Antibody data
- Antibody Data
- Antigen structure
- References [1]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 341801 - Provider product page
- Provider
- BioLegend
- Product name
- Alexa Fluor® 647 anti-human LAP (TGF-รข1) [BG/hLAP]
- Antibody type
- Monoclonal
- Antigen
- LAP
- Description
- TGF-β1 (transforming growth factor β1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many kinds of cells. Platelets express high level of TGF-β. TGF-β is synthesized as a large protein precursor and then secreted as a complex of TGF-β and LAP (latency-associated peptide). TGF-β requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-β binds to the integrins αvβ1, αvβ6, αvβ8 and α8β1 through RGD domain. TGF-β plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-β is believed to be important in regulation of the development of Treg, Th17, and Th9 cells. Recent study has shown that LAP is an activated Treg surface marker.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references The impact of inflammatory licensing on heme oxygenase-1-mediated induction of regulatory T cells by human mesenchymal stem cells.
Mougiakakos D, Jitschin R, Johansson CC, Okita R, Kiessling R, Le Blanc K
Blood 2011 May 5;117(18):4826-35
Blood 2011 May 5;117(18):4826-35
No comments: Submit comment
No validations: Submit validation data