‑7a suppresses cell proliferation via the TGF‑β/SMAD signaling pathway in cervical cancer.
Lei Y, Ma X, Jin X, He Y, Yang J, Zhao Y, Chen J, Gao T
PloS one 2026;21(3):e0344168
PloS one 2026;21(3):e0344168
TAPI-1 Combined With Silicone Stents Alleviated Severe Traumatic Tracheal Stenosis via the ADAM17/TGF-β1 Pathway.
Yang Z, Pan L, Xie T, Wu H, Liu K, Li Y
Canadian respiratory journal 2026;2026:9485331
Canadian respiratory journal 2026;2026:9485331
LncRNA RMST knockout inhibits fibrosis by down-regulating Smad3 during mouse skin wound healing.
Zhou Z, Huang X, Chen C, Zou T, Hai Y, Dong G, Li S
Biochemistry and biophysics reports 2026 Mar;45:102386
Biochemistry and biophysics reports 2026 Mar;45:102386
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
Bhamidipati K, McIntyre ABR, Kazerounian S, Ce G, Wong SW, Tran M, Prell SA, Lau R, Khedgikar V, Altmann C, Small A, Madhu R, Presti SR, Anufrieva KS, Blazar PE, Lange JK, Seifert JA, Accelerating Medicines Partnership RA/SLE Network, Accelerating Medicines Partnership: Autoimmune and Immune-Mediated Diseases Network (AMP-AIM), Colorado Interdisciplinary Joint Biology Program (CUIJBP) Consortium, Moreland LW, Croft AP, Smith MH, Donlin LT, Lewis MJ, Jonsson AH, Pitzalis C, Thomas R, Gravallese EM, Brenner MB, Korsunsky I, Wechalekar MD, Wei K
Nature immunology 2026 Mar;27(3):556-571
Nature immunology 2026 Mar;27(3):556-571
HKDC1 promotes the H3K18 lactylation of the promoter of ORMDL3 to induce the activation of hepatic stellate cells in liver cirrhosis.
Zhang Y, Li L, Li G, Zhu J, Qi Z, Zhang C
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168140
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168140
Gut microbiota dysbiosis and metabolic abnormalities promote oxidative stress and fibrosis in idiopathic pulmonary fibrosis.
Bai B, Li F, Zheng P, Hua C, Li X, Guo D, Zhao W
Scientific reports 2026 Mar 5;16(1)
Scientific reports 2026 Mar 5;16(1)
The chitosan collagen salvianolic membrane mitigates intervertebral disc degeneration through suppression of the Wnt/β-catenin signaling.
Yu Z, Kuang J, Wan X, Liang C, Wu F, Shu Z, Liang W, Wan X, Gong J
In vitro cellular & developmental biology. Animal 2026 Mar 20;
In vitro cellular & developmental biology. Animal 2026 Mar 20;
Suppression of LTBP1 enhances the sensitivity of bladder cancer to cisplatin.
Li Z, Yu Y, Liu F, Wu Y, Zang Y, Ding Y, Zhang Z
Scientific reports 2026 Mar 13;16(1)
Scientific reports 2026 Mar 13;16(1)
Far Infrared Radiation Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Modulation of the p53/TGF-β Signaling Pathway.
Li J, Chang J, Chu W, Jiang Y, Sun S, Ding X, Zhang L, Shi L
International journal of molecular sciences 2026 Mar 10;27(6)
International journal of molecular sciences 2026 Mar 10;27(6)
Class Effect of SGLT2 Inhibitors Against Doxorubicin-Induced Cardiotoxicity via Regulating Adenosine Kinase Mediated-Cardiac Oxidative Stress.
Yan J, Lin K, Dai S, Zhang Y, Zheng R, Shi S, Tang Z, Lai X, Huang W, Su L
Cardiovascular drugs and therapy 2026 Jun;40(3):971-985
Cardiovascular drugs and therapy 2026 Jun;40(3):971-985
Integrating WGCNA and network pharmacology to unravel the multi-target mechanisms of Ludangshen Oral liquid against nephrotic syndrome: Involvement of TGF-β1/Smad3 and gut microbiota.
Cheng Z, Xiang W, Chen X, Xu X, Hou W, Gao J, Zhou J
Fitoterapia 2026 Jun;191:107239
Fitoterapia 2026 Jun;191:107239
S100A8/A9 promotes renal fibrosis by driving macrophage-to-myofibroblast transition via the TLR4/NF-κB pathway.
Chen X, Zha W, Shen J, Li L, Fu Y, Tian P, Zheng B, Li C
International immunopharmacology 2026 Jun 15;179:116646
International immunopharmacology 2026 Jun 15;179:116646
CACNB2 overexpression suppresses atrial fibroblast activation and atrial fibrosis to mitigate atrial fibrillation.
Zhang D, Li Z, Li N, Zhang H
Cellular signalling 2026 Jul;143:112448
Cellular signalling 2026 Jul;143:112448
The role of the IL-33/ST2/MAPK signalling pathway in macrophage polarisation and endometrial fibrosis.
Li G, Xu F, Luo S, Jin Y, Yuan L, Yang X, Xuan T, Liu D
International immunopharmacology 2026 Jul 1;180:116743
International immunopharmacology 2026 Jul 1;180:116743
HNRNPC Promotes Keloid Progression by Modulating the Stability of N(6)-Methyladenosine-Modified WDR77 mRNA and Expression of TGF-β and SMAD3.
Zhan Y, Zeng N, Yu J, Wu Y, Zhu K, Yang Z, Guo X, Zhang Q, Liu Z
The Journal of investigative dermatology 2026 Jan;146(1):236-248.e6
The Journal of investigative dermatology 2026 Jan;146(1):236-248.e6
Calhm6 Governs Macrophage Polarization Through Chp1-Camk4-Creb1 Axis and Ectosomal Delivery in Inflammatory Responses.
Xin Y, Xiong X, Zhang Y, Zhang S, Zhang S, Yang Y, Liang Y, Zang L, Chen X, Li W, Halalmeh I, Zhou R, Li Z, Liu H, Geng J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e02395
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Jan;13(1):e02395
Recombinant BMP9 Reinforces Gut Vascular Barrier in Experimental Colitis.
Li S, Zhou X, Wang Y, Yao B, Zhu S, Lin R, Sun Q, Lu J, Hu M, Wang W, Zhong L
Biomedicines 2026 Jan 28;14(2)
Biomedicines 2026 Jan 28;14(2)
A New Histology-Based Prognostic Index for Acute Lymphoblastic Leukemia: Preliminary Results of the "ALL Urayasu Classification".
Mitsumori T, Nitta H, Takizawa H, Iizuka-Honma H, Furuya C, Maruo S, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Noguchi M
Journal of clinical medicine 2026 Jan 17;15(2)
Journal of clinical medicine 2026 Jan 17;15(2)
MARCHF1-mediated SULF1 degradation blocks THBS2/TGF-β/SMAD2/3 signaling to reverse colon cancer metastasis and 5-FU resistance.
Li H, Xie Y
iScience 2026 Jan 16;29(1):114476
iScience 2026 Jan 16;29(1):114476
Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut-liver axis.
Zhang L, Chen J, Ge SJ, Huang TY, Shi X, Chen YY, Lu CH
Life metabolism 2026 Feb;5(1):loaf036
Life metabolism 2026 Feb;5(1):loaf036
Combined strategy of dual-module cerium nanosystem composite extracellular vesicles regulate ROS in the tissue microenvironment to promote periodontitis recovery.
Ren H, Liu P, Sun Z, Yu Z, Guo H, Cai X, Wei Y, Li Z, Wu M, Xu X, Wang J, Xuan K
Materials today. Bio 2026 Feb;36:102625
Materials today. Bio 2026 Feb;36:102625
Polystyrene Microplastics Exposure Aggravates Clear Cell Renal Cell Carcinoma Progression via the NF-κB and TGF-β Signaling Pathways.
Ye S, Xiang J, Zhou S, Ge Q, Anwaier A, Chang K, Wei G, Lu J, Tian X, Zhu S, Jiang Y, Zhang W, Cai T, Xu M, Ye D, Xu D, Wang T, Zhang H, Xu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e18500
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Feb;13(8):e18500
Interleukin-7 induces EMT to promote tumor growth and metastasis in NSCLC via Notch1/TGF-β pathway.
Shao Y, Cheng H, Ni W, Zhang A, Li C, Li X, Fu Y, Ming J
Scientific reports 2026 Feb 5;16(1)
Scientific reports 2026 Feb 5;16(1)
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fu T, Sun S, Wang Z, Zhao F, Zhen J, Ji X, Xue F, Mu Q, Wang Y, Liu Y, Wan Q
Cardiovascular diabetology 2026 Feb 3;25(1)
Cardiovascular diabetology 2026 Feb 3;25(1)
KLF7 as a biomarker for the pre-metastatic state promotes colorectal cancer liver metastasis via TGFβ autocrine signaling.
Fang X, Huang H, Zhao Z, Yang L, Huang F, Li J, Meng Z, He S, Li T, Yang S, Suo M, Lv J, Chen Y, Zhang C, Li N
Cancer letters 2026 Feb 28;639:218123
Cancer letters 2026 Feb 28;639:218123
Succinate Mediates Immune-Angiogenic Response by Activating Macrophage M2 Polarization in Oxygen-Induced Retinopathy.
Shen T, Lin R, Zheng T, Yu J, Cai W
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71545
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71545
Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease.
Yin J, Liu M, Zhang L, Hu T, Yu Q, Kong R, Liu Z, Pang Z, Chen L, Zhou C, Ye Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71498
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71498
IGFBP-5/TGF-β1 mediated crosstalk between endothelial and tubular epithelial cells promotes interstitial fibrosis.
Wang S, Song C, Chi K, Fu Z, Zhang X, Geng X, Liu C, Cai G, Chen X, He JC, Hong Q, Wu D
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Feb 27;41(3):531-544
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2026 Feb 27;41(3):531-544
CD44 is associated with papillary thyroid carcinoma metastasis via potential modulation of the immunosuppressive tumor microenvironment.
Adeerjiang Y, Huo MH, Ma L, Li XX, Tian Y, Bai C, Wang BW, Qu X, Yao XY, Ma LL, Gan XX, Kuang JY, Liang HZ, Qiang BR, Wang R, Bao JL, Jiang S, Du GL
Clinical and experimental medicine 2026 Feb 25;26(1)
Clinical and experimental medicine 2026 Feb 25;26(1)
Dose-Dependent Hepatotoxicity of Diethyl Phthalate in Female Wistar Rats.
Yavaş MC, Gökdemir GŞ, Kalkan KT, Varol S, Cantürk Tan F
Toxics 2026 Feb 16;14(2)
Toxics 2026 Feb 16;14(2)
Hypoxia-preconditioned mesenchymal stromal cell-derived exosomes attenuate LPS-induced acute lung injury and early epithelial remodeling in mice: evidence for a miR-486a-5p-Skp2-GATA4 axis.
Lin Q, Zou S, Lin C, Lin J, Wu Y, Liu R, Lei L
Respiratory research 2026 Feb 10;27(1)
Respiratory research 2026 Feb 10;27(1)
Xijiaqi Formula attenuates myocardial infarction-induced chronic heart failure by inhibiting TGF-β1/Smads-mediated fibroblast activation.
Zhang Q, Chen J, Zhou LN, Wu XF, Wu YZ, Li WT, Xia GY, Xia H, Shang HC, Wei XH, Lin S
Pharmaceutical biology 2026 Dec;64(1):46-66
Pharmaceutical biology 2026 Dec;64(1):46-66
PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF-β/Smad Signalling Pathway.
Zhang H, Zhang L, Feng Z, Li X, Qiu Z, Wang X, Qian L
Cell proliferation 2026 Apr;59(4):e70123
Cell proliferation 2026 Apr;59(4):e70123
Macrophage CBX4 Potentiates Atherosclerosis by its SUMO E3 Ligase Activity.
Zhao Z, Xu S, Ma J, Zhang Z, Liang S, Guo J
Cardiovascular drugs and therapy 2026 Apr;40(2):447-460
Cardiovascular drugs and therapy 2026 Apr;40(2):447-460
Angiopoietin-like protein 6 protects against methionine-choline deficient diet induced liver fibrosis by suppressing hepatic stellate cells activation via TGF-β1/Smad3 pathway.
Tang X, Wen S, Zhang J, Li B, Dong Z, Zhang Q, Zhang T, Wang Y, Zhu J, Zhang Y
International journal of biological macromolecules 2026 Apr;356:151571
International journal of biological macromolecules 2026 Apr;356:151571
Role and mechanism of tetrahedral DNA nanostructures in the repair of urethral injury in rats.
Guo C, Li J
Molecular medicine reports 2026 Apr;33(4)
Molecular medicine reports 2026 Apr;33(4)
Zinc Attenuates Cadmium and High-Fat Diet-Induced Cardiomyopathy by Enhancing Metallothionein-Mediated Cardiac Protection.
Liang Y, Shi Y, Su Q, Gu C, Wu R
Biological trace element research 2026 Apr;204(4):2083-2097
Biological trace element research 2026 Apr;204(4):2083-2097
The FOXC2-LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma.
Yao J, Xu T, Wang C, Wang C, Xie J, Zheng R, Wang K, Jiang X, Hu Z, Jing H, Li L, Liu T
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e16382
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(20):e16382
Gallic acid: A promising anti-non-small cell lung cancer compound targeting early growth response protein-1 for apoptosis and ferroptosis.
Li BB, Zhang JT, Jiang YY, Li X, Wang DN, Zang JM, Liu ZL, Hu FX, Zhu X, Shen CC, Zhang W, Xu F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 19;156:158220
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr 19;156:158220
1-O-acetylbritannilactone alleviates high-fat diet-induced fatty liver by covalently targeting NLRP3.
Jin T, Zhao Y, Xu T, Fang Y, Cui Y, Liu W, Xiong Y, Ye J, Luo W, Hong B, Liang G, Hu X, Huang L, Wang Y
International immunopharmacology 2026 Apr 1;174:116351
International immunopharmacology 2026 Apr 1;174:116351
Overexpression of Decorin Optimizes the Treatment Efficacy of Umbilical Cord Mesenchymal Stem Cells in Bleomycin-Induced Pulmonary Fibrosis in Rats.
Zhi Y, Shu M, Tang P, Li Y, Guo M, Deng J, Mo H, Wu M, Liu B, Mai Y, Ling J, Zhao X, Zhang X, Zuo W
Stem cells international 2025;2025:6324980
Stem cells international 2025;2025:6324980
TGF-β-Smad2/3 signaling in high-altitude pulmonary hypertension in rats: Role and mechanisms via macrophage M2 polarization.
Ma W, Ma Y, Bai Y, Guo C, Zhang Q, Su X
Open medicine (Warsaw, Poland) 2025;20(1):20251279
Open medicine (Warsaw, Poland) 2025;20(1):20251279
Tetrahedral Framework Nucleic Acids Inhibit Oxidative Stress and Cardiomyocyte Apoptosis in Doxorubicin-Induced Cardiotoxicity.
Pan H, Ye Q, Li Y, Ma L, Ni Y
International journal of nanomedicine 2025;20:9275-9289
International journal of nanomedicine 2025;20:9275-9289
ShenQi ShenKang Granule Alleviates Chronic Kidney Disease by Inhibiting the PI3K/AKT/mTOR Pathway and Restoring Autophagy Flux and Mitochondrial Integrity.
Xia C, Zhang J, Chen H, Zhou S, Jiang W, Zheng H, Lin Z, Tan Q, Sun W
Drug design, development and therapy 2025;19:3925-3947
Drug design, development and therapy 2025;19:3925-3947
Remote Continuous Microinjury-Triggered Cytokines Facilitate Severe Diabetic Foot Ulcer Healing via the Ras/Raf/MEK/ERK Pathway.
Huang X, Liu J, Wu X, Mo Y, Luo X, Yang Y, Yang C, Liang X, Liang R, Chen Y, Fan Z, Lu W, Chen Y, Hua Q
Journal of inflammation research 2025;18:1755-1772
Journal of inflammation research 2025;18:1755-1772
Cannabidiol Alleviates Intestinal Fibrosis in Mice with Ulcerative Colitis by Regulating Transforming Growth Factor Signaling Pathway.
Wang Y, Ji X, Wang X, Sun M, Li C, Wu D
Journal of inflammation research 2025;18:1-15
Journal of inflammation research 2025;18:1-15
SPHK1-mediated M2 macrophage polarization drives TGF-β1-dependent thrombus fibrosis.
Chen X, Li F, Ma G, Qiang H, Chen M, Chen S, Huang Y, Lai X, Lin Q, Deng C
Frontiers in immunology 2025;16:1681485
Frontiers in immunology 2025;16:1681485
Lactobacillus rhamnosus GG attenuates MASLD/MASH progression by modulating gut microbiota and metabolic pathways.
Wang SL, Liang S, Li SY, Fu JW, Wang ZY, Zhu DQ, Chen N
Frontiers in microbiology 2025;16:1586678
Frontiers in microbiology 2025;16:1586678
The miR-941/FOXN4/TGF-β feedback loop induces N2 polarization of neutrophils and enhances tumor progression of lung adenocarcinoma.
Zhang X, Huang X, Zhang X, Lai L, Zhu B, Lin P, Kang Z, Yin D, Tian D, Chen Z, Gao J
Frontiers in immunology 2025;16:1561081
Frontiers in immunology 2025;16:1561081
Dl-3-n-butylphthalide attenuates DOX-induced cardiotoxicity in mice by inhibiting Nrf2/Keap1 complex formation.
Yan Y, Fang M, Zhao C, Lin X, Tong C, Xiang C, Ran Y, Wang X, Li S, Chen G, Fu L
Frontiers in pharmacology 2025;16:1542296
Frontiers in pharmacology 2025;16:1542296
TSP-1-CD47-integrin α4β1 axis drives T cell infiltration and synovial inflammation in rheumatoid arthritis.
Hu J, Wang X, Ge C, Qi W, Li Z, Wang Y, Lai W, Ji W, Xu H
Frontiers in immunology 2025;16:1524304
Frontiers in immunology 2025;16:1524304
Knockdown of PDPN in astrocytes reduces hippocampal inflammation in T2DM mice.
Wang X, Wang Q, Cai Z, Ni C, Wang H, Liu H, Zhao Y, Wang J, Liu S, Wang X
Frontiers in immunology 2025;16:1503807
Frontiers in immunology 2025;16:1503807
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.
Tang Q, Dong J, Zhang F, Zhao D, Yang Q, Wen J, Sun Y, Wei J, Liu Z
Frontiers in pharmacology 2025;16:1489210
Frontiers in pharmacology 2025;16:1489210
Exosomes of human adipose stem cells mitigate irradiation injury to salivary glands by inhibiting epithelial-mesenchymal transition through miR-199a-3p targeting Twist1 and regulating TGFβ1/Smad3 pathway.
Guo X, Huang Z, Wu F, Jiang W, Li Y, Wang T, Tran SD, Lin Z, Su X
Theranostics 2025;15(5):1622-1641
Theranostics 2025;15(5):1622-1641
Curcumin-primed milk-derived extracellular vesicles remodel hair follicle microenvironment for the treatment of androgenetic alopecia.
Hou C, Wang S, Li Z, Huang Q, Jiang Y, Zhou X, Ou R, Li D, Xu Y
Regenerative biomaterials 2025;12:rbaf051
Regenerative biomaterials 2025;12:rbaf051
Development and functional evaluation of recombinant type III collagen intrauterine implant gel.
Wang X, Fan X, Zhai Y, Li J, Sun H, Li J, Le H, Zhang F, Zhang L, Wang J, Chu Y, Cui P
Regenerative biomaterials 2025;12:rbaf013
Regenerative biomaterials 2025;12:rbaf013
Identify of blood glucose metabolism regulation pathways and related proteins in the db/db mouse model through iTRAQ quantitative mass spectrometry.
Yue Y, Dong S, Wu Z, Dong Y, Chen Q, Wang H, Liu C, Yang D
Acta diabetologica 2025 Sep;62(9):1417-1428
Acta diabetologica 2025 Sep;62(9):1417-1428
Dl-3-n-butylphthalide attenuates acute myocardial infarction by inhibiting the binding of Nrf2/Keap1.
Yan Y, Huang Z, Cheng L, Zhao S, Gao H, Chen K, Huang F, Mou L, Chen G, Fu L, Xu G
Toxicology and applied pharmacology 2025 Sep;502:117424
Toxicology and applied pharmacology 2025 Sep;502:117424
Reduced FGF9 Leads to Kidney Injury Through Regulating Renal Tubular Epithelial Cell EMT in Diabetes.
Chen WQ, Sun C, Zhang X, Ye X, Liu Y, Wang HD, Liu L, Li D, Wang J, Shi M, Yang F, Reichetzeder C, Hocher B, Yang X, Guan B, Wang G
Journal of cellular and molecular medicine 2025 Sep;29(18):e70856
Journal of cellular and molecular medicine 2025 Sep;29(18):e70856
Resveratrol ameliorates streptozotocin induced renal inflammation and promotes autophagy by mediating the SphK1 pathway via Sirt1 in Wistar rats.
Feng F, Li S, Shi J, Chen W, Deng Y
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115588
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Sep;203:115588
Transglutaminase 2 in human peritoneal dialysis-related peritoneal injury.
Kunoki S, Ikeno M, Tatsukawa H, Sakai Y, Kinashi H, Kamiya K, Suzuki M, Mizuno M, Yamaguchi M, Sasakura H, Morioka Y, Banshodani M, Tawada M, Iwabu M, Ishimoto T, Takeuchi K, Hitomi K, Kawanishi H, Ito Y
Physiological reports 2025 Sep;13(18):e70567
Physiological reports 2025 Sep;13(18):e70567
FGL1-mediated lymph node metastasis in stage T1 non-small cell lung cancer: therapeutic targeting.
Tang XY, Zhang RZ, Feng ZB, Zhou YL, Du WG, Shu C, Shen Y, Li MC, Cai JC, Yan XL, Ma N, Zhao JB
Experimental hematology & oncology 2025 Sep 29;14(1):117
Experimental hematology & oncology 2025 Sep 29;14(1):117
LCN2-positive alveolar type II cells promote silica-induced pulmonary fibrosis via STAT3-TGF-β1-Smad3-mediated signaling.
Xie Z, Li X, Zhang M, Cao H, Wang F, Yan R, Ye H, Mu M, Wang J, Wang F, Tao X
Toxicology and applied pharmacology 2025 Sep 27;505:117579
Toxicology and applied pharmacology 2025 Sep 27;505:117579
Yishen Qufeng formula mediates ferroptosis to improve renal fibrosis in unilateral ureteral obstruction rats.
Gao J, Wei Y, Zhang W, Yu Y, Ge H, Tian F, Zhou E
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120376
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120376
Kaempferol improves mitochondrial homeostasis via mitochondrial dynamics and mitophagy in diabetic kidney disease.
Xia C, Zhang J, Chen H, Jiang W, Zhou S, Zheng H, Sun W
International immunopharmacology 2025 Sep 23;162:115121
International immunopharmacology 2025 Sep 23;162:115121
The protective role of Agrin and CAF22 in hypertensive nephropathy.
Yuan C, Zhang P, Zhan Z, Guo Y, Huang P, Qian J, Wang W, Shan P
International immunopharmacology 2025 Sep 23;162:115107
International immunopharmacology 2025 Sep 23;162:115107
Pancreatic stellate cells promote pancreatic regeneration in chronic pancreatitis via exosomal lncRNA MALAT1-Induced acinar-ductal metaplasia.
Han D, Wen C, Li J, Xu W, Mo W, Dai W, Xu X, Xu X
Biochemical and biophysical research communications 2025 Sep 16;780:152468
Biochemical and biophysical research communications 2025 Sep 16;780:152468
Attenuation of Pulmonary Fibrosis by the MyD88 Inhibitor TJ-M2010-5 Through Autophagy Induction in Mice.
Yang Y, Li Z, Zhao M, Zhao Y, Zou Z, Xie Y, Zhang L, Du D, Zhou P
Biomedicines 2025 Sep 10;13(9)
Biomedicines 2025 Sep 10;13(9)
Dietary addition of magnesium hydride nanoparticles: a breakthrough in combating high-fat diet-induced chronic kidney disease.
Lu H, Chen W, Ying Y, Gu D, Li R, Li X, Cheng J, Sun X, Zhang Y, Liu W, Shen H
Medical gas research 2025 Sep 1;15(3):374-382
Medical gas research 2025 Sep 1;15(3):374-382
PSG1 in Regulating Proliferation and Migration of Human Umbilical Vein Endothelial Cells Through the TGF-β/Orai3 Signaling Pathway.
Yang Y, Yang Q, Lai S, Lin M, Yuan L, Nie G, Fan X
The journal of obstetrics and gynaecology research 2025 Oct;51(10):e70092
The journal of obstetrics and gynaecology research 2025 Oct;51(10):e70092
Vericiguat as a novel PPARα ligand alleviates pressure-overload-induced heart failure.
Zhang P, Yuan C, Zhan Z, Zhou J, Huang P, Wang W, Qian J, Shan P
Toxicology and applied pharmacology 2025 Oct;503:117473
Toxicology and applied pharmacology 2025 Oct;503:117473
Dapagliflozin ameliorates high glucose-induced epithelial-mesenchymal transition via up-regulating ACE2 mediated by EZH2 in diabetic nephropathy.
Wang S, Zhang X, Chong N, Chen D, Shu J, Wang R, Wang Q, Xu Y
Journal of endocrinological investigation 2025 Oct;48(10):2499-2509
Journal of endocrinological investigation 2025 Oct;48(10):2499-2509
Deciphering age‑related differences in wound healing: Insights from the interaction between endothelial cells and fibroblasts.
Li J, Zhu D, Zhang M, Li Z, Liang L, Huang Y, Guo X, Kong Y, Fu X, Huang S
Molecular medicine reports 2025 Oct;32(4)
Molecular medicine reports 2025 Oct;32(4)
Isoimperatorin Reduces Synovial Inflammation and Fibrosis in Knee Osteoarthritis via the cAMP Signalling Pathway.
Jie L, Liu J, Zhu Z, Huang Z, Liu Y, Liu G, Shen X, Li Y, Shi X
Journal of cellular and molecular medicine 2025 Oct;29(19):e70880
Journal of cellular and molecular medicine 2025 Oct;29(19):e70880
Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease.
Liu Z, Huang T, Hong Y, Yang Y, Chen W, Zeng Q, Chen Q, Yang Y, Ying X, Zeng W, Wu Z, Zhao T, Wan X, Chen J, Ai K, Huang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e05168
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Oct;12(37):e05168
Wuhu decoction regulates ROS/AMPK/mTOR pathway-mediated dendritic cells autophagy and pyroptosis for the treatment of respiratory syncytial virus-induced asthma.
Ding Y, Luo J, Deng YJ, Liu JL, Wang MQ, Hu Y
Journal of thoracic disease 2025 Oct 31;17(10):7810-7825
Journal of thoracic disease 2025 Oct 31;17(10):7810-7825
Anemoside B4 improves cardiac function after myocardial infarction by regulating HTR2A/ERK pathway.
Lv M, Sun Q, Yu Y, Yu D
International immunopharmacology 2025 Oct 30;164:115394
International immunopharmacology 2025 Oct 30;164:115394
TMEM16F phospholipid scramblase regulates tumorigenesis by modulating the tumor immune microenvironment.
Wu M, Shi P, Huang J, Ni X, Lai R, Cao K, Cai M, Yu H, Zhao W, Zhang Y
Proceedings of the National Academy of Sciences of the United States of America 2025 Oct 21;122(42):e2513910122
Proceedings of the National Academy of Sciences of the United States of America 2025 Oct 21;122(42):e2513910122
Simultaneously induce apoptosis and inhibiting metastasis of Triple negative breast cancer Enabled by a highly potent NIR fluorescent inhibitor.
Zhao Q, Wu J, Yao J, Liu Z, Li C, Sun Q
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2025 Oct 15;339:126183
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 2025 Oct 15;339:126183
Transcription factor MEOX1 accelerates pulmonary fibrosis by regulating mitophagy and senescence.
Fang L, Lyu L, Zhong H, Lin J, Ren P, Wang Y, Yin Y, Zhang M, Qu Y
European journal of pharmacology 2025 Oct 15;1005:178043
European journal of pharmacology 2025 Oct 15;1005:178043
Bacteroides vulgatus alleviates heart failure via butyric acid-TGF-β1/MAPK pathway.
Du Z, Zhang W, Wang Y, Fang X, Zhang Y, Xiao Y, Zeng X, Yuan S, Jiang Y, Guo X, Hua K, Yang X, Zhao X, Liu Y, Lu Y, Tu P
Journal of advanced research 2025 Oct 14;
Journal of advanced research 2025 Oct 14;
TNAP-induced CD47 membrane expression enhances TGF-β1 conversion in liver fibrosis.
Gao L, Peng F, Qi P, Zhang H, Chi H, Deng L, Liang X, Sun M, Ma W, Yang C, Liu Q, Wei X, Li Y, Zhao J
Hepatology communications 2025 Oct 1;9(10)
Hepatology communications 2025 Oct 1;9(10)
YOD1 mediates isoproterenol-induced cardiac remodeling by deubiquitinating PKM2 and reducing PKM2 tetramerization in cardiomyocytes.
Zheng QS, Xiong YQ, Xu JC, Qian JF, Luo W, Wang QY, Zhao YN, Luo Y, Cui YQ, Fang Y, Guo XC, Chen DD, Wang Y, Liang G
Acta pharmacologica Sinica 2025 Nov;46(11):2938-2950
Acta pharmacologica Sinica 2025 Nov;46(11):2938-2950
MicroRNA-93-5p alleviates uric acid-induced fibrosis in renal tubular epithelial cells by regulating the SMAD5/Id2 signaling pathway.
Lu X, Ma C, Li D, Yang J, Sun Y, Liu B, Zhao B, Li H
Cellular signalling 2025 Nov;135:112081
Cellular signalling 2025 Nov;135:112081
LXR-β regulates microglial efferocytosis and neuroinflammation in CPSP via STAT6 activation.
Zang H, Hu Y, Ji X, Chen Y, He X, Wan L, Yao W, Zhang C, Zhu C, Liu T
Brain, behavior, and immunity 2025 Nov;130:106089
Brain, behavior, and immunity 2025 Nov;130:106089
Immunohistochemical Expression of TNFR1, IL-6, and TGF-β1 in the Synovial Tissue of Patients with Hip Osteoarthritis.
Todorović P, Jurić I, Kelam N, Rošin M, Čarić D, Boban D, Kopilaš A, Vukojević K
Biomedicines 2025 Nov 7;13(11)
Biomedicines 2025 Nov 7;13(11)
Shenqi compound ameliorates renal fibrosis in diabetic kidney disease by inhibiting LRG1/TGF-β/Smad signaling pathway.
Yuan Y, Liu L, Chen N, Tang S, Qi Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157355
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157355
HMGA1 drives EMT in obliterative bronchiolitis through epigenetic regulation of chromatin accessibility in pulmonary epithelial cells.
Xia T, Hou Z, Wang S, Sun J, Yang H, Miao P, Liu C, Zheng W, Wei L
Clinical epigenetics 2025 Nov 18;17(1):192
Clinical epigenetics 2025 Nov 18;17(1):192
Nrf2 alleviates excessive deposition of extracellular matrix in mammary fibrosis through TGF/Smad and ROS signals.
Kan X, Xu P, Yu M, Guo W, Cao Y, Hu G, Liu J, Fu S, Bi J
Scientific reports 2025 Nov 10;15(1):39252
Scientific reports 2025 Nov 10;15(1):39252
Absence of astrocytic ceruloplasmin reverses the senescence process with aging of learning and memory abilities.
Li ZD, Kang S, Li H, Yu P, Xie R, Li C, Jing Q, Gong Z, Li L, Li Z, Geng M, Zhang Z, Li Y, Chang YZ
Redox biology 2025 May;82:103611
Redox biology 2025 May;82:103611
Multifunctional quercetin-hordein-chitosan nanoparticles: A non-antibiotic strategy for accelerated wound healing.
Liang T, Lu C, Zhao M, Cao X, Hao J, Zhang X, Fu H, Cao Q, Li L, Jiang J
International journal of biological macromolecules 2025 May;305(Pt 1):140943
International journal of biological macromolecules 2025 May;305(Pt 1):140943
Effects of Extracorporeal Shockwave Therapy on Wound Healing in Rats.
Sugiyama T, Murakami H, Tanaka S, Yoshida S, Sato T, Hiraoka K
Cureus 2025 May;17(5):e83369
Cureus 2025 May;17(5):e83369
Subchondral injection of human umbilical cord mesenchymal stem cells ameliorates knee osteoarthritis by inhibiting osteoblast apoptosis and TGF-beta activity.
Wu C, Xu H, Wu Z, Huang H, Ge Q, Xu J, Chen J, Wang P, Yuan W, Jin H, Tong P
Stem cell research & therapy 2025 May 9;16(1):235
Stem cell research & therapy 2025 May 9;16(1):235
Mechanistic insights into Y-Box binding protein-1 mediated regulation of lipid metabolism and oxidative stress in NAFLD via INHBE/TNF-β pathway.
Ren Z, Wang R, Wei J, Ma Z, Ke X
Biomolecules & biomedicine 2025 May 8;25(7):1528-1539
Biomolecules & biomedicine 2025 May 8;25(7):1528-1539
Exploring the wound-healing mechanism of Cayratia japonica extract: A combined experimental and network pharmacology study.
Cheng M, Hou Y, Chen Q, Ge S, Chen C, Zheng X, Zhang C
Journal of ethnopharmacology 2025 May 12;347:119810
Journal of ethnopharmacology 2025 May 12;347:119810
Lentinan alleviates cadmium-induced kidney injury by reducing cadmium accumulation via promoting cadmium excretion and metallothionein synthesis and regulating silencing information regulator1/nuclear factor erythroid 2-related factor 2/nuclear factor kappa-B signaling pathway.
Wang X, Zhao G, Zhao Q, Hu M, Wang Y, Li Q, Wang S, Qiao M, Shen Y, Li N, Huang X, Wang D, Gan RY, Song L
Journal of food science 2025 Mar;90(3):e70163
Journal of food science 2025 Mar;90(3):e70163
Lnc PVT1 facilitates TGF-β1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC.
Wang J, Lv ZY, Li P, Zhang Y, Li X, Shen DF
Molecular and cellular biochemistry 2025 Mar;480(3):1611-1625
Molecular and cellular biochemistry 2025 Mar;480(3):1611-1625
Ergothioneine Ameliorates Liver Fibrosis by Inhibiting Glycerophospholipids Metabolism and TGF-β/Smads Signaling Pathway: Based on Metabonomics and Network Pharmacology.
Mao Y, Xie Z, Zhang X, Fu Y, Yu X, Deng L, Zhang X, Hou B, Wang X, Ma M, Ren F
Journal of applied toxicology : JAT 2025 Mar;45(3):514-530
Journal of applied toxicology : JAT 2025 Mar;45(3):514-530
Decorin-mediated dermal papilla cell-derived exosomes regulate hair follicle growth and development through miR-129-2-3p/SMAD3/TGF-β axis.
Li J, Zhao B, Yu Y, Bao Z, Zheng F, Cai J, Chen Y, Wu X
International journal of biological macromolecules 2025 Mar;295:139292
International journal of biological macromolecules 2025 Mar;295:139292
Targeting the E Prostanoid Receptor EP4 Mitigates Cardiac Fibrosis Induced by β-Adrenergic Activation.
Xu H, Mao X, Wang Y, Zhu C, Liang B, Zhao Y, Zhou M, Ye L, Hong M, Shao H, Wang Y, Li H, Qi Y, Yang Y, Chen L, Guan Y, Zhang X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2413324
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(12):e2413324
Apabetalone alleviates ligature-induced periodontitis by inhibiting M1 macrophage polarization via an immunometabolic shift.
Bian T, Li H, Liu H, Guo M, Zhang Y, Hu P, Chen M
International immunopharmacology 2025 Mar 26;150:114279
International immunopharmacology 2025 Mar 26;150:114279
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota.
Yang F, Gao Y, Xie S, Yang W, Wang Q, Ye W, Sun L, Zhou J, Feng X
Food & function 2025 Mar 17;16(6):2316-2334
Food & function 2025 Mar 17;16(6):2316-2334
Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis.
Bhamidipati K, McIntyre ABR, Kazerounian S, Ce G, Tran M, Prell SA, Lau R, Khedgikar V, Altmann C, Small A, Wong V, Madhu R, Presti S, Anufrieva KS, Blazar PE, Lange JK, Seifert J, Accelerating Medicines Partnership: RA/SLE Network, Accelerating Medicines Partnership: Autoimmune and Immune-Mediated Diseases Network (AMP-AIM), Moreland LW, Croft AP, Lewis MJ, Thomas R, Jonsson AH, Pitzalis C, Gravallese EM, Brenner MB, Korsunsky I, Wechalekar MD, Wei K
bioRxiv : the preprint server for biology 2025 Mar 17;
bioRxiv : the preprint server for biology 2025 Mar 17;
A New Histology-Based Prognostic Index for Acute Myeloid Leukemia: Preliminary Results for the "AML Urayasu Classification".
Mitsumori T, Nitta H, Takizawa H, Iizuka-Honma H, Furuya C, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2025 Mar 15;14(6)
Journal of clinical medicine 2025 Mar 15;14(6)
Brown adipose tissue transplantation ameliorates hindlimb ischemic damage in diabetic mice.
Lu T, Liu A, Li C, Li Y, Yang B, Liu Q, Jiang H
Scientific reports 2025 Mar 14;15(1):8820
Scientific reports 2025 Mar 14;15(1):8820
Bronchopulmonary dysplasia demonstrates dysregulated autotaxin/lysophosphatidic acid signaling in a neonatal mouse model.
Ha AW, Sudhadevi T, Jafri A, Mayer C, MacFarlane PM, Natarajan V, Harijith A
Pediatric research 2025 Jun;97(7):2462-2474
Pediatric research 2025 Jun;97(7):2462-2474
Macrophage Changes and High-Throughput Sequencing in Aging Mouse Intervertebral Disks.
Wang W, Jiang C, Chen JH, Chen YL, Zhang ZW, Yang ZC, Li J, Li XC
JOR spine 2025 Jun;8(2):e70061
JOR spine 2025 Jun;8(2):e70061
Curcumin-loaded platelets with hydroxypropyl chitin hydrogel composite system through photo-activation for effective hemostasis management and wound healing.
Zhao XY, Lu JY, Zheng L, Yan M, Zhang SH, Chen S, Zhang Q, Jiang X, Tan Y, Li TF, Leng F
International journal of biological macromolecules 2025 Jun;314:144291
International journal of biological macromolecules 2025 Jun;314:144291
Enhancing BMSC chondrogenesis with a dynamic viscoelastic hyaluronan hydrogel loaded with kartogenin for cartilage repair.
Li G, Ni R, Shi Z, Mao H, Luo Y, Cao X, Zhang C, Liu Y, Jin Z, Chen J, Fu J, Zhang H, Zhu Y
International journal of biological macromolecules 2025 Jun;312:144042
International journal of biological macromolecules 2025 Jun;312:144042
Lycium barbarum polysaccharide alleviate cadmium-induced mitochondrial dysfunction mediated pyroptosis in duck liver.
Song J, Luo X, Xiong L, Li S, Chen Y, Liu W, Yuan Y, Ma Y, Bian J, Liu Z, Zou H
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
International journal of biological macromolecules 2025 Jun;311(Pt 4):143989
Prognostic value of protein expression, tumor morphology and location within the pancreas in pancreatic ductal adenocarcinoma.
Nishida H, Ando K, Kaimori R, Kawamura K, Daa T
Oncology letters 2025 Jun;29(6):288
Oncology letters 2025 Jun;29(6):288
Cyr61 promotes D-gal-induced aging C2C12 cell fibrosis by modulating Wnt/β-catenin signaling pathways.
Huang X, Kui X, Ma J, Chen J, Huang Y, He B
Mechanisms of ageing and development 2025 Jun;225:112067
Mechanisms of ageing and development 2025 Jun;225:112067
Effect of COL11A1 on oral squamous cell carcinoma.
Liu YH, Li D, Zhang HL, Zhang BH, Song WJ, Li TK
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102183
Journal of stomatology, oral and maxillofacial surgery 2025 Jun;126(3S):102183
Intratracheal Administration of Polystyrene Micro(nano)plastics with a Mixed Particle Size Promote Pulmonary Fibrosis in Rats by Activating TGF-β1 Signaling and Destabilizing Mitochondrial Dynamics and Mitophagy in a Dose- and Time-Dependent Manner.
Xia S, Yuan C, Long W, Wu Z, Li X, Wang N, Gao M, Li Z, Li P, Liu P, Qu X, Sun L
Toxics 2025 Jun 9;13(6)
Toxics 2025 Jun 9;13(6)
SiRNA-Targeting TGF-β1 Based on Nanoparticle-Coated Ureteral Stents to Inhibit Ureteral Stricture.
Meng W, Li N, Lv F, Chen B, Lu S, Zhang J, Zhang T, Tao Q, Zhou Y, Ma L, Guan Y
ACS biomaterials science & engineering 2025 Jun 9;11(6):3477-3487
ACS biomaterials science & engineering 2025 Jun 9;11(6):3477-3487
Aerobic Exercise Upregulates Renal-Derived ELABELA to Improve Myocardial Fibrosis by Activating APJ-AMPK-Sirt1 and Inhibiting TGFβ1-Smad2/3 Signaling Pathways in Myocardial Infarction Mice.
Ren W, Xi Y, Ma Y, Duan X, Wang T, Yu M, Qin S, Gong DW, Tian Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70734
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 30;39(12):e70734
Scutellarin prevents obesity-induced renal fibrosis via reduced activation of AP-1.
Yi H, Jiang Y, Li W, Shen L, Zhang W, Li S, Xu Y, Li F
Journal of translational medicine 2025 Jun 2;23(1):611
Journal of translational medicine 2025 Jun 2;23(1):611
METTL3 Modulates Radiation-Induced Cardiac Fibrosis via the Akt/mTOR Pathway.
Qiao S, Tang C, Zhu J, Feng Y, Xiang L, Zhu J, Gu X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70666
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jun 15;39(11):e70666
Huangkui capsule, an extract from Abelmoschus manihot (L.) medic, inhibits adrenal aldosterone synthesis and renal ERK/EGR1 pathway in the treatment of diabetic kidney disease.
Saxu R, Tang H, Yu H, Ge H, Gu HF
Journal of ethnopharmacology 2025 Jun 12;349:119936
Journal of ethnopharmacology 2025 Jun 12;349:119936
Endoplasmic reticulum stress contributes to the development of ocular graft-vs-host disease in the eyelids and the ocular surface.
Sato S, Ogawa Y, Shimizu E, Asai K, Negishi K, Tsubota K, Hirayama M
The ocular surface 2025 Jul;37:115-131
The ocular surface 2025 Jul;37:115-131
Quercetin protects against neuronal toxicity by activating the PI3K/Akt/GSK-3β pathway in vivo models of MPTP-induced Parkinson's disease.
Li Y, Man M, Tian Y, Zhao G, Liu F, Zhao J, Huang S, Xue J, Chang W
Inflammopharmacology 2025 Jul;33(7):4063-4076
Inflammopharmacology 2025 Jul;33(7):4063-4076
M2 Macrophage-Derived Extracellular Vesicles Reprogram Immature Neutrophils into Anxa1(hi) Neutrophils to Enhance Inflamed Bone Regeneration.
Yao Y, Yin Y, Shuai F, Lam W, Zhou T, Xie Y, He X, Han X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2416159
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2416159
Isoquercitrin Alleviates Diabetic Nephropathy by Inhibiting STAT3 Phosphorylation and Dimerization.
Xuan C, Chen D, Zhang S, Li C, Fang Q, Chen D, Liu J, Jiang X, Zhang Y, Shen W, Cai G, Chen X, Li P
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2414587
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2414587
Growth hormone combined with estrogen improves intrauterine adhesion fibrosis by downregulating endometrial microbial citraconic acid to target β-catenin protein.
Zeng Y, Yang Y, Zeng F, Feng Q
mSystems 2025 Jul 22;10(7):e0169224
mSystems 2025 Jul 22;10(7):e0169224
Activation of Hippocampal ACE2 Prevents the Dysbiosis-induced Depression-like Behavior in Mice by Enhanced Neurogenesis and Neuroprotection via Mas Receptor.
Takahashi K, Nakagawasai O, Kurokawa K, Miyagawa K, Mochida-Saito A, Takeda H, Tsuji M
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 18;20(1):71
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2025 Jul 18;20(1):71
Liraglutide inhibits the development of colorectal cancer by regulating TGF-β/Smad3 signaling pathway and affecting epithelial-mesenchymal transition.
Li X, Fan M, Huang R, Wang K, Huang H
Discover oncology 2025 Jul 18;16(1):1371
Discover oncology 2025 Jul 18;16(1):1371
Secreted phosphoprotein 1 promotes the activation of keloid fibroblasts via the CD44/TGF-β1/Smad pathway.
Tu Y, Xiong Y, Liu O, Peng Y
Experimental cell research 2025 Jul 15;450(2):114658
Experimental cell research 2025 Jul 15;450(2):114658
Exploring PU.1 as a Therapeutic Target to Mitigate Oxidative Stress and Inflammation in Peritoneal Dialysis-Induced Peritoneal Fibrosis.
Zhong S, Su W, Wang Y, Liu D, Li X, Ma F, Xu L, Gao J, Wang H, Sun J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jul 15;39(13):e70766
Human adipose-derived mesenchymal stem cell-derived exosomes induce epithelial remodeling and anti-scar healing revealed by single-cell RNA sequencing.
Fu Y, Xie JL, Zhang XL, Xie GM, Zhang XM, Han YT, Xu MM, Zhang J, Zhang J
Journal of nanobiotechnology 2025 Jul 14;23(1):506
Journal of nanobiotechnology 2025 Jul 14;23(1):506
TGF-β3 promotes vascular normalization of prostate cancer to potentiate immunotherapy and chemotherapy.
Teng Q, Wang N, Lei H, Tong T, Guan Y, Huang M, Cao F, Xu B, Yang J, Huo Y, Chen W, Bi R, Wang X, Wang Z, Tian FY, Zhao B, Pang J
Cancer immunology, immunotherapy : CII 2025 Jul 12;74(8):268
Cancer immunology, immunotherapy : CII 2025 Jul 12;74(8):268
MST3 Regulates AMPK and YAP-Hippo Signaling in Cell Models Relevant to Renal Fibrosis.
Chan CH, Lu TJ, Bao BY, Chu PC, Chen YK, Syu SL, Jeng WY, Lu TL
Biomolecules & therapeutics 2025 Jul 1;33(4):704-715
Biomolecules & therapeutics 2025 Jul 1;33(4):704-715
THBS4 downregulation alters trophoblast function in preeclampsia via the TGF-β1/Smad signaling cascade.
Shi H, Mao Y, Cui J, Ma R, Yang Z, Zhao Y
American journal of physiology. Cell physiology 2025 Jul 1;329(1):C170-C182
American journal of physiology. Cell physiology 2025 Jul 1;329(1):C170-C182
Increased glucose concentration modifies TGF-β1 and NFκB signaling pathways in aniridia limbal fibroblasts, in vitro.
Li Z, Stachon T, Häcker S, Fries FN, Chai N, Seitz B, Shi L, Hsu SL, Li S, Liu S, Amini M, Suiwal S, Szentmáry N
Experimental eye research 2025 Jan;250:110163
Experimental eye research 2025 Jan;250:110163
ACE2 Inhibits Dermal Regeneration Through Ang II in Tissue Expansion.
Bai R, Liang B, Guo Y, Liu W, Wen Z, Wang Z, Zhang Y, Du J, Song Y, Yu Z, Ma X
Journal of cosmetic dermatology 2025 Jan;24(1):e16767
Journal of cosmetic dermatology 2025 Jan;24(1):e16767
Sang-Bai-Pi extract and its constituent regiafuran C ameliorate renal fibrosis through TGF-β/Smad and Wnt/β-catenin signaling pathways.
Wei QH, Pan YB, Tian LL, Wang YS, Wang JY, Liu X, Zhang H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156351
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156351
Inhibition of PKM2 by shikonin impedes TGF-β1 expression by repressing histone lactylation to alleviate renal fibrosis.
Xiang T, Wang X, Huang S, Zhou K, Fei S, Zhou B, Yue K, Li Q, Xue S, Dai Y, Zhang J, Ni H, Sun C, Huang X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156324
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156324
Xibining inhibition of the PI3K-AKT pathway reduces M1 macrophage polarization to ameliorate KOA synovial inflammation and nociceptive sensitization.
Jie L, Zhang L, Fu H, Kang J, Huang Z, Zhu Z, Yin S, Wu P, Wang P, Mei W, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156281
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jan;136:156281
Tumor-associated neutrophils attenuate the immunosensitivity of hepatocellular carcinoma.
Teo JMN, Chen Z, Chen W, Tan RJY, Cao Q, Chu Y, Ma D, Chen L, Yu H, Lam KH, Lee TKW, Chakarov S, Becher B, Zhang N, Li Z, Ma S, Xue R, Ling GS
The Journal of experimental medicine 2025 Jan 6;222(1)
The Journal of experimental medicine 2025 Jan 6;222(1)
Therapeutic effects of Mudan granules on diabetic retinopathy: Mitigating fibrogenesis caused by FBN2 deficiency and inflammation associated with TNF-α elevation.
Long P, Guo C, Wen T, Luo T, Yang L, Li Y, Wen A, Wang W, Wen X, He M
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118963
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118963
Qianyang Yuyin granules alleviate hypertension-induced vascular remodeling by inhibiting the phenotypic switch of vascular smooth muscle cells.
Fan Y, Jialiken D, Zheng Z, Zhang W, Zhang S, Zheng Y, Sun Z, Zhang H, Yan X, Liu M, Fang Z
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118896
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118896
Mitochondrial transfer of drug-loaded artificial mitochondria for enhanced anti-Glioma therapy through synergistic apoptosis/ferroptosis/immunogenic cell death.
Song M, Yuan J, Zhang G, Sun M, Zhang Y, Su X, Lv R, Zhao Y, Shi Y, Zhao L
Acta biomaterialia 2025 Jan 24;193:514-530
Acta biomaterialia 2025 Jan 24;193:514-530
SR9009 attenuates TGF-β1-induced renal fibrotic responses by inhibiting the NOX4/p38 signaling pathway in NRK-49F cells.
Takaguri A, Shinohe S, Noro R, Sakuraba M, Satoh C, Ohashi R, Satoh K
European journal of pharmacology 2025 Jan 15;987:177162
European journal of pharmacology 2025 Jan 15;987:177162
Enhancing Gene Delivery to Breast Cancer with Highly Efficient siRNA Loading and pH-Responsive Small Extracellular Vesicles.
Kim G, Zhu R, Yu S, Fan B, Jeon H, Leon J, Webber MJ, Wang Y
ACS biomaterials science & engineering 2025 Jan 13;11(1):213-227
ACS biomaterials science & engineering 2025 Jan 13;11(1):213-227
Injectable agents for the induction of Peyronie's disease in model rats: a comparative study.
Du GJ, Xing SY, Wu N, Wang T, Jiang YH, Song T, Yang BB, Dai YT
Asian journal of andrology 2025 Jan 1;27(1):96-100
Asian journal of andrology 2025 Jan 1;27(1):96-100
Ubiquitin-specific protease 25 improves myocardial ischemia-reperfusion injury by deubiquitinating NLRP3 and negatively regulating NLRP3 inflammasome activity in cardiomyocytes.
Ye B, Xu D, Zhong L, Wang Y, Wang W, Xu H, Han X, Min J, Wu G, Huang W, Liang G
Clinical and translational medicine 2025 Feb;15(2):e70243
Clinical and translational medicine 2025 Feb;15(2):e70243
Platelet-Monocyte Aggregate Instigates Inflammation and Vasculopathy in Kawasaki Disease.
Zhang Y, Jia C, Guo M, Chen Q, Wen Y, Wang T, Xie Y, Fan X, Gao J, Yarovinsky TO, Liu R, Jiang Z, Wang M, Zhou J, Che D, Fu L, Edelson R, Gu X, Hwa J, Tang WH
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2406282
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2406282
Platelet-rich fibrin attenuates inflammation and fibrosis in vulvar lichen sclerosus via the TGF-β/SMAD3 pathway.
Sun SH, Fan HH, Wang XW, Bing BD, Hu YJ
Archives of dermatological research 2025 Feb 7;317(1):360
Archives of dermatological research 2025 Feb 7;317(1):360
β-elemene inhibits tumor-promoting in small cell lung cancer by affecting M2 macrophages and TGF-β.
Huang W, Fu B, Xu H
BMC pulmonary medicine 2025 Feb 28;25(1):97
BMC pulmonary medicine 2025 Feb 28;25(1):97
Molecular mechanism of Gancao Xiexin Decoction regulating EMT and suppressing hepatic metastasis of gastric cancer via the TGF-β1/SMAD pathway.
Liu W, Lu D, Jia S, Yang Y, Meng F, Du Y, Yang Y, Yuan L, Nan Y
Journal of ethnopharmacology 2025 Feb 27;342:119430
Journal of ethnopharmacology 2025 Feb 27;342:119430
ITIH5-mediated fibroblast/macrophage crosstalk exacerbates cardiac remodelling after myocardial infarction.
Wu Y, Meng L, Zhan S, Li M, Huang J, Chen X, Chen L, Gao X, Chen H, Chen H, Zhong Y, Xu L, Xu Y
Journal of translational medicine 2025 Feb 24;23(1):224
Journal of translational medicine 2025 Feb 24;23(1):224
CCN2 mediates fibroblast-macrophage interaction in knee arthrofibrosis based on single-cell RNA-seq analysis.
Li Z, Jiang J, Cai K, Qiao Y, Zhang X, Wang L, Kang Y, Wu X, Zhao B, Wang X, Zhang T, Lin Z, Wu J, Lu S, Gao H, Jin H, Xu C, Huangfu X, James Z, Chen Q, Zheng X, Liu NN, Zhao J
Bone research 2025 Feb 24;13(1):26
Bone research 2025 Feb 24;13(1):26
Cryoablation-induced modulation of Treg cells and the TGF-β pathway in lung adenocarcinoma: implications for increased antitumor immunity.
Lin S, Liu D, Liang T, Zhuang Y, Wang X, Ma S, Li Q, Hu K
BMC medicine 2025 Feb 14;23(1):89
BMC medicine 2025 Feb 14;23(1):89
Differences in tumor angiogenesis and related factors between lung adenocarcinomas manifesting as pure ground glass opacity and solid nodules.
Qu R, Zhang Y, Qin S, Xiong J, Fu X, Li L, Tu D, Cai Y
Discover oncology 2025 Feb 13;16(1):180
Discover oncology 2025 Feb 13;16(1):180
Long-term glucosamine supplementation aggravates atrial fibrillation susceptibility by impairing AMPK signaling.
Qin X, Gong H, Jin L, Wang Y, Dang K, Li H, Zheng Q
Life sciences 2025 Feb 1;362:123380
Life sciences 2025 Feb 1;362:123380
IMUP promotes fatty acid metabolism and lung cancer progression by regulating TGF-β/SMAD3 signaling pathway.
Wu S, Liu F, Yao X, Lei Y, Wang W
Tissue & cell 2025 Dec;97:103061
Tissue & cell 2025 Dec;97:103061
Analysis of potential targets of 20S-protopanaxadiol on diabetic nephropathy based on network pharmacology, molecular docking, and experimental validation.
Li C, Ma C, Zhao R, Li X, Yu H, Yuan M
Renal failure 2025 Dec;47(1):2526688
Renal failure 2025 Dec;47(1):2526688
Panaxatriol saponins exert anti-renal fibrosis by suppressing TNF-α mediated inflammation and TGF-β1/Smad3 signaling pathway.
Yi S, Li F, Ma X, Xu Y, Lai W, Chen H, Fan J, Mao N, Ren S
Renal failure 2025 Dec;47(1):2516774
Renal failure 2025 Dec;47(1):2516774
Bosutinib alleviates peritoneal fibrosis by regulating mesothelial-to-mesenchymal transition through inhibition of the PI3K/AKT pathway.
Wang Q, Dou H, Zhang L, Fu J, Rao Q, Song L, Li L, Chen G, Li C, Zhang P
Biochemical pharmacology 2025 Dec;242(Pt 4):117412
Biochemical pharmacology 2025 Dec;242(Pt 4):117412
Regulation of phosphatase and tensin homolog by complement component 5a (C5a) and its receptor (C5aR1) in lupus nephritis: A novel therapeutic target.
Ma Y, Wang Y, Zhao P, Cheng L, Li L, Li R, Zhou X
Journal of cell communication and signaling 2025 Dec;19(4):e70055
Journal of cell communication and signaling 2025 Dec;19(4):e70055
Viscoelastic Hydrogel with Mechanomodulatory Tension Shielding and Time-Dependent Immunomodulatory Effects for Scarless Healing.
Kuan CH, Wang YN, Liao EF, Wang WH, Kung PJ, Huang WY, Chen SH, Chen SH, Hu JJ, Lin SJ, Wang TW
Advanced healthcare materials 2025 Dec;14(32):e01954
Advanced healthcare materials 2025 Dec;14(32):e01954
Bmi-1 overexpression mitigates vitamin D deficiency-induced pulmonary fibrosis via TIME pathway.
Zhang J, Huang M, Zhou J, Chen H, Wang Z, Jin J, Shu L, Miao D
Cellular signalling 2025 Dec;136:112180
Cellular signalling 2025 Dec;136:112180
NIR-II Responsive Multifunctional Scaffold Enabling "Kill-Modulation-Build" Synergistic Therapy for Infectious Bone Defects.
Yang Q, Lou S, Zhang Y, Fang Z, Xing C, Wang W, Han M, Wang Z, Tang BZ, Zhang M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e08948
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(47):e08948
TGF-β1 promotes collagen synthesis in systemic sclerosis via upregulating P4HA3.
Chen Z, Lin Y, Huang Y, Chen Z, Gong Y, Hou Z, Lin L
Journal of translational autoimmunity 2025 Dec;11:100323
Journal of translational autoimmunity 2025 Dec;11:100323
Pachymic Acid Suppresses Endometrial Cancer Cell Migration by Inhibiting the NR3C1/TGF-β/Smad Signaling Pathway.
Wang Y, Ma L
Chemical biology & drug design 2025 Dec;106(6):e70226
Chemical biology & drug design 2025 Dec;106(6):e70226
HMGB1-enhanced autophagic degradation of E-cadherin facilitates mesothelial trans-differentiation and postoperative peritoneal adhesion.
Yuan X, Yang S, Qu C, Zhang R, Ren Y, Sun Y, Li E, Li G, Zhang J, Du J, Shen T, Jiang Z, Li X
BMC gastroenterology 2025 Dec 30;26(1):83
BMC gastroenterology 2025 Dec 30;26(1):83
Excessive collagen type VII mediates pleural fibrosis via increasing extracellular matrix stiffness.
Li Q, He XL, Chen SJ, Niu Q, Cao TZ, Cui XL, Jia ZH, Zhang HD, Feng X, Jiang YH, Liang LM, Cheng PP, Hu SH, Xiong L, Wang M, Ye H, Ma WL
The Journal of clinical investigation 2025 Dec 15;135(24)
The Journal of clinical investigation 2025 Dec 15;135(24)
Integrative analysis of non-small cell lung cancer identifies Jumonji domain-containing 6/ETS homologous factor axis as a target to overcome radioresistance.
Wang M, Xu L, Alu A, Li P, Liu J, Chen S, He X, Han X, Yang L, Pu Q, Wei X
Signal transduction and targeted therapy 2025 Dec 1;10(1):391
Signal transduction and targeted therapy 2025 Dec 1;10(1):391
Tanshinone IIA ameliorates septic immunosuppression by balancing the Th17/Treg cell ratio and modulating Treg function after induction of autophagy.
Ou H, Sun B, Jiang Y, Gao M
Archives of biochemistry and biophysics 2025 Aug;770:110451
Archives of biochemistry and biophysics 2025 Aug;770:110451
Concurrent inhibition of tumor growth and metastasis by a lipidated nanophotosensitizer tracing and disabling tumor extracellular vesicles.
Miao G, Shang Z, Wang X, Zhang J, Xu M, He P, Zhong Q, Zhao X, Tan G, Wang X
Nature cancer 2025 Aug;6(8):1438-1457
Nature cancer 2025 Aug;6(8):1438-1457
Rehmannioside A alleviates renal inflammation and fibrosis in hypertensive nephropathy via AT1R/MAPK14/IL-17 signaling pathway.
Liu F, Wang J, Sun Z, Yu X
Biochemical and biophysical research communications 2025 Aug 30;776:152237
Biochemical and biophysical research communications 2025 Aug 30;776:152237
Sanleng Wan inhibits endometriosis progression by regulating sphingolipid metabolism via the S1P/S1PR1-Akt axis based on serum metabolomics and network pharmacology.
Fu Z, Zhou H, Liu H, Li X, Cao L, Zheng W
Journal of ethnopharmacology 2025 Aug 29;352:120153
Journal of ethnopharmacology 2025 Aug 29;352:120153
Maimendong decoction and its active ingredient, ophiopogonin D, alleviate bleomycin-induced pulmonary fibrosis by regulating the behavior of lung fibroblasts.
Yang M, Zhang X, Bao S, Yang S, Zhang Y, Liu Y, Li C, Zou J, Li J, Yan S
Chinese medicine 2025 Aug 29;20(1):135
Chinese medicine 2025 Aug 29;20(1):135
ZC3H11A mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice.
Chen C, Liu Q, Tang C, Rong Y, Zhao X, Li D, Lu F, Qu J, Liu X
eLife 2025 Aug 27;12
eLife 2025 Aug 27;12
Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion.
Qiao G, Li C, Wang M, Zhang W, Shi J, Meng B, Zhang L, Zhang R, Qi H, Xin S
BMC gastroenterology 2025 Aug 20;25(1):605
BMC gastroenterology 2025 Aug 20;25(1):605
The protective role of ureteral stents in reducing fibrosis and preventing stricture in ureteral injuries of different severities.
Gu H, Yang T, Qin Z, Zhang S, Wang L, Zhao Z
BMC urology 2025 Aug 19;25(1):204
BMC urology 2025 Aug 19;25(1):204
Taurine alleviated paraquat-induced oxidative stress and gut-liver axis damage in weaned piglets by regulating the Nrf2/Keap1 and TLR4/NF-κB signaling pathways.
Chen C, Qi M, Zhang W, Chen F, Sun Z, Sun W, Tang W, Yang Z, Zhao X, Tang Z
Journal of animal science and biotechnology 2025 Aug 18;16(1):117
Journal of animal science and biotechnology 2025 Aug 18;16(1):117
Sorafenib inhibits ovarian inflammation and fibrosis in polycystic ovary syndrome by targeting the PDGFA/PDGFRα/NF-κB pathway in granulosa cells†.
Liu X, Wang Y, Wang Y, Bai Y, Kang A, Cai Q, Liu H, Zhang M, Xu C, Zhang F
Biology of reproduction 2025 Aug 13;113(2):423-435
Biology of reproduction 2025 Aug 13;113(2):423-435
Circadian clock gene BMAL1 is involved in transforming growth factor β1-induced fibrotic response in NRK-49F cells.
Takaguri A, Noro R, Shinohe S, Murayama R, Sakuraba M, Nomura R, Satoh K
Cell biology international 2025 Apr;49(4):365-373
Cell biology international 2025 Apr;49(4):365-373
Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways.
Wu N, Zhao Y, Xiao M, Liu H, Chen H, Liu B, Wang X, Fan X
Inflammation 2025 Apr;48(2):950-962
Inflammation 2025 Apr;48(2):950-962
Uniform and controllable surface nano-structure on polyetheretherketone implants can regulate mechanical property to enhance soft tissue integration through Piezo1/TGF-β1 signaling axis.
Liu S, Chen Y, Zhou G, Sun C, Ma M, Huang R, Li X, Liang X, Shi C, Wu W, Yan X, Wang L, Han J
Materials today. Bio 2025 Apr;31:101645
Materials today. Bio 2025 Apr;31:101645
Itaconate promotes mitophagy to inhibit neuronal ferroptosis after subarachnoid hemorrhage.
Wang G, Li Z, Han W, Tian Q, Liu C, Jiang S, Xiang X, Zhao X, Wang L, Liao J, Li M
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):991-1004
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):991-1004
MSC exosomes and MSC exosomes loaded with LncRNA H19 as nanotherapeutics regulate the neurogenetic potential of Müller Glial Cells in dry age-related macular degeneration.
Tang Y, Cheng C, Ding R, Qian J, Liu M, Guo Y, Li Q
Free radical biology & medicine 2025 Apr;231:178-192
Free radical biology & medicine 2025 Apr;231:178-192
Banxia Xiexin Decoction inhibits colitis-associated colorectal cancer development by modulating STAT3 signaling and gut microbiota.
Yue Y, Su L, Wang Y, Li X, Xiao X, Xie J, Yan S
Chinese herbal medicines 2025 Apr;17(2):380-391
Chinese herbal medicines 2025 Apr;17(2):380-391
CpG-Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2-Mediated Remodeling of Tumor-Associated Macrophages.
Xiong J, Huang J, Xu H, Wu Q, Zhao J, Chen Y, Fan G, Guan H, Xiao R, He Z, Wu S, Ouyang W, Wang S, Zhang L, Xia P, Zhang W, Wu M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412881
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(15):e2412881
Alleviation of obesity cardiomyopathy by Fisetin through the inhibition of NF-κB/MAPK signaling.
Liu X, Zhu J, Li C, Tong C, Zhao C, Lin X, Wang Y, Alinejad T, Wu H, Chen G, Li L
International immunopharmacology 2025 Apr 4;151:114319
International immunopharmacology 2025 Apr 4;151:114319
Single-cell sequencing unveils the transcriptomic landscape of castration-resistant prostate cancer-associated fibroblasts and their association with prognosis and immunotherapy response.
Qiu Y, Wang Y, Liu J, Sun K, Liu B, Hou Q
BMC cancer 2025 Apr 30;25(1):813
BMC cancer 2025 Apr 30;25(1):813
Single-nucleus RNA sequencing and spatial transcriptomics reveal the mechanism by which Xiaozhiling injection treats internal hemorrhoids.
Ke MH, Huang SY, Lin WG, Xu ZG, Zheng XX, Liu XB, Cheng YM, Li ZF
World journal of gastrointestinal surgery 2025 Apr 27;17(4):103494
World journal of gastrointestinal surgery 2025 Apr 27;17(4):103494
Cornua cervi degelatinatum inhibits breast cancer stem-like cell properties and metastasis via miR-148a-3p-mediated TGF-β/Smad2 pathway.
Ma Y, Song B, Peng J, Wei F, Hao Y, Wen Y, Lv H, Shi X, Wang Y, Peng T
Journal of ethnopharmacology 2025 Apr 25;346:119709
Journal of ethnopharmacology 2025 Apr 25;346:119709
Thymidine Phosphorylase Promotes Abdominal Aortic Aneurysm via VSMC Modulation and Matrix Remodeling in Mice and Humans.
Hong L, Yue H, Cai D, DeHart A, Toloza-Alvarez G, Du L, Zhou X, Fan X, Huang H, Chen S, Rahaman SO, Zhuang J, Li W
Cardiovascular therapeutics 2024;2024:1129181
Cardiovascular therapeutics 2024;2024:1129181
Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition.
Lu J, Sun W, Liu B, Zhang J, Wang R, Goltzman D, Miao D
International journal of biological sciences 2024;20(6):2008-2026
International journal of biological sciences 2024;20(6):2008-2026
Serum amyloid A contributes to radiation-induced lung injury by activating macrophages through FPR2/Rac1/NF-κB pathway.
Liu X, Song Y, Hu S, Bai Y, Zhang J, Tai G, Shao C, Pan Y
International journal of biological sciences 2024;20(12):4941-4956
International journal of biological sciences 2024;20(12):4941-4956
Lysozyme promotes renal fibrosis through the JAK/STAT3 signal pathway in diabetic nephropathy.
Ren Y, Yu M, Zheng D, He W, Jin J
Archives of medical science : AMS 2024;20(1):233-247
Archives of medical science : AMS 2024;20(1):233-247
Geniposide ameliorates bleomycin-induced pulmonary fibrosis in mice by inhibiting TGF-β/Smad and p38MAPK signaling pathways.
Yin JB, Wang YX, Fan SS, Shang WB, Zhu YS, Peng XR, Zou C, Zhang X
PloS one 2024;19(9):e0309833
PloS one 2024;19(9):e0309833
Melatonin serves as a novel treatment in bladder fibrosis through TGF-β1/Smad and EMT.
Zhang Y, Gong S, He W, Yuan J, Dong D, Zhang J, Wang H, Chen B
PloS one 2024;19(3):e0295104
PloS one 2024;19(3):e0295104
TAK-242 alleviates diabetic cardiomyopathy via inhibiting pyroptosis and TLR4/CaMKII/NLRP3 pathway.
Zhao X, Zhang J, Xu F, Shang L, Liu Q, Shen C
Open life sciences 2024;19(1):20220957
Open life sciences 2024;19(1):20220957
Pretreatment of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes with Quercetin Enhances the Healing of Diabetic Skin Wounds by Modulating Host-Microbiota Interactions.
Wu S, Zhou Z, Li Y, Wu R, Jiang J
International journal of nanomedicine 2024;19:12557-12581
International journal of nanomedicine 2024;19:12557-12581
RASSF4 Attenuates Metabolic Dysfunction-Associated Steatotic Liver Disease Progression via Hippo Signaling and Suppresses Hepatocarcinogenesis.
Xu C, Fang T, Qu J, Miao Y, Tian L, Zhang M, Zhuang H, Sun B, Chen L
Cellular and molecular gastroenterology and hepatology 2024;18(2):101348
Cellular and molecular gastroenterology and hepatology 2024;18(2):101348
Therapeutic Effects of Qingchang Tongluo Decoction on Intestinal Fibrosis in Crohn's Disease: Network Pharmacology, Molecular Docking and Experiment Validation.
Li Y, Hu J, Au R, Cheng C, Xu F, Li W, Wu Y, Cui Y, Zhu L, Shen H
Drug design, development and therapy 2024;18:3269-3293
Drug design, development and therapy 2024;18:3269-3293
Huang Gan Formula Alleviates Systemic Inflammation and Uremia in Adenine-Induced Chronic Kidney Disease Rats May Associate with Modification of Gut Microbiota and Colonic Microenvironment.
Zhao J, Zhao C, Xun T, Wang X, Wei S, Ye C, Zhang M, Guo D, Yang X
Drug design, development and therapy 2024;18:13-28
Drug design, development and therapy 2024;18:13-28
Tiaogan Bushen Xiaoji Formula Enhances the Sensitivity of Estrogen Receptor- Positive Breast Cancer to Tamoxifen by Inhibiting the TGF-β/SMAD Pathway.
Lu J, Li Z, Liu X, Xu B, Zhang W
Cancer management and research 2024;16:1189-1204
Cancer management and research 2024;16:1189-1204
Knockdown ATG5 gene by rAAV9 alleviates doxorubicin-induced cardiac toxicity by inhibiting GATA4 autophagic degradation.
Xu AL, Shen Z, Wang SH, Luan HY, Xu Y, Kang ZC, Liao ZQ, Liu J, Duan XL, Bian WH, Sun H, Xie X
Frontiers in pharmacology 2024;15:1496380
Frontiers in pharmacology 2024;15:1496380
Profiling hypoxia signaling reveals a lncRNA signature contributing to immunosuppression in high-grade glioma.
Li X, Xu J, Li X, Shi J, Wei C, Liang Q
Frontiers in immunology 2024;15:1471388
Frontiers in immunology 2024;15:1471388
Polygonatum cyrtonema polysaccharides reshape the gut microbiota to ameliorate dextran sodium sulfate-induced ulcerative colitis in mice.
Lin C, Song D, Wang S, Chu Y, Chi C, Jia S, Lin M, He C, Jiang C, Gong F, Chen Q
Frontiers in pharmacology 2024;15:1424328
Frontiers in pharmacology 2024;15:1424328
Mingjing granule inhibits the subretinal fibrovascular membrane of two-stage laser-induced neovascular age-related macular degeneration in rats.
Li X, Li J, Zeng W, Wang B, Du M, Liang L, Gao Y
Frontiers in pharmacology 2024;15:1384418
Frontiers in pharmacology 2024;15:1384418
Single-cell RNA sequencing reveals S100a9(hi) macrophages promote the transition from acute inflammation to fibrotic remodeling after myocardial ischemia‒reperfusion.
Shen S, Zhang M, Wang X, Liu Q, Su H, Sun B, Guo Z, Tian B, Gan H, Gong C, Ma L
Theranostics 2024;14(3):1241-1259
Theranostics 2024;14(3):1241-1259
Activating autophagy promotes skin regeneration induced by mechanical stretch during tissue expansion.
Du J, Liu W, Song Y, Zhang Y, Dong C, Xiong S, Huang Z, Wang T, Ding J, He Q, Yu Z, Ma X
Burns & trauma 2024;12:tkad057
Burns & trauma 2024;12:tkad057
TNFSF15 variant predicts disease progression in Chinese patients with Crohn's disease.
Zhang Q, Wang W, Xiang B, Lin D, Hu J, Zhao J, Lin J, Liu T, Deng J, Zhang M, Zhi M
Gastroenterology report 2024;12:goae103
Gastroenterology report 2024;12:goae103
Quercetin alleviates PM(2.5)-induced chronic lung injury in mice by targeting ferroptosis.
Ding S, Jiang J, Li Y
PeerJ 2024;12:e16703
PeerJ 2024;12:e16703
Ultra-small curcumin-ruthenium coordination polymer nanodots prevent renal ischemia-reperfusion injury and the progression to chronic kidney disease.
Liu X, Yu Q, Mao HB, Hu JB, Liu WH
Frontiers in bioengineering and biotechnology 2024;12:1506909
Frontiers in bioengineering and biotechnology 2024;12:1506909
Amorphous curcumin-based hydrogels to reduce the incidence of post-surgical intrauterine adhesions.
Zhang W, He Y, Chu Y, Zhai Y, Qian S, Wang X, Jiang P, Cui P, Zhang Y, Wang J
Regenerative biomaterials 2024;11:rbae043
Regenerative biomaterials 2024;11:rbae043
Melatonin Attenuates Diabetic Retinopathy by Regulating EndMT of Retinal Vascular Endothelial Cells via Inhibiting the HDAC7/FOXO1/ZEB1 Axis.
Ning J, Pan M, Yang H, Wang Z, Wang X, Guo K, Feng Y, Xie T, Chen Y, Chen C, Liu S, Zhang Y, Wang Y, Yan X, Han J
Journal of pineal research 2024 Sep;76(6):e13008
Journal of pineal research 2024 Sep;76(6):e13008
Cyy-272, an indazole derivative, effectively mitigates obese cardiomyopathy as a JNK inhibitor.
Liu X, Cheng LT, Ye QR, Gao HC, Zhu JW, Zhao K, Liu HM, Wang YJ, Alinejad T, Zhang XH, Chen GZ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117172
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117172
Mechanism of Zhenwu Decoction modulating TLR4/NF-κB/HIF-1α loop through miR-451 to delay renal fibrosis in type 2 CRS.
Xu X, Wang Y, Song Q, Zheng H, Lv J, Fu Z, Mao X, Li Y, Wu H, Zhang B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155632
Oxysophoridine inhibits oxidative stress and inflammation in hepatic fibrosis via regulating Nrf2 and NF-κB pathways.
Chen JY, Yang YJ, Meng XY, Lin RH, Tian XY, Zhang Y, Lai WF, Yang C, Ma XQ, Huang MQ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155585
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155585
Kindlin-2 mediates Peyronie's disease through activation of TGF-β/Smad signaling pathway under the presence of TGF-β1.
Yang X, Wu J, Cai T, Shan J, Cui Y
Cellular signalling 2024 Sep;121:111286
Cellular signalling 2024 Sep;121:111286
Knockdown of programmed cell death factor 4 restores erectile function by attenuating apoptosis in rats with bilateral cavernous nerve crush injury.
Ge Y, Xia T, Feng Z, Xi Y, Hu D, Hong Y, Tang B, Wu J, Chen J, Xiao H
Andrology 2024 Sep;12(6):1439-1448
Andrology 2024 Sep;12(6):1439-1448
Platelets promote primary hepatocellular carcinoma metastasis through TGF-β1-mediated cancer cell autophagy.
Lu M, Gong X, Zhang YM, Guo YW, Zhu Y, Zeng XB, Gao JH, Liu LM, Shu D, Ma R, Liang HF, Zhang RY, Xu Y, Zhang BX, Lu YJ, Ming ZY
Cancer letters 2024 Sep 28;600:217161
Cancer letters 2024 Sep 28;600:217161
Gut commensal Alistipes as a potential pathogenic factor in colorectal cancer.
Fu J, Li G, Li X, Song S, Cheng L, Rui B, Jiang L
Discover oncology 2024 Sep 27;15(1):473
Discover oncology 2024 Sep 27;15(1):473
Syn-COM: A Multi-Level Predictive Synergy Framework for Innovative Drug Combinations.
Shi Y, Liu J, Guan S, Wang S, Yu C, Yu Y, Li B, Zhang Y, Yang W, Wang Z
Pharmaceuticals (Basel, Switzerland) 2024 Sep 18;17(9)
Pharmaceuticals (Basel, Switzerland) 2024 Sep 18;17(9)
S-Methyl-L-cysteine targeting MsrA attenuates Ang II-induced oxidative stress and atrial remodeling via the p38 MAPK signaling pathway.
Xu B, Xu Y, Ren W, Meng S, Hong T, Cao Z, Xiao X, Guo X, Yu L, Zhao J, Wang H
Food & function 2024 Sep 16;15(18):9165-9175
Food & function 2024 Sep 16;15(18):9165-9175
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Bao Z, Li J, Cai J, Yao S, Yang N, Yang J, Zhao B, Chen Y, Wu X
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
Blocking Sigmar1 exacerbates methamphetamine-induced hypertension.
Xu ZZ, Zhou J, Duan K, Li XT, Chang S, Huang W, Lu Q, Tao J, Xie WB
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167284
Biochimica et biophysica acta. Molecular basis of disease 2024 Oct;1870(7):167284
Activation of SIRT3 by Tanshinone IIA ameliorates renal fibrosis by suppressing the TGF-β/TSP-1 pathway and attenuating oxidative stress.
Fan Y, Kang S, Shao T, Xu L, Chen J
Cellular signalling 2024 Oct;122:111348
Cellular signalling 2024 Oct;122:111348
The Effect of Metformin on Radiation-Induced Lung Fibrosis in Mice.
Chen YZ, Zhao L, Wei W, Gu J, Liu ZH, Shan WY, Dong J, Li C, Qin LQ, Xu JY
Dose-response : a publication of International Hormesis Society 2024 Oct-Dec;22(4):15593258241308051
Dose-response : a publication of International Hormesis Society 2024 Oct-Dec;22(4):15593258241308051
CircGNAO1 suppresses hepatocellular carcinoma progression and metastasis via sponging miR-182-5p and regulating FOXO1 expression.
Ju L, Luo Y, Shan J, Lu R, Chen L, Shao J, Bian Z, Yao M
International immunopharmacology 2024 Oct 25;140:112873
International immunopharmacology 2024 Oct 25;140:112873
Drugs targeting TGF-β/Notch interaction attenuate hypertrophic scar formation by optic atrophy 1-mediated mitochondrial fusion.
Huo D, Bi XY, Zeng JL, Dai DM, Dong XL
Molecular and cellular biochemistry 2024 Nov;479(11):3049-3061
Molecular and cellular biochemistry 2024 Nov;479(11):3049-3061
Rapamycin alleviates irradiation-induced parotid injury by enhancing the whole gland homeostasis.
Zhu Z, Song J, Zhang C, Zhang J, Shan Z
Oral diseases 2024 Nov;30(8):5050-5061
Oral diseases 2024 Nov;30(8):5050-5061
Targeting delivery of mifepristone to endometrial dysfunctional macrophages for endometriosis therapy.
Zhang M, Ye Y, Chen Z, Wu X, Chen Y, Zhao P, Zhao M, Zheng C
Acta biomaterialia 2024 Nov;189:505-518
Acta biomaterialia 2024 Nov;189:505-518
Effect of Ritanserin and Duloxetine on the Gene Expression of Primary Aniridia and Healthy Human Limbal Stromal Cells, In Vitro.
Li Z, Szentmáry N, Fries FN, Suiwal S, Chai N, Seitz B, Shi L, Amini M, Stachon T
Ophthalmology and therapy 2024 Nov;13(11):2931-2950
Ophthalmology and therapy 2024 Nov;13(11):2931-2950
Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation.
Chen Y, Jin H, Ali W, Zhuang T, Sun J, Wang T, Song J, Ma Y, Yuan Y, Bian J, Liu Z, Zou H
Poultry science 2024 Nov;103(11):104152
Poultry science 2024 Nov;103(11):104152
Single-cell sequencing reveals cellular heterogeneity of nucleus pulposus in intervertebral disc degeneration.
Jia S, Liu H, Yang T, Gao S, Li D, Zhang Z, Zhang Z, Gao X, Liang Y, Liang X, Wang Y, Meng C
Scientific reports 2024 Nov 8;14(1):27245
Scientific reports 2024 Nov 8;14(1):27245
Up-regulation of IL-1β and sPLA2-III in the medial prefrontal cortex contributes to orofacial and somatic hyperalgesia induced by malocclusion via glial-neuron crosstalk.
Feng HN, Zhong LQ, Xu CX, Wang TT, Wu H, Wang L, Traub RJ, Chen X, Cao DY
European journal of pharmacology 2024 Nov 5;982:176933
European journal of pharmacology 2024 Nov 5;982:176933
Targeting GPR39 in structure-based drug discovery reduces Ang II-induced hypertension.
Hua D, Huang W, Xie Q, Xu W, Tang L, Liu M, Wu X, Zhang Q, Cao X, Li P, Sheng Y
Communications biology 2024 Nov 5;7(1):1441
Communications biology 2024 Nov 5;7(1):1441
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Wang J, Xia Z, Qing B, Chen Y, Gu L, Chen H, Ge Z, Yuan Y
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Gastrodin attenuates diabetic cardiomyopathy characterized by myocardial fibrosis by inhibiting the KLK8-PAR1 signaling axis.
Zhang M, Zhang Y, He J, Wang X, Wang Y, Li L, Tao L, Zhang M, Shen X
Chinese medicine 2024 Nov 22;19(1):164
Chinese medicine 2024 Nov 22;19(1):164
Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling.
Shen Z, Zhang Y, Bu G, Fang L
International immunopharmacology 2024 Nov 15;141:112778
International immunopharmacology 2024 Nov 15;141:112778
Exosome-derived circ-001422 promotes tumor-associated macrophage M2 polarization to accelerate the progression of glioma.
Cao W, Zeng Z, Sun J, Chen Y, Kuang F, Luo S, Lan J, Lei S
Communications biology 2024 Nov 13;7(1):1504
Communications biology 2024 Nov 13;7(1):1504
Multifunctional SEBS/AgNWs Nanocomposite Films with Antimicrobial, Antioxidant, and Anti-Inflammatory Properties Promote Infected Wound Healing.
Chen C, Amona FM, Chen J, Chen X, Ke Y, Tang S, Xu J, Chen X, Pang Y
ACS applied materials & interfaces 2024 Nov 13;16(45):61751-61764
ACS applied materials & interfaces 2024 Nov 13;16(45):61751-61764
Long-term swimming exercise attenuates right ventricular hypertrophy via modulating meta-inflammation in monocrotaline-induced pulmonary hypertensive rats.
Chen Z, Wang J, Qin X, Di N, Deng H, Li X
Biochemical and biophysical research communications 2024 Nov 12;733:150710
Biochemical and biophysical research communications 2024 Nov 12;733:150710
High relative humidity environment alleviates hypoxia-induced pulmonary arterial hypertension in mice.
Song J, Cheng J, Ju W, Hu D, Zhuang D
Biochemical and biophysical research communications 2024 Nov 12;733:150681
Biochemical and biophysical research communications 2024 Nov 12;733:150681
CD8(+) tissue-resident memory T cells are essential in bleomycin-induced pulmonary fibrosis.
Feng X, Yu F, He XL, Cheng PP, Niu Q, Zhao LQ, Li Q, Cui XL, Jia ZH, Ye SY, Liang LM, Song LJ, Xiong L, Xiang F, Wang X, Ma WL, Ye H
American journal of physiology. Cell physiology 2024 Nov 1;327(5):C1178-C1191
American journal of physiology. Cell physiology 2024 Nov 1;327(5):C1178-C1191
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice.
Wang Y, Gu YH, Ren KW, Xie X, Wang SH, Zhu XX, Wang L, Yang XL, Bi HL
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322
Hypertension research : official journal of the Japanese Society of Hypertension 2024 May;47(5):1309-1322
Macrophage-specific FGFR1 deletion alleviates high-fat-diet-induced liver inflammation by inhibiting the MAPKs/TNF pathways.
Zhao YN, Liu ZD, Yan T, Xu TX, Jin TY, Jiang YS, Zuo W, Lee KY, Huang LJ, Wang Y
Acta pharmacologica Sinica 2024 May;45(5):988-1001
Acta pharmacologica Sinica 2024 May;45(5):988-1001
Macrophages promote the transition from myocardial ischemia reperfusion injury to cardiac fibrosis in mice through GMCSF/CCL2/CCR2 and phenotype switching.
Shen SC, Xu J, Cheng C, Xiang XJ, Hong BY, Zhang M, Gong C, Ma LK
Acta pharmacologica Sinica 2024 May;45(5):959-974
Acta pharmacologica Sinica 2024 May;45(5):959-974
The circadian clock gene, BMAL1, promotes radiosensitization in nasopharyngeal carcinoma by inhibiting the epithelial-to-mesenchymal transition via the TGF-β1/Smads/Snail1 axis.
Li Y, Zhou Y, Zhao C, Liu L, He Q, Shang K, Xu X, Luo X, Zhou D, Jin F
Oral oncology 2024 May;152:106798
Oral oncology 2024 May;152:106798
Dachengqi decoction ameliorates sepsis-induced liver injury by inhibiting the TGF-β1/Smad3 pathways.
Pan G, Wu Y, Liu Y, Zhou F, Li S, Yang S
Journal of traditional and complementary medicine 2024 May;14(3):256-265
Journal of traditional and complementary medicine 2024 May;14(3):256-265
The extracellular matrix differentially directs myoblast motility and differentiation in distinct forms of muscular dystrophy: Dystrophic matrices alter myoblast motility.
Long AM, Kwon JM, Lee G, Reiser NL, Vaught LA, O'Brien JG, Page PGT, Hadhazy M, Reynolds JC, Crosbie RH, Demonbreun AR, McNally EM
Matrix biology : journal of the International Society for Matrix Biology 2024 May;129:44-58
Matrix biology : journal of the International Society for Matrix Biology 2024 May;129:44-58
Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelial-mesenchymal transition.
Shi YX, Xu L, Wang X, Zhang KK, Zhang CY, Liu HY, Ding PP, Shi W, Liu ZY
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155461
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155461
Cross-species single-cell analysis uncovers the immunopathological mechanisms associated with IgA nephropathy progression.
Chen X, Wang T, Chen L, Zhao Y, Deng Y, Shen W, Li L, Yin Z, Zhang C, Cai G, Zhang M, Chen X
JCI insight 2024 May 8;9(9)
JCI insight 2024 May 8;9(9)
Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation.
Chen K, Ha S, Xu L, Liu C, Liu Y, Wu X, Li Z, Wu S, Yang B, Chen Z
Journal of translational medicine 2024 May 8;22(1):437
Journal of translational medicine 2024 May 8;22(1):437
Exosomes derived from adipose tissue-derived stem cells alleviated H(2)O(2)-induced oxidative stress and endothelial-to-mesenchymal transition in human umbilical vein endothelial cells by inhibition of the mir-486-3p/Sirt6/Smad signaling pathway.
Li Y, Xiao Y, Shang Y, Xu C, Han C, Hu D, Han J, Wang H
Cell biology and toxicology 2024 May 25;40(1):39
Cell biology and toxicology 2024 May 25;40(1):39
Neferine mitigates angiotensin II-induced atrial fibrillation and fibrosis via upregulation of Nrf2/HO-1 and inhibition of TGF-β/p-Smad2/3 pathways.
Jiang XX, Zhang R, Wang HS
Aging 2024 May 21;16(10):8630-8644
Aging 2024 May 21;16(10):8630-8644
Fluorescent Chiral Quantum Dots to Unveil Origin-Dependent Exosome Uptake and Cargo Release.
Kim G, Zhu R, Zhang Y, Jeon H, Shirinichi F, Wang Y
ACS applied bio materials 2024 May 20;7(5):3358-3374
ACS applied bio materials 2024 May 20;7(5):3358-3374
MicroRNA-142-3p alleviated high salt-induced cardiac fibrosis via downregulating optineurin-mediated mitophagy.
Li Y, Zhao K, Hu Y, Yang F, Li P, Liu Y
iScience 2024 May 17;27(5):109764
iScience 2024 May 17;27(5):109764
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis.
Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, Zou L, Chen S, Zhu L, Zhao Q, Zhan G, Ouyang L, Peng C, Han B, Zhang J, Fu L
Signal transduction and targeted therapy 2024 May 15;9(1):133
Signal transduction and targeted therapy 2024 May 15;9(1):133
Inhibition of sugar-binding activity of Galectins-8 by thiogalactoside (TDG) attenuates secondary brain damage and improves long-term prognosis following intracerebral hemorrhage.
Song J, Bai H, Chen S, Xing Y, Lou J
Heliyon 2024 May 15;10(9):e30422
Heliyon 2024 May 15;10(9):e30422
Glioma-derived exosome Lncrna Agap2-As1 promotes glioma proliferation and metastasis by mediating Tgf-β1 secretion of myeloid-derived suppressor cells.
Tian Y, Gao X, Yang X, Chen S, Ren Y
Heliyon 2024 May 15;10(9):e29949
Heliyon 2024 May 15;10(9):e29949
Therapeutic Potential of Fucoidan in Alleviating Histamine-Induced Liver Injury: Insights from Mice Studies.
Zhang M, Liu H, Xu L, Zhang X, Chen W, Wang C
Foods (Basel, Switzerland) 2024 May 14;13(10)
Foods (Basel, Switzerland) 2024 May 14;13(10)
Nicotinamide Mononucleotide Supplementation Alleviates Doxorubicin-Induced Multi-Organ Fibrosis.
Wen F, Xu A, Wei W, Yang S, Xi Z, Ge Y, Wu S, Ju Z
International journal of molecular sciences 2024 May 13;25(10)
International journal of molecular sciences 2024 May 13;25(10)
Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
Chen J, Zhang Z, Feng L, Liu W, Wang X, Chen H, Zou H
Archives of biochemistry and biophysics 2024 Mar;753:109892
Archives of biochemistry and biophysics 2024 Mar;753:109892
Therapeutic potential and mechanisms of Rifaximin in ameliorating iron overload-induced ferroptosis and liver fibrosis in vivo and in vitro.
Yuan Q, Fang Y, Guo J, Zhang Z, Liao J, Kuang J
Toxicology and applied pharmacology 2024 Mar;484:116845
Toxicology and applied pharmacology 2024 Mar;484:116845
Arctium lappa L. polysaccharides enhanced the therapeutic effects of nasal ectomesenchymal stem cells against liver fibrosis by inhibiting the Wnt/β-catenin pathway.
Xiang W, Yin G, Liu H, Wei J, Yu X, Xie Y, Zhang L, XueTang, Jiang W, Lu N
International journal of biological macromolecules 2024 Mar;261(Pt 1):129670
International journal of biological macromolecules 2024 Mar;261(Pt 1):129670
OTUD1 promotes isoprenaline- and myocardial infarction-induced heart failure by targeting PDE5A in cardiomyocytes.
Wang Q, Liang S, Qian J, Xu J, Zheng Q, Wang M, Guo X, Min J, Wu G, Zhuang Z, Luo W, Liang G
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167018
Biochimica et biophysica acta. Molecular basis of disease 2024 Mar;1870(3):167018
Natural intestinal metabolite xylitol reduces BRD4 levels to mitigate renal fibrosis.
Tan Z, Wang Z, Zeng Q, Liu X, Zhang Y, Li S, Huang J, Zeng Y, Huang Z, Jin C, Fu N, Zhao Q, Mu Y, Wang Z, Xiao J, Yang H, Ke G
Clinical and translational science 2024 Mar;17(3):e13770
Clinical and translational science 2024 Mar;17(3):e13770
The XPO1 inhibitor selinexor ameliorates bleomycin-induced pulmonary fibrosis in mice via GBP5/NLRP3 inflammasome signaling.
Zhang J, Zhang Y, Chen Q, Qi Y, Zhang X
International immunopharmacology 2024 Mar 30;130:111734
International immunopharmacology 2024 Mar 30;130:111734
The Effect of Salvianolic Acid A on Tumor-Associated Macrophage Polarization and Its Mechanisms in the Tumor Microenvironment of Triple-Negative Breast Cancer.
Tang C, Jiang ST, Li CX, Jia XF, Yang WL
Molecules (Basel, Switzerland) 2024 Mar 26;29(7)
Molecules (Basel, Switzerland) 2024 Mar 26;29(7)
Bicyclol alleviates obesity-induced renal injury by inhibiting JNK and NF-κB-mediated inflammation.
Zhang L, Wang J, Xu T, Luo Y, Cai Z, Jiang Y, Jin T, Bao H, Wang Y
International immunopharmacology 2024 Mar 10;129:111609
International immunopharmacology 2024 Mar 10;129:111609
Structural characterization of an inulin neoseries-type fructan from Ophiopogonis Radix and the therapeutic effect on liver fibrosis in vivo.
Liu W, Zhang L, Wei X, Xu Y, Fang Q, Qi S, Chen J, Wang C, Wang S, Qin L, Liu P, Wu J
Carbohydrate polymers 2024 Mar 1;327:121659
Carbohydrate polymers 2024 Mar 1;327:121659
BATF promotes extramedullary infiltration through TGF-β1/Smad/MMPs axis in acute myeloid leukemia.
Zhang R, Miao J, Zhai M, Liu R, Li F, Xu X, Huang L, Wang T, Yang R, Yang R, Wang Y, He A, Wang J
Molecular carcinogenesis 2024 Jun;63(6):1146-1159
Molecular carcinogenesis 2024 Jun;63(6):1146-1159
Bicyclol Alleviates Streptozotocin-induced Diabetic Cardiomyopathy By Inhibiting Chronic Inflammation And Oxidative Stress.
Zhang L, Hu C, Jin B, Bai B, Liao J, Jin L, Wang M, Zhu W, Wu X, Zheng L, Xu X, Jiang Y, Wang Y, He Y
Cardiovascular drugs and therapy 2024 Jun;38(3):555-568
Cardiovascular drugs and therapy 2024 Jun;38(3):555-568
Engineered Surfaces That Promote Capture of Latent Proteins to Facilitate Integrin-Mediated Mechanical Activation of Growth Factors.
Dhawan U, Williams JA, Windmill JFC, Childs P, Gonzalez-Garcia C, Dalby MJ, Salmeron-Sanchez M
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(23):e2310789
Advanced materials (Deerfield Beach, Fla.) 2024 Jun;36(23):e2310789
Dual-crosslinking gelatin-hyaluronic acid methacrylate based biomimetic PDAC desmoplastic niche enhances tumor-associated macrophages recruitment and M2-like polarization.
Wu D, Gong T, Sun Z, Yao X, Wang D, Chen Q, Guo Q, Li X, Guo Y, Lu Y
International journal of biological macromolecules 2024 Jun;269(Pt 1):131826
International journal of biological macromolecules 2024 Jun;269(Pt 1):131826
HUC-MSCs combined with platelet lysate treat diabetic chronic cutaneous ulcers in Bama miniature pig.
Gao Y, Chen L, Li Y, Sun S, Ran X
Regenerative therapy 2024 Jun;26:1138-1149
Regenerative therapy 2024 Jun;26:1138-1149
Cupric-polymeric nanoreactors integrate into copper metabolism to promote chronic diabetic wounds healing.
Tang Q, Tan Y, Leng S, Liu Q, Zhu L, Wang C
Materials today. Bio 2024 Jun;26:101087
Materials today. Bio 2024 Jun;26:101087
Compound SJ-12 attenuates streptozocin-induced diabetic cardiomyopathy by stabilizing SERCA2a.
Lou S, Zhu W, Yu T, Zhang Q, Wang M, Jin L, Xiong Y, Xu J, Wang Q, Chen G, Liang G, Hu X, Luo W
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167140
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167140
Synergistic effects of photodynamic therapy and chemotherapy: Activating the intrinsic/extrinsic apoptotic pathway of anoikis for triple-negative breast cancer treatment.
Zhang T, Wang X, Wang D, Lei M, Hu Y, Chen Z, Li Y, Luo Y, Zhang L, Zhu Y
Biomaterials advances 2024 Jun;160:213859
Biomaterials advances 2024 Jun;160:213859
A New Histology-Based Prognostic Index for Aggressive T-Cell lymphoma: Preliminary Results of the "TCL Urayasu Classification".
Nitta H, Takizawa H, Mitsumori T, Iizuka-Honma H, Ochiai T, Furuya C, Araki Y, Fujishiro M, Tomita S, Hashizume A, Sawada T, Miyake K, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2024 Jun 30;13(13)
Journal of clinical medicine 2024 Jun 30;13(13)
Potential Involvement of M1 Macrophage and VLA4/VCAM-1 Pathway in the Valvular Damage Due to Rheumatic Heart Disease.
Xian S, Li Y, Bai L, Tang S, Meng Z, Wen H, Huang F, Zeng Z
Frontiers in bioscience (Landmark edition) 2024 Jun 18;29(6):219
Frontiers in bioscience (Landmark edition) 2024 Jun 18;29(6):219
Sodium arsenite induces hepatic stellate cells activation by m(6)A modification of TGF-β1 during liver fibrosis.
Qiu T, Hou K, Zhang J, Wang N, Yao X, Yang G, Jiang L, Dong J, Miao M, Bai J, Sun X
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Ecotoxicology and environmental safety 2024 Jun 15;278:116435
Carnosol attenuates angiotensin II-induced cardiac remodeling and inflammation via directly binding to p38 and inhibiting p38 activation.
Xu D, Ye B, Lin L, Jin Y, Jiang Y, Zheng Z, Chen Y, Han X, Wang W, Wu G, Zhuang Z, Shan P, Liang G
International immunopharmacology 2024 Jun 15;134:112143
International immunopharmacology 2024 Jun 15;134:112143
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
CD34+ synovial fibroblasts exhibit high osteogenic potential in synovial chondromatosis.
Li X, Sun H, Li D, Cai Z, Xu J, Ma R
Cell and tissue research 2024 Jul;397(1):37-50
Cell and tissue research 2024 Jul;397(1):37-50
Carnosol prevents cardiac remodeling and ventricular arrhythmias in pressure overload-induced heart failure mice.
Fang Z, Lu M, Huang R, Wang G, Yushanjiang F, Jiang X, Li J
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
Phytotherapy research : PTR 2024 Jul;38(7):3763-3781
MicroRNA-322-5p targeting Smurf2 regulates the TGF-β/Smad pathway to protect cardiac function and inhibit myocardial infarction.
Guo L, Li K, Ma Y, Niu H, Li J, Shao X, Li N, Sun Y, Wang H
Human cell 2024 Jul;37(4):972-985
Human cell 2024 Jul;37(4):972-985
Honokiol Mitigates Metabolic-Associated Fatty Liver Disease by Regulating Nrf2 and RIPK3 Signaling Pathways.
Cao W, Chen Z, Lin C, Lin X, Chen Y, Zhang J
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024 Jul;35(7):551-559
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024 Jul;35(7):551-559
miR-451a was selectively sorted into exosomes and promoted the progression of esophageal squamous cell carcinoma through CAB39.
Wang L, Liu H, Wu Q, Liu Y, Yan Z, Chen G, Shang Y, Xu S, Zhou Q, Yan T, Cheng X
Cancer gene therapy 2024 Jul;31(7):1060-1069
Cancer gene therapy 2024 Jul;31(7):1060-1069
Estrogen inhibits TGF‑β1‑stimulated cardiac fibroblast differentiation and collagen synthesis by promoting Cdc42.
Xu J, Wang F, Li Y, Li P, Zhang Y, Xu G, Sun K, Huang Y
Molecular medicine reports 2024 Jul;30(1)
Molecular medicine reports 2024 Jul;30(1)
Chitosan-modified dihydromyricetin liposomes promote the repair of liver injury in mice suffering from diabetes mellitus.
Ding Q, Liu X, Zhang S, Chai G, Ma S, Sun S, Shen L, Gao Y, Ding C, Zhao T, Liu W
International journal of biological macromolecules 2024 Jul;273(Pt 2):133040
International journal of biological macromolecules 2024 Jul;273(Pt 2):133040
Resistance exercise upregulates Irisin expression and suppresses myocardial fibrosis following myocardial infarction via activating AMPK-Sirt1 and inactivating TGFβ1-Smad2/3.
Li H, Qin S, Tang J, Wang T, Ren W, Di L, Bo W, Ma Y, Wu F, Xu Z, Song W, Cai M, Xi Y, Tian Z
Acta physiologica (Oxford, England) 2024 Jul;240(7):e14163
Acta physiologica (Oxford, England) 2024 Jul;240(7):e14163
SH-Alb inhibits phenotype remodeling of pro-fibrotic macrophage to attenuate liver fibrosis through SIRT3-SOD2 axis.
Wu N, Ma S, Ding H, Cao H, Liu T, Tian M, Liu Q, Bian H, Yu Z, Liu C, Wang L, Feng Y, Wu H, Qi J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116919
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jul;176:116919
Platelet-Derived TGF-β1 Promotes Deep Vein Thrombosis.
Zhang S, Li Y, Zhang J, Sun Y, Chu X, Gui X, Tong H, Ding Y, Ju W, Xu M, Li Z, Zeng L, Xu K, Qiao J
Thrombosis and haemostasis 2024 Jul;124(7):641-648
Thrombosis and haemostasis 2024 Jul;124(7):641-648
Neurosteroid [3α,5α]-3-Hydroxy-pregnan-20-one Enhances the CX3CL1-CX3CR1 Pathway in the Brain of Alcohol-Preferring Rats with Sex-Specificity.
Balan I, Grusca A, Chéry SL, Materia BR, O'Buckley TK, Morrow AL
Life (Basel, Switzerland) 2024 Jul 9;14(7)
Life (Basel, Switzerland) 2024 Jul 9;14(7)
ATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8(+) T cells.
Huang TX, Huang HS, Dong SW, Chen JY, Zhang B, Li HH, Zhang TT, Xie Q, Long QY, Yang Y, Huang LY, Zhao P, Bi J, Lu XF, Pan F, Zou C, Fu L
Nature communications 2024 Jul 6;15(1):5680
Nature communications 2024 Jul 6;15(1):5680
Atf3-mediated metabolic reprogramming in hepatic macrophage orchestrates metabolic dysfunction-associated steatohepatitis.
Hu S, Li R, Gong D, Hu P, Xu J, Ai Y, Zhao X, Hu C, Xu M, Liu C, Chen S, Fan J, Zhao Z, Zhang Z, Wu H, Xu Y
Science advances 2024 Jul 26;10(30):eado3141
Science advances 2024 Jul 26;10(30):eado3141
Effect of luteolin on glioblastoma's immune microenvironment and tumor growth suppression.
Zong S, Li X, Zhang G, Hu J, Li H, Guo Z, Zhao X, Chen J, Wang Y, Jing Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155611
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul 25;130:155611
Seabuckthorn (Hippophae rhamnoides, L.) pulp oil prevents ultraviolet-induced damage in human fibroblasts.
Okamoto T, Nakashima F, Shibata T, Mori D
Bioscience, biotechnology, and biochemistry 2024 Jul 22;88(8):948-955
Bioscience, biotechnology, and biochemistry 2024 Jul 22;88(8):948-955
Endothelial progenitor cells control remodeling of uterine spiral arteries for the establishment of utero-placental circulation.
Tan B, Lin L, Yuan Y, Long Y, Kang Y, Huang B, Huang LF, Li JH, Tong C, Qi HB
Developmental cell 2024 Jul 22;59(14):1842-1859.e12
Developmental cell 2024 Jul 22;59(14):1842-1859.e12
Construction of the pulmonary bio-adhesive delivery system of nintedanib nanocrystalline for effective treatment of pulmonary fibrosis.
Yun CX, Huan ML, Zhu X, Wan YH, Zou JB, Zhang BL
International journal of pharmaceutics 2024 Jul 20;660:124302
International journal of pharmaceutics 2024 Jul 20;660:124302
STAT4 Mediates IL-6 Trans-Signaling Arrhythmias in High Fat Diet Guinea Pig Heart.
Corbin A, Aromolaran KA, Aromolaran AS
International journal of molecular sciences 2024 Jul 17;25(14)
International journal of molecular sciences 2024 Jul 17;25(14)
FLASH Proton Radiation Therapy Mitigates Inflammatory and Fibrotic Pathways and Preserves Cardiac Function in a Preclinical Mouse Model of Radiation-Induced Heart Disease.
Kim K, Kim MM, Skoufos G, Diffenderfer ES, Motlagh SAO, Kokkorakis M, Koliaki I, Morcos G, Shoniyozov K, Griffin J, Hatzigeorgiou AG, Metz JM, Lin A, Feigenberg SJ, Cengel KA, Ky B, Koumenis C, Verginadis II
International journal of radiation oncology, biology, physics 2024 Jul 15;119(4):1234-1247
International journal of radiation oncology, biology, physics 2024 Jul 15;119(4):1234-1247
Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways.
Wu J, Song Y, Wang J, Wang T, Yang L, Shi Y, Song B, Yu Z
Heliyon 2024 Jul 15;10(13):e33802
Heliyon 2024 Jul 15;10(13):e33802
Targeting of G protein-coupled receptor 39 alleviates angiotensin II-induced renal damage by reducing ribonucleotide reductase M2.
Hua D, Huang W, Xu W, Zhang Y, Xie Q, Li P, Sheng Y
Experimental cell research 2024 Jul 1;440(1):114102
Experimental cell research 2024 Jul 1;440(1):114102
17β-Estradiol mediates TGFBR3/Smad2/3 signaling to attenuate the fibrosis of TGF-β1-induced bovine endometrial epithelial cells via GPER.
Fang Z, Wang Q, Duan H, Sheng X, Qi X, Xing K, Liu B, Chang D, Guo Y, Wang X, Xiao L
Journal of cellular physiology 2024 Jan;239(1):166-179
Journal of cellular physiology 2024 Jan;239(1):166-179
Maternal obstructive sleep apnea aggravates metabolic dysfunction-associated fatty liver disease via HMGB1-TLR4 signaling-mediated endoplasmic reticulum stress in male offspring rats.
Wang R, Feng W, Wang Y, Jiang Y, Lin Y, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Biochimica et biophysica acta. Molecular basis of disease 2024 Jan;1870(1):166889
Multi-omic analysis revealed the therapeutic mechanisms of Alpinia oxyphylla fructus water extract against bladder overactivity in spontaneously hypertensive rats.
Tie Y, Sun Z, Tong X, Cheng M, Wu Y, Shi Z, Xu P, Xue M, Xu L, Zhou X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155154
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jan;123:155154
Platycodin D ameliorates ammonia-induced pulmonary fibrosis by repressing TGF-β1-mediated extracellular matrix remodeling.
Lian W, Ge S, Pang Q
Chemical biology & drug design 2024 Jan;103(1):e14446
Chemical biology & drug design 2024 Jan;103(1):e14446
Transcriptomics Reveals the Mechanism of Platycodin D Targeting TGFβ for Anti-Lung Cancer Activity.
Feng M, Wang XJ, Liu Y, Zhang W, Wang Y, Zhang C, Bao S
Integrative cancer therapies 2024 Jan-Dec;23:15347354241263041
Integrative cancer therapies 2024 Jan-Dec;23:15347354241263041
The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix.
O'Brien JG, Willis AB, Long AM, Kwon J, Lee G, Li FW, Page PG, Vo AH, Hadhazy M, Spencer MJ, Crosbie RH, Demonbreun AR, McNally EM
JCI insight 2024 Jan 4;9(3)
JCI insight 2024 Jan 4;9(3)
Maimendong decoction regulates M2 macrophage polarization to suppress pulmonary fibrosis via PI3K/Akt/FOXO3a signalling pathway-mediated fibroblast activation.
Shuangshuang H, Mengmeng S, Lan Z, Fang Z, Yu L
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117308
Journal of ethnopharmacology 2024 Jan 30;319(Pt 3):117308
Phthalides from the rhizome of Ligusticum chuanxiong Hort. attenuate diabetic nephropathy in mice.
Qi XY, Peng GC, Han QT, Yan J, Chen LZ, Wang T, Xu LT, Liu MJ, Xu ZP, Wang XN, Shen T
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117247
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117247
Quercetin inhibits mesothelial-mesenchymal transition and alleviates postoperative peritoneal adhesions by blocking the TGF-β1/PI3K/AKT pathway.
Li G, Ren Y, Li E, Deng K, Qu C, Zhang J, Zhang L, Wang X, Lian J, Zhou H, Wang Z, Shen T, Li X, Jiang Z
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117242
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117242
Protein lysine acetylation played an important role in NH(3)-induced AEC2 damage and pulmonary fibrosis in piglets.
Wang X, Zhang D, Zhu Y, Li D, Shen L, Wang Q, Gao Y, Li X, Yu M
The Science of the total environment 2024 Jan 15;908:168303
The Science of the total environment 2024 Jan 15;908:168303
17β-Estradiol inhibits hydrogen peroxide-induced senescence and apoptosis in human umbilical vein endothelial cells by regulating the THBS1/TGF-β/Smad axis.
Lv Y, Huang Y, Fan H, Zhao Y, Ma L, Lan Y, Li C, Chen P, Lou Z, Zhou J
Molecular and cellular endocrinology 2024 Jan 15;580:112111
Molecular and cellular endocrinology 2024 Jan 15;580:112111
JOSD2 mediates isoprenaline-induced heart failure by deubiquitinating CaMKIIδ in cardiomyocytes.
Xu J, Liang S, Wang Q, Zheng Q, Wang M, Qian J, Yu T, Lou S, Luo W, Zhou H, Liang G
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):18
Cellular and molecular life sciences : CMLS 2024 Jan 10;81(1):18
Rehmannia glutinosa Libosch and Cornus officinalis Sieb herb couple ameliorates renal interstitial fibrosis in CKD rats by inhibiting the TGF-β1/MAPK signaling pathway.
Zhu JH, Wang L, Ma ZX, Duan JA, Tao JH
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117039
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117039
Edaravone dexborneol alleviates cerebral ischemia-reperfusion injury through NF-κB/NLRP3 signal pathway.
Shen G, Lou C, Li Q, Zhao B, Luo Y, Wu F, Jiao D, Fang M, Geng Y
Anatomical record (Hoboken, N.J. : 2007) 2024 Feb;307(2):372-384
Anatomical record (Hoboken, N.J. : 2007) 2024 Feb;307(2):372-384
A dihydromyricetin-loaded phellinus igniarius polysaccharide/l-arginine modified chitosan-based hydrogel for promoting wound recovery in diabetic mice via JNK and TGF-β/Smad signaling pathway.
Yang J, Zhang L, Sun S, Zhang S, Ding Q, Chai G, Yu W, Zhao T, Shen L, Gao Y, Liu W, Ding C
International journal of biological macromolecules 2024 Feb;259(Pt 1):129124
International journal of biological macromolecules 2024 Feb;259(Pt 1):129124
Chitosan-crosslinked polyvinyl alcohol anti-swelling hydrogel designed to prevent abdominal wall adhesion.
Huang Y, Zheng J, Zeng G, Xu H, Lv Y, Liang X, Jin L, Jiang X
Materials today. Bio 2024 Feb;24:100931
Materials today. Bio 2024 Feb;24:100931
Gynostemma pentaphyllum Makino extract induces hair growth and exhibits an anti-graying effect via multiple mechanisms.
Liu X, Lv X, Ji T, Hu H, Chang L
Journal of cosmetic dermatology 2024 Feb;23(2):648-657
Journal of cosmetic dermatology 2024 Feb;23(2):648-657
Transcription factor c-Maf drives macrophages to promote hypertrophic scar formation.
Yang L, Song Y, Wang T, Cui Z, Wu J, Shi Y, Yu Z, Song B
Journal of cosmetic dermatology 2024 Feb;23(2):639-647
Journal of cosmetic dermatology 2024 Feb;23(2):639-647
The novel antibody fusion protein rhNRG1-HER3i promotes heart regeneration by enhancing NRG1-ERBB4 signaling pathway.
Wang X, Wu H, Tang L, Fu W, He Y, Zeng C, Wang WE
Journal of molecular and cellular cardiology 2024 Feb;187:26-37
Journal of molecular and cellular cardiology 2024 Feb;187:26-37
Autophagic degradation of MVBs in LSECs promotes Aldosterone induced-HSCs activation.
Chen T, Zhang Y, Zhang Y, Ning Z, Xu Q, Lin Y, Gong J, Li J, Chen Z, Meng Y, Li Y, Li X
Hepatology international 2024 Feb;18(1):273-288
Hepatology international 2024 Feb;18(1):273-288
Multi-omics sequencing revealed endostar combined with cisplatin treated non small cell lung cancer via anti-angiogenesis.
Wang Y, Ren H
BMC cancer 2024 Feb 8;24(1):187
BMC cancer 2024 Feb 8;24(1):187
Analysis of genetic variant associated with heart failure mortality implicates thymic stromal lymphopoietin as mediator of strain-induced myocardial fibroblast-mast cell crosstalk and fibrosis.
Pimpalwar N, Celik S, Karbalaei Sadegh M, Czuba T, Gidlöf O, Smith JG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 29;38(4):e23510
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Feb 29;38(4):e23510
Assessing the effects of tempol on renal fibrosis, inflammation, and oxidative stress in a high-salt diet combined with 5/6 nephrectomy rat model: utilizing oxidized albumin as a biomarker.
Liu B, Hu Y, Tian D, Dong J, Li BF
BMC nephrology 2024 Feb 23;25(1):64
BMC nephrology 2024 Feb 23;25(1):64
Novel prognostic marker TGFBI affects the migration and invasion function of ovarian cancer cells and activates the integrin αvβ3-PI3K-Akt signaling pathway.
Wang H, Xu YH, Guo Y
Journal of ovarian research 2024 Feb 23;17(1):50
Journal of ovarian research 2024 Feb 23;17(1):50
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution.
Adzraku SY, Cao C, Zhou Q, Yuan K, Hao X, Li Y, Yuan S, Huang Y, Xu K, Qiao J, Ju W, Zeng L
Cell death & disease 2024 Feb 21;15(2):159
Cell death & disease 2024 Feb 21;15(2):159
KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Zhang H, Xia T, Xia Z, Zhou H, Li Z, Wang W, Zhai X, Jin B
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Cellular and molecular life sciences : CMLS 2024 Feb 19;81(1):96
Dual effect of vitamin D(3) on breast cancer-associated fibroblasts.
Łabędź N, Anisiewicz A, Stachowicz-Suhs M, Banach J, Kłopotowska D, Maciejczyk A, Gazińska P, Piotrowska A, Dzięgiel P, Matkowski R, Wietrzyk J
BMC cancer 2024 Feb 15;24(1):209
BMC cancer 2024 Feb 15;24(1):209
Calcitriol promotes M2 polarization of tumor-associated macrophages in 4T1 mouse mammary gland cancer via the induction of proinflammatory cytokines.
Stachowicz-Suhs M, Łabędź N, Anisiewicz A, Banach J, Kłopotowska D, Milczarek M, Piotrowska A, Dzięgiel P, Maciejczyk A, Matkowski R, Wietrzyk J
Scientific reports 2024 Feb 15;14(1):3778
Scientific reports 2024 Feb 15;14(1):3778
The TGFβ1/SMADs/Snail1 signaling axis mediates pericyte-derived fibrous scar formation after spinal cord injury.
Huang Y, Liu R, Meng T, Zhang B, Ma J, Liu X
International immunopharmacology 2024 Feb 15;128:111482
International immunopharmacology 2024 Feb 15;128:111482
Icariin Regulates EMT and Stem Cell-Like Character in Breast Cancer through Modulating lncRNA NEAT1/TGFβ/SMAD2 Signaling Pathway.
Song B, Wei F, Peng J, Wei X, Liu M, Nie Z, Ma Y, Peng T
Biological & pharmaceutical bulletin 2024 Feb 10;47(2):399-410
Biological & pharmaceutical bulletin 2024 Feb 10;47(2):399-410
Jingfang Granule mitigates Coxsackievirus B3-induced myocardial damage by modulating mucolipin 1 expression.
Sun B, Lin L, Yao T, Yao J, Zhang G, Li Y, Li C
Journal of ethnopharmacology 2024 Feb 10;320:117396
Journal of ethnopharmacology 2024 Feb 10;320:117396
METTL3 silencing inhibits ferroptosis to suppress ovarian fibrosis in PCOS by upregulating m6A modification of GPX4.
Shen C, Jiang Y, Lin J, Guo Q, Fang D
Journal of molecular histology 2024 Dec;55(6):1163-1175
Journal of molecular histology 2024 Dec;55(6):1163-1175
Geniposide alleviates heart failure with preserved ejection fraction in mice by regulating cardiac oxidative stress via MMP2/SIRT1/GSK3β pathway.
Han YL, Yan TT, Li HX, Chen SS, Zhang ZZ, Wang MY, Chen MJ, Chen YL, Yang XX, Wei LL, Duan YJ, Zhang S
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Acta pharmacologica Sinica 2024 Dec;45(12):2567-2578
Alleviation of colitis by honeysuckle MIR2911 via direct regulation of gut microbiota.
Li W, Ding J, Chen S, Chen J, Wang C, Li J, Shi H, Yin X, Wang J, Liu J, Song H, Zhou Z, Jiang X, Jiang W, Jiang Y, Cao M, Li B, Li J, Li L, Zhang Y
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:123-137
Journal of controlled release : official journal of the Controlled Release Society 2024 Dec;376:123-137
Macrophage polarization and macrophage-related factor expression in hypertrophy of the ligamentum flavum.
Jiang C, Wang W, Chen YL, Chen JH, Zhang ZW, Li J, Yang ZC, Li XC
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 2024 Dec;33(12):4476-4487
Simultaneous targeting of TGF-β1/PD-L1 via a hydrogel-nanoparticle system to remodel the ECM and immune microenvironment for limiting adhesion formation.
Yang QQ, Jin J, Sun J, Zhang L, Tang JB, Zhou YL
Acta biomaterialia 2024 Dec;190:447-462
Acta biomaterialia 2024 Dec;190:447-462
Sec13 promotes glycolysis by inhibiting Ubqln1 mediated Pgm1 ubiquitination in ALI.
Wu D, Zhang H, Li F, Liu S, Wang Y, Zhang Z, Wang J, Wu Q
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167475
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167475
Corrigendum to "Suppression of miR-143-3p contributes to the anti-fibrosis effect of atorvastatin on myocardial tissues via the modulation of Smad2 activity" [Experimental and Molecular Pathology 112 (2020) 104346].
Yu B, Yu M, Zhang H, Xie D, Nie W, Shi K
Experimental and molecular pathology 2024 Dec;140:104945
Experimental and molecular pathology 2024 Dec;140:104945
Suyin Detoxification Granule alleviates trimethylamine N-oxide-induced tubular ferroptosis and renal fibrosis to prevent chronic kidney disease progression.
Ge H, Wei Y, Zhang W, Yong C, Chen Y, Zhou E
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156195
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156195
Aucubin ameliorates atherosclerosis by modulating tryptophan metabolism and inhibiting endothelial-mesenchymal transitions via gut microbiota regulation.
Luo Z, Yang L, Zhu T, Fan F, Wang X, Liu Y, Zhan H, Luo D, Guo J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156122
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156122
Isoastragaloside I attenuates cholestatic liver diseases by ameliorating liver injury, regulating bile acid metabolism and restoring intestinal barrier.
Zhang L, Jiang X, Shi J, Zhang J, Shi X, Xie Z, Chen G, Zhang H, Mu Y, Chen J, Qi S, Liu P, Liu W
Journal of ethnopharmacology 2024 Dec 5;335:118649
Journal of ethnopharmacology 2024 Dec 5;335:118649
A multi-omics approach identifies the key role of disorders of sphingolipid metabolism in Ang II-induced hypertensive cardiomyopathy myocardial remodeling.
Qu Y, Ma D, Wu T, Wang H, Tian Z, Liu X, Wang Y
Scientific reports 2024 Dec 5;14(1):30379
Scientific reports 2024 Dec 5;14(1):30379
MS4A3 regulates hematopoietic myeloid differentiation through ROS/TGF-β/p38MAPK pathway.
Dong Y, Yue T, Wang X, Huo Q, Li W, Zhang S, Zhao Y, Li D
International immunopharmacology 2024 Dec 25;143(Pt 3):113578
International immunopharmacology 2024 Dec 25;143(Pt 3):113578
Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling.
Su P, Liu L, Gong Y, Peng S, Yan X, Bai M, Xu E, Li Y
International immunopharmacology 2024 Dec 25;143(Pt 3):113538
International immunopharmacology 2024 Dec 25;143(Pt 3):113538
METTL14 downregulates GLUT9 through m6A methylation and attenuates hyperuricemia-induced fibrosis in mouse renal tubular epithelial cells.
Yang J, Jiang T, Lu X, Li X, Zhou X, Guo X, Ma C, Xie X, Li D, Yu S, An J, Zhao B, Li H
International immunopharmacology 2024 Dec 25;143(Pt 1):113308
International immunopharmacology 2024 Dec 25;143(Pt 1):113308
Characterization of the Ocular Phenotype in a Col4a3 Knockout Mouse Model of Alport Syndrome.
Belamkar A, Luo Q, Mahajan N, Abhyankar S, Jones BA, Sodhi RK, Pattabiraman PP, Levi M, Bhatwadekar AD
Investigative ophthalmology & visual science 2024 Dec 2;65(14):29
Investigative ophthalmology & visual science 2024 Dec 2;65(14):29
Has_circ_0002360 facilitates immune evasion by enhancing heterogeneous nuclear ribonucleoprotein A1 stability, thereby promoting malignant progression in non-small cell lung cancer.
Fan J, Xue L, Lu R, Liu J, Luo J
Experimental cell research 2024 Dec 1;443(2):114312
Experimental cell research 2024 Dec 1;443(2):114312
Lactate-induced activation of tumor-associated fibroblasts and IL-8-mediated macrophage recruitment promote lung cancer progression.
Gu X, Zhu Y, Su J, Wang S, Su X, Ding X, Jiang L, Fei X, Zhang W
Redox biology 2024 Aug;74:103209
Redox biology 2024 Aug;74:103209
Vaspin facilitates the proliferation and osteogenic differentiation of periodontal ligament stem cells.
Jing Z, Feng X, Li X, Zhang X, Pan C
Journal of periodontal research 2024 Aug;59(4):812-820
Journal of periodontal research 2024 Aug;59(4):812-820
Ginkgo biloba Extract 50 (GBE50) Exerts Antifibrotic and Antioxidant Effects on Pulmonary Fibrosis in Mice by Regulating Nrf2 and TGF-β1/Smad Pathways.
Liang W, Yang H, Pan L, Wei S, Li Z, Zhang P, Li R, Wu Y, Liu M, Liu X
Applied biochemistry and biotechnology 2024 Aug;196(8):4807-4822
Applied biochemistry and biotechnology 2024 Aug;196(8):4807-4822
A ROS-responsive and scavenging hydrogel for postoperative abdominal adhesion prevention.
Zhang T, Huang Y, Gong Y, Shi X, Xiao D, Ren L, Dai X, Zeng Z, Zhao C
Acta biomaterialia 2024 Aug;184:98-113
Acta biomaterialia 2024 Aug;184:98-113
Macrophage-Derived Nanosponges Adsorb Cytokines and Modulate Macrophage Polarization for Renal Cell Carcinoma Immunotherapy.
Jiang Y, Nie D, Hu Z, Zhang C, Chang L, Li Y, Li Z, Hu W, Li H, Li S, Xu C, Liu S, Yang F, Wen W, Han D, Zhang K, Qin W
Advanced healthcare materials 2024 Aug;13(20):e2400303
Advanced healthcare materials 2024 Aug;13(20):e2400303
Exosomal miR-106a-5p derived from intermittently hypoxic non-small-cell lung cancer increases tumor malignancy.
Ren J, Jin Z, Huang Y
Physiological reports 2024 Aug;12(15):e16157
Physiological reports 2024 Aug;12(15):e16157
EEPD1 attenuates radiation-induced cardiac hypertrophy and apoptosis by degrading FOXO3A in cardiomyocytes.
Yu K, Su X, Zhou T, Cai X, Zhang M
Acta biochimica et biophysica Sinica 2024 Aug 29;56(12):1733-1747
Acta biochimica et biophysica Sinica 2024 Aug 29;56(12):1733-1747
Activation of P2X7 Receptor Mediates the Abnormal Ovulation Induced by Chronic Restraint Stress and Chronic Cold Stress.
Fan X, Wang J, Ma Y, Chai D, Han S, Xiao C, Huang Y, Wang X, Wang J, Wang S, Xiao L, Zhang C
Biology 2024 Aug 15;13(8)
Biology 2024 Aug 15;13(8)
TRPV1 signaling of perirenal adipose tissue promotes DOCA-Salt-induced hypertension and kidney injury.
Hua D, Huang W, Huang W, Xie Q, Tang L, Wu X, Gao M, Xu T, Zhang Y, Li P, Sun W, Kong X
Journal of hypertension 2024 Aug 1;42(8):1409-1420
Journal of hypertension 2024 Aug 1;42(8):1409-1420
BMSC-derived Exosomes Ameliorate Peritoneal Dialysis-associated Peritoneal Fibrosis via the Mir-27a-3p/TP53 Pathway.
Zhao JL, Zhao L, Zhan QN, Liu M, Zhang T, Chu WW
Current medical science 2024 Apr;44(2):333-345
Current medical science 2024 Apr;44(2):333-345
HBI-8000 improves heart failure with preserved ejection fraction via the TGF-β1/MAPK signalling pathway.
Tian J, Li W, Zeng L, Li Y, Du J, Li Y, Li B, Su G
Journal of cellular and molecular medicine 2024 Apr;28(7):e18238
Journal of cellular and molecular medicine 2024 Apr;28(7):e18238
Herb pair of Rhubarb-Astragalus mitigates renal interstitial fibrosis through downregulation of autophagy via p38-MAPK/TGF-β1 and p38-MAPK/smad2/3 pathways.
Li J, Qin X, Xu W, Zhang H, Huang S, Yang Y, Qin M, Mi Z, Zhong X
The international journal of biochemistry & cell biology 2024 Apr;169:106549
The international journal of biochemistry & cell biology 2024 Apr;169:106549
Assessment of cellular senescence potential of PM2.5 using 3D human lung fibroblast spheroids in vitro model.
Xu S, Ma L, Wu T, Tian Y, Wu L
Toxicology research 2024 Apr;13(2):tfae037
Toxicology research 2024 Apr;13(2):tfae037
Jin-Gui-Shen-Qi Wan alleviates fibrosis in mouse diabetic nephropathy via MHC class II.
Liang D, Liu L, Qi Y, Nan F, Huang J, Tang S, Tang J, Chen N
Journal of ethnopharmacology 2024 Apr 24;324:117745
Journal of ethnopharmacology 2024 Apr 24;324:117745
Spatiotemporal orchestration of macrophage activation trajectories by Vγ4 T cells during skin wound healing.
Hu W, Zhang X, Liu Z, Yang J, Sheng H, Liu Z, Chen C, Shang R, Chen Y, Lu Y, Hu X, Huang Y, Yin W, Cai X, Fan D, Yan L, Hao J, Luo G, He W
iScience 2024 Apr 19;27(4):109545
iScience 2024 Apr 19;27(4):109545
Identification of a novel FOXO3 agonist that protects against alcohol induced liver injury.
Peng J, Liang G, Li Y, Mao S, Zhang C, Wang Y, Li Z
Biochemical and biophysical research communications 2024 Apr 16;704:149690
Biochemical and biophysical research communications 2024 Apr 16;704:149690
B Lymphocytes Balance Th1/Th2 to Participate in Fibrotic Hypersensitivity Pneumonia Induced by Pigeon Shedding.
Wu C, Ding W, Li Y, Wang W, Lian Z, Muhataer X, Zhou Y, Li Q, Yang X
International archives of allergy and immunology 2023;184(2):122-131
International archives of allergy and immunology 2023;184(2):122-131
DNMT3A-mediated epigenetic silencing of SOX17 contributes to endothelial cell migration and fibroblast activation in wound healing.
Yu X, Ma X, Zhou J
PloS one 2023;18(10):e0292684
PloS one 2023;18(10):e0292684
Molecular mechanism by which the Notch signaling pathway regulates autophagy in a rat model of pulmonary fibrosis in pigeon breeder's lung.
Li Y, Lian Z, Li Q, Ding W, Wang W, Zhang L, Muhataer X, Zhou Y, Yang X, Wu C
Open medicine (Warsaw, Poland) 2023;18(1):20230629
Open medicine (Warsaw, Poland) 2023;18(1):20230629
Combined Verapamil-Polydopamine Nanoformulation Inhibits Adhesion Formation in Achilles Tendon Injury Using Rat Model.
Li S, Gong F, Zhou Z, Gong X
International journal of nanomedicine 2023;18:115-126
International journal of nanomedicine 2023;18:115-126
Stimulation of Liver Fibrosis by N2 Neutrophils in Wilson's Disease.
Mi X, Song Y, Deng C, Yan J, Li Z, Li Y, Zheng J, Yang W, Gong L, Shi J
Cellular and molecular gastroenterology and hepatology 2023;16(5):657-684
Cellular and molecular gastroenterology and hepatology 2023;16(5):657-684
Pathological granuloma fibrosis induced by agar-embedded Mycobacterium abscessus in C57BL/6JNarl mice.
Yang SJ, Hsu CH, Lai CY, Tsai PC, Song YD, Yeh CC, Chen YY, Dou HY
Frontiers in immunology 2023;14:1277745
Frontiers in immunology 2023;14:1277745
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Tan Y, Kang J, Li H, Zhong A, Liu Y, Zhang Z, Huang R, Cheng X, Peng W
Frontiers in immunology 2023;14:1149810
Frontiers in immunology 2023;14:1149810
Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α.
Zhao Z, Liu L, Chen H, Li S, Guo Y, Hou X, Yang J
Frontiers in pharmacology 2023;14:1138265
Frontiers in pharmacology 2023;14:1138265
Apolipoprotein A-I attenuates peritoneal fibrosis associated with peritoneal dialysis by inhibiting oxidative stress and inflammation.
Lu J, Gao J, Sun J, Wang H, Sun H, Huang Q, Zhang Y, Zhong S
Frontiers in pharmacology 2023;14:1106339
Frontiers in pharmacology 2023;14:1106339
FN1 mRNA 3'-UTR supersedes traditional fibronectin 1 in facilitating the invasion and metastasis of gastric cancer through the FN1 3'-UTR-let-7i-5p-THBS1 axis.
Pan S, Zhu J, Liu P, Wei Q, Zhang S, An W, Tong Y, Cheng Z, Liu F
Theranostics 2023;13(14):5130-5150
Theranostics 2023;13(14):5130-5150
S100 calcium-binding protein A9 promotes skin regeneration through toll-like receptor 4 during tissue expansion.
Zhang Y, Song Y, Du J, Liu W, Dong C, Huang Z, Zhang Z, Yang L, Wang T, Xiong S, Dong L, Guo Y, Dang J, He Q, Yu Z, Ma X
Burns & trauma 2023;11:tkad030
Burns & trauma 2023;11:tkad030
Antimicrobial peptide-modified AIE visual composite wound dressing for promoting rapid healing of infected wounds.
Chen Y, Qian H, Peng D, Jiang Y, Liu Q, Tan Y, Feng L, Cheng B, Li G
Frontiers in bioengineering and biotechnology 2023;11:1338172
Frontiers in bioengineering and biotechnology 2023;11:1338172
The m6A reader YTHDC1-mediated lncRNA CTBP1-AS2 m6A modification accelerates cholangiocarcinoma progression.
Jin Z, Liu Y
Heliyon 2023 Sep;9(9):e19816
Heliyon 2023 Sep;9(9):e19816
TGF-β1 mediates tumor immunosuppression aggravating at the late stage post-high-light-dose photodynamic therapy.
Han L, Huang X, Zhao B, Zhu H, Wang R, Liu S, Lin H, Feng F, Ma X, Liu F, Xue J, Liu W
Cancer immunology, immunotherapy : CII 2023 Sep;72(9):3079-3095
Cancer immunology, immunotherapy : CII 2023 Sep;72(9):3079-3095
Complement Regulatory Protein CD46 Manifests a Unique Role in Promoting the Migration of Bladder Cancer Cells.
Nguyen TT, Thanh HD, Do MH, Jung C
Chonnam medical journal 2023 Sep;59(3):160-166
Chonnam medical journal 2023 Sep;59(3):160-166
Exosomal miR-21-5p derived from multiple myeloma cells promote renal epithelial-mesenchymal transition through targeting TGF-β/SMAD7 signalling pathway.
Liu L, Liu L, Liu R, Liu J, Cheng Q
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):711-718
Clinical and experimental pharmacology & physiology 2023 Sep;50(9):711-718
Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury.
Sung EA, Park MH, Henegariu O, Sime PJ, Chae WJ
The American journal of pathology 2023 Sep;193(9):1130-1142
The American journal of pathology 2023 Sep;193(9):1130-1142
Mining host candidate regulators of schistosomiasis-induced liver fibrosis in response to artesunate therapy through transcriptomics approach.
Yuan Y, Lv X, Wu Y, Weng Y, Dai F, Ding H, Chen R, Zheng B, Zhao W, Tong Q, Ding J, Lou D, Lai Y, Chu X, Zhao L, Lu S, Kong Q
PLoS neglected tropical diseases 2023 Sep;17(9):e0011626
PLoS neglected tropical diseases 2023 Sep;17(9):e0011626
Glioma-derived small extracellular vesicles induce pericyte-phenotype transition of glioma stem cells under hypoxic conditions.
Cheng Y, Li S, Hou Y, Wan W, Wang K, Fu S, Yuan Y, Yang K, Ye X
Cellular signalling 2023 Sep;109:110754
Cellular signalling 2023 Sep;109:110754
AZGP1 activation by lenvatinib suppresses intrahepatic cholangiocarcinoma epithelial-mesenchymal transition through the TGF-β1/Smad3 pathway.
Deng L, Bao W, Zhang B, Zhang S, Chen Z, Zhu X, He B, Wu L, Chen X, Deng T, Chen B, Yu Z, Wang Y, Chen G
Cell death & disease 2023 Sep 5;14(9):590
Cell death & disease 2023 Sep 5;14(9):590
Possible New Histological Prognostic Index for Large B-Cell Lymphoma.
Nitta H, Takizawa H, Mitsumori T, Iizuka-Honma H, Araki Y, Fujishiro M, Tomita S, Kishikawa S, Hashizume A, Sawada T, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical medicine 2023 Sep 30;12(19)
Journal of clinical medicine 2023 Sep 30;12(19)
Long non-coding RNA MIDEAS-AS1 inhibits growth and metastasis of triple-negative breast cancer via transcriptionally activating NCALD.
Luo D, Liang Y, Wang Y, Ye F, Jin Y, Li Y, Han D, Wang Z, Chen B, Zhao W, Wang L, Chen X, Jiang L, Yang Q
Breast cancer research : BCR 2023 Sep 28;25(1):109
Breast cancer research : BCR 2023 Sep 28;25(1):109
δ-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis.
He X, Wang D, Yi Y, Tan Y, Wu M, Wang H, Hu W, Chen H, Zhang Q, Wu Y
Cell death discovery 2023 Sep 22;9(1):349
Cell death discovery 2023 Sep 22;9(1):349
MYCT1 attenuates renal fibrosis and tubular injury in diabetic kidney disease.
Li X, Fan QL, Ma TK, Liu C, Shi H, Sun YY, Wang Y, Ding DX, Tang A, Qin Y, Yang Q, Ding H, Li HY, Fu WN
iScience 2023 Sep 15;26(9):107609
iScience 2023 Sep 15;26(9):107609
Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway.
Zou TF, Liu ZG, Cao PC, Zheng SH, Guo WT, Wang TX, Chen YL, Duan YJ, Li QS, Liao CZ, Xie ZL, Han JH, Yang XX
Acta pharmacologica Sinica 2023 Oct;44(10):2065-2074
Acta pharmacologica Sinica 2023 Oct;44(10):2065-2074
CHI3L1 promotes myocardial fibrosis via regulating lncRNA TUG1/miR-495-3p/ETS1 axis.
Sun Y, Shan X, Guo J, Liu X, Ma D
Apoptosis : an international journal on programmed cell death 2023 Oct;28(9-10):1436-1451
Apoptosis : an international journal on programmed cell death 2023 Oct;28(9-10):1436-1451
LGR4 promotes tumorigenesis by activating TGF-β1/Smad signaling pathway in multiple myeloma.
Yi Z, Ma T, Liu J, Tie W, Li Y, Bai J, Li L, Zhang L
Cellular signalling 2023 Oct;110:110814
Cellular signalling 2023 Oct;110:110814
Unveiling poly(rC)-binding protein 2 as the target protein for curcusone C against prostate cancer: mechanism validation through click chemistry-activity based proteomics profiling approach.
Huang L, Ma B, Zhang C, Shi J, Shen R, Zhang E, Lian C, Wang C, Liu J
BMC cancer 2023 Oct 9;23(1):957
BMC cancer 2023 Oct 9;23(1):957
Blockade of TGF-β signalling alleviates human adipose stem cell senescence induced by native ECM in obesity visceral white adipose tissue.
Han X, Li W, He X, Lu X, Zhang Y, Li Y, Bi G, Ma X, Huang X, Bai R, Zhang H
Stem cell research & therapy 2023 Oct 8;14(1):291
Stem cell research & therapy 2023 Oct 8;14(1):291
Novel pterostilbene derivatives ameliorate heart failure by reducing oxidative stress and inflammation through regulating Nrf2/NF-κB signaling pathway.
Yang X, Liu Z, Fang M, Zou T, Zhang Z, Meng X, Wang T, Meng H, Chen Y, Duan Y, Li Q
European journal of medicinal chemistry 2023 Oct 5;258:115602
European journal of medicinal chemistry 2023 Oct 5;258:115602
A circular RNA activated by TGFβ promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability.
Li K, Guo J, Ming Y, Chen S, Zhang T, Ma H, Fu X, Wang J, Liu W, Peng Y
Nature communications 2023 Oct 28;14(1):6876
Nature communications 2023 Oct 28;14(1):6876
The Dual-Mode Transition of Myofibroblasts Derived from Hepatic Stellate Cells in Liver Fibrosis.
Yan M, Xie Y, Yao J, Li X
International journal of molecular sciences 2023 Oct 23;24(20)
International journal of molecular sciences 2023 Oct 23;24(20)
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
IKVAV peptide-containing hydrogel decreases fibrous scar after spinal cord injury by inhibiting fibroblast migration and activation.
Jiang T, Li S, Xu B, Liu K, Qiu T, Dai H
Behavioural brain research 2023 Oct 18;455:114683
Behavioural brain research 2023 Oct 18;455:114683
C3aR Antagonist Alleviates C3a Induced Tubular Profibrotic Phenotype Transition via Restoring PPARα/CPT-1α Mediated Mitochondrial Fatty Acid Oxidation in Renin-Dependent Hypertension.
Wang C, Wang Z, Xu J, Ma H, Jin K, Xu T, Pan X, Feng X, Zhang W
Frontiers in bioscience (Landmark edition) 2023 Oct 17;28(10):238
Frontiers in bioscience (Landmark edition) 2023 Oct 17;28(10):238
Alleviative effect of melatonin against the nephrotoxicity induced by cadmium exposure through regulating renal oxidative stress, inflammatory reaction, and fibrosis in a mouse model.
Yang Z, He Y, Ma Q, Wang H, Zhang Q
Ecotoxicology and environmental safety 2023 Oct 15;265:115536
Ecotoxicology and environmental safety 2023 Oct 15;265:115536
Multi-omic analysis reveals metabolic pathways that characterize right-sided colon cancer liver metastasis.
Morris MT, Jain A, Sun B, Kurbatov V, Muca E, Zeng Z, Jin Y, Roper J, Lu J, Paty PB, Johnson CH, Khan SA
Cancer letters 2023 Oct 10;574:216384
Cancer letters 2023 Oct 10;574:216384
Local administration of liposomal-based Plekhf1 gene therapy attenuates pulmonary fibrosis by modulating macrophage polarization.
Yan L, Hou C, Liu J, Wang Y, Zeng C, Yu J, Zhou T, Zhou Q, Duan S, Xiong W
Science China. Life sciences 2023 Nov;66(11):2571-2586
Science China. Life sciences 2023 Nov;66(11):2571-2586
Integrated network pharmacology to investigate the mechanism of Salvia miltiorrhiza Bunge in the treatment of myocardial infarction.
Huang X, Zhang M, Song Y, Sun B, Lin L, Song X, Li C
Journal of cellular and molecular medicine 2023 Nov;27(22):3514-3525
Journal of cellular and molecular medicine 2023 Nov;27(22):3514-3525
Disfunction of communication among immune cells in minimal-deviation adenocarcinoma of the cervix as an immunotherapeutic opportunity.
Zhang H, Liu C, Zhai X, Zhang Q, Zhou Y, Huang H, Ding M, Shi Q, Liu Y, Tang Y, Liu G, Wang H
International immunopharmacology 2023 Nov;124(Pt A):110907
International immunopharmacology 2023 Nov;124(Pt A):110907
Compound c17 alleviates inflammatory cardiomyopathy in streptozotocin-induced diabetic mice by targeting MyD88.
Zhang Q, Zhu W, Lou S, Bao H, Zhou Y, Cai Z, Ye J, Cui Y, Wang M, Jin L, Liang G, Luo W, Wang Y
International immunopharmacology 2023 Nov;124(Pt A):110863
International immunopharmacology 2023 Nov;124(Pt A):110863
INHBA gene silencing inhibits proliferation, migration, and invasion of osteosarcoma cells by repressing TGF-β signaling pathway activation.
Zhang H, Huang Y, Wen Q, Li Y, Guo L, Ge N
Journal of orthopaedic surgery and research 2023 Nov 8;18(1):848
Journal of orthopaedic surgery and research 2023 Nov 8;18(1):848
Schisandrin B Alleviates Renal Tubular Cell Epithelial-Mesenchymal Transition and Mitochondrial Dysfunction by Kielin/Chordin-like Protein Upregulation via Akt Pathway Inactivation and Adenosine 5'-Monophosphate (AMP)-Activated Protein Kinase Pathway Activation in Diabetic Kidney Disease.
Liu W, Li F, Guo D, Du C, Zhao S, Li J, Yan Z, Hao J
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Molecules (Basel, Switzerland) 2023 Nov 29;28(23)
Activation of KrasG12D in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma.
Chaudhary P, Xu X, Wang G, Hoj JP, Rampersad RR, Asselin-Labat ML, Ting S, Kim W, Tamayo P, Pendergast AM, Onaitis MW
Cancer research communications 2023 Nov 24;3(11):2400-2411
Cancer research communications 2023 Nov 24;3(11):2400-2411
BSHXF-medicated serum combined with ADSCs regulates the TGF-β1/Smad pathway to repair oxidatively damaged NPCs and its component analysis.
Duan J, Li Z, Liu E, Long H, Chen L, Yang S
Journal of ethnopharmacology 2023 Nov 15;316:116692
Journal of ethnopharmacology 2023 Nov 15;316:116692
Metformin Attenuates TGF-β1-Induced Fibrosis in Salivary Gland: A Preliminary Study.
Wang L, Zhong NN, Wang X, Peng B, Chen Z, Wei L, Li B, Li Y, Cheng Y
International journal of molecular sciences 2023 Nov 13;24(22)
International journal of molecular sciences 2023 Nov 13;24(22)
Establishment and application of the BRP prognosis model for idiopathic pulmonary fibrosis.
Cheng X, Feng Z, Pan B, Liu Q, Han Y, Zou L, Rong P, Meng J
Journal of translational medicine 2023 Nov 11;21(1):805
Journal of translational medicine 2023 Nov 11;21(1):805
Green Pea (Pisum sativum L.) Hull Polyphenol Extract Alleviates NAFLD through VB6/TLR4/NF-κB and PPAR Pathways.
Guo F, Xiong H, Tsao R, Shahidi F, Wen X, Liu J, Jiang L, Sun Y
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Journal of agricultural and food chemistry 2023 Nov 1;71(43):16067-16078
Electroacupuncture alleviates intrauterine adhesion through regulating autophagy in rats.
Liu J, Zhu Q, Pan Y, Hao S, Wang Z, Cui C, Li J, Huang Y, Xia L, Xu T, Cheng J, Shen J, Xia Y
Molecular human reproduction 2023 Nov 1;29(11)
Molecular human reproduction 2023 Nov 1;29(11)
Salidroside alleviates dexamethasone-induced inhibition of bone formation via transforming growth factor-beta/Smad2/3 signaling pathway.
Xie B, Zhou H, Liu H, Liao S, Zhou C, Xu D
Phytotherapy research : PTR 2023 May;37(5):1938-1950
Phytotherapy research : PTR 2023 May;37(5):1938-1950
Ambient particulate matter exposure plus chronic ethanol ingestion exacerbates hepatic fibrosis by triggering the mitochondrial ROS-ferroptosis signaling pathway in mice.
Ding S, Jiang J, Zhang G, Yu M, Zheng Y
Ecotoxicology and environmental safety 2023 May;256:114897
Ecotoxicology and environmental safety 2023 May;256:114897
Crosstalk between the JAK2 and TGF-β1 signaling pathways in scleroderma-related interstitial lung disease targeted by baricitinib.
Wang D, Wei Y, Xu L, Zhang J
Advances in rheumatology (London, England) 2023 May 16;63(1):22
Advances in rheumatology (London, England) 2023 May 16;63(1):22
USP22 aggravated diabetic renal tubulointerstitial fibrosis progression through deubiquitinating and stabilizing Snail1.
Zhao X, He X, Wei W, Huang K
European journal of pharmacology 2023 May 15;947:175671
European journal of pharmacology 2023 May 15;947:175671
COL12A1 as a prognostic biomarker links immunotherapy response in breast cancer.
Yan Y, Liang Q, Liu Y, Zhou S, Xu Z
Endocrine-related cancer 2023 May 1;30(5)
Endocrine-related cancer 2023 May 1;30(5)
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
A combination of umbilical cord mesenchymal stem cells and monosialotetrahexosy 1 ganglioside alleviates neuroinflammation in traumatic brain injury.
Fang Y, Qiu W, Li X, Jin Q, Yan H, Yu N, Zhao J, Tan Y, Zhao Z
Experimental brain research 2023 Mar;241(3):713-726
Experimental brain research 2023 Mar;241(3):713-726
Chronic spinal cord compression associated with intervertebral disc degeneration in SPARC-null mice.
Li ZY, Zhou AF, Li G, Zhou LY, Pu PM, Zhu K, Zheng Z, Wang YJ, Liang QQ, Yao M, Cui XJ
Neural regeneration research 2023 Mar;18(3):634-642
Neural regeneration research 2023 Mar;18(3):634-642
Chondroitin polymerizing factor predicts a poor prognosis and promotes breast cancer progression via the upstream TGF-β1/SMAD3 and JNK axis activation.
Pan QF, Ouyang WW, Zhang MQ, He S, Yang SY, Zhang J
Journal of cell communication and signaling 2023 Mar;17(1):89-102
Journal of cell communication and signaling 2023 Mar;17(1):89-102
Exosomal lncRNA HOTAIR promotes osteoclast differentiation by targeting TGF-β/PTHrP/RANKL pathway.
Zhang C, Yang J, Zhu Z, Qin J, Yang L, Zhao X, Su W, Cai Y, Yang J, Wang F, Chen W, Gu H, Deng H, Wang Z
Basic & clinical pharmacology & toxicology 2023 Mar;132(3):242-252
Basic & clinical pharmacology & toxicology 2023 Mar;132(3):242-252
Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.
Huang Z, Shen S, Wang M, Li W, Wu G, Huang W, Luo W, Liang G
EMBO reports 2023 Mar 6;24(3):e56135
EMBO reports 2023 Mar 6;24(3):e56135
Chronic Exposure to TDI Induces Cell Migration and Invasion via TGF-β1 Signal Transduction.
Han DH, Shin MK, Oh JW, Lee J, Sung JS, Kim M
International journal of molecular sciences 2023 Mar 24;24(7)
International journal of molecular sciences 2023 Mar 24;24(7)
Improvement of vaginal probiotics Lactobacillus crispatus on intrauterine adhesion in mice model and in clinical practice.
Wu F, Kong Y, Chen W, Liang D, Xiao Q, Hu L, Tan X, Wei J, Liu Y, Deng X, Liu Z, Chen T
BMC microbiology 2023 Mar 22;23(1):78
BMC microbiology 2023 Mar 22;23(1):78
IGFBP2 derived from PO-MSCs promote epithelial barrier destruction by activating FAK signaling in nasal polyps.
You B, Zhang T, Zhang W, Pei Y, Huang D, Lei Y, Zhang S, Qiu C, Zhang J, Gu Z, Cheng L, Chen J
iScience 2023 Mar 17;26(3):106151
iScience 2023 Mar 17;26(3):106151
Possible mechanisms associated with immune escape and apoptosis on anti-hepatocellular carcinoma effect of Mu Ji Fang granules.
Zhang YB, Bao YR, Wang S, Li TJ, Tai H, Leng JP, Yang XX, Wang BC, Meng XS
World journal of gastrointestinal oncology 2023 Mar 15;15(3):504-522
World journal of gastrointestinal oncology 2023 Mar 15;15(3):504-522
Ultrasound-mediated mesoporous silica nanoparticles loaded with PDLIM5 siRNA inhibit gefitinib resistance in NSCLC cells by attenuating EMT.
Wu H, Lv WH, Zhu YY, Jia YY, Nie F
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Mar 1;182:106372
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2023 Mar 1;182:106372
Simultaneous neutralization of TGF-β and IL-6 attenuates Staphylococcus aureus-induced arthritic inflammation through differential modulation of splenic and synovial macrophages.
Ghosh R, Dey R, Sawoo R, Bishayi B
Scandinavian journal of immunology 2023 Jun;97(6):e13252
Scandinavian journal of immunology 2023 Jun;97(6):e13252
Luteolin reduces cardiac damage caused by hyperlipidemia in Sprague-Dawley rats.
Dong M, Luo Y, Lan Y, He Q, Xu L, Pei Z
Heliyon 2023 Jun;9(6):e17613
Heliyon 2023 Jun;9(6):e17613
TGF-β-induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease.
Tang Q, Markby GR, MacNair AJ, Tang K, Tkacz M, Parys M, Phadwal K, MacRae VE, Corcoran BM
Cell proliferation 2023 Jun;56(6):e13435
Cell proliferation 2023 Jun;56(6):e13435
Porcupine inhibitor CGX1321 alleviates heart failure with preserved ejection fraction in mice by blocking WNT signaling.
Wu H, Tang LX, Wang XM, Li LP, Chen XK, He YJ, Yang DZ, Shi Y, Shou JL, Zhang ZS, Wang L, Lu BJ, An SM, Zeng CY, Wang WE
Acta pharmacologica Sinica 2023 Jun;44(6):1149-1160
Acta pharmacologica Sinica 2023 Jun;44(6):1149-1160
Efficacy of Danggui Buxue decoction on diabetic nephropathy-induced renal fibrosis in rats and possible mechanism.
Ye Z, Xian W, Ling GU, Zihang LI, Jingtian Z, Wenkai W, Liang Z, Mei X
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Jun;43(3):507-513
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Jun;43(3):507-513
Naringin regulates endoplasmic reticulum stress and mitophagy through the ATF3/PINK1 signaling axis to alleviate pulmonary fibrosis.
Wei Y, Sun L, Liu C, Li L
Naunyn-Schmiedeberg's archives of pharmacology 2023 Jun;396(6):1155-1169
Naunyn-Schmiedeberg's archives of pharmacology 2023 Jun;396(6):1155-1169
Downregulation of fatty acid oxidation led by Hilpda increases G2/M arrest/delay-induced kidney fibrosis.
Liu L, Liu T, Jia R, Zhang L, Lv Z, He Z, Qu Y, Sun S, Tai F
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166701
Biochimica et biophysica acta. Molecular basis of disease 2023 Jun;1869(5):166701
AAV9-Tspyl2 gene therapy retards bleomycin-induced pulmonary fibrosis by modulating downstream TGF-β signaling in mice.
Zhang S, Tong X, Liu S, Huang J, Zhang L, Zhang T, Wang D, Fan H
Cell death & disease 2023 Jun 30;14(6):389
Cell death & disease 2023 Jun 30;14(6):389
The super-healing MRL strain promotes muscle growth in muscular dystrophy through a regenerative extracellular matrix.
O'Brien JG, Willis AB, Long AM, Kwon J, Lee G, Li F, Page PGT, Vo AH, Hadhazy M, Crosbie RH, Demonbreun AR, McNally EM
bioRxiv : the preprint server for biology 2023 Jun 30;
bioRxiv : the preprint server for biology 2023 Jun 30;
Peptidomics Analysis Reveals the Buccal Gland of Jawless Vertebrate Lamprey as a Source of Multiple Bioactive Peptides.
Wang Y, Sun F, Wang Z, Duan X, Li Q, Pang Y, Gou M
Marine drugs 2023 Jun 29;21(7)
Marine drugs 2023 Jun 29;21(7)
Role of TGF-beta1 and TNF-alpha1 produced by neoplastic cells in the pathogenesis of fibrosis in patients with hematologic neoplasms.
Takizawa H, Araki Y, Fujishiro M, Tomita S, Kishikawa S, Hashizume A, Mitsumori T, Nitta H, Iizuka-Honma H, Sawada T, Okubo M, Sekiguchi Y, Ando M, Noguchi M
Journal of clinical and experimental hematopathology : JCEH 2023 Jun 28;63(2):83-89
Journal of clinical and experimental hematopathology : JCEH 2023 Jun 28;63(2):83-89
Macrophage Dectin-1 mediates Ang II renal injury through neutrophil migration and TGF-β1 secretion.
Ye S, Huang H, Xiao Y, Han X, Shi F, Luo W, Chen J, Ye Y, Zhao X, Huang W, Wang Y, Lai D, Liang G, Fu G
Cellular and molecular life sciences : CMLS 2023 Jun 20;80(7):184
Cellular and molecular life sciences : CMLS 2023 Jun 20;80(7):184
Degradable Temperature-Sensitive Hydrogel Loaded with Heparin Effectively Prevents Post-Operative Tissue Adhesions.
Lang P, Liu T, Huang S, Zhou Z, Zhang M, Lin Y, He Q, Yao Y, Liu Z, Zhang L
ACS biomaterials science & engineering 2023 Jun 12;9(6):3618-3631
ACS biomaterials science & engineering 2023 Jun 12;9(6):3618-3631
Sparganii Rhizoma alleviates pulmonary fibrosis by inhibiting fibroblasts differentiation and epithelial-mesenchymal transition mediated by TGF-β1/ Smad2/3 pathway.
Liu J, Gao D, Ding Q, Zhang B, Zhu W, Shi Y
Journal of ethnopharmacology 2023 Jun 12;309:116305
Journal of ethnopharmacology 2023 Jun 12;309:116305
Fibroblast growth factor 10 delays the progression of osteoarthritis by attenuating synovial fibrosis via inhibition of IL-6/JAK2/STAT3 signaling in vivo and in vitro.
Su W, Zheng X, Zhou H, Yang S, Zhu X
Molecular immunology 2023 Jul;159:46-57
Molecular immunology 2023 Jul;159:46-57
Distinct cellular immune profiles in lung adenocarcinoma manifesting as pure ground glass opacity versus solid nodules.
Qu R, Ye F, Hu S, Wang B, Qin S, Xiong J, Fu X, Li L, Cai Y
Journal of cancer research and clinical oncology 2023 Jul;149(7):3775-3788
Journal of cancer research and clinical oncology 2023 Jul;149(7):3775-3788
Endothelin-1 production via placental (pro)renin receptor in a mouse model of preeclampsia.
Mishima S, Mitsui T, Tani K, Ooba H, Mitoma T, Ohira A, Maki J, Kirino S, Eto E, Hayata K, Masuyama H
Placenta 2023 Jul;138:44-50
Placenta 2023 Jul;138:44-50
Sacha inchi albumin delays skin-aging by alleviating inflammation, oxidative stress and regulating gut microbiota in d-galactose induced-aging mice.
Zeng J, An M, Tian W, Wang K, Du B, Li P
Journal of the science of food and agriculture 2023 Jul;103(9):4470-4480
Journal of the science of food and agriculture 2023 Jul;103(9):4470-4480
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.
Sun W, Wang Q, Zhang R, Zhang N
Food & function 2023 Jul 31;14(15):7247-7269
Food & function 2023 Jul 31;14(15):7247-7269
Metformin suppressed tendon injury-induced adhesion via hydrogel-nanoparticle sustained-release system.
Jie Li Z, Bing Luo C, Liang Wang H, Sun J, Qian Yang Q, Lang Zhou Y
International journal of pharmaceutics 2023 Jul 25;642:123190
International journal of pharmaceutics 2023 Jul 25;642:123190
Wen-Shen-Jian-Pi-Hua-Tan decoction protects against early obesity-related glomerulopathy by improving renal bile acid composition and suppressing lipogenesis, inflammation, and fibrosis.
Song D, Zhang A, Hu X, Zeng M, Zhou H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul 25;116:154861
Different exercise training intensities prevent type 2 diabetes mellitus-induced myocardial injury in male mice.
Pei Z, Zhou R, Yao W, Dong S, Liu Y, Gao Z
iScience 2023 Jul 21;26(7):107080
iScience 2023 Jul 21;26(7):107080
Resveratrol plays an anti-fibrotic and anti-autophagy role by stimulating miR-192-5p expression in urethral fibrosis.
Lv J, Zhang R, Li D, Liu Y
Functional & integrative genomics 2023 Jul 14;23(3):241
Functional & integrative genomics 2023 Jul 14;23(3):241
Antiandrogen treatment induces stromal cell reprogramming to promote castration resistance in prostate cancer.
Wang H, Li N, Liu Q, Guo J, Pan Q, Cheng B, Xu J, Dong B, Yang G, Yang B, Wang X, Gu Y, Zhang G, Lian Y, Zhang W, Zhang M, Li T, Zang Y, Tan M, Li Q, Wang X, Yu Z, Jiang J, Huang H, Qin J
Cancer cell 2023 Jul 10;41(7):1345-1362.e9
Cancer cell 2023 Jul 10;41(7):1345-1362.e9
Knockdown of ABCB7 inhibits esophageal cancer progression by inhibiting the TGF-β/Smad signaling.
Feng S, Jia J, Lv G, Wang Y
Archives of biochemistry and biophysics 2023 Jul 1;742:109620
Archives of biochemistry and biophysics 2023 Jul 1;742:109620
Tartary buckwheat flavonoids alleviates high-fat diet induced kidney fibrosis in mice by inhibiting MAPK and TGF-β1/Smad signaling pathway.
Liu S, Fu S, Jin Y, Geng R, Li Y, Zhang Y, Liu J, Guo W
Chemico-biological interactions 2023 Jul 1;379:110533
Chemico-biological interactions 2023 Jul 1;379:110533
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Pan C, Fei Q, Jin J, Zheng J, Wu D, Li H, Huang X, Kong X
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
Ginsenoside Rg3 liposomes regulate tumor microenvironment for the treatment of triple negative breast cancer.
Miao L, Ma H, Dong T, Zhao C, Gao T, Wu T, Xu H, Zhang J
Drug development and industrial pharmacy 2023 Jan;49(1):139-148
Drug development and industrial pharmacy 2023 Jan;49(1):139-148
Dectin-1 plays a deleterious role in high fat diet-induced NAFLD of mice through enhancing macrophage activation.
Wang MX, Luo W, Ye L, Jin LM, Yang B, Zhang QH, Qian JC, Wang Y, Zhang Y, Liang G
Acta pharmacologica Sinica 2023 Jan;44(1):120-132
Acta pharmacologica Sinica 2023 Jan;44(1):120-132
Overexpression of LAG3, TIM3, and A2aR in adenoid cystic carcinoma and mucoepidermoid carcinoma.
Zhang MJ, Wu CC, Wang S, Yang LL, Sun ZJ
Oral diseases 2023 Jan;29(1):175-187
Oral diseases 2023 Jan;29(1):175-187
Interference of ALOX5 alleviates inflammation and fibrosis in high glucose‑induced renal mesangial cells.
Chen X, Xie H, Liu Y, Ou Q, Deng S
Experimental and therapeutic medicine 2023 Jan;25(1):34
Experimental and therapeutic medicine 2023 Jan;25(1):34
Formin protein DIAPH1 positively regulates PD-L1 expression and predicts the therapeutic response to anti-PD-1/PD-L1 immunotherapy.
Mei J, Cai Y, Wang H, Xu R, Zhou J, Lu J, Yang X, Pan J, Liu C, Xu J, Zhu Y
Clinical immunology (Orlando, Fla.) 2023 Jan;246:109204
Clinical immunology (Orlando, Fla.) 2023 Jan;246:109204
Enhanced osteoarthritis therapy by nanoengineered mesenchymal stem cells using biomimetic CuS nanoparticles loaded with plasmid DNA encoding TGF-β1.
Cai Y, Wu C, Ou Q, Zeng M, Xue S, Chen J, Lu Y, Ding C
Bioactive materials 2023 Jan;19:444-457
Bioactive materials 2023 Jan;19:444-457
The effects of taraxasterol on liver fibrosis revealed by RNA sequencing.
He H, Xu B, Ge P, Gao Y, Wei M, Li T, Zhang R, Li B, Cao H, Zhang K
International immunopharmacology 2023 Jan;114:109481
International immunopharmacology 2023 Jan;114:109481
Sodium houttuyfonate against cardiac fibrosis attenuates isoproterenol-induced heart failure by binding to MMP2 and p38.
Tan R, You Q, Cui J, Wang M, Song N, An K, Lin L, Adu-Amankwaah J, Yuan J, Sun H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154590
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jan;109:154590
Study on the treatment of postmenopausal osteoporosis with quercetin in Liuwei Dihuang Pill based on network pharmacology.
Zhu F, Li W, Wang L, Dai B, Liu Z, Wu H, Deng T
Journal of orthopaedic surgery and research 2023 Jan 9;18(1):21
Journal of orthopaedic surgery and research 2023 Jan 9;18(1):21
COVID-19-associated monocytic encephalitis (CAME): histological and proteomic evidence from autopsy.
Zhang PP, He ZC, Yao XH, Tang R, Ma J, Luo T, Zhu C, Li TR, Liu X, Zhang D, Zhang S, Ping YF, Leng L, Bian XW
Signal transduction and targeted therapy 2023 Jan 6;8(1):24
Signal transduction and targeted therapy 2023 Jan 6;8(1):24
Irisin ameliorates D-galactose-induced skeletal muscle fibrosis via the PI3K/Akt pathway.
Wu Y, Wu Y, Yu J, Zhang Y, Li Y, Fu R, Sun Y, Zhao K, Xiao Q
European journal of pharmacology 2023 Jan 15;939:175476
European journal of pharmacology 2023 Jan 15;939:175476
20-Hydroxytetraenoic acid induces hepatic fibrosis via the TGF-β1/Smad3 signaling pathway.
Li B, Ma Y, Tan L, Ren H, Wu L, Su Q, Song J, Chen W, Gong P, Jin Y
Toxicology letters 2023 Jan 15;373:1-12
Toxicology letters 2023 Jan 15;373:1-12
Expression of transforming growth factor-β1 and autophagy markers in the bladder of rats with neurogenic lower urinary tract injury.
Ma L, Mu Y, Li X, Zhang M, An W, Zeng F
Spinal cord 2023 Feb;61(2):154-159
Spinal cord 2023 Feb;61(2):154-159
Mechanism of YY1 mediating autophagy dependent ferroptosis in PM2.5 induced cardiac fibrosis.
Hu H, Li L, Zhang H, Zhang Y, Liu Q, Chen M, Ning J, Pang Y, Hu W, Niu Y, Zhang R
Chemosphere 2023 Feb;315:137749
Chemosphere 2023 Feb;315:137749
Pirfenidone suppressed triple-negative breast cancer metastasis by inhibiting the activity of the TGF-β/SMAD pathway.
Luo D, Zeng X, Zhang S, Li D, Cheng Z, Wang Y, Long J, Hu Z, Long S, Zhou J, Zhang S, Zeng Z
Journal of cellular and molecular medicine 2023 Feb;27(3):456-469
Journal of cellular and molecular medicine 2023 Feb;27(3):456-469
Exosomes Derived from AT2R-Overexpressing BMSC Prevent Restenosis After Carotid Artery Injury by Attenuating the Injury-Induced Neointimal Hyperplasia.
Zou X, Liao Y, Liu Z, Xu X, Sun W, Qin H, Wang H, Liu J, Jing T
Journal of cardiovascular translational research 2023 Feb;16(1):112-126
Journal of cardiovascular translational research 2023 Feb;16(1):112-126
A small-molecule JNK inhibitor JM-2 attenuates high-fat diet-induced non-alcoholic fatty liver disease in mice.
Jin L, Wang M, Yang B, Ye L, Zhu W, Zhang Q, Lou S, Zhang Y, Luo W, Liang G
International immunopharmacology 2023 Feb;115:109587
International immunopharmacology 2023 Feb;115:109587
Hypoxia-Driven TGFβ Modulation of Side Population Cells in Breast Cancer: The Potential Role of ERα.
Mallini P, Chen M, Mahkamova K, Lennard TWJ, Pan Y, Wei D, Stemke-Hale K, Kirby JA, Lash GE, Meeson A
Cancers 2023 Feb 9;15(4)
Cancers 2023 Feb 9;15(4)
Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds with Endoplasmic Reticulum Stress-Relieving Properties for Promoted Scarless Wound Healing.
Dou Z, Li B, Wu L, Qiu T, Wang X, Zhang X, Shen Y, Lu M, Yang Y
ACS applied materials & interfaces 2023 Feb 8;15(5):6297-6311
ACS applied materials & interfaces 2023 Feb 8;15(5):6297-6311
Study on the mechanism of aging-related erectile dysfunction based on bioinformatics and experimental verification.
Sun T, Liu Y, Chen Y, Xu W, Wang T, Liu K, Liu J
Translational andrology and urology 2023 Feb 28;12(2):197-208
Translational andrology and urology 2023 Feb 28;12(2):197-208
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Chen SJ, Huang Y, Yu F, Feng X, Zheng YY, Li Q, Niu Q, Jiang YH, Zhao LQ, Wang M, Cheng PP, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ma WL, Ye H
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
C1Q labels a highly aggressive macrophage-like leukemia population indicating extramedullary infiltration and relapse.
Yang LX, Zhang CT, Yang MY, Zhang XH, Liu HC, Luo CH, Jiang Y, Wang ZM, Yang ZY, Shi ZP, Yang YC, Wei RQ, Zhou L, Mi J, Zhou AW, Yao ZR, Xia L, Yan JS, Lu Y
Blood 2023 Feb 16;141(7):766-786
Blood 2023 Feb 16;141(7):766-786
Gut microbiota and bile acids partially mediate the improvement of fibroblast growth factor 21 on methionine-choline-deficient diet-induced non-alcoholic fatty liver disease mice.
Lin D, Sun Q, Liu Z, Pan J, Zhu J, Wang S, Jia S, Zheng M, Li X, Gong F
Free radical biology & medicine 2023 Feb 1;195:199-218
Free radical biology & medicine 2023 Feb 1;195:199-218
Let-7 suppresses liver fibrosis by inhibiting hepatocyte apoptosis and TGF-β production.
Song J, Lv H, Liu B, Hao M, Taylor HS, Zhang X, Li D, Huang Y
Molecular metabolism 2023 Dec;78:101828
Molecular metabolism 2023 Dec;78:101828
DLK1 overexpression improves sepsis-induced cardiac dysfunction and fibrosis in mice through the TGF-β1/Smad3 signaling pathway and MMPs.
Zeng N, Jian Z, Xu J, Zheng S, Fan Y, Xiao F
Journal of molecular histology 2023 Dec;54(6):655-664
Journal of molecular histology 2023 Dec;54(6):655-664
Exosomes derived from human dermal fibroblasts protect against UVB‑induced skin photoaging.
Park AY, Lee JO, Jang Y, Kim YJ, Lee JM, Kim SY, Kim BJ, Yoo KH
International journal of molecular medicine 2023 Dec;52(6)
International journal of molecular medicine 2023 Dec;52(6)
Transforming Growth Factor β1 Ameliorates Microglial Activation in Perioperative Neurocognitive Disorders.
Lin D, Sun Y, Wang Y, Yang D, Shui M, Wang Y, Xue Z, Huang X, Zhang Y, Wu A, Wei C
Neurochemical research 2023 Dec;48(12):3512-3524
Neurochemical research 2023 Dec;48(12):3512-3524
ABT-263 exerts a protective effect on upper urinary tract damage by alleviating neurogenic bladder fibrosis.
Wen Y, Wu J, Pu Q, He X, Wang J, Feng J, Zhang Y, Si F, Wen JG, Yang J
Renal failure 2023 Dec;45(1):2194440
Renal failure 2023 Dec;45(1):2194440
Vitamin D3 alleviates lung fibrosis of type 2 diabetic rats via SIRT3 mediated suppression of pyroptosis.
Tang L, Zhang D, Zhang Y, Peng Y, Li M, Song H, Chen H, Li W, Li X
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1618-1627
Apoptosis : an international journal on programmed cell death 2023 Dec;28(11-12):1618-1627
Autopsy analysis reveals increased macrophage infiltration and cell apoptosis in COVID-19 patients with severe pulmonary fibrosis.
Xiao SQ, Wen TZ, Chen XY, Chen HY, Li Z, He ZC, Luo T, Tang R, Fu WJ, Cao MF, Chen L, Niu Q, Wang S, Lan Y, Ge J, Li QR, Guo HT, Wang YX, Ping YF, Shen H, Wang Y, Ding YQ, Bian XW, Yao XH
Pathology, research and practice 2023 Dec;252:154920
Pathology, research and practice 2023 Dec;252:154920
Protocatechuic aldehyde increases pericyte coverage and mitigates pericyte damage to enhance the atherosclerotic plaque stability.
Zhang L, Li Y, Yang W, Lin L, Li J, Liu D, Li C, Wu J, Li Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115742
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Dec;168:115742
BMAL1 inhibits renal fibrosis and renal interstitial inflammation by targeting the ERK1/2/ELK-1/Egr-1 axis.
Chen W, Zhao S, Xing J, Yu W, Rao T, Zhou X, Ruan Y, Li S, Xia Y, Song T, Zou F, Li W, Cheng F
International immunopharmacology 2023 Dec;125(Pt B):111140
International immunopharmacology 2023 Dec;125(Pt B):111140
ACTN1 promotes HNSCC tumorigenesis and cisplatin resistance by enhancing MYH9-dependent degradation of GSK-3β and integrin β1-mediated phosphorylation of FAK.
Cui L, Lu Y, Zheng J, Guo B, Zhao X
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Journal of experimental & clinical cancer research : CR 2023 Dec 7;42(1):335
Oleanolic acid derivative alleviates cardiac fibrosis through inhibiting PTP1B activity and regulating AMPK/TGF-β/Smads pathway.
Wang AH, Ma HY, Yi YL, Zhu SJ, Yu ZW, Zhu J, Mei S, Bahetibike S, Lu YQ, Huang LT, Yang RY, Rui-Wang, Xiao SL, Qi R
European journal of pharmacology 2023 Dec 5;960:176116
European journal of pharmacology 2023 Dec 5;960:176116
An injectable and light curable hyaluronic acid composite gel with anti-biofilm, anti-inflammatory and pro-healing characteristics for accelerating infected wound healing.
Lin X, Fu T, Lei Y, Xu J, Wang S, He F, Xie Z, Zhang L
International journal of biological macromolecules 2023 Dec 31;253(Pt 5):127190
International journal of biological macromolecules 2023 Dec 31;253(Pt 5):127190
Proteomic analysis reveals the aging-related pathways contribute to pulmonary fibrogenesis.
Zhang T, Yuan X, Jiang M, Liu B, Zhai N, Zhang Q, Song X, Lv C, Zhang J, Li H
Aging 2023 Dec 22;15(24):15382-15401
Aging 2023 Dec 22;15(24):15382-15401
Succinate-induced macrophage polarization and RBP4 secretion promote vascular sprouting in ocular neovascularization.
Shen T, Lin R, Hu C, Yu D, Ren C, Li T, Zhu M, Wan Z, Su T, Wu Y, Cai W, Yu J
Journal of neuroinflammation 2023 Dec 21;20(1):308
Journal of neuroinflammation 2023 Dec 21;20(1):308
Fluorescent Chiral Quantum Dots to Unveil Origin-Dependent Exosome Uptake and Cargo Release.
Kim G, Zhu R, Zhang Y, Jeon H, Wang Y
bioRxiv : the preprint server for biology 2023 Dec 21;
bioRxiv : the preprint server for biology 2023 Dec 21;
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
Bai J, Qian B, Cai T, Chen Y, Li T, Cheng Y, Wu Z, Liu C, Ye M, Du Y, Fu W
Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
Sirt1 Overexpression Inhibits Fibrous Scar Formation and Improves Functional Recovery After Cerebral Ischemic Injury Through the Deacetylation of 14-3-3ζ.
Chen Y, Huang J, Liu J, Zhu H, Li X, Wen J, Tian M, Ren J, Zhou L, Yang Q
Molecular neurobiology 2023 Aug;60(8):4795-4810
Molecular neurobiology 2023 Aug;60(8):4795-4810
Uncovering pharmacological mechanisms of Phellinus linteus on focal segmental glomeruloscleosis rats through tandem mass tag-based quantitative proteomic analysis, network pharmacology analysis and experimental validation.
Feng W, Ruchun Y, Yuewen T
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Aug;43(4):744-750
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2023 Aug;43(4):744-750
Identification of circulating T-cell immunoglobulin and mucin domain 4 as a potential biomarker for coronary heart disease.
Wang M, Gong K, Zhu X, Chen S, Zhou J, Zhang H, Han J, Ma L, Duan Y
MedComm 2023 Aug;4(4):e320
MedComm 2023 Aug;4(4):e320
Matrix stiffness-induced α-tubulin acetylation is required for skin fibrosis formation through activation of Yes-associated protein.
Wen D, Gao Y, Liu Y, Ho C, Sun J, Huang L, Liu Y, Li Q, Zhang Y
MedComm 2023 Aug;4(4):e319
MedComm 2023 Aug;4(4):e319
Neonatal-Tissue-Derived Extracellular Vesicle Therapy (NEXT): A Potent Strategy for Precision Regenerative Medicine.
Lou P, Liu S, Wang Y, Lv K, Zhou X, Li L, Zhang Y, Chen Y, Cheng J, Lu Y, Liu J
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
Advanced materials (Deerfield Beach, Fla.) 2023 Aug;35(33):e2300602
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Wang X, Zhou Y, Sun Q, Zhang Q, Zhou H, Zhang J, Du Y, Wang Y, Yuan K, Xu L, Zhang M, Yan D, Zeng L, Xu K, Sang W
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Dectin-1 deficiency alleviates diabetic cardiomyopathy by attenuating macrophage-mediated inflammatory response.
Yang N, Wang M, Lin K, Wang M, Xu D, Han X, Zhao X, Wang Y, Wu G, Luo W, Liang G, Shan P
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166710
Biochimica et biophysica acta. Molecular basis of disease 2023 Aug;1869(6):166710
High SNRPA1 expression leads to poor prognosis in patients with lung adenocarcinoma.
Yang JJ, Yang YJ, Gu YL, Tong L, Liu YF, Zhang JG
The clinical respiratory journal 2023 Aug;17(8):719-732
The clinical respiratory journal 2023 Aug;17(8):719-732
MALAT1 binds to miR-188-3p to regulate ALOX5 activity in the lung inflammatory response of neonatal bronchopulmonary dysplasia.
Feng DD, Chen JH, Chen YF, Cao Q, Li BJ, Chen XQ, Jin R, Zhou GP
Molecular immunology 2023 Aug;160:67-79
Molecular immunology 2023 Aug;160:67-79
Systemic Pharmacology Reveals the Potential Targets and Signaling Mechanisms in the Adjuvant Treatment of Brucellosis with Traditional Chinese Medicine.
Zhao T, Zhang Y, Liu L, Deng X, Guo J, Cao S, Zhu D, Xu J, Nikolaevna UV, Maratbek S, Wang Z, Sun Z, Gu X, Zhang H
ACS omega 2023 Aug 8;8(31):28797-28812
ACS omega 2023 Aug 8;8(31):28797-28812
Hypoxic Postconditioning Promotes Angiogenesis After Ischemic Stroke.
Shi W, Ren C, Zhang W, Gao C, Yu W, Ji X, Chang L
Neuroscience 2023 Aug 21;526:35-47
Neuroscience 2023 Aug 21;526:35-47
HOXA11 promotes lymphatic metastasis of gastric cancer via transcriptional activation of TGFβ1.
Li Z, Lu T, Chen Z, Yu X, Wang L, Shen G, Huang H, Li Z, Ren Y, Guo W, Hu Y
iScience 2023 Aug 18;26(8):107346
iScience 2023 Aug 18;26(8):107346
TNFSF14/LIGHT promotes cardiac fibrosis and atrial fibrillation vulnerability via PI3Kγ/SGK1 pathway-dependent M2 macrophage polarisation.
Wu Y, Zhan S, Chen L, Sun M, Li M, Mou X, Zhang Z, Xu L, Xu Y
Journal of translational medicine 2023 Aug 14;21(1):544
Journal of translational medicine 2023 Aug 14;21(1):544
Melatonin increases susceptibility to atrial fibrillation in obesity via Akt signaling impairment in response to lipid overload.
Qin X, Fu Y, Fan J, Liu B, Liu P, Zhang Y, Jiang T, Zheng Q
Journal of pineal research 2023 Apr;74(3):e12851
Journal of pineal research 2023 Apr;74(3):e12851
LncRNA CFAR promotes cardiac fibrosis via the miR-449a-5p/LOXL3/mTOR axis.
Zhang M, Zhang B, Wang X, Song J, Tong M, Dong Z, Xu J, Liu M, Jiang Y, Wang N, Wang Y, Du Z, Liu Y, Zhang R, Xu C
Science China. Life sciences 2023 Apr;66(4):783-799
Science China. Life sciences 2023 Apr;66(4):783-799
Relaxin-2 Prevents Erectile Dysfunction by Cavernous Nerve, Endothelial and Histopathological Protection Effects in Rats with Bilateral Cavernous Nerve Injury.
Liu K, Sun T, Xu W, Song J, Chen Y, Ruan Y, Li H, Cui K, Zhang Y, Feng Y, Pan J, Liang E, Xin Z, Wang T, Wang S, Liu J, Luan Y
The world journal of men's health 2023 Apr;41(2):434-445
The world journal of men's health 2023 Apr;41(2):434-445
Epiberberine regulates lipid synthesis through SHP (NR0B2) to improve non-alcoholic steatohepatitis.
Zhou LM, Fan JH, Xu MM, Xiong MY, Wang QJ, Chai X, Li XD, Li XG, Ye XL
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166639
Biochimica et biophysica acta. Molecular basis of disease 2023 Apr;1869(4):166639
Vagus nerve stimulation is a potential treatment for ischemic stroke.
Liu YL, Wang SR, Ma JX, Yu LH, Jia GW
Neural regeneration research 2023 Apr;18(4):825-831
Neural regeneration research 2023 Apr;18(4):825-831
Inhibition of Transglutaminase 2 Reduces Peritoneal Injury in a Chlorhexidine-Induced Peritoneal Fibrosis Model.
Kunoki S, Tatsukawa H, Sakai Y, Kinashi H, Kariya T, Suzuki Y, Mizuno M, Yamaguchi M, Sasakura H, Ikeno M, Takeuchi K, Ishimoto T, Hitomi K, Ito Y
Laboratory investigation; a journal of technical methods and pathology 2023 Apr;103(4):100050
Laboratory investigation; a journal of technical methods and pathology 2023 Apr;103(4):100050
Activation of NRF2 Signaling Pathway Delays the Progression of Hyperuricemic Nephropathy by Reducing Oxidative Stress.
Qiao P, Sun Y, Wang Y, Lin S, An Y, Wang L, Liu J, Huang Y, Yang B, Zhou H
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
Antioxidants (Basel, Switzerland) 2023 Apr 28;12(5)
AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling.
Da X, Li Z, Huang X, He Z, Yu Y, Tian T, Xu C, Yao Y, Wang QK
Nature communications 2023 Apr 20;14(1):2265
Nature communications 2023 Apr 20;14(1):2265
Promoted Skin Wound Healing by Tail-Amputated Eisenia foetida Proteins via the Ras/Raf/MEK/ERK Signaling Pathway.
Li T, Sun Y, Wang J, Zhang C, Sun Y
ACS omega 2023 Apr 18;8(15):13935-13943
ACS omega 2023 Apr 18;8(15):13935-13943
Metformin Collaborates with PINK1/Mfn2 Overexpression to Prevent Cardiac Injury by Improving Mitochondrial Function.
Ma Z, Liu Z, Li X, Zhang H, Han D, Xiong W, Zhou H, Yang X, Zeng Q, Ren H, Xu D
Biology 2023 Apr 11;12(4)
Biology 2023 Apr 11;12(4)
Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.
Ren KW, Yu XH, Gu YH, Xie X, Wang Y, Wang SH, Li HH, Bi HL
Frontiers in cardiovascular medicine 2022;9:957903
Frontiers in cardiovascular medicine 2022;9:957903
Neuroprotection of cannabidiol in epileptic rats: Gut microbiome and metabolome sequencing.
Gong X, Liu L, Li X, Xiong J, Xu J, Mao D, Liu L
Frontiers in nutrition 2022;9:1028459
Frontiers in nutrition 2022;9:1028459
CIDEC: A Potential Factor in Diabetic Vascular Inflammation.
Song FQ, Zhou HM, Ma WX, Li YL, Hu BA, Shang YY, Wang ZH, Zhong M, Zhang W, Ti Y
Journal of vascular research 2022;59(2):114-123
Journal of vascular research 2022;59(2):114-123
Pterostilbene, a Resveratrol Derivative, Improves Ectopic Lipid Deposition in the Kidneys of Mice Induced by a High-Fat Diet.
Gu W, Yang L, Wang X, Geng J, Li X, Zheng K, Guan Y, Hou X, Wang C, Song G
Kidney & blood pressure research 2022;47(8):514-522
Kidney & blood pressure research 2022;47(8):514-522
Iodine-125 Seeds Inhibit Carcinogenesis of Hepatocellular Carcinoma Cells by Suppressing Epithelial-Mesenchymal Transition via TGF-β1/Smad Signaling.
Yang C, Xiao Y, Du Y, Xiong J, Deng L, Liang Q, Yuan J, He C, He F, Huang X
Disease markers 2022;2022:9230647
Disease markers 2022;2022:9230647
Loureirin A Exerts Antikeloid Activity by Antagonizing the TGF-β1/Smad Signalling Pathway.
Ma H, Duan X, Zhang R, Li H, Guo Y, Tian Y, Huang M, Chen G, Wang Z, Li L
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8661288
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8661288
The Hair Growth-Promoting Effect of Gardenia florida Fruit Extract and Its Molecular Regulation.
Liu X, Ji T, Hu H, Lv X, Zhu G
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8498974
Evidence-based complementary and alternative medicine : eCAM 2022;2022:8498974
PM2.5 Exposure Induces Lung Injury and Fibrosis by Regulating Ferroptosis via TGF-β Signaling.
Guo L, Bai S, Ding S, Zhao L, Xu S, Wang X
Disease markers 2022;2022:7098463
Disease markers 2022;2022:7098463
Multifunctional Drug-Loaded Phase-Change Nanoparticles Inhibit the Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Affecting the Activity of Activated Hepatic Stellate Cells.
Zou X, Li T, Mao Y, Zhu M, Chen X, Niu J, Dong T, Jiang J, Yang X
BioMed research international 2022;2022:6441179
BioMed research international 2022;2022:6441179
The Traditional Chinese Medicine Formula FTZ Protects against Cardiac Fibrosis by Suppressing the TGFβ1-Smad2/3 Pathway.
Zhang Y, Wang D, Wu K, Shao X, Diao H, Wang Z, Sun M, Huang X, Li Y, Tang X, Yan M, Guo J
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5642307
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5642307
Wound Healing Effects of Dracontomelon dao on Bacterial Infection Wounds in Rats and Its Potential Mechanisms under Simulated Space Environment.
Wen J, Xu Z, Ma X, Zhao Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:4593201
Evidence-based complementary and alternative medicine : eCAM 2022;2022:4593201
Fufang Xueshuantong Improves Diabetic Cardiomyopathy by Regulating the Wnt/β-Catenin Pathway.
Peng M, Liu H, Ji Q, Ma P, Niu Y, Ning S, Sun H, Pang X, Yang Y, Zhang Y, Han J, Hao G
International journal of endocrinology 2022;2022:3919161
International journal of endocrinology 2022;2022:3919161
Pyrrosia petiolosa Extract Ameliorates Ethylene Glycol-Induced Urolithiasis in Rats by Inhibiting Oxidative Stress and Inflammatory Response.
Zhou F, Wang X
Disease markers 2022;2022:1913067
Disease markers 2022;2022:1913067
HBO1 as an Important Target for the Treatment of CCL4-Induced Liver Fibrosis and Aged-Related Liver Aging and Fibrosis.
Xing B, Lan H, Li H
Oxidative medicine and cellular longevity 2022;2022:1881519
Oxidative medicine and cellular longevity 2022;2022:1881519
Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.
Zhang M, Lin D, Luo C, Wei P, Cui K, Chen Z
Oxidative medicine and cellular longevity 2022;2022:1247806
Oxidative medicine and cellular longevity 2022;2022:1247806
Paeoniflorin attenuates monocrotaline-induced pulmonary arterial hypertension in rats by suppressing TAK1-MAPK/NF-κB pathways.
Yu M, Wu X, Wang J, He M, Han H, Hu S, Xu J, Yang M, Tan Q, Wang Y, Wang H, Xie W, Kong H
International journal of medical sciences 2022;19(4):681-694
International journal of medical sciences 2022;19(4):681-694
Blockade of SK4 channels suppresses atrial fibrillation by attenuating atrial fibrosis in canines with prolonged atrial pacing.
Wang Y, Yao Y, Ma Y, He S, Yang M, Cao Z, Liudi S, Fu Y, Chen H, Wang X, Huang C, Zhao Q
International journal of medical sciences 2022;19(14):1995-2007
International journal of medical sciences 2022;19(14):1995-2007
GPC1 promotes the growth and migration of colorectal cancer cells through regulating the TGF-β1/SMAD2 signaling pathway.
Lu F, Chen S, Shi W, Su X, Wu H, Liu M
PloS one 2022;17(6):e0269094
PloS one 2022;17(6):e0269094
Inhibition of Ureteral Stricture by Pirfenidone-Loaded Nanoparticle-Coated Ureteral Stents with Slow-Release Pirfenidone.
Jiang Z, Wang J, Meng W, Zhou Y, Ma L, Guan Y
International journal of nanomedicine 2022;17:6579-6591
International journal of nanomedicine 2022;17:6579-6591
Exosome Derived from Mesenchymal Stem Cells Alleviates Pathological Scars by Inhibiting the Proliferation, Migration and Protein Expression of Fibroblasts via Delivering miR-138-5p to Target SIRT1.
Zhao W, Zhang R, Zang C, Zhang L, Zhao R, Li Q, Yang Z, Feng Z, Zhang W, Cui R
International journal of nanomedicine 2022;17:4023-4038
International journal of nanomedicine 2022;17:4023-4038
Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.
Liu C, Gao R, Tang Y, Chen H, Zhang X, Sun Y, Zhao Q, Lv P, Wang H, Ye-Lehmann S, Liu J, Chen C
Frontiers in neuroscience 2022;16:925300
Frontiers in neuroscience 2022;16:925300
Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-β1/Smad2/3 Signaling.
Hu H, Mao G, Zheng J, Guo F
Drug design, development and therapy 2022;16:4223-4234
Drug design, development and therapy 2022;16:4223-4234
Dexmedetomidine post-conditioning protects blood-brain barrier integrity by modulating microglia/macrophage polarization via inhibiting NF-κB signaling pathway in intracerebral hemorrhage.
Guo H, Zhang W, Wang Z, Li Z, Zhou J, Yang Z
Frontiers in molecular neuroscience 2022;15:977941
Frontiers in molecular neuroscience 2022;15:977941
MULT1-Encoding DNA Alleviates Schistosomiasis-Associated Hepatic Fibrosis via Modulating Cellular Immune Response.
Yang L, Sun L, Cao Y, Wang Q, Song A, Zhu R, Liu W, Lu S
Journal of inflammation research 2022;15:4027-4045
Journal of inflammation research 2022;15:4027-4045
Hepatic TGFβr1 Deficiency Attenuates Lipopolysaccharide/D-Galactosamine-Induced Acute Liver Failure Through Inhibiting GSK3β-Nrf2-Mediated Hepatocyte Apoptosis and Ferroptosis.
Huang S, Wang Y, Xie S, Lai Y, Mo C, Zeng T, Kuang S, Deng G, Zhou C, Chen Y, Huang S, Gao L, Lv Z
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672
Cellular and molecular gastroenterology and hepatology 2022;13(6):1649-1672
Endoglin aggravates peritoneal fibrosis by regulating the activation of TGF-β/ALK/Smads signaling.
Huang Q, Xiao R, Lu J, Zhang Y, Xu L, Gao J, Sun J, Wang H
Frontiers in pharmacology 2022;13:973182
Frontiers in pharmacology 2022;13:973182
Fisetin reduces the senescent tubular epithelial cell burden and also inhibits proliferative fibroblasts in murine lupus nephritis.
Ijima S, Saito Y, Nagaoka K, Yamamoto S, Sato T, Miura N, Iwamoto T, Miyajima M, Chikenji TS
Frontiers in immunology 2022;13:960601
Frontiers in immunology 2022;13:960601
TIM-4 in macrophages contributes to nasal polyp formation through the TGF-β1-mediated epithelial to mesenchymal transition in nasal epithelial cells.
Qin D, Liu P, Zhou H, Jin J, Gong W, Liu K, Chen S, Huang J, Fan W, Tao Z, Xu Y
Frontiers in immunology 2022;13:941608
Frontiers in immunology 2022;13:941608
ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model.
Zhan Z, Li A, Zhang W, Wu X, He J, Li Z, Li Y, Sun J, Zhang H
Frontiers in endocrinology 2022;13:914865
Frontiers in endocrinology 2022;13:914865
Kangfuxiaoyanshuan alleviates uterine inflammation and adhesion via inhibiting NF-κB p65 and TGF-β/MMP-2 signaling pathway in pelvic inflammatory disease rats.
Fan L, Liu Z, Zhang Z, Li T, Zong X, Bai H
Frontiers in pharmacology 2022;13:894149
Frontiers in pharmacology 2022;13:894149
Astragalus propinquus schischkin and Salvia miltiorrhiza bunge promote angiogenesis to treat myocardial ischemia via Ang-1/Tie-2/FAK pathway.
Zhang MX, Huang XY, Song Y, Xu WL, Li YL, Li C
Frontiers in pharmacology 2022;13:1103557
Frontiers in pharmacology 2022;13:1103557
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice.
Gu YH, Ren KW, Wang Y, Wang SH, Yu XH, Xu LW, Li HH, Bi HL
Frontiers in pharmacology 2022;13:1021361
Frontiers in pharmacology 2022;13:1021361
Non-invasive photobiomodulation treatment in an Alzheimer Disease-like transgenic rat model.
Yang L, Wu C, Parker E, Li Y, Dong Y, Tucker L, Brann DW, Lin HW, Zhang Q
Theranostics 2022;12(5):2205-2231
Theranostics 2022;12(5):2205-2231
High Expression of TGF-β1 Contributes to Hepatocellular Carcinoma Prognosis via Regulating Tumor Immunity.
Jin X, Zhang S, Wang N, Guan L, Shao C, Lin Y, Liu J, Li Y
Frontiers in oncology 2022;12:861601
Frontiers in oncology 2022;12:861601
Umbilical Cord Mesenchymal Stem Cells Ameliorate Kidney Injury in MRL/Ipr Mice Through the TGF-β1 Pathway.
Huang C, Meng M, Li S, Liu S, Li L, Su Y, Gao H, He S, Zhao Y, Zhang M, Hou Z, Wang W, Wang X
Frontiers in cell and developmental biology 2022;10:876054
Frontiers in cell and developmental biology 2022;10:876054
A Case of Colonic Micropapillary Carcinoma with a High Frequency of Apoptosis.
Arai K, Iwasaki T, Ishimatsu H, Tsuchiya C, Kubota A, Sonoda A, Ohata K
Journal of gastrointestinal cancer 2022 Sep;53(3):809-816
Journal of gastrointestinal cancer 2022 Sep;53(3):809-816
Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections.
Wang Y, Liu S, Li L, Li L, Zhou X, Wan M, Lou P, Zhao M, Lv K, Yuan Y, Chen Y, Lu Y, Cheng J, Liu J
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:118-132
Journal of controlled release : official journal of the Controlled Release Society 2022 Sep;349:118-132
Sex-Dependent Effects of Chronic Microdrive Implantation on Acquisition of Trace Eyeblink Conditioning.
Rapp AP, Hark TJ, Power JM, Savas JN, Matthew Oh M, Disterhoft JF
Neurobiology of learning and memory 2022 Sep;193:107649
Neurobiology of learning and memory 2022 Sep;193:107649
N-Acetyl-l-tryptophan inhibits CCl(4)-induced hepatic fibrogenesis via regulating TGF-β1/SMAD and Hippo/YAP1 signal.
Ma T, Cheng H, Li T, Chen Y, Cai T, Bai J, Wu Z, Xia X, Liang T, Du Y, Fu W
Bioorganic chemistry 2022 Sep;126:105899
Bioorganic chemistry 2022 Sep;126:105899
Loss of BTK ameliorates the pathological cardiac fibrosis and dysfunction.
Wang B, Tan Y, Zhou W, Yang J, Jiang Y, Liu X, Zhan Z
Matrix biology : journal of the International Society for Matrix Biology 2022 Sep;112:171-189
Matrix biology : journal of the International Society for Matrix Biology 2022 Sep;112:171-189
β-Lapachone, an NQO1 activator, alleviates diabetic cardiomyopathy by regulating antioxidant ability and mitochondrial function.
Wu PY, Lai SY, Su YT, Yang KC, Chau YP, Don MJ, Lu KH, Shy HT, Lai SM, Kung HN
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154255
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154255
Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation.
Li L, Zhu G, Fu G, Zha W, Li H
International journal of molecular sciences 2022 Sep 9;23(18)
International journal of molecular sciences 2022 Sep 9;23(18)
Alamandine alleviated heart failure and fibrosis in myocardial infarction mice.
Zhao K, Xu T, Mao Y, Wu X, Hua D, Sheng Y, Li P
Biology direct 2022 Sep 27;17(1):25
Biology direct 2022 Sep 27;17(1):25
NR2F1 Regulates TGF-β1-Mediated Epithelial-Mesenchymal Transition Affecting Platinum Sensitivity and Immune Response in Ovarian Cancer.
Liang Q, Xu Z, Liu Y, Peng B, Cai Y, Liu W, Yan Y
Cancers 2022 Sep 24;14(19)
Cancers 2022 Sep 24;14(19)
Daidzein alleviates doxorubicin-induced heart failure via the SIRT3/FOXO3a signaling pathway.
Li H, Zhang M, Wang Y, Gong K, Yan T, Wang D, Meng X, Yang X, Chen Y, Han J, Duan Y, Zhang S
Food & function 2022 Sep 22;13(18):9576-9588
Food & function 2022 Sep 22;13(18):9576-9588
Fucoxanthin ameliorated myocardial fibrosis in STZ-induced diabetic rats and cell hypertrophy in HG-induced H9c2 cells by alleviating oxidative stress and restoring mitophagy.
Zheng D, Chen L, Li G, Jin L, Wei Q, Liu Z, Yang G, Li Y, Xie X
Food & function 2022 Sep 22;13(18):9559-9575
Food & function 2022 Sep 22;13(18):9559-9575
Suppression of NADPH oxidase 4 inhibits PM(2.5)-induced cardiac fibrosis through ROS-P38 MAPK pathway.
Wu M, Xing Q, Duan H, Qin G, Sang N
The Science of the total environment 2022 Sep 1;837:155558
The Science of the total environment 2022 Sep 1;837:155558
Carbon tetrachloride exposure induces ovarian damage through oxidative stress and inflammatory mediated ovarian fibrosis.
Xue L, Li X, Zhu X, Zhang J, Zhou S, Tang W, Chen D, Chen Y, Dai J, Wu M, Wu M, Wang S
Ecotoxicology and environmental safety 2022 Sep 1;242:113859
Ecotoxicology and environmental safety 2022 Sep 1;242:113859
TGF-β1 peptide-based inhibitor P144 ameliorates renal fibrosis after ischemia-reperfusion injury by modulating alternatively activated macrophages.
Li D, Zhang J, Yuan S, Wang C, Chang J, Tong Y, Liu R, Sang T, Li L, Li J, Ouyang Q, Chen X
Cell proliferation 2022 Oct;55(10):e13299
Cell proliferation 2022 Oct;55(10):e13299
Electroacupuncture attenuates chronic salpingitis transforming growth factor-β1/p38 mitogen-activated protein kinase signaling pathway.
Xijiao HU, Yinglong C, Huanan K, Shuoxi LI, Yawen W, Jinzhe L, Yiming S, Li L
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):781-787
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2022 Oct;42(5):781-787
Inhibition of Ubiquitin-specific Protease 4 Attenuates Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells via Transforming Growth Factor Beta Receptor Type I.
Pu JY, Zhang Y, Wang LX, Wang J, Zhou JH
Current medical science 2022 Oct;42(5):1000-1006
Current medical science 2022 Oct;42(5):1000-1006
Established new compound IMB16-4 self-emulsifying drug delivery systems for increasing oral bioavailability and enhancing anti-hepatic fibrosis effect.
Niu X, Meng Y, Wang Y, Li G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113657
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113657
Curcumin analog JM-2 alleviates diabetic cardiomyopathy inflammation and remodeling by inhibiting the NF-κB pathway.
Wang M, Jin L, Zhang Q, Zhu W, He H, Lou S, Luo W, Han X, Liang G
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113590
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Oct;154:113590
The application of proteomics and metabolomics to reveal the molecular mechanism of Nutmeg-5 in ameliorating cardiac fibrosis following myocardial infarction.
Yan T, Zhu X, Zhang X, Jia X, Liu J, Wang X, Xiao Y, Xiao Z, Liu T, Dong Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154382
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154382
Peimine ameliorates pulmonary fibrosis via the inhibition of M2-type macrophage polarization through the suppression of P38/Akt/STAT6 signals.
Cai ZH, Tian YG, Li JZ, Zhao P, Li JS, Mei X, Bai YP
Bioscience reports 2022 Oct 28;42(10)
Bioscience reports 2022 Oct 28;42(10)
Puerarin ameliorates myocardial remodeling of spontaneously hypertensive rats through inhibiting TRPC6-CaN-NFATc3 pathway.
Yan J, Honglei Y, Yun W, Sheng D, Yun H, Anhua Z, Na F, Min L, Dandan S, Jing W, Junming T, Wenjun Z, Xiju H
European journal of pharmacology 2022 Oct 15;933:175254
European journal of pharmacology 2022 Oct 15;933:175254
The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice.
Zhou W, Wu WH, Si ZL, Liu HL, Wang H, Jiang H, Liu YF, Alolga RN, Chen C, Liu SJ, Bian XY, Shan JJ, Li J, Tan NH, Zhang ZH
Nature communications 2022 Oct 14;13(1):6081
Nature communications 2022 Oct 14;13(1):6081
Celastrol attenuates renal injury in 5/6 nephrectomized rats via inhibiting epithelial-mesenchymal transition and transforming growth factor-β1/Smad3 pathway.
Tang YW, Yang RC, Wan F, Tang XL, Zhang HQ, Lin Y
Experimental biology and medicine (Maywood, N.J.) 2022 Nov;247(21):1947-1955
Experimental biology and medicine (Maywood, N.J.) 2022 Nov;247(21):1947-1955
The silencing of lnc-NONHSAT071210 suppresses the proliferation, fibrosis, migration, and invasion of TGFβ1-treated lung epithelial cells.
Liu Y, Lu F, Li X, Yang Y, Yang J
Annals of translational medicine 2022 Nov;10(22):1239
Annals of translational medicine 2022 Nov;10(22):1239
The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.
Fu HY, Xu JM, Ai X, Dang FT, Tan X, Yu HY, Feng J, Yang WX, Ma HT, Tu RF, Gupta AK, Manandhar LK, Bao WM, Tang YM
Cells 2022 Nov 26;11(23)
Cells 2022 Nov 26;11(23)
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
The programmed site-specific delivery of LY3200882 and PD-L1 siRNA boosts immunotherapy for triple-negative breast cancer by remodeling tumor microenvironment.
Zhang P, Qin C, Liu N, Zhou X, Chu X, Lv F, Gu Y, Yin L, Liu J, Zhou J, Huo M
Biomaterials 2022 May;284:121518
Biomaterials 2022 May;284:121518
Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling.
Sun Y, Liu B, Xie J, Jiang X, Xiao B, Hu X, Xiang J
Molecular medicine reports 2022 May;25(5)
Molecular medicine reports 2022 May;25(5)
Colistin-induced pulmonary toxicity involves the activation of NOX4/TGF-β/mtROS pathway and the inhibition of Akt/mTOR pathway.
Dai C, Li M, Sun T, Zhang Y, Wang Y, Shen Z, Velkov T, Tang S, Shen J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 May;163:112966
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2022 May;163:112966
Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury.
Zheng J, Wang Y, Wang Z, Chen W, Luo M, Zhang C, Wang Y, Chen L, Wu F, Yang W, Yang Z, Wang Y, Shi C
Free radical research 2022 May-Jun;56(5-6):411-426
Free radical research 2022 May-Jun;56(5-6):411-426
Downregulation of lncRNA Miat contributes to the protective effect of electroacupuncture against myocardial fibrosis.
Qi W, Li X, Ren Y, Liu X, Fu H, Wang X, Li X, Xiong J, Zheng Q, Cai D, Liang F
Chinese medicine 2022 May 17;17(1):57
Chinese medicine 2022 May 17;17(1):57
Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling.
Yoshikawa S, Nagao M, Toh R, Shinohara M, Iino T, Irino Y, Nishimori M, Tanaka H, Satomi-Kobayashi S, Ishida T, Hirata KI
American journal of physiology. Heart and circulatory physiology 2022 May 1;322(5):H749-H761
American journal of physiology. Heart and circulatory physiology 2022 May 1;322(5):H749-H761
The miR-214-3p/c-Ski axis modulates endothelial-mesenchymal transition in human coronary artery endothelial cells in vitro and in mice model in vivo.
Wang J, Li H, Lv Z, Luo X, Deng W, Zou T, Zhang Y, Sang W, Wang X
Human cell 2022 Mar;35(2):486-497
Human cell 2022 Mar;35(2):486-497
Effects of transforming growth factor beta-activated kinase 1 (TAK1) on apoptosis of HK-2 cells in the high glucose environment.
Wang Y, Zhao L, Qiu D, Shi Y, Duan H
Bioengineered 2022 Mar;13(3):5880-5891
Bioengineered 2022 Mar;13(3):5880-5891
MicroRNA-130a attenuates cardiac fibrosis after myocardial infarction through TGF-β/Smad signaling by directly targeting TGF-β receptor 1.
Feng Y, Bao Y, Ding J, Li H, Liu W, Wang X, Guan H, Chen Z
Bioengineered 2022 Mar;13(3):5779-5791
Bioengineered 2022 Mar;13(3):5779-5791
Ameliorating role of microRNA-378 carried by umbilical cord mesenchymal stem cells-released extracellular vesicles in mesangial proliferative glomerulonephritis.
Chen W, Zhang F, Hou X, Xu H, Tang D
Cell communication and signaling : CCS 2022 Mar 9;20(1):28
Cell communication and signaling : CCS 2022 Mar 9;20(1):28
The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis.
Cheng X, Ai K, Yi L, Liu W, Li Y, Wang Y, Zhang D
Cell death & disease 2022 Mar 4;13(3):207
Cell death & disease 2022 Mar 4;13(3):207
Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.
Yi Y, Wu M, Zhou X, Xiong M, Tan Y, Yu H, Liu Z, Wu Y, Zhang Q
Stem cell research & therapy 2022 Mar 21;13(1):119
Stem cell research & therapy 2022 Mar 21;13(1):119
Daidzein suppresses TGF-β1-induced cardiac fibroblast activation via the TGF-β1/SMAD2/3 signaling pathway.
Shu J, Hu L, Wu Y, Chen L, Huang K, Wang Z, Liang M
European journal of pharmacology 2022 Mar 15;919:174805
European journal of pharmacology 2022 Mar 15;919:174805
Chelerythrine inhibits the progression of glioblastoma by suppressing the TGFB1-ERK1/2/Smad2/3-Snail/ZEB1 signaling pathway.
Zhu M, Niu J, Jiang J, Dong T, Chen Y, Yang X, Liu P
Life sciences 2022 Mar 15;293:120358
Life sciences 2022 Mar 15;293:120358
Layer-by-Layer Pirfenidone/Cerium Oxide Nanocapsule Dressing Promotes Wound Repair and Prevents Scar Formation.
He J, Meng X, Meng C, Zhao J, Chen Y, Zhang Z, Zhang Y
Molecules (Basel, Switzerland) 2022 Mar 11;27(6)
Molecules (Basel, Switzerland) 2022 Mar 11;27(6)
Protection of CAPE-pNO(2) Against Chronic Myocardial Ischemia by the TGF-Β1/Galectin-3 Pathway In Vivo and In Vitro.
Wan Q, Zhang L, Zhou Q, Han Y, Li Z, Li B
Inflammation 2022 Jun;45(3):1039-1058
Inflammation 2022 Jun;45(3):1039-1058
Non-Invasive Local Acoustic Therapy Ameliorates Diabetic Heart Fibrosis by Suppressing ACE-Mediated Oxidative Stress and Inflammation in Cardiac Fibroblasts.
Weng L, Li L, Zhao K, Xu T, Mao Y, Shu H, Chen X, Chen J, Wu J, Guo X, Tu J, Zhang D, Sun W, Kong X
Cardiovascular drugs and therapy 2022 Jun;36(3):413-424
Cardiovascular drugs and therapy 2022 Jun;36(3):413-424
Overexpression of G Protein-Coupled Receptor 40 Protects Obesity-Induced Cardiomyopathy Through the SIRT1/LKB1/AMPK Pathway.
Li SN, Yu YL, Wang BY, Qiao SY, Hu MM, Wang H, Fu CN, Dong B
Human gene therapy 2022 Jun;33(11-12):598-613
Human gene therapy 2022 Jun;33(11-12):598-613
Erectile dysfunction in hypospadiac male adult rats induced by maternal exposure to di-n-butyl phthalate.
Zhou X, Wang S, Zhou R, Zhang T, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhou X, Song N
Toxicology 2022 Jun 15;475:153227
Toxicology 2022 Jun 15;475:153227
CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7.
Teng S, Liu G, Li L, Ou J, Yu Y
Biochemical and biophysical research communications 2022 Jun 11;608:128-134
Biochemical and biophysical research communications 2022 Jun 11;608:128-134
Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis.
Wu Y, Wu Y, Yang Y, Yu J, Wu J, Liao Z, Guo A, Sun Y, Zhao Y, Chen J, Xiao Q
Aging cell 2022 Jul;21(7):e13659
Aging cell 2022 Jul;21(7):e13659
Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration.
Wang J, Song J, Song G, Feng Y, Pan J, Yang X, Xin Z, Hu P, Sun T, Liu K, Xu W, Wang T, Wang S, Liu J, Ruan Y
Andrology 2022 Jul;10(5):984-996
Andrology 2022 Jul;10(5):984-996
Sestrin2 remedies podocyte injury via orchestrating TSP-1/TGF-β1/Smad3 axis in diabetic kidney disease.
Song S, Shi C, Bian Y, Yang Z, Mu L, Wu H, Duan H, Shi Y
Cell death & disease 2022 Jul 30;13(7):663
Cell death & disease 2022 Jul 30;13(7):663
The Chinese medicine Fufang Zhenzhu Tiaozhi capsule protects against atherosclerosis by suppressing EndMT via modulating Akt1/β-catenin signaling pathway.
Diao H, Cheng J, Huang X, Huang B, Shao X, Zhao J, Lan D, Zhu Q, Yan M, Zhang Y, Rong X, Guo J
Journal of ethnopharmacology 2022 Jul 15;293:115261
Journal of ethnopharmacology 2022 Jul 15;293:115261
Serum and glucocorticoid-regulated kinase 1 regulates transforming growth factor β1-connective tissue growth factor pathway in chronic rhinosinusitis.
Lai Y, Zhang P, Wang H, Hu L, Song X, Zhang J, Jiang W, Han M, Liu Q, Hu G, Sun X, Li H, Wang D
Clinical immunology (Orlando, Fla.) 2022 Jan;234:108895
Clinical immunology (Orlando, Fla.) 2022 Jan;234:108895
Fucoidan-functionalized activated platelet-hitchhiking micelles simultaneously track tumor cells and remodel the immunosuppressive microenvironment for efficient metastatic cancer treatment.
Guo R, Deng M, He X, Li M, Li J, He P, Liu H, Li M, Zhang Z, He Q
Acta pharmaceutica Sinica. B 2022 Jan;12(1):467-482
Acta pharmaceutica Sinica. B 2022 Jan;12(1):467-482
Artesunate attenuates atherosclerosis by inhibiting macrophage M1-like polarization and improving metabolism.
Wang X, Du H, Li X
International immunopharmacology 2022 Jan;102:108413
International immunopharmacology 2022 Jan;102:108413
The role of regulatory T cells on the activation of astrocytes in the brain of high-fat diet mice following lead exposure.
Wu L, Li S, Li C, He B, Lv L, Wang J, Wang J, Wang W, Zhang Y
Chemico-biological interactions 2022 Jan 5;351:109740
Chemico-biological interactions 2022 Jan 5;351:109740
Histone lysine-specific demethylase 1 induced renal fibrosis via decreasing sirtuin 3 expression and activating TGF-β1/Smad3 pathway in diabetic nephropathy.
Dong L, Yu L, Zhong J
Diabetology & metabolic syndrome 2022 Jan 4;14(1):2
Diabetology & metabolic syndrome 2022 Jan 4;14(1):2
A fragment of cell adhesion molecule L1 reduces amyloid-β plaques in a mouse model of Alzheimer's disease.
Hu J, Lin SL, Schachner M
Cell death & disease 2022 Jan 10;13(1):48
Cell death & disease 2022 Jan 10;13(1):48
Decreased Monocyte Count Is Associated With Gestational Diabetes Mellitus Development, Macrosomia, and Inflammation.
Huang X, Zha B, Zhang M, Li Y, Wu Y, Zhang R, Sheng L, Xu J, Yu Z, Gao C, Chen Z, Ding H, Ma L, Zhang Y, Zang S, Zhang TN, Liu J
The Journal of clinical endocrinology and metabolism 2022 Jan 1;107(1):192-204
The Journal of clinical endocrinology and metabolism 2022 Jan 1;107(1):192-204
Chronic exposure to biomass ambient particulate matter triggers alveolar macrophage polarization and activation in the rat lung.
Wang S, Chen Y, Hong W, Li B, Zhou Y, Ran P
Journal of cellular and molecular medicine 2022 Feb;26(4):1156-1168
Journal of cellular and molecular medicine 2022 Feb;26(4):1156-1168
Esomeprazole alleviates fibrosis in systemic sclerosis by modulating AhR/Smad2/3 signaling.
Liu J, Pi Z, Xiao Y, Zeng Z, Yu J, Zou P, Tang B, Qiu X, Tang R, Shi Y, Xiao R
Pharmacological research 2022 Feb;176:106057
Pharmacological research 2022 Feb;176:106057
Uncaria Rhynchophylla attenuates angiotensin Ⅱ-induced myocardial fibrosis via suppression of the RhoA/ROCK1 pathway.
Xie L, Wang T, Lin S, Lu Z, Wang Y, Shen Z, Cheng Y, Shen A, Peng J, Chu J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112607
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Feb;146:112607
Sodium butyrate alleviates pre-eclampsia in pregnant rats by improving the gut microbiota and short-chain fatty acid metabolites production.
Yong W, Zhao Y, Jiang X, Li P
Journal of applied microbiology 2022 Feb;132(2):1370-1383
Journal of applied microbiology 2022 Feb;132(2):1370-1383
Hyperglycemia induces miR-26-5p down-regulation to overexpress PFKFB3 and accelerate epithelial-mesenchymal transition in gastric cancer.
He X, Cheng X, Ding J, Xiong M, Chen B, Cao G
Bioengineered 2022 Feb;13(2):2902-2917
Bioengineered 2022 Feb;13(2):2902-2917
Berberine ameliorates erectile dysfunction in rats with streptozotocin-induced diabetes mellitus through the attenuation of apoptosis by inhibiting the SPHK1/S1P/S1PR2 and MAPK pathways.
Liu K, Sun T, Luan Y, Chen Y, Song J, Ling L, Yuan P, Li R, Cui K, Ruan Y, Lan R, Wang T, Wang S, Liu J, Rao K
Andrology 2022 Feb;10(2):404-418
Andrology 2022 Feb;10(2):404-418
A comprehensive analysis on the relationship between BDE-209 exposure and erectile dysfunction.
Zhou X, Song L, Cong R, Luan J, Zhou X, Wang Y, Yao L, Zhang X, Ren X, Zhang T, Yu M, Song N
Chemosphere 2022 Dec;308(Pt 3):136486
Chemosphere 2022 Dec;308(Pt 3):136486
A novel chemokine-based signature for prediction of prognosis and therapeutic response in glioma.
Fan W, Wang D, Li G, Xu J, Ren C, Sun Z, Wang Z, Ma W, Zhao Z, Bao Z, Jiang T, Zhang Y
CNS neuroscience & therapeutics 2022 Dec;28(12):2090-2103
CNS neuroscience & therapeutics 2022 Dec;28(12):2090-2103
Phosphatidylserine liposome multilayers mediate the M1-to-M2 macrophage polarization to enhance bone tissue regeneration.
Toita R, Kang JH, Tsuchiya A
Acta biomaterialia 2022 Dec;154:583-596
Acta biomaterialia 2022 Dec;154:583-596
Endogenous neutralization of TGF-β and IL-6 ameliorates septic arthritis by altering RANKL/OPG interaction in lymphocytes.
Ghosh R, Dey R, Sawoo R, Haque W, Bishayi B
Molecular immunology 2022 Dec;152:183-206
Molecular immunology 2022 Dec;152:183-206
A novel murine model of combined hepatocellular carcinoma and intrahepatic cholangiocarcinoma.
Xu RC, Wang F, Sun JL, Abuduwaili W, Zhang GC, Liu ZY, Liu TT, Dong L, Shen XZ, Zhu JM
Journal of translational medicine 2022 Dec 9;20(1):579
Journal of translational medicine 2022 Dec 9;20(1):579
Paeoniflorin-free subfraction of Paeonia lactiflora Pall. shows the potential of anti-hepatic fibrosis: an integrated analysis of network pharmacology and experimental validation.
Zhang Q, Wu Y, Ge M, Xia G, Xia H, Wang L, Wei X, He H, Lin S
Journal of ethnopharmacology 2022 Dec 5;299:115678
Journal of ethnopharmacology 2022 Dec 5;299:115678
Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease.
Wang Y, Xiong B, Lin H, Li Q, Yang H, Qiao Y, Li Q, Xu Z, Lyu W, Qu W, Liu W, Chen Y, Feng F, Sun H
European journal of medicinal chemistry 2022 Dec 15;244:114806
European journal of medicinal chemistry 2022 Dec 15;244:114806
Exercise-derived peptide protects against pathological cardiac remodeling.
Yin A, Yuan R, Xiao Q, Zhang W, Xu K, Yang X, Yang W, Xu L, Wang X, Zhuang F, Li Y, Cai Z, Sun Z, Zhou B, He B, Shen L
EBioMedicine 2022 Aug;82:104164
EBioMedicine 2022 Aug;82:104164
Artificial Intelligence-Assisted Bioinformatics, Microneedle, and Diabetic Wound Healing: A "New Deal" of an Old Drug.
Xue Y, Chen C, Tan R, Zhang J, Fang Q, Jin R, Mi X, Sun D, Xue Y, Wang Y, Xiong R, Lu H, Tan W
ACS applied materials & interfaces 2022 Aug 24;14(33):37396-37409
ACS applied materials & interfaces 2022 Aug 24;14(33):37396-37409
Adropin Carried by Reactive Oxygen Species-Responsive Nanocapsules Ameliorates Renal Lipid Toxicity in Diabetic Mice.
Yu M, Wang D, Zhong D, Xie W, Luo J
ACS applied materials & interfaces 2022 Aug 24;14(33):37330-37344
ACS applied materials & interfaces 2022 Aug 24;14(33):37330-37344
The compound losartan cream inhibits scar formation via TGF-β/Smad pathway.
Zhao WY, Zhang LY, Wang ZC, Fang QQ, Wang XF, Du YZ, Shi BH, Lou D, Xuan GD, Tan WQ
Scientific reports 2022 Aug 22;12(1):14327
Scientific reports 2022 Aug 22;12(1):14327
Endothelial Loss of ETS1 Impairs Coronary Vascular Development and Leads to Ventricular Non-Compaction.
Wang L, Lin L, Qi H, Chen J, Grossfeld P
Circulation research 2022 Aug 19;131(5):371-387
Circulation research 2022 Aug 19;131(5):371-387
Expression of HHLA2, TMIGD2, and GITR in salivary gland adenoid cystic carcinoma and mucoepidermoid carcinoma.
Zhang MJ, Wang S, Wu CC, Wu L, Sun ZJ
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2022 Apr;51(4):379-387
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2022 Apr;51(4):379-387
Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy.
Zou R, Nie C, Pan S, Wang B, Hong X, Xi S, Bai J, Yu M, Liu J, Yang W
Free radical biology & medicine 2022 Apr;183:35-50
Free radical biology & medicine 2022 Apr;183:35-50
Guizhi Fuling pill attenuates liver fibrosis in vitro and in vivo via inhibiting TGF-β1/Smad2/3 and activating IFN-γ/Smad7 signaling pathways.
Liu Z, Xu B, Ding Y, Ding X, Yang Z
Bioengineered 2022 Apr;13(4):9357-9368
Bioengineered 2022 Apr;13(4):9357-9368
Exogenous pancreatic kininogenase protects against tacrolimus-induced renal injury by inhibiting PI3K/AKT signaling: The role of bradykinin receptors.
Ding J, Jin J, Na Lei Y, Cui S, Ying Li H, Lan Zheng H, Guo Piao S, Ji Jiang Y, Ying Xuan M, Zhe Jin J, Shun Jin Y, Pyo Lee J, Ha Chung B, Soon Choi B, Woo Yang C, Li C
International immunopharmacology 2022 Apr;105:108547
International immunopharmacology 2022 Apr;105:108547
Ginsenoside Rh4 Suppresses Metastasis of Gastric Cancer via SIX1-Dependent TGF-β/Smad2/3 Signaling Pathway.
Jiang H, Ma P, Duan Z, Liu Y, Shen S, Mi Y, Fan D
Nutrients 2022 Apr 9;14(8)
Nutrients 2022 Apr 9;14(8)
Pinocembrin mediates antiarrhythmic effects in rats with isoproterenol-induced cardiac remodeling.
Chen X, Wan W, Ran Q, Ye T, Sun Y, Liu Z, Liu X, Shi S, Qu C, Zhang C, Yang B
European journal of pharmacology 2022 Apr 5;920:174799
European journal of pharmacology 2022 Apr 5;920:174799
A positive feedback loop: RAD18-YAP-TGF-β between triple-negative breast cancer and macrophages regulates cancer stemness and progression.
Yan X, He Y, Yang S, Zeng T, Hua Y, Bao S, Yang F, Duan N, Sun C, Liang Y, Fu Z, Huang X, Li W, Yin Y
Cell death discovery 2022 Apr 12;8(1):196
Cell death discovery 2022 Apr 12;8(1):196
Bisphenol A impairs macrophages through inhibiting autophagy via AMPK/mTOR signaling pathway and inducing apoptosis.
Wu M, Cong Y, Wang K, Yu H, Zhang X, Ma M, Duan Z, Pei X
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
Ecotoxicology and environmental safety 2022 Apr 1;234:113395
Cartilage Endplate Stem Cells Transdifferentiate Into Nucleus Pulposus Cells via Autocrine Exosomes.
Luo L, Gong J, Zhang H, Qin J, Li C, Zhang J, Tang Y, Zhang Y, Chen J, Zhou Y, Tian Z, Liu Y, Liu M
Frontiers in cell and developmental biology 2021;9:648201
Frontiers in cell and developmental biology 2021;9:648201
Blockade of Exosome Release Suppresses Atrial Fibrillation by Alleviating Atrial Fibrosis in Canines With Prolonged Atrial Pacing.
Yao Y, He S, Wang Y, Cao Z, Liu D, Fu Y, Chen H, Wang X, Zhao Q
Frontiers in cardiovascular medicine 2021;8:699175
Frontiers in cardiovascular medicine 2021;8:699175
Pilose Antler Peptide-3.2KD Ameliorates Adriamycin-Induced Myocardial Injury Through TGF-β/SMAD Signaling Pathway.
Xu Y, Qu X, Zhou J, Lv G, Han D, Liu J, Liu Y, Chen Y, Qu P, Huang X
Frontiers in cardiovascular medicine 2021;8:659643
Frontiers in cardiovascular medicine 2021;8:659643
Early Passive Leg Movement Prevents Against the Development of Heart Failure With Preserved Ejection Fraction in Rats.
Liu J, Ji XX, Fu Y, Zhang WC, Ji HF, Liu JW, Cheng XS, Dong YF
Frontiers in cardiovascular medicine 2021;8:655009
Frontiers in cardiovascular medicine 2021;8:655009
Human Tissue Kallikrein 1 Is Downregulated in Elderly Human Prostates and Possesses Potential In Vitro Antioxidative and Antifibrotic Effects in Rodent Prostates.
Zhang M, Luo C, Lin D, Cui K, Chen Z, Liu J
Oxidative medicine and cellular longevity 2021;2021:8877540
Oxidative medicine and cellular longevity 2021;2021:8877540
Ursolic Acid Regulates Intestinal Microbiota and Inflammatory Cell Infiltration to Prevent Ulcerative Colitis.
Sheng Q, Li F, Chen G, Li J, Li J, Wang Y, Lu Y, Li Q, Li M, Chai K
Journal of immunology research 2021;2021:6679316
Journal of immunology research 2021;2021:6679316
Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways.
Ji J, Yu Q, Dai W, Wu L, Feng J, Zheng Y, Li Y, Guo C
PPAR research 2021;2021:6651839
PPAR research 2021;2021:6651839
Osthole Attenuates Bleomycin-Induced Pulmonary Fibrosis by Modulating NADPH Oxidase 4-Derived Oxidative Stress in Mice.
Fang L, Wang W, Chen J, Zuo A, Gao H, Yan T, Wang P, Lu Y, Lv R, Xu F, Chen Y, Lyu L
Oxidative medicine and cellular longevity 2021;2021:3309944
Oxidative medicine and cellular longevity 2021;2021:3309944
FSTL3 is a Prognostic Biomarker in Gastric Cancer and is Correlated with M2 Macrophage Infiltration.
Liu YJ, Li JP, Zhang Y, Nie MJ, Zhang YH, Liu SL, Zou X
OncoTargets and therapy 2021;14:4099-4117
OncoTargets and therapy 2021;14:4099-4117
Pathologic role of peptidyl-prolyl isomerase Pin1 in pulmonary artery remodeling.
Wu C, Ha Y, Zou Y, Liao X, Zhang S, Zhang X, Li R, Xing J, Jie W, Guo J, Li J, Shen Z
American journal of translational research 2021;13(10):11162-11177
American journal of translational research 2021;13(10):11162-11177
METTL3/METTL14 Transactivation and m(6)A-Dependent TGF-β1 Translation in Activated Kupffer Cells.
Feng Y, Dong H, Sun B, Hu Y, Yang Y, Jia Y, Jia L, Zhong X, Zhao R
Cellular and molecular gastroenterology and hepatology 2021;12(3):839-856
Cellular and molecular gastroenterology and hepatology 2021;12(3):839-856
Targeting ADAR1 suppresses progression and peritoneal metastasis of gastric cancer through Wnt / β-catenin pathway.
Li Z, Huang Y, Xu Y, Wang X, Wang H, Zhao S, Liu H, Yu G, Che X
Journal of Cancer 2021;12(24):7334-7348
Journal of Cancer 2021;12(24):7334-7348
Construction and Analysis of Immune Infiltration-Related ceRNA Network for Kidney Stones.
Xia Y, Zhou X, Ye Z, Yu W, Ning J, Ruan Y, Yuan R, Lin F, Ye P, Zheng D, Rao T, Cheng F
Frontiers in genetics 2021;12:774155
Frontiers in genetics 2021;12:774155
The Extracellular Matrix Enriched With Exosomes for the Treatment on Pulmonary Fibrosis in Mice.
Yu Y, Liu X, Zhao Z, Xu Z, Qiao Y, Zhou Y, Qiao H, Zhong J, Dai J, Suo G
Frontiers in pharmacology 2021;12:747223
Frontiers in pharmacology 2021;12:747223
Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2.
Tong X, Zhang S, Wang D, Zhang L, Huang J, Zhang T, Fan H
Frontiers in pharmacology 2021;12:709819
Frontiers in pharmacology 2021;12:709819
Reynoutrin Improves Ischemic Heart Failure in Rats Via Targeting S100A1.
Yang W, Tu H, Tang K, Huang H, Ou S, Wu J
Frontiers in pharmacology 2021;12:703962
Frontiers in pharmacology 2021;12:703962
IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer.
Gao W, Wen H, Liang L, Dong X, Du R, Zhou W, Zhang X, Zhang C, Xiang R, Li N
Theranostics 2021;11(6):2564-2580
Theranostics 2021;11(6):2564-2580
TIPE2 Suppresses Malignancy of Pancreatic Cancer Through Inhibiting TGFβ1 Mediated Signaling Pathway.
Feng F, Liu C, Bian H, Cai W, Zhou Y, Zhou L, Zhuang Z
Frontiers in oncology 2021;11:680985
Frontiers in oncology 2021;11:680985
tRNA-Derived Fragment tRF-17-79MP9PP Attenuates Cell Invasion and Migration via THBS1/TGF-β1/Smad3 Axis in Breast Cancer.
Mo D, He F, Zheng J, Chen H, Tang L, Yan F
Frontiers in oncology 2021;11:656078
Frontiers in oncology 2021;11:656078
The lncRNA ADAMTS9-AS2 Regulates RPL22 to Modulate TNBC Progression via Controlling the TGF-β Signaling Pathway.
Ni K, Huang Z, Zhu Y, Xue D, Jin Q, Zhang C, Gu C
Frontiers in oncology 2021;11:654472
Frontiers in oncology 2021;11:654472
Identifying miRNA modules associated with progression of keloids through weighted gene co-expression network analysis and experimental validation in vitro.
Lv W, Ren Y, Wu M, Luo X, Yu J, Zhang Q, Wu Y
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
Burns : journal of the International Society for Burn Injuries 2021 Sep;47(6):1359-1372
IGF-1-Expressing Placenta-Derived Mesenchymal Stem Cells Promote Scalding Wound Healing.
Cheng S, Lv R, Xu J, Hirman AR, Du L
The Journal of surgical research 2021 Sep;265:100-113
The Journal of surgical research 2021 Sep;265:100-113
Sustained-Release Hydrogel-Based Rhynchophylline Delivery System Improved Injured Tendon Repair.
Yang QQ, Zhang L, Ju F, Zhou YL
Colloids and surfaces. B, Biointerfaces 2021 Sep;205:111876
Colloids and surfaces. B, Biointerfaces 2021 Sep;205:111876
A negative feedback loop involving NF-κB/TIR8 regulates IL-1β-induced epithelial- myofibroblast transdifferentiation in human tubular cells.
Jiang K, Zhang Y, He F, Zhang M, Li T, Tu Z, Xu D, Zhang M, Han L, Guo L, Zhou H, Wang D
Journal of cell communication and signaling 2021 Sep;15(3):393-403
Journal of cell communication and signaling 2021 Sep;15(3):393-403
Costunolide Loaded in pH-Responsive Mesoporous Silica Nanoparticles for Increased Stability and an Enhanced Anti-Fibrotic Effect.
Niu X, Wang X, Niu B, Meng Y, He H, Wang Y, Li G
Pharmaceuticals (Basel, Switzerland) 2021 Sep 23;14(10)
Pharmaceuticals (Basel, Switzerland) 2021 Sep 23;14(10)
KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.
Tian Y, Wang Z, Zheng X, Song W, Cai L, Rane M, Zhao Y
Toxicology and applied pharmacology 2021 Sep 15;427:115654
Toxicology and applied pharmacology 2021 Sep 15;427:115654
Prenatal exposure to propylparaben at human-relevant doses accelerates ovarian aging in adult mice.
Li M, Zhou S, Wu Y, Li Y, Yan W, Guo Q, Xi Y, Chen Y, Li Y, Wu M, Zhang J, Wei J, Wang S
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117254
Environmental pollution (Barking, Essex : 1987) 2021 Sep 15;285:117254
Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
Ma X, Qin C, Chen M, Yu HH, Chu YH, Chen TJ, Bosco DB, Wu LJ, Bu BT, Wang W, Tian DS
Journal of neuroinflammation 2021 Sep 15;18(1):201
Journal of neuroinflammation 2021 Sep 15;18(1):201
Effect of different exercise training intensities on age-related cardiac damage in male mice.
Pei Z, Yang C, Guo Y, Dong M, Wang F
Aging 2021 Sep 14;13(17):21700-21711
Aging 2021 Sep 14;13(17):21700-21711
Alpha-ketoglutarate ameliorates pressure overload-induced chronic cardiac dysfunction in mice.
An D, Zeng Q, Zhang P, Ma Z, Zhang H, Liu Z, Li J, Ren H, Xu D
Redox biology 2021 Oct;46:102088
Redox biology 2021 Oct;46:102088
Effects of endurance exercise on serum inflammatory cytokine level and kidney structure in a rat diabetes model.
Lin S, Jin S, Zhou F, Hu Y, Zhang M
Experimental and therapeutic medicine 2021 Oct;22(4):1125
Experimental and therapeutic medicine 2021 Oct;22(4):1125
RORγt agonist synergizes with CTLA-4 antibody to inhibit tumor growth through inhibition of Treg cells via TGF-β signaling in cancer.
Tian EM, Yu MC, Feng M, Lu LX, Liu CL, Shen LA, Wang YH, Xie Q, Zhu D
Pharmacological research 2021 Oct;172:105793
Pharmacological research 2021 Oct;172:105793
Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism.
Xian Z, Tian J, Zhang Y, Meng J, Zhao Y, Li C, Yi Y, Han J, Liu S, Wang L, Pan C, Wang D, Wang F, Liang A
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:112081
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:112081
Long noncoding RNA SGO1-AS1 inactivates TGFβ signaling by facilitating TGFB1/2 mRNA decay and inhibits gastric carcinoma metastasis.
Huang D, Zhang K, Zheng W, Zhang R, Chen J, Du N, Xia Y, Long Y, Gu Y, Xu J, Deng M
Journal of experimental & clinical cancer research : CR 2021 Oct 28;40(1):342
Journal of experimental & clinical cancer research : CR 2021 Oct 28;40(1):342
The overexpression of Tipe2 in CRC cells suppresses survival while endogenous Tipe2 accelerates AOM/DSS induced-tumor initiation.
Li Y, Zhang N, Ma C, Xu W, Jin G, Zheng Y, Zhang L, Liu B, Gao C, Liu S
Cell death & disease 2021 Oct 26;12(11):1001
Cell death & disease 2021 Oct 26;12(11):1001
METTL3 improves cardiomyocyte proliferation upon myocardial infarction via upregulating miR-17-3p in a DGCR8-dependent manner.
Zhao K, Yang C, Zhang J, Sun W, Zhou B, Kong X, Shi J
Cell death discovery 2021 Oct 13;7(1):291
Cell death discovery 2021 Oct 13;7(1):291
Phenolic Compounds from Mori Cortex Ameliorate Sodium Oleate-Induced Epithelial-Mesenchymal Transition and Fibrosis in NRK-52e Cells through CD36.
Ruan Y, Yuan PP, Wei YX, Zhang Q, Gao LY, Li PY, Chen Y, Fu Y, Cao YG, Zheng XK, Feng WS
Molecules (Basel, Switzerland) 2021 Oct 11;26(20)
Molecules (Basel, Switzerland) 2021 Oct 11;26(20)
Low-intensity pulsed ultrasound prevents prolonged hypoxia-induced cardiac fibrosis through HIF-1α/DNMT3a pathway via a TRAAK-dependent manner.
Zhao K, Weng L, Xu T, Yang C, Zhang J, Ni G, Guo X, Tu J, Zhang D, Sun W, Kong X
Clinical and experimental pharmacology & physiology 2021 Nov;48(11):1500-1514
Clinical and experimental pharmacology & physiology 2021 Nov;48(11):1500-1514
Nicotine exacerbates tacrolimus-induced renal injury by programmed cell death.
Jiang YJ, Cui S, Luo K, Ding J, Nan QY, Piao SG, Xuan MY, Zheng HL, Jin YJ, Jin JZ, Lee JP, Chung BH, Choi BS, Yang CW, Li C
The Korean journal of internal medicine 2021 Nov;36(6):1437-1449
The Korean journal of internal medicine 2021 Nov;36(6):1437-1449
Maiwei Yangfei decoction prevents bleomycin-induced pulmonary fibrosis in mice.
Xu Y, Peng W, Han D, Feng F, Wang Z, Gu C, Zhou X, Wu Q
Experimental and therapeutic medicine 2021 Nov;22(5):1306
Experimental and therapeutic medicine 2021 Nov;22(5):1306
Injectable self-assembling peptide nanofiber hydrogel as a bioactive 3D platform to promote chronic wound tissue regeneration.
Lou P, Liu S, Wang Y, Pan C, Xu X, Zhao M, Liao G, Yang G, Yuan Y, Li L, Zhang J, Chen Y, Cheng J, Lu Y, Liu J
Acta biomaterialia 2021 Nov;135:100-112
Acta biomaterialia 2021 Nov;135:100-112
SPARC knockdown attenuated TGF-β1-induced fibrotic effects through Smad2/3 pathways in human pterygium fibroblasts.
Fan J, Zhang X, Jiang Y, Chen L, Sheng M, Chen Y
Archives of biochemistry and biophysics 2021 Nov 30;713:109049
Archives of biochemistry and biophysics 2021 Nov 30;713:109049
Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGF-β1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction.
Ma Y, Kuang Y, Bo W, Liang Q, Zhu W, Cai M, Tian Z
International journal of molecular sciences 2021 Nov 15;22(22)
International journal of molecular sciences 2021 Nov 15;22(22)
SAA1 is transcriptionally activated by STAT3 and accelerates renal interstitial fibrosis by inducing endoplasmic reticulum stress.
Zhang F, Zhou X, Zou H, Liu L, Li X, Ruan Y, Xie Y, Shi M, Xiao Y, Wang Y, Zhou Y, Wu Y, Guo B
Experimental cell research 2021 Nov 1;408(1):112856
Experimental cell research 2021 Nov 1;408(1):112856
CLEC-1 Acts as a Negative Regulator of Dectin-1 Induced Host Inflammatory Response Signature in Aspergillus fumigatus Keratitis.
Zhu G, Lyu L, Yang H, Lee J, Sun J, Zhang J, Xue S, Yan H, Wang L, Chen X, Che C
Investigative ophthalmology & visual science 2021 May 3;62(6):28
Investigative ophthalmology & visual science 2021 May 3;62(6):28
Splicing factor SRSF6 mediates pleural fibrosis.
Liang LM, Xiong L, Cheng PP, Chen SJ, Feng X, Zhou YY, Niu Q, Wang M, Chen Q, Song LJ, Yu F, He XL, Xiang F, Wang X, Ye H, Ma WL
JCI insight 2021 May 24;6(10)
JCI insight 2021 May 24;6(10)
Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFβ1/MAPK signaling pathway.
Wu HH, Meng TT, Chen JM, Meng FL, Wang SY, Liu RH, Chen JN, Ning B, Li Y, Su GH
Biochemical and biophysical research communications 2021 May 14;553:172-179
Biochemical and biophysical research communications 2021 May 14;553:172-179
CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis.
Yi L, Ai K, Li H, Qiu S, Li Y, Wang Y, Li X, Zheng P, Chen J, Wu D, Xiang X, Chai X, Yuan Y, Zhang D
Aging 2021 May 11;13(9):12780-12799
Aging 2021 May 11;13(9):12780-12799
Glucagon-like peptide-1 (GLP-1) improved diabetic lung fibrosis via AMPK and microRNA-27a (miR-27a).
Liu J, Li X, Lu S, Zheng X, Zhang X, Zhao W
Annals of translational medicine 2021 Mar;9(6):492
Annals of translational medicine 2021 Mar;9(6):492
Epiberberine ameliorated diabetic nephropathy by inactivating the angiotensinogen (Agt) to repress TGFβ/Smad2 pathway.
Xiao Y, Deng J, Li C, Gong X, Gui Z, Huang J, Zhang Y, Liu Y, Ye X, Li X
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153488
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Mar;83:153488
Dopamine receptor D2 inhibition alleviates diabetic hepatic stellate cells fibrosis by regulating the TGF-β1/Smads and NFκB pathways.
Zhao B, Li S, Guo Z, Chen Z, Zhang X, Xu C, Chen J, Wei C
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Clinical and experimental pharmacology & physiology 2021 Mar;48(3):370-380
Umbilical cord-derived mesenchymal stem cells exert anti-fibrotic action on hypertrophic scar-derived fibroblasts in co-culture by inhibiting the activation of the TGF β1/Smad3 pathway.
Meng X, Gao X, Chen X, Yu J
Experimental and therapeutic medicine 2021 Mar;21(3):210
Experimental and therapeutic medicine 2021 Mar;21(3):210
Relationship between podoplanin-expressing cancer-associated fibroblasts and the immune microenvironment of early lung squamous cell carcinoma.
Suzuki J, Aokage K, Neri S, Sakai T, Hashimoto H, Su Y, Yamazaki S, Nakamura H, Tane K, Miyoshi T, Sugano M, Kojima M, Fujii S, Kuwata T, Ochiai A, Tsuboi M, Ishii G
Lung cancer (Amsterdam, Netherlands) 2021 Mar;153:1-10
Lung cancer (Amsterdam, Netherlands) 2021 Mar;153:1-10
Apigenin protects mice against 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced cholestasis.
Zheng S, Cao P, Yin Z, Wang X, Chen Y, Yu M, Xu B, Liao C, Duan Y, Zhang S, Han J, Yang X
Food & function 2021 Mar 15;12(5):2323-2334
Food & function 2021 Mar 15;12(5):2323-2334
Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-β/p38/MK2 signaling pathway.
Cheng J, Ren C, Cheng R, Li Y, Liu P, Wang W, Liu L
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Mar 1;25(2):131-137
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 2021 Mar 1;25(2):131-137
Compound Danshen Dripping Pill inhibits doxorubicin or isoproterenol-induced cardiotoxicity.
Feng K, Liu Y, Sun J, Zhao C, Duan Y, Wang W, Yan K, Yan X, Sun H, Hu Y, Han J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111531
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Jun;138:111531
COL5A1 Variants Cause Aortic Dissection by Activating TGF-β-Signaling Pathway.
Chen P, Yu B, Li Z, Chen Y, Sun Y, Wang DW
Journal of the American Heart Association 2021 Jun;10(11):e019276
Journal of the American Heart Association 2021 Jun;10(11):e019276
Pre-emptive pharmacological inhibition of fatty acid-binding protein 4 attenuates kidney fibrosis by reprogramming tubular lipid metabolism.
Chen Y, Dai Y, Song K, Huang Y, Zhang L, Zhang C, Yan Q, Gao H
Cell death & disease 2021 Jun 3;12(6):572
Cell death & disease 2021 Jun 3;12(6):572
Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis.
Wu Y, Wang Q, Jiang MY, Huang YY, Zhu Z, Han C, Tian YJ, Zhang B, Luo HB
Journal of medicinal chemistry 2021 Jul 8;64(13):9537-9549
Journal of medicinal chemistry 2021 Jul 8;64(13):9537-9549
Anti-anemia drug FG4592 retards the AKI-to-CKD transition by improving vascular regeneration and antioxidative capability.
Wu M, Chen W, Miao M, Jin Q, Zhang S, Bai M, Fan J, Zhang Y, Zhang A, Jia Z, Huang S
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
Clinical science (London, England : 1979) 2021 Jul 30;135(14):1707-1726
Mesenchymal stem cells ameliorate renal fibrosis by galectin-3/Akt/GSK3β/Snail signaling pathway in adenine-induced nephropathy rat.
Tang H, Zhang P, Zeng L, Zhao Y, Xie L, Chen B
Stem cell research & therapy 2021 Jul 16;12(1):409
Stem cell research & therapy 2021 Jul 16;12(1):409
MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme.
Shi Y, Jiang J, Cui Y, Chen Y, Dong T, An H, Liu P
DNA and cell biology 2021 Jan;40(1):93-100
DNA and cell biology 2021 Jan;40(1):93-100
Tormentic acid inhibits hepatic stellate cells activation via blocking PI3K/Akt/mTOR and NF-κB signalling pathways.
Lin X, Li Y, Zhang X, Wei Y, Wen S, Lu Z, Huang Q, Wei J
Cell biochemistry and function 2021 Jan;39(1):77-87
Cell biochemistry and function 2021 Jan;39(1):77-87
Naringin attenuates renal interstitial fibrosis by regulating the TGF-β/Smad signaling pathway and inflammation.
Wang R, Wu G, Dai T, Lang Y, Chi Z, Yang S, Dong D
Experimental and therapeutic medicine 2021 Jan;21(1):66
Experimental and therapeutic medicine 2021 Jan;21(1):66
Inhibition of proliferation-linked signaling cascades with atractylenolide I reduces myofibroblastic phenotype and renal fibrosis.
Guo Y, Xiao Y, Zhu H, Guo H, Zhou Y, Shentu Y, Zheng C, Chen C, Bai Y
Biochemical pharmacology 2021 Jan;183:114344
Biochemical pharmacology 2021 Jan;183:114344
PM2.5 inducing myocardial fibrosis mediated by Ang II/ERK1/2/TGF-β(1) signaling pathway in mice model.
Zang X, Zhao J, Lu C
Journal of the renin-angiotensin-aldosterone system : JRAAS 2021 Jan-Dec;22(1):14703203211003786
Journal of the renin-angiotensin-aldosterone system : JRAAS 2021 Jan-Dec;22(1):14703203211003786
Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Mitochondrial Damage and Inflammation by Stabilizing Mitochondrial DNA.
Zhao M, Liu S, Wang C, Wang Y, Wan M, Liu F, Gong M, Yuan Y, Chen Y, Cheng J, Lu Y, Liu J
ACS nano 2021 Jan 26;15(1):1519-1538
ACS nano 2021 Jan 26;15(1):1519-1538
Involvement of miR-27a-3p in diabetic nephropathy via affecting renal fibrosis, mitochondrial dysfunction, and endoplasmic reticulum stress.
Wu L, Wang Q, Guo F, Ma X, Wang J, Zhao Y, Yan Y, Qin G
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Journal of cellular physiology 2021 Feb;236(2):1454-1468
Knockdown of long non‑coding RNA ANRIL inhibits the proliferation and promotes the apoptosis of Burkitt lymphoma cells through the TGF‑β1 signaling pathway.
Mao S, Jin J, Li Z, Yang W
Molecular medicine reports 2021 Feb;23(2)
Molecular medicine reports 2021 Feb;23(2)
HOXA10 mediates epithelial-mesenchymal transition to promote gastric cancer metastasis partly via modulation of TGFB2/Smad/METTL3 signaling axis.
Song C, Zhou C
Journal of experimental & clinical cancer research : CR 2021 Feb 9;40(1):62
Journal of experimental & clinical cancer research : CR 2021 Feb 9;40(1):62
Hepatic connective tissue growth factor expression and regulation differ between non-steatotic and non-alcoholic steatotic livers from brain-dead donor.
Yang DJ, Shi JH, Xia ZP, Guo WZ, Ahmed MS, Zhang SJ
Scientific reports 2021 Feb 16;11(1):3857
Scientific reports 2021 Feb 16;11(1):3857
Phosphorylated nuclear factor erythroid 2-related factor 2 promotes the secretion of C-C motif chemokine ligand 2 and the recruitment of M2 macrophages.
Huang Z, Li X, Zhou T, Jiang Y, Shi JH
Annals of translational medicine 2021 Dec;9(23):1719
Annals of translational medicine 2021 Dec;9(23):1719
Identifying the clinical presentations, progression, and sequela of pelvic inflammatory disease through physiological, histological and ultrastructural evaluation of a rat animal model.
Fan L, Liu Z, Zhang Z, Li T, Li H, Chen J, Zong X, Zhang X, Chen X, Bai H, Wang F, Shang C
Annals of translational medicine 2021 Dec;9(23):1710
Annals of translational medicine 2021 Dec;9(23):1710
The potential of Zishen Yutai pills to facilitate endometrial recovery and restore fertility after induced abortion in rats.
Li M, Ning N, Liu Y, Li X, Mei Q, Zhou J, Huang Q, Xiang W, Zhang L, Xu X
Pharmaceutical biology 2021 Dec;59(1):1505-1516
Pharmaceutical biology 2021 Dec;59(1):1505-1516
Ginsenoside Rg2 alleviates myocardial fibrosis by regulating TGF-β1/Smad signalling pathway.
Wang Q, Fu W, Yu X, Xu H, Sui D, Wang Y
Pharmaceutical biology 2021 Dec;59(1):106-113
Pharmaceutical biology 2021 Dec;59(1):106-113
Preparation of casein phosphopeptides calcium complex and the promotion in calcium cellular uptake through transcellular transport pathway.
Li H, Duan S, Yuan P, Liu J, Wang X, Liu Y, Peng Y, Pan C, Xia K
Journal of food biochemistry 2021 Dec;45(12):e14001
Journal of food biochemistry 2021 Dec;45(12):e14001
Network pharmacology and experimental validation to explore the molecular mechanisms of Bushen Huoxue for the treatment of premature ovarian insufficiency.
Cao Y, Chen Y, Wang P, Lu J, Han X, She J
Bioengineered 2021 Dec;12(2):10345-10362
Bioengineered 2021 Dec;12(2):10345-10362
Effective-compound combination inhibits the M2-like polarization of macrophages and attenuates the development of pulmonary fibrosis by increasing autophagy through mTOR signaling.
Zhao P, Cai Z, Tian Y, Li J, Li K, Li M, Bai Y, Li J
International immunopharmacology 2021 Dec;101(Pt B):108360
International immunopharmacology 2021 Dec;101(Pt B):108360
MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet.
Zhao K, Mao Y, Ye X, Ma J, Sun L, Li P, Li Y
European journal of pharmacology 2021 Dec 5;912:174587
European journal of pharmacology 2021 Dec 5;912:174587
Pterostilbene Ameliorates Renal Damage in Diabetic Rats by Suppressing Hyperglycemia with Inhibition of Inflammatory and Fibrotic Responses.
Ding RR, Huang GY, Zhang YJ, Sun HL, Liu YM, Xu Z, Li WJ, Li X
Biomedical and environmental sciences : BES 2021 Dec 20;34(12):1015-1019
Biomedical and environmental sciences : BES 2021 Dec 20;34(12):1015-1019
Arsenic-induced lung inflammation and fibrosis in a rat model: Contribution of the HMGB1/RAGE, PI3K/AKT, and TGF-β1/SMAD pathways.
Wang W, Zheng F, Zhang A
Toxicology and applied pharmacology 2021 Dec 1;432:115757
Toxicology and applied pharmacology 2021 Dec 1;432:115757
Plasminogen Activator Urokinase Receptor Implies Immunosuppressive Features and Acts as an Unfavorable Prognostic Biomarker in Glioma.
Zeng F, Li G, Liu X, Zhang K, Huang H, Jiang T, Zhang Y
The oncologist 2021 Aug;26(8):e1460-e1469
The oncologist 2021 Aug;26(8):e1460-e1469
Prenatal exposure to di-n-butyl phthalate induces erectile dysfunction in male adult rats.
Zhou X, Zhang T, Song L, Wang Y, Zhang Q, Cong R, Ji C, Luan J, Yao L, Zhang W, Song N, Wang S
Ecotoxicology and environmental safety 2021 Aug;219:112323
Ecotoxicology and environmental safety 2021 Aug;219:112323
CIDEC silencing attenuates diabetic nephropathy via inhibiting apoptosis and promoting autophagy.
Zheng GS, Tan YM, Shang YY, Liu YP, Hu BA, Wang D, Han L, Wang ZH, Zhang W, Ti Y, Zhong M
Journal of diabetes investigation 2021 Aug;12(8):1336-1345
Journal of diabetes investigation 2021 Aug;12(8):1336-1345
Ophiocordyceps lanpingensis polysaccharides alleviate chronic kidney disease through MAPK/NF-κB pathway.
Zhou S, He Y, Zhang W, Xiong Y, Jiang L, Wang J, Cui X, Qu Y, Ge F
Journal of ethnopharmacology 2021 Aug 10;276:114189
Journal of ethnopharmacology 2021 Aug 10;276:114189
FZD2 promotes TGF-β-induced epithelial-to-mesenchymal transition in breast cancer via activating notch signaling pathway.
Tuluhong D, Chen T, Wang J, Zeng H, Li H, Dunzhu W, Li Q, Wang S
Cancer cell international 2021 Apr 8;21(1):199
Cancer cell international 2021 Apr 8;21(1):199
Inhibitory effects of alkaline extract from the pericarp of Citrus reticulata Blanco on collagen behavior in bleomycin-induced pulmonary fibrosis.
Li RF, Chen XY, Xu Y, Feng FC, He HL, Zhou XM
Journal of ethnopharmacology 2021 Apr 6;269:113761
Journal of ethnopharmacology 2021 Apr 6;269:113761
High expression of COL5A2, a member of COL5 family, indicates the poor survival and facilitates cell migration in gastric cancer.
Tan Y, Chen Q, Xing Y, Zhang C, Pan S, An W, Xu H
Bioscience reports 2021 Apr 30;41(4)
Bioscience reports 2021 Apr 30;41(4)
Transcriptional Suppression of Diabetic Nephropathy with Novel Gene Silencer Pyrrole-Imidazole Polyamides Preventing USF1 Binding to the TGF-β1 Promoter.
Okamura M, Fukuda N, Horikoshi S, Kobayashi H, Tsunemi A, Akiya Y, Endo M, Matsumoto T, Abe M
International journal of molecular sciences 2021 Apr 29;22(9)
International journal of molecular sciences 2021 Apr 29;22(9)
An integrated network pharmacology and transcriptomic method to explore the mechanism of the total Rhizoma Coptidis alkaloids in improving diabetic nephropathy.
Xiao Y, Liu Y, Lai Z, Huang J, Li C, Zhang Y, Gong X, Deng J, Ye X, Li X
Journal of ethnopharmacology 2021 Apr 24;270:113806
Journal of ethnopharmacology 2021 Apr 24;270:113806
Concentrated small extracellular vesicles from menstrual blood-derived stromal cells improve intrauterine adhesion, a pre-clinical study in a rat model.
Zhang S, Chang Q, Li P, Tong X, Feng Y, Hao X, Zhang X, Yuan Z, Tan J
Nanoscale 2021 Apr 21;13(15):7334-7347
Nanoscale 2021 Apr 21;13(15):7334-7347
Transient Receptor Potential Channel 6 Knockout Ameliorates Kidney Fibrosis by Inhibition of Epithelial-Mesenchymal Transition.
Zhang Y, Yin N, Sun A, Wu Q, Hu W, Hou X, Zeng X, Zhu M, Liao Y
Frontiers in cell and developmental biology 2020;8:602703
Frontiers in cell and developmental biology 2020;8:602703
Gut Microbiota Modulates Intestinal Pathological Injury in Schistosoma japonicum-Infected Mice.
Zhang B, Wu X, Song Q, Ning A, Liang J, Song L, Liu J, Zhang Y, Yuan D, Sun X, Wu Z
Frontiers in medicine 2020;7:588928
Frontiers in medicine 2020;7:588928
Glutamate-Cysteine Ligase Catalytic Subunit Attenuated Hepatitis C Virus-Related Liver Fibrosis and Suppressed Endoplasmic Reticulum Stress.
Fu N, Li D, Li W, Zhao W, Zhang S, Liu L, Zhao S, Du J, Kong L, Wang R, Zhang Y, Nan Y
Frontiers in molecular biosciences 2020;7:199
Frontiers in molecular biosciences 2020;7:199
Ginsenoside Rb1 Ameliorates Age-Related Myocardial Dysfunction by Regulating the NF-κB Signaling Pathway.
Ke SY, Liu DH, Wu L, Yu XG, Wang M, Shi GY, Wen RH, Zhou B, Hao BS, Liu Y, Zhu JM, Qian XX
The American journal of Chinese medicine 2020;48(6):1369-1383
The American journal of Chinese medicine 2020;48(6):1369-1383
Effect of prednisolone on glyoxalase 1 in an inbred mouse model of aristolochic acid nephropathy using a proteomics method with fluorogenic derivatization-liquid chromatography-tandem mass spectrometry.
Chen SM, Lin CE, Chen HH, Cheng YF, Cheng HW, Imai K
PloS one 2020;15(1):e0227838
PloS one 2020;15(1):e0227838
Synergistic effect of Huyang Yangkun Formula and embryonic stem cells on 4-vinylcyclohexene diepoxide induced premature ovarian insufficiency in mice.
Li M, Xie L, Li Y, Liu J, Nie G, Yang H
Chinese medicine 2020;15:83
Chinese medicine 2020;15:83
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Ndibalema AR, Kabuye D, Wen S, Li L, Li X, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Expression and Prognostic Value of Id-4 in Patients with Esophageal Squamous Cell Carcinoma.
Wang X, Lu Q, Fei X, Zhao Y, Shi B, Li C, Chen H
OncoTargets and therapy 2020;13:1225-1234
OncoTargets and therapy 2020;13:1225-1234
Fatty acid extracts facilitate cutaneous wound healing through activating AKT, ERK, and TGF-β/Smad3 signaling and promoting angiogenesis.
Zong J, Jiang J, Shi P, Liu J, Wang W, Li B, Zhao T, Pan T, Zhang Z, Bi L, Diao Y, Wang S
American journal of translational research 2020;12(2):478-492
American journal of translational research 2020;12(2):478-492
TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9.
Chao M, Liu N, Sun Z, Jiang Y, Jiang T, Xv M, Jia L, Tu Y, Wang L
Frontiers in immunology 2020;11:592080
Frontiers in immunology 2020;11:592080
Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence.
Zhang L, Tong X, Huang J, Wu M, Zhang S, Wang D, Liu S, Fan H
Frontiers in pharmacology 2020;11:553690
Frontiers in pharmacology 2020;11:553690
Hyperoside Attenuates Bleomycin-Induced Pulmonary Fibrosis Development in Mice.
Huang J, Tong X, Zhang L, Zhang Y, Wang L, Wang D, Zhang S, Fan H
Frontiers in pharmacology 2020;11:550955
Frontiers in pharmacology 2020;11:550955
Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy.
Xu Z, Wu Y, Wang F, Li X, Wang P, Li Y, Wu J, Li Y, Jiang T, Pan X, Zhang X, Xie L, Xiao J, Liu Y
Frontiers in pharmacology 2020;11:52
Frontiers in pharmacology 2020;11:52
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1.
Yang Y, Wang Y, He Z, Liu Y, Chen C, Wang Y, Wang DW, Wang H
Frontiers in pharmacology 2020;11:1136
Frontiers in pharmacology 2020;11:1136
Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells.
Li J, Liu J, Yue W, Xu K, Cai W, Cui F, Li Z, Wang W, He J
Journal of cellular and molecular medicine 2020 Sep;24(18):10501-10511
Journal of cellular and molecular medicine 2020 Sep;24(18):10501-10511
YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways.
Liu J, Gao M, Xu S, Chen Y, Wu K, Liu H, Wang J, Yang X, Wang J, Liu W, Bao X, Chen J
Cell reports 2020 Sep 8;32(10):108120
Cell reports 2020 Sep 8;32(10):108120
Obg-like ATPase 1 inhibited oral carcinoma cell metastasis through TGFβ/SMAD2 axis in vitro.
Liu J, Yang Q, Xiao KC, Dobleman T, Hu S, Xiao GG
BMC molecular and cell biology 2020 Sep 14;21(1):65
BMC molecular and cell biology 2020 Sep 14;21(1):65
Genome-wide pathogenesis interpretation using a heat diffusion-based systems genetics method and implications for gene function annotation.
Quan Y, Zhang QY, Lv BM, Xu RF, Zhang HY
Molecular genetics & genomic medicine 2020 Oct;8(10):e1456
Molecular genetics & genomic medicine 2020 Oct;8(10):e1456
Potential hazardous effects of printing room PM2.5 exposure include promotion of lung inflammation and subsequent injury.
Zou C, Yang H, Cui L, Cao X, Huang H, Chen T
Molecular medicine reports 2020 Oct;22(4):3213-3224
Molecular medicine reports 2020 Oct;22(4):3213-3224
The TGF-β1/COX-2-dependant pathway serves a key role in the generation of OKC-induced M2-polarized macrophage-like cells and angiogenesis.
Cheng G, Gao J, Wang L, Ding Y, Wu Q, Wang Q, Xiao J, Wang S
Oncology letters 2020 Oct;20(4):39
Oncology letters 2020 Oct;20(4):39
Exosomes derived from TSG-6 modified mesenchymal stromal cells attenuate scar formation during wound healing.
Jiang L, Zhang Y, Liu T, Wang X, Wang H, Song H, Wang W
Biochimie 2020 Oct;177:40-49
Biochimie 2020 Oct;177:40-49
A Histomorphological Study of the Divergent Corpus Spongiosum Surrounding the Urethral Plate in Hypospadias.
Bao X, Huang Y, Lyu Y, Xi Z, Xie H, Fu Q, Song L, Chen F
Urology 2020 Oct;144:188-193
Urology 2020 Oct;144:188-193
Si-Miao-Yong-An Decoction attenuates isoprenaline-induced myocardial fibrosis in AMPK-driven Akt/mTOR and TGF-β/SMAD3 pathways.
Zhao Y, Sun D, Chen Y, Zhan K, Meng Q, Zhang X, Zhu L, Yao X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110522
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Oct;130:110522
Induction of SPARC on Oxidative Stress, Inflammatory Phenotype Transformation, and Apoptosis of Human Brain Smooth Muscle Cells Via TGF-β1-NOX4 Pathway.
Tan X, Li T, Zhu S, Zhong W, Li F, Wang Y
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
Journal of molecular neuroscience : MN 2020 Nov;70(11):1728-1741
Short hairpin RNA attenuates liver fibrosis by regulating the PPAR‑γ and NF‑κB pathways in HBV‑induced liver fibrosis in mice.
Ye L, Chen T, Cao J, Sun L, Li W, Zhang C
International journal of oncology 2020 Nov;57(5):1116-1128
International journal of oncology 2020 Nov;57(5):1116-1128
Anti‑proliferative effect of honokiol on SW620 cells through upregulating BMP7 expression via the TGF‑β1/p53 signaling pathway.
Li Q, Ma Y, Liu XL, Mu L, He BC, Wu K, Sun WJ
Oncology reports 2020 Nov;44(5):2093-2107
Oncology reports 2020 Nov;44(5):2093-2107
Chronic inflammation promotes proliferation in the prostatic stroma in rats with experimental autoimmune prostatitis: study for a novel method of inducing benign prostatic hyperplasia in a rat model.
Zhang M, Luo C, Cui K, Xiong T, Chen Z
World journal of urology 2020 Nov;38(11):2933-2943
World journal of urology 2020 Nov;38(11):2933-2943
Inhibition of microRNA-150-5p alleviates cardiac inflammation and fibrosis via targeting Smad7 in high glucose-treated cardiac fibroblasts.
Che H, Wang Y, Li Y, Lv J, Li H, Liu Y, Dong R, Sun Y, Xu X, Zhao J, Wang L
Journal of cellular physiology 2020 Nov;235(11):7769-7779
Journal of cellular physiology 2020 Nov;235(11):7769-7779
Involvement of FATP2-mediated tubular lipid metabolic reprogramming in renal fibrogenesis.
Chen Y, Yan Q, Lv M, Song K, Dai Y, Huang Y, Zhang L, Zhang C, Gao H
Cell death & disease 2020 Nov 20;11(11):994
Cell death & disease 2020 Nov 20;11(11):994
KGF-2 and FGF-21 poloxamer 407 hydrogel coordinates inflammation and proliferation homeostasis to enhance wound repair of scalded skin in diabetic rats.
Yang X, Yang R, Chen M, Zhou Q, Zheng Y, Lu C, Bi J, Sun W, Huang T, Li L, Gong J, Li X, Hui Q, Wang X
BMJ open diabetes research & care 2020 May;8(1)
BMJ open diabetes research & care 2020 May;8(1)
Chitosan-calcium alginate dressing promotes wound healing: A preliminary study.
Zhao WY, Fang QQ, Wang XF, Wang XW, Zhang T, Shi BH, Zheng B, Zhang DD, Hu YY, Ma L, Tan WQ
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2020 May;28(3):326-337
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2020 May;28(3):326-337
TGF-β/Smad and JAK/STAT pathways are involved in the anti-fibrotic effects of propylene glycol alginate sodium sulphate on hepatic fibrosis.
Xu S, Mao Y, Wu J, Feng J, Li J, Wu L, Yu Q, Zhou Y, Zhang J, Chen J, Ji J, Chen K, Wang F, Dai W, Fan X, Guo C
Journal of cellular and molecular medicine 2020 May;24(9):5224-5237
Journal of cellular and molecular medicine 2020 May;24(9):5224-5237
Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.
Zeng Y, Hua YQ, Wang W, Zhang H, Xu XL
Biochemical pharmacology 2020 May;175:113927
Biochemical pharmacology 2020 May;175:113927
Protective effects and mechanisms of Rehmannia glutinosa leaves total glycoside on early kidney injury in db/db mice.
Xu Z, Dai XX, Zhang QY, Su SL, Yan H, Zhu Y, Shang EX, Qian DW, Duan JA
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109926
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109926
Inhibition of vascular calcification by microRNA-155-5p is accompanied by the inactivation of TGF-β1/Smad2/3 signaling pathway.
Zhao F, Wu Y, Yang W, Wu D, Wang C, Zhang F
Acta histochemica 2020 May;122(4):151551
Acta histochemica 2020 May;122(4):151551
Small airway remodeling in diabetic and smoking chronic obstructive pulmonary disease patients.
Wu N, Wu Z, Sun J, Yan M, Wang B, Du X, Liu Y
Aging 2020 May 5;12(9):7927-7944
Aging 2020 May 5;12(9):7927-7944
Possible Roles of Periostin in the Formation of Hemodialysis Vascular Access Stenosis after Polytetrafluoroethylene Graft Implantation in Dogs.
Watase K, Jin D, Terai K, Kanemiya T, Nakakura H, Shibahara N, Arima S, Takai S
International journal of molecular sciences 2020 May 4;21(9)
International journal of molecular sciences 2020 May 4;21(9)
Co-transplantation with adipose-derived cells to improve parathyroid transplantation in a mice model.
Cui Q, Zhang D, Kong D, Tang J, Liao X, Yang Q, Ren J, Gong Y, Wu G
Stem cell research & therapy 2020 May 26;11(1):200
Stem cell research & therapy 2020 May 26;11(1):200
The ancient Chinese formula Longdan Xiegan Tang improves antipsychotic-induced hyperprolactinemia by repairing the hypothalamic and pituitary TGF-β1 signaling in rats.
Ren L, Liu W, Wang C, Yang Y, Huang X, Wang C, Li Y
Journal of ethnopharmacology 2020 May 23;254:112572
Journal of ethnopharmacology 2020 May 23;254:112572
Human-like collagen promotes the healing of acetic acid-induced gastric ulcers in rats by regulating NOS and growth factors.
Xing M, Fu R, Liu Y, Wang P, Ma P, Zhu C, Fan D
Food & function 2020 May 1;11(5):4123-4137
Food & function 2020 May 1;11(5):4123-4137
Thymosinβ4 alleviates cholestatic liver fibrosis in mice through downregulating PDGF/PDGFR and TGFβ/Smad pathways.
Chen C, Li X, Wang L
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2020 Mar;52(3):324-330
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 2020 Mar;52(3):324-330
Treatment with a probiotic combination reduces abdominal adhesion in rats by decreasing intestinal inflammation and restoring microbial composition.
Deng X, Zheng C, Wang S, Yang R, Liu Z, Chen T
Oncology reports 2020 Mar;43(3):986-998
Oncology reports 2020 Mar;43(3):986-998
Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ.
Zhang ZH, He JQ, Zhao YY, Chen HC, Tan NH
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
Acta pharmacologica Sinica 2020 Mar;41(3):373-382
microRNA-141 inhibits TGF-β1-induced epithelial-to-mesenchymal transition through inhibition of the TGF-β1/SMAD2 signalling pathway in endometriosis.
Wang S, Zhang M, Zhang T, Deng J, Xia X, Fang X
Archives of gynecology and obstetrics 2020 Mar;301(3):707-714
Archives of gynecology and obstetrics 2020 Mar;301(3):707-714
TGFB1-induced autophagy affects the pattern of pancreatic cancer progression in distinct ways depending on SMAD4 status.
Liang C, Xu J, Meng Q, Zhang B, Liu J, Hua J, Zhang Y, Shi S, Yu X
Autophagy 2020 Mar;16(3):486-500
Autophagy 2020 Mar;16(3):486-500
Tectorigenin attenuates diabetic nephropathy by improving vascular endothelium dysfunction through activating AdipoR1/2 pathway.
Yang S, Ma C, Wu H, Zhang H, Yuan F, Yang G, Yang Q, Jia L, Liang Z, Kang L
Pharmacological research 2020 Mar;153:104678
Pharmacological research 2020 Mar;153:104678
Babao Dan inhibits the migration and invasion of gastric cancer cells by suppressing epithelial-mesenchymal transition through the TGF-β/Smad pathway.
Liu J, Chen Y, Cao Z, Guan B, Peng J, Chen Y, Zhan Z, Sferra TJ, Sankararaman S, Lin J
The Journal of international medical research 2020 Jun;48(6):300060520925598
The Journal of international medical research 2020 Jun;48(6):300060520925598
Kidney targeted delivery of asiatic acid using a FITC labeled renal tubular-targeting peptide modified PLGA-PEG system.
He J, Chen H, Zhou W, Chen M, Yao Y, Zhang Z, Tan N
International journal of pharmaceutics 2020 Jun 30;584:119455
International journal of pharmaceutics 2020 Jun 30;584:119455
Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway.
Liu X, Mi X, Wang Z, Zhang M, Hou J, Jiang S, Wang Y, Chen C, Li W
Cell death & disease 2020 Jun 12;11(6):454
Cell death & disease 2020 Jun 12;11(6):454
Correction of immunosuppression in aged septic rats by human ghrelin and growth hormone through the vagus nerve-dependent inhibition of TGF-β production.
Zhou M, Aziz M, Ochani M, Wang P
Molecular medicine (Cambridge, Mass.) 2020 Jul 16;26(1):71
Molecular medicine (Cambridge, Mass.) 2020 Jul 16;26(1):71
Paeoniflorin ameliorates antipsychotic-induced hyperprolactinemia in rats by attenuating impairment of the dopamine D2 receptor and TGF-β1 signaling pathways in the hypothalamus and pituitary.
Huang X, Ren L, Hou L, Fan H, Wang C, Wang C, Li Y
Journal of ethnopharmacology 2020 Jul 15;257:112862
Journal of ethnopharmacology 2020 Jul 15;257:112862
Retinoic acid attenuates cardiac injury induced by hyperglycemia in pre- and post-delivery mice.
Liu Y, Zhao J, Lu M, Wang H, Tang F
Canadian journal of physiology and pharmacology 2020 Jan;98(1):6-14
Canadian journal of physiology and pharmacology 2020 Jan;98(1):6-14
miRNA‑342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6.
Jiang ZH, Tang YZ, Song HN, Yang M, Li B, Ni CL
International journal of molecular medicine 2020 Jan;45(1):45-52
International journal of molecular medicine 2020 Jan;45(1):45-52
Hydrogen sulfide attenuates cigarette smoke-induced airway remodeling by upregulating SIRT1 signaling pathway.
Guan R, Wang J, Cai Z, Li Z, Wang L, Li Y, Xu J, Li D, Yao H, Liu W, Deng B, Lu W
Redox biology 2020 Jan;28:101356
Redox biology 2020 Jan;28:101356
Connexin32 ameliorates renal fibrosis in diabetic mice by promoting K48-linked NADPH oxidase 4 polyubiquitination and degradation.
Chen Z, Sun X, Chen Q, Lan T, Huang K, Xiao H, Lin Z, Yang Y, Liu P, Huang H
British journal of pharmacology 2020 Jan;177(1):145-160
British journal of pharmacology 2020 Jan;177(1):145-160
N6-Methyladenosine Regulates the Expression and Secretion of TGFβ1 to Affect the Epithelial-Mesenchymal Transition of Cancer Cells.
Li J, Chen F, Peng Y, Lv Z, Lin X, Chen Z, Wang H
Cells 2020 Jan 25;9(2)
Cells 2020 Jan 25;9(2)
Tumor Cell-Derived TGFβ1 Attenuates Antitumor Immune Activity of T Cells via Regulation of PD-1 mRNA.
Wu P, Geng B, Chen Q, Zhao E, Liu J, Sun C, Zha C, Shao Y, You B, Zhang W, Li L, Meng X, Cai J, Li X
Cancer immunology research 2020 Dec;8(12):1470-1484
Cancer immunology research 2020 Dec;8(12):1470-1484
Oral cancer cell‑derived exosomes modulate natural killer cell activity by regulating the receptors on these cells.
Zhu X, Qin X, Wang X, Wang Y, Cao W, Zhang J, Chen W
International journal of molecular medicine 2020 Dec;46(6):2115-2125
International journal of molecular medicine 2020 Dec;46(6):2115-2125
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Li Y, Liu M, Yi J, Song X, Zheng X, Liu D, Wang S, Chu C, Yang J
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
Acta biochimica et biophysica Sinica 2020 Dec 29;52(12):1325-1336
β2-microglobulin as a biomarker of pulmonary fibrosis development in COPD patients.
Wu Z, Yan M, Zhang M, Wu N, Ma G, Wang B, Fan Y, Du X, Ding C, Liu Y
Aging 2020 Dec 21;13(1):1251-1263
Aging 2020 Dec 21;13(1):1251-1263
LncRNA Gm16410 regulates PM(2.5)-induced lung Endothelial-Mesenchymal Transition via the TGF-β1/Smad3/p-Smad3 pathway.
Ma K, Li C, Xu J, Ren F, Xu X, Liu C, Niu B, Li F
Ecotoxicology and environmental safety 2020 Dec 1;205:111327
Ecotoxicology and environmental safety 2020 Dec 1;205:111327
Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.
Wu L, Mo W, Feng J, Li J, Yu Q, Li S, Zhang J, Chen K, Ji J, Dai W, Wu J, Xu X, Mao Y, Guo C
British journal of pharmacology 2020 Aug;177(16):3760-3777
British journal of pharmacology 2020 Aug;177(16):3760-3777
Baicalein Alleviates Erectile Dysfunction Associated With Streptozotocin-Induced Type I Diabetes by Ameliorating Endothelial Nitric Oxide Synthase Dysfunction, Inhibiting Oxidative Stress and Fibrosis.
Chen Y, Zhou B, Yu Z, Yuan P, Sun T, Gong J, Zhang Y, Wang T, Wang S, Liu K, Liu J
The journal of sexual medicine 2020 Aug;17(8):1434-1447
The journal of sexual medicine 2020 Aug;17(8):1434-1447
USP9X prevents AGEs-induced upregulation of FN and TGF-β1 through activating Nrf2-ARE pathway in rat glomerular mesangial cells.
Huang K, Zhao X
Experimental cell research 2020 Aug 15;393(2):112100
Experimental cell research 2020 Aug 15;393(2):112100
RIG-I aggravates interstitial fibrosis via c-Myc-mediated fibroblast activation in UUO mice.
Zhou Z, Ni J, Li J, Huo C, Miao N, Yin F, Cheng Q, Xu D, Xie H, Chen P, Zheng P, Zhang Y, Zhou L, Zhang W, Yu C, Liu J, Lu L
Journal of molecular medicine (Berlin, Germany) 2020 Apr;98(4):527-540
Journal of molecular medicine (Berlin, Germany) 2020 Apr;98(4):527-540
Fangjihuangqi Decoction inhibits MDA-MB-231 cell invasion in vitro and decreases tumor growth and metastasis in triple-negative breast cancer xenografts tumor zebrafish model.
Guo Y, Fan Y, Pei X
Cancer medicine 2020 Apr;9(7):2564-2578
Cancer medicine 2020 Apr;9(7):2564-2578
LncRNA MIAT/miR-133a-3p axis regulates atrial fibrillation and atrial fibrillation-induced myocardial fibrosis.
Yao L, Zhou B, You L, Hu H, Xie R
Molecular biology reports 2020 Apr;47(4):2605-2617
Molecular biology reports 2020 Apr;47(4):2605-2617
Melatonin alleviates cardiac fibrosis via inhibiting lncRNA MALAT1/miR-141-mediated NLRP3 inflammasome and TGF-β1/Smads signaling in diabetic cardiomyopathy.
Che H, Wang Y, Li H, Li Y, Sahil A, Lv J, Liu Y, Yang Z, Dong R, Xue H, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5282-5298
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Apr;34(4):5282-5298
4-Octyl itaconate protects against renal fibrosis via inhibiting TGF-β/Smad pathway, autophagy and reducing generation of reactive oxygen species.
Tian F, Wang Z, He J, Zhang Z, Tan N
European journal of pharmacology 2020 Apr 15;873:172989
European journal of pharmacology 2020 Apr 15;873:172989
The circular RNA CDR1as regulate cell proliferation via TMED2 and TMED10.
Yang X, Li S, Wu Y, Ge F, Chen Y, Xiong Q
BMC cancer 2020 Apr 15;20(1):312
BMC cancer 2020 Apr 15;20(1):312
Effect of sarcolipin-mediated cell transdifferentiation in sarcopenia-associated skeletal muscle fibrosis.
Chen QN, Fan Z, Lyu AK, Wu J, Guo A, Yang YF, Chen JL, Xiao Q
Experimental cell research 2020 Apr 1;389(1):111890
Experimental cell research 2020 Apr 1;389(1):111890
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473
Theranostics 2019;9(5):1453-1473
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Zhu Y, Yu F, Tan Y, Hong Y, Meng T, Liu Y, Dai S, Qiu G, Yuan H, Hu F
Theranostics 2019;9(23):6764-6779
Theranostics 2019;9(23):6764-6779
Methane-Rich Saline Counteracts Cholestasis-Induced Liver Damage via Regulating the TLR4/NF-κB/NLRP3 Inflammasome Pathway.
Li Z, Chen D, Jia Y, Feng Y, Wang C, Tong Y, Cui R, Qu K, Liu C, Zhang J
Oxidative medicine and cellular longevity 2019;2019:6565283
Oxidative medicine and cellular longevity 2019;2019:6565283
Isorhamnetin Inhibits Liver Fibrosis by Reducing Autophagy and Inhibiting Extracellular Matrix Formation via the TGF-β1/Smad3 and TGF-β1/p38 MAPK Pathways.
Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, Han Y, Deng J, Zhou Y
Mediators of inflammation 2019;2019:6175091
Mediators of inflammation 2019;2019:6175091
TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21.
Li X, Li C, Zhu G, Yuan W, Xiao ZA
International archives of allergy and immunology 2019;179(4):304-319
International archives of allergy and immunology 2019;179(4):304-319
Dioscin ameliorates peritoneal fibrosis by inhibiting epithelial-to-mesenchymal transition of human peritoneal mesothelial cells via the TLR4/MyD88/NF-κB signaling pathway.
Shao Q, Jiang C, Xia Y, Zhao M, Zhang Q, Jin B, Liu J
International journal of clinical and experimental pathology 2019;12(3):867-875
International journal of clinical and experimental pathology 2019;12(3):867-875
Disulfiram inhibits epithelial-mesenchymal transition through TGFβ-ERK-Snail pathway independently of Smad4 to decrease oral squamous cell carcinoma metastasis.
Bu W, Wang Z, Meng L, Li X, Liu X, Chen Y, Xin Y, Li B, Sun H
Cancer management and research 2019;11:3887-3898
Cancer management and research 2019;11:3887-3898
Comparative Immunopathology of Cetacean morbillivirus Infection in Free-Ranging Dolphins From Western Mediterranean, Northeast-Central, and Southwestern Atlantic.
Díaz-Delgado J, Groch KR, Ressio R, Riskallah IPJ, Sierra E, Sacchini S, Quesada-Canales Ó, Arbelo M, Fernández A, Santos-Neto E, Ikeda J, de Carvalho RR, Azevedo AF, Lailson-Brito J Jr, Flach L, Kanamura CT, Fernandes NCCA, Cogliati B, Centelleghe C, Mazzariol S, Di Renzo L, Di Francesco G, Di Guardo G, Catão-Dias JL
Frontiers in immunology 2019;10:485
Frontiers in immunology 2019;10:485
The Reversal Effect of Sigma-1 Receptor (S1R) Agonist, SA4503, on Atrial Fibrillation After Depression and Its Underlying Mechanism.
Liu X, Qu C, Shi S, Ye T, Wang L, Liu S, Zhang C, Liang J, Hu D, Yang B
Frontiers in physiology 2019;10:1346
Frontiers in physiology 2019;10:1346
Coriolus versicolor alleviates diabetic cardiomyopathy by inhibiting cardiac fibrosis and NLRP3 inflammasome activation.
Wang Y, Li H, Li Y, Zhao Y, Xiong F, Liu Y, Xue H, Yang Z, Ni S, Sahil A, Che H, Wang L
Phytotherapy research : PTR 2019 Oct;33(10):2737-2748
Phytotherapy research : PTR 2019 Oct;33(10):2737-2748
Effects of ubiquitin-proteasome inhibitor on the expression levels of TNF-α and TGF-β1 in mice with viral myocarditis.
Zhang H, Yu J, Sun H, Zhao Y, Wang J, Zhang J, Meng B
Experimental and therapeutic medicine 2019 Oct;18(4):2799-2804
Experimental and therapeutic medicine 2019 Oct;18(4):2799-2804
Hyperoside protects against heart failure-induced liver fibrosis in rats.
Guo X, Zhu C, Liu X, Ge Y, Jiang X, Zhao W
Acta histochemica 2019 Oct;121(7):804-811
Acta histochemica 2019 Oct;121(7):804-811
The effect of topical ramipril and losartan cream in inhibiting scar formation.
Zheng B, Fang QQ, Wang XF, Shi BH, Zhao WY, Chen CY, Zhang MX, Zhang LY, Hu YY, Shi P, Ma L, Tan WQ
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109394
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Oct;118:109394
CD36 promotes the epithelial-mesenchymal transition and metastasis in cervical cancer by interacting with TGF-β.
Deng M, Cai X, Long L, Xie L, Ma H, Zhou Y, Liu S, Zeng C
Journal of translational medicine 2019 Oct 26;17(1):352
Journal of translational medicine 2019 Oct 26;17(1):352
Biomimetic electrical stimulation induces rat bone marrow mesenchymal stem cells to differentiate into cardiomyocyte-like cells via TGF-beta 1 in vitro.
He X, Li L, Tang M, Zeng Y, Li H, Yu X
Progress in biophysics and molecular biology 2019 Nov;148:47-53
Progress in biophysics and molecular biology 2019 Nov;148:47-53
Distribution of platelets, transforming growth factor-β1, platelet-derived growth factor-BB, vascular endothelial growth factor and matrix metalloprotease-9 in advanced platelet-rich fibrin and concentrated growth factor matrices.
Takahashi A, Tsujino T, Yamaguchi S, Isobe K, Watanabe T, Kitamura Y, Okuda K, Nakata K, Kawase T
Journal of investigative and clinical dentistry 2019 Nov;10(4):e12458
Journal of investigative and clinical dentistry 2019 Nov;10(4):e12458
Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner.
Wei Z, Zhao D, Zhang Y, Chen Y, Zhang S, Li Q, Zeng P, Li X, Zhang W, Duan Y, Han J, Yang X
Biochemical and biophysical research communications 2019 Nov 19;519(4):854-860
Biochemical and biophysical research communications 2019 Nov 19;519(4):854-860
Tissue plasminogen activator disrupts the blood-brain barrier through increasing the inflammatory response mediated by pericytes after cerebral ischemia.
Yang E, Cai Y, Yao X, Liu J, Wang Q, Jin W, Wu Q, Fan W, Qiu L, Kang C, Wu J
Aging 2019 Nov 18;11(22):10167-10182
Aging 2019 Nov 18;11(22):10167-10182
Anti-osteoporosis effects of osteoking via reducing reactive oxygen species.
Qin D, Zhang H, Zhang H, Sun T, Zhao H, Lee WH
Journal of ethnopharmacology 2019 Nov 15;244:112045
Journal of ethnopharmacology 2019 Nov 15;244:112045
Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis.
Hong W, Zhang G, Lu H, Guo Y, Zheng S, Zhu H, Xiao Y, Papa APD, Wu C, Sun L, Chen B, Bai Y
Cell communication and signaling : CCS 2019 Nov 12;17(1):145
Cell communication and signaling : CCS 2019 Nov 12;17(1):145
Rosiglitazone attenuates paraquat-induced lung fibrosis in rats in a PPAR gamma-dependent manner.
Zhang H, You L, Zhao M
European journal of pharmacology 2019 May 15;851:133-143
European journal of pharmacology 2019 May 15;851:133-143
Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90.
Yu Z, Jv Y, Cai L, Tian X, Huo X, Wang C, Zhang B, Sun C, Ning J, Feng L, Zhang H, Ma X
Toxicology and applied pharmacology 2019 May 15;371:63-73
Toxicology and applied pharmacology 2019 May 15;371:63-73
Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer.
Evans R, Flores-Borja F, Nassiri S, Miranda E, Lawler K, Grigoriadis A, Monypenny J, Gillet C, Owen J, Gordon P, Male V, Cheung A, Noor F, Barber P, Marlow R, Francesch-Domenech E, Fruhwirth G, Squadrito M, Vojnovic B, Tutt A, Festy F, De Palma M, Ng T
Cell reports 2019 May 14;27(7):1967-1978.e4
Cell reports 2019 May 14;27(7):1967-1978.e4
miR-4739 mediates pleural fibrosis by targeting bone morphogenetic protein 7.
Wang M, Xiong L, Jiang LJ, Lu YZ, Liu F, Song LJ, Xiang F, He XL, Yu F, Shuai SY, Ma WL, Ye H
EBioMedicine 2019 Mar;41:670-682
EBioMedicine 2019 Mar;41:670-682
TGFβi is involved in the chondrogenic differentiation of mesenchymal stem cells and is dysregulated in osteoarthritis.
Ruiz M, Maumus M, Fonteneau G, Pers YM, Ferreira R, Dagneaux L, Delfour C, Houard X, Berenbaum F, Rannou F, Jorgensen C, Noël D
Osteoarthritis and cartilage 2019 Mar;27(3):493-503
Osteoarthritis and cartilage 2019 Mar;27(3):493-503
Toxicity Effects of Methylene Blue on Rat Intervertebral Disc Annulus Fibrosus Cells.
Zhang L, Liu Y, Huang Z, Nan L, Wang F, Zhou S, Wang J, Feng X
Pain physician 2019 Mar;22(2):155-164
Pain physician 2019 Mar;22(2):155-164
Activated CRH receptors inhibit autophagy by repressing conversion of LC3BI to LC3BII.
Jin L, Qian Y, Zhou J, Dai L, Cao C, Zhu C, Li S
Cellular signalling 2019 Jun;58:119-130
Cellular signalling 2019 Jun;58:119-130
The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis.
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, Chen X, Yu X, Sun L, Yu X
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Journal of cellular and molecular medicine 2019 Jun;23(6):4229-4243
Bronchial epithelial cell extracellular vesicles ameliorate epithelial-mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization.
He S, Chen D, Hu M, Zhang L, Liu C, Traini D, Grau GE, Zeng Z, Lu J, Zhou G, Xie L, Sun S
Nanomedicine : nanotechnology, biology, and medicine 2019 Jun;18:259-271
Nanomedicine : nanotechnology, biology, and medicine 2019 Jun;18:259-271
Inhibitory effects of total ginsenoside on bleomycin-induced pulmonary fibrosis in mice.
Yang L, Chen PP, Luo M, Shi WL, Hou DS, Gao Y, Xu SF, Deng J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jun;114:108851
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jun;114:108851
Role of PM(2.5) in the development and progression of COPD and its mechanisms.
Zhao J, Li M, Wang Z, Chen J, Zhao J, Xu Y, Wei X, Wang J, Xie J
Respiratory research 2019 Jun 13;20(1):120
Respiratory research 2019 Jun 13;20(1):120
Aspirin inhibits inflammation and scar formation in the injury tendon healing through regulating JNK/STAT-3 signalling pathway.
Wang Y, He G, Tang H, Shi Y, Kang X, Lyu J, Zhu M, Zhou M, Yang M, Mu M, Chen W, Zhou B, Zhang J, Tang K
Cell proliferation 2019 Jul;52(4):e12650
Cell proliferation 2019 Jul;52(4):e12650
miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma.
Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, Zhu D, Wang X, Zhu Y, Wang H
Brain research bulletin 2019 Jul;149:21-31
Brain research bulletin 2019 Jul;149:21-31
Protective effects of Rosavin on bleomycin-induced pulmonary fibrosis via suppressing fibrotic and inflammatory signaling pathways in mice.
Xin X, Yao D, Zhang K, Han S, Liu D, Wang H, Liu X, Li G, Huang J, Wang J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108870
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Jul;115:108870
The transcription factor LEF1 promotes tumorigenicity and activates the TGF-β signaling pathway in esophageal squamous cell carcinoma.
Zhao Y, Zhu J, Shi B, Wang X, Lu Q, Li C, Chen H
Journal of experimental & clinical cancer research : CR 2019 Jul 11;38(1):304
Journal of experimental & clinical cancer research : CR 2019 Jul 11;38(1):304
α‑lipoic acid protects against carbon tetrachloride‑induced liver cirrhosis through the suppression of the TGF‑β/Smad3 pathway and autophagy.
Liu G, Liu J, Pian L, Gui S, Lu B
Molecular medicine reports 2019 Feb;19(2):841-850
Molecular medicine reports 2019 Feb;19(2):841-850
Dynamics of elastin in liver fibrosis: Accumulates late during progression and degrades slowly in regression.
Chen W, Yan X, Xu A, Sun Y, Wang B, Huang T, Wang H, Cong M, Wang P, Yang A, Jia J, You H
Journal of cellular physiology 2019 Dec;234(12):22613-22622
Journal of cellular physiology 2019 Dec;234(12):22613-22622
Identification of novel TGF-β regulated genes with pro-migratory roles.
Liu Q, Borcherding N, Shao P, Cao H, Zhang W, Qi HH
Biochimica et biophysica acta. Molecular basis of disease 2019 Dec 1;1865(12):165537
Biochimica et biophysica acta. Molecular basis of disease 2019 Dec 1;1865(12):165537
Anti-inflammatory effects of hederagenin on diabetic cardiomyopathy via inhibiting NF-κB and Smads signaling pathways in a type-2 diabetic mice model.
Li Y, Dong J, Shang Y, Zhao Q, Li P, Wu B
RSC advances 2019 Aug 19;9(45):26238-26247
RSC advances 2019 Aug 19;9(45):26238-26247
Empagliflozin prevents cardiomyopathy via sGC-cGMP-PKG pathway in type 2 diabetes mice.
Xue M, Li T, Wang Y, Chang Y, Cheng Y, Lu Y, Liu X, Xu L, Li X, Yu X, Sun B, Chen L
Clinical science (London, England : 1979) 2019 Aug 15;133(15):1705-1720
Clinical science (London, England : 1979) 2019 Aug 15;133(15):1705-1720
SRT1720 retards renal fibrosis via inhibition of HIF1A/GLUT1 in diabetic nephropathy.
Han W, Wang C, Yang Z, Mu L, Wu M, Chen N, Du C, Duan H, Shi Y
The Journal of endocrinology 2019 Apr;241(1):85-98
The Journal of endocrinology 2019 Apr;241(1):85-98
Astaxanthin ameliorates renal interstitial fibrosis and peritubular capillary rarefaction in unilateral ureteral obstruction.
Zhao J, Meng M, Zhang J, Li L, Zhu X, Zhang L, Wang C, Gao M
Molecular medicine reports 2019 Apr;19(4):3168-3178
Molecular medicine reports 2019 Apr;19(4):3168-3178
Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration.
Rusmini P, Cortese K, Crippa V, Cristofani R, Cicardi ME, Ferrari V, Vezzoli G, Tedesco B, Meroni M, Messi E, Piccolella M, Galbiati M, Garrè M, Morelli E, Vaccari T, Poletti A
Autophagy 2019 Apr;15(4):631-651
Autophagy 2019 Apr;15(4):631-651
Genetic screens reveal mechanisms for the transcriptional regulation of tissue-specific genes in normal cells and tumors.
Naciri I, Laisné M, Ferry L, Bourmaud M, Gupta N, Di Carlo S, Huna A, Martin N, Peduto L, Bernard D, Kirsh O, Defossez PA
Nucleic acids research 2019 Apr 23;47(7):3407-3421
Nucleic acids research 2019 Apr 23;47(7):3407-3421
Transcriptional regulation of autophagy-lysosomal function in BRAF-driven melanoma progression and chemoresistance.
Li S, Song Y, Quach C, Guo H, Jang GB, Maazi H, Zhao S, Sands NA, Liu Q, In GK, Peng D, Yuan W, Machida K, Yu M, Akbari O, Hagiya A, Yang Y, Punj V, Tang L, Liang C
Nature communications 2019 Apr 12;10(1):1693
Nature communications 2019 Apr 12;10(1):1693
The Role of Alpha-Lipoic Acid in the Pathomechanism of Acute Ischemic Stroke.
Wang Q, Lv C, Sun Y, Han X, Wang S, Mao Z, Xin Y, Zhang B
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(1):42-53
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(1):42-53
Renal Denervation Effects on Myocardial Fibrosis and Ventricular Arrhythmias in Rats with Ischemic Cardiomyopathy.
Zhang B, Li X, Chen C, Jiang W, Lu D, Liu Q, Wang K, Yan Y, Jiang Z, Geng J, Xu H, Shan Q
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2471-2479
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2471-2479
Gossypol Promotes Bone Formation in Ovariectomy-Induced Osteoporosis through Regulating Cell Apoptosis.
Liang J, Chen C, Liu H, Liu X, Li Z, Hu J, Zhao H
BioMed research international 2018;2018:3635485
BioMed research international 2018;2018:3635485
Glucagon-Like Peptide-1 Mediates the Protective Effect of the Dipeptidyl Peptidase IV Inhibitor on Renal Fibrosis via Reducing the Phenotypic Conversion of Renal Microvascular Cells in Monocrotaline-Treated Rats.
Xu J, Wang J, Cheng Y, Li X, He M, Zhu J, Han H, Wei G, Kong H, Xie W, Wang H, Zuo X
BioMed research international 2018;2018:1864107
BioMed research international 2018;2018:1864107
Zoledronate inhibits fibroblasts' proliferation and activation via targeting TGF-β signaling pathway.
Zhao Z, Shen W, Zhu H, Lin L, Jiang G, Zhu Y, Song H, Wu L
Drug design, development and therapy 2018;12:3021-3031
Drug design, development and therapy 2018;12:3021-3031
EDIL3 depletion suppress epithelial-mesenchymal transition of lens epithelial cells via transforming growth factor β pathway.
Zhang R, Wei YH, Zhao CY, Song HY, Shen N, Cui X, Gao X, Qi ZT, Zhong M, Shen W
International journal of ophthalmology 2018;11(1):18-24
International journal of ophthalmology 2018;11(1):18-24
Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart.
Liu F, Wen Y, Kang J, Wei C, Wang M, Zheng Z, Peng J
International journal of molecular medicine 2018 Sep;42(3):1436-1444
International journal of molecular medicine 2018 Sep;42(3):1436-1444
Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus.
Zhao Z, Han Y, Zhang Z, Li W, Ji X, Liu X, Jin J, Xu S, Cui H, Cheng Z, Wang Q, Wang X, Guo X, Wang Y, Liu H
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:151-158
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Sep;105:151-158
Angiotensin II upregulates fibroblast-myofibroblast transition through Cx43-dependent CaMKII and TGF-β1 signaling in neonatal rat cardiac fibroblasts.
Cao L, Chen Y, Lu L, Liu Y, Wang Y, Fan J, Yin Y
Acta biochimica et biophysica Sinica 2018 Sep 1;50(9):843-852
Acta biochimica et biophysica Sinica 2018 Sep 1;50(9):843-852
Antifibrotic Agent Pirfenidone Protects against Development of Radiation-Induced Pulmonary Fibrosis in a Murine Model.
Qin W, Liu B, Yi M, Li L, Tang Y, Wu B, Yuan X
Radiation research 2018 Oct;190(4):396-403
Radiation research 2018 Oct;190(4):396-403
Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway.
Ye X, He L, Ma J, Li Y, Zhang M, Yang J, Zhang J, Xiao F, Wei H
Molecular medicine reports 2018 Oct;18(4):3611-3618
Molecular medicine reports 2018 Oct;18(4):3611-3618
Quercetin ameliorates podocyte injury via inhibition of oxidative stress and the TGF-β1/Smad pathway in DN rats.
Gao F, He X, Liang S, Liu S, Liu H, He Q, Chen L, Jiang H, Zhang Y
RSC advances 2018 Oct 15;8(62):35413-35421
RSC advances 2018 Oct 15;8(62):35413-35421
Knockdown of NLRP3 alleviates high glucose or TGFB1-induced EMT in human renal tubular cells.
Song S, Qiu D, Luo F, Wei J, Wu M, Wu H, Du C, Du Y, Ren Y, Chen N, Duan H, Shi Y
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Journal of molecular endocrinology 2018 Oct 1;61(3):101-113
Acteoside relieves mesangial cell injury by regulating Th22 cell chemotaxis and proliferation in IgA nephropathy.
Gan L, Li X, Zhu M, Chen C, Luo H, Zhou Q
Renal failure 2018 Nov;40(1):364-370
Renal failure 2018 Nov;40(1):364-370
Study on Cardiotoxicity and Mechanism of "Fuzi" Extracts Based on Metabonomics.
Huang G, Yang L, Zhou W, Tang X, Wang Y, Ma Z, Gao S, Gao Y
International journal of molecular sciences 2018 Nov 7;19(11)
International journal of molecular sciences 2018 Nov 7;19(11)
Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma.
Hu B, Mao Z, Jiang X, He D, Wang Z, Wang X, Zhu Y, Wang H
Brain research 2018 Nov 1;1698:204-212
Brain research 2018 Nov 1;1698:204-212
Cardioprotection of CAPE-oNO(2) against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-κB pathway in vivo and in vitro.
Li D, Wang X, Huang Q, Li S, Zhou Y, Li Z
Redox biology 2018 May;15:62-73
Redox biology 2018 May;15:62-73
FSTL1 interacts with VIM and promotes colorectal cancer metastasis via activating the focal adhesion signalling pathway.
Gu C, Wang X, Long T, Wang X, Zhong Y, Ma Y, Hu Z, Li Z
Cell death & disease 2018 May 29;9(6):654
Cell death & disease 2018 May 29;9(6):654
Hepatoprotection of auraptene from peels of citrus fruits against thioacetamide-induced hepatic fibrosis in mice by activating farnesoid X receptor.
Gao X, Wang C, Ning C, Liu K, Wang X, Liu Z, Sun H, Ma X, Sun P, Meng Q
Food & function 2018 May 23;9(5):2684-2694
Food & function 2018 May 23;9(5):2684-2694
LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1α signaling.
Li A, Peng R, Sun Y, Liu H, Peng H, Zhang Z
Cell death & disease 2018 May 1;9(5):461
Cell death & disease 2018 May 1;9(5):461
Overexpression of zinc-α2-glycoprotein suppressed seizures and seizure-related neuroflammation in pentylenetetrazol-kindled rats.
Liu Y, Wang T, Liu X, Wen Y, Xu T, Yu X, Wei X, Ding X, Mo L, Yin M, Tan X, Chen L
Journal of neuroinflammation 2018 Mar 22;15(1):92
Journal of neuroinflammation 2018 Mar 22;15(1):92
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation.
Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, Han X, Tang Z, Ma X, Liu K, Peng J
Toxicology letters 2018 Mar 1;284:37-45
Toxicology letters 2018 Mar 1;284:37-45
Ambient fine particulate matter exposure induces reversible cardiac dysfunction and fibrosis in juvenile and older female mice.
Qin G, Xia J, Zhang Y, Guo L, Chen R, Sang N
Particle and fibre toxicology 2018 Jun 25;15(1):27
Particle and fibre toxicology 2018 Jun 25;15(1):27
microRNA-21 regulates astrocytic reaction post-acute phase of spinal cord injury through modulating TGF-β signaling.
Liu R, Wang W, Wang S, Xie W, Li H, Ning B
Aging 2018 Jun 23;10(6):1474-1488
Aging 2018 Jun 23;10(6):1474-1488
Overexpression of YOD1 Promotes the Migration of Human Oral Keratinocytes by Enhancing TGF-β3 Signaling.
Ju Q, Li MX, Chen G, Wang HX, Shi QM, Ge X, Ding Z, Wang Q, Xu LC
Biomedical and environmental sciences : BES 2018 Jul;31(7):499-506
Biomedical and environmental sciences : BES 2018 Jul;31(7):499-506
Photobiomodulation therapy promotes neurogenesis by improving post-stroke local microenvironment and stimulating neuroprogenitor cells.
Yang L, Tucker D, Dong Y, Wu C, Lu Y, Li Y, Zhang J, Liu TC, Zhang Q
Experimental neurology 2018 Jan;299(Pt A):86-96
Experimental neurology 2018 Jan;299(Pt A):86-96
Curcumin Attenuates on Carbon Tetrachloride-Induced Acute Liver Injury in Mice via Modulation of the Nrf2/HO-1 and TGF-β1/Smad3 Pathway.
Peng X, Dai C, Liu Q, Li J, Qiu J
Molecules (Basel, Switzerland) 2018 Jan 19;23(1)
Molecules (Basel, Switzerland) 2018 Jan 19;23(1)
HOXC8 promotes proliferation and migration through transcriptional up-regulation of TGFβ1 in non-small cell lung cancer.
Liu H, Zhang M, Xu S, Zhang J, Zou J, Yang C, Zhang Y, Gong C, Kai Y, Li Y
Oncogenesis 2018 Jan 17;7(2):1
Oncogenesis 2018 Jan 17;7(2):1
Baicalin inhibits pressure overload-induced cardiac fibrosis through regulating AMPK/TGF-β/Smads signaling pathway.
Xiao Y, Ye J, Zhou Y, Huang J, Liu X, Huang B, Zhu L, Wu B, Zhang G, Cai Y
Archives of biochemistry and biophysics 2018 Feb 15;640:37-46
Archives of biochemistry and biophysics 2018 Feb 15;640:37-46
Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway.
Wang EM, Fan QL, Yue Y, Xu L
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Medical science monitor : international medical journal of experimental and clinical research 2018 Feb 11;24:846-854
Effects of garlic polysaccharide on alcoholic liver fibrosis and intestinal microflora in mice.
Wang Y, Guan M, Zhao X, Li X
Pharmaceutical biology 2018 Dec;56(1):325-332
Pharmaceutical biology 2018 Dec;56(1):325-332
Combination antitumor immunotherapy with VEGF and PIGF siRNA via systemic delivery of multi-functionalized nanoparticles to tumor-associated macrophages and breast cancer cells.
Song Y, Tang C, Yin C
Biomaterials 2018 Dec;185:117-132
Biomaterials 2018 Dec;185:117-132
NLRP3 deficiency ameliorates renal inflammation and fibrosis in diabetic mice.
Wu M, Han W, Song S, Du Y, Liu C, Chen N, Wu H, Shi Y, Duan H
Molecular and cellular endocrinology 2018 Dec 15;478:115-125
Molecular and cellular endocrinology 2018 Dec 15;478:115-125
Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization.
Lu H, Wu L, Liu L, Ruan Q, Zhang X, Hong W, Wu S, Jin G, Bai Y
Biochemical pharmacology 2018 Aug;154:203-212
Biochemical pharmacology 2018 Aug;154:203-212
Intrinsic renal cells induce lymphocytosis of Th22 cells from IgA nephropathy patients through B7-CTLA-4 and CCL-CCR pathways.
Gan L, Zhou Q, Li X, Chen C, Meng T, Pu J, Zhu M, Xiao C
Molecular and cellular biochemistry 2018 Apr;441(1-2):191-199
Molecular and cellular biochemistry 2018 Apr;441(1-2):191-199
Inhibition of tumor-promoting stroma to enforce subsequently targeting AT(1)R on tumor cells by pathological inspired micelles.
Zhu Y, Wen L, Shao S, Tan Y, Meng T, Yang X, Liu Y, Liu X, Yuan H, Hu F
Biomaterials 2018 Apr;161:33-46
Biomaterials 2018 Apr;161:33-46
Thymoquinone protects against cardiac damage from doxorubicin-induced heart failure in Sprague-Dawley rats.
Pei Z, Hu J, Bai Q, Liu B, Cheng D, Liu H, Na R, Yu Q
RSC advances 2018 Apr 17;8(26):14633-14639
RSC advances 2018 Apr 17;8(26):14633-14639
Emodin Alleviates Sodium Taurocholate-Induced Pancreatic Acinar Cell Injury via MicroRNA-30a-5p-Mediated Inhibition of High-Temperature Requirement A/Transforming Growth Factor Beta 1 Inflammatory Signaling.
Xiang H, Tao X, Xia S, Qu J, Song H, Liu J, Shang D
Frontiers in immunology 2017;8:1488
Frontiers in immunology 2017;8:1488
TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer.
Zhuang J, Shen L, Yang L, Huang X, Lu Q, Cui Y, Zheng X, Zhao X, Zhang D, Huang R, Guo H, Yan J
Theranostics 2017;7(12):3053-3067
Theranostics 2017;7(12):3053-3067
Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling.
Wang L, Hu L, Zhou X, Xiong Z, Zhang C, Shehada HMA, Hu B, Song J, Chen L
Scientific reports 2017 Oct 17;7(1):13321
Scientific reports 2017 Oct 17;7(1):13321
TGF-β1/Smad3 Signaling Pathway Mediates T-2 Toxin-Induced Decrease of Type II Collagen in Cultured Rat Chondrocytes.
Li Y, Zou N, Wang J, Wang KW, Li FY, Chen FX, Sun BY, Sun DJ
Toxins 2017 Nov 5;9(11)
Toxins 2017 Nov 5;9(11)
Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.
Wei J, Zhang G, Zhang X, Xu D, Gao J, Fan J
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
Plant foods for human nutrition (Dordrecht, Netherlands) 2017 Dec;72(4):425-431
CAPE-pNO(2) ameliorated diabetic nephropathy through regulating the Akt/NF-κB/ iNOS pathway in STZ-induced diabetic mice.
Wang X, Li D, Fan L, Xiao Q, Zuo H, Li Z
Oncotarget 2017 Dec 29;8(70):114506-114525
Oncotarget 2017 Dec 29;8(70):114506-114525
Gender differences in fibrosis remodeling in patients with long-standing persistent atrial fibrillation.
Li Z, Wang Z, Yin Z, Zhang Y, Xue X, Han J, Zhu Y, Zhang J, Emmert MY, Wang H
Oncotarget 2017 Aug 8;8(32):53714-53729
Oncotarget 2017 Aug 8;8(32):53714-53729
Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT.
Liu Q, Tong D, Liu G, Xu J, Do K, Geary K, Zhang D, Zhang J, Zhang Y, Li Y, Bi G, Lan W, Jiang J
Cell death & disease 2017 Aug 24;8(8):e3007
Cell death & disease 2017 Aug 24;8(8):e3007
Let‑7a suppresses cell proliferation via the TGF‑β/SMAD signaling pathway in cervical cancer.
Wu T, Chen X, Peng R, Liu H, Yin P, Peng H, Zhou Y, Sun Y, Wen L, Yi H, Li A, Zhang Z
Oncology reports 2016 Dec;36(6):3275-3282
Oncology reports 2016 Dec;36(6):3275-3282
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