Antibody data
- Antibody Data
- Antigen structure
- References [1]
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- Product number
- 341803 - Provider product page
- Provider
- BioLegend
- Product name
- PerCP/Cy5.5 anti-human LAP (TGF-1)
- Antibody type
- Monoclonal
- Antigen
- LAP
- Description
- TGF-β1 (transforming growth factor β1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many kinds of cells. Platelets express high level of TGF-β. TGF-β is synthesized as a large protein precursor and then secreted as a complex of TGF-β and LAP (latency-associated peptide). TGF-β requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-β binds to the integrins αvβ1, αvβ6, αvβ8 and α8β1 through RGD domain. TGF-β plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-β is believed to be important in regulation of the development of Treg, Th17, and Th9 cells. Recent study has shown that LAP is an activated Treg surface marker.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Far-Red dye
- Isotype
- IgG
- Vial size
- 25 tests
- Storage
- The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Submitted references Generation of human regulatory gammadelta T cells by TCRgammadelta stimulation in the presence of TGF-beta and their involvement in the pathogenesis of systemic lupus erythematosus.
Li X, Kang N, Zhang X, Dong X, Wei W, Cui L, Ba D, He W
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 15;186(12):6693-700
Journal of immunology (Baltimore, Md. : 1950) 2011 Jun 15;186(12):6693-700
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