341803

antibody from BioLegend
Targeting: TGFB1 CED, DPD1, TGFB, TGFbeta
Provider product page for 341803
Flow cytometry

Antibody data

Product number
341803 - Provider product page
Provider
BioLegend
Product name
PerCP/Cy5.5 anti-human LAP (TGF-‰1)
Antibody type
Monoclonal
Antigen
LAP
Description
TGF-β1 (transforming growth factor β1) is a multifunctional cytokine which regulates cellular proliferation and differentiation. It is ubiquitously expressed by many kinds of cells. Platelets express high level of TGF-β. TGF-β is synthesized as a large protein precursor and then secreted as a complex of TGF-β and LAP (latency-associated peptide). TGF-β requires activation before it binds to its receptors and exerts functions. It has been reported that LAP-TGF-β binds to the integrins αvβ1, αvβ6, αvβ8 and α8β1 through RGD domain. TGF-β plays important roles in control proliferation and differentiation of epithelial cells, endothelial cells, fibroblasts, neurons, osteoclasts, and osteoblasts. TGF-β is believed to be important in regulation of the development of Treg, Th17, and Th9 cells. Recent study has shown that LAP is an activated Treg surface marker.
Reactivity
Human
Host
Mouse
Conjugate
Far-Red dye
Isotype
IgG
Vial size
25 tests
Storage
The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
TGFB1 protein structure - 341803 shown in red.