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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [18]
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- Product number
- BAF240 - Provider product page
- Provider
- R&D Systems
- Product name
- TGF-beta 1 Biotinylated Antibody
- Antibody type
- Polyclonal
- Description
- Antigen Affinity-purified from egg yolks. Detects human TGF-beta 1 in ELISAs and Western blots. In sandwich immunoassays, when used in combination with the rhTGF-beta sRII/Fc chimera (Catalog # 341-BR), approximately 15% cross-reactivity with recombinant human (rh) Latent TGF-beta 1 is observed, 1% cross-reactivity with rhTGF-beta 1.2 is observed, and 3% cross-reactivity with recombinant amphibian (ra) TGF-beta 5 is observed. When used in combination with the monoclonal capture antibody (Catalog # MAB2402), approximately 5% cross-reactivity with TGF-beta 1.2 is observed and 1% cross-reactivity with rhTGF-beta 2, recombinant chicken TGF-beta 3, and raTGF-beta 5 is observed.
- Host
- Chicken/Avian
- Conjugate
- Biotin
- Isotype
- IgY
- Vial size
- 50 ug
- Concentration
- LYOPH
- Storage
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Submitted references TGF‑β1 upregulates the expression of lncRNA‑ATB to promote atherosclerosis.
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.
Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1).
Oral Escherichia coli colonization factor antigen I fimbriae ameliorate arthritis via IL-35, not IL-27.
C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Activation of Toll-like receptor 3 augments myofibroblast differentiation.
In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid.
In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid.
Antigen-induced regulatory T cells in HBV chronically infected patients.
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression.
trans fatty acids and systemic inflammation in heart failure.
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4.
Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4.
Yu H, Ma S, Sun L, Gao J, Zhao C
Molecular medicine reports 2019 May;19(5):4222-4228
Molecular medicine reports 2019 May;19(5):4222-4228
Bifunctional immune checkpoint-targeted antibody-ligand traps that simultaneously disable TGFβ enhance the efficacy of cancer immunotherapy.
Ravi R, Noonan KA, Pham V, Bedi R, Zhavoronkov A, Ozerov IV, Makarev E, V Artemov A, Wysocki PT, Mehra R, Nimmagadda S, Marchionni L, Sidransky D, Borrello IM, Izumchenko E, Bedi A
Nature communications 2018 Feb 21;9(1):741
Nature communications 2018 Feb 21;9(1):741
Role of a Novel Human Leukocyte Antigen-DQA1*01:02;DRB1*15:01 Mixed Isotype Heterodimer in the Pathogenesis of "Humanized" Multiple Sclerosis-like Disease.
Kaushansky N, Eisenstein M, Boura-Halfon S, Hansen BE, Nielsen CH, Milo R, Zeilig G, Lassmann H, Altmann DM, Ben-Nun A
The Journal of biological chemistry 2015 Jun 12;290(24):15260-78
The Journal of biological chemistry 2015 Jun 12;290(24):15260-78
Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
Hsiao HW, Hsu TS, Liu WH, Hsieh WC, Chou TF, Wu YJ, Jiang ST, Lai MZ
Nature communications 2015 Feb 19;6:6353
Nature communications 2015 Feb 19;6:6353
Induction and activation of latent transforming growth factor-β1 are carried out by two distinct domains of pregnancy-specific glycoprotein 1 (PSG1).
Ballesteros A, Mentink-Kane MM, Warren J, Kaplan GG, Dveksler GS
The Journal of biological chemistry 2015 Feb 13;290(7):4422-31
The Journal of biological chemistry 2015 Feb 13;290(7):4422-31
Oral Escherichia coli colonization factor antigen I fimbriae ameliorate arthritis via IL-35, not IL-27.
Kochetkova I, Thornburg T, Callis G, Holderness K, Maddaloni M, Pascual DW
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):804-16
Journal of immunology (Baltimore, Md. : 1950) 2014 Jan 15;192(2):804-16
C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes.
Liu F, Chen HY, Huang XR, Chung AC, Zhou L, Fu P, Szalai AJ, Lan HY
Diabetologia 2011 Oct;54(10):2713-23
Diabetologia 2011 Oct;54(10):2713-23
Activation of Toll-like receptor 3 augments myofibroblast differentiation.
Sugiura H, Ichikawa T, Koarai A, Yanagisawa S, Minakata Y, Matsunaga K, Hirano T, Akamatsu K, Ichinose M
American journal of respiratory cell and molecular biology 2009 Jun;40(6):654-62
American journal of respiratory cell and molecular biology 2009 Jun;40(6):654-62
In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid.
Saurer L, McCullough KC, Summerfield A
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3504-14
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3504-14
In vitro induction of mucosa-type dendritic cells by all-trans retinoic acid.
Saurer L, McCullough KC, Summerfield A
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3504-14
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):3504-14
Antigen-induced regulatory T cells in HBV chronically infected patients.
Barboza L, Salmen S, Goncalves L, Colmenares M, Peterson D, Montes H, Cartagirone R, Gutiérrez Mdel C, Berrueta L
Virology 2007 Nov 10;368(1):41-9
Virology 2007 Nov 10;368(1):41-9
Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
Blood 2007 May 15;109(10):4272-9
Blood 2007 May 15;109(10):4272-9
Transforming growth factor beta 1(TGF-beta1) down-regulates TNFalpha-induced RANTES production in rheumatoid synovial fibroblasts through NF-kappaB-mediated transcriptional repression.
Cho ML, Min SY, Chang SH, Kim KW, Heo SB, Lee SH, Park SH, Cho CS, Kim HY
Immunology letters 2006 Jun 15;105(2):159-66
Immunology letters 2006 Jun 15;105(2):159-66
trans fatty acids and systemic inflammation in heart failure.
Mozaffarian D, Rimm EB, King IB, Lawler RL, McDonald GB, Levy WC
The American journal of clinical nutrition 2004 Dec;80(6):1521-5
The American journal of clinical nutrition 2004 Dec;80(6):1521-5
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM
The Journal of experimental medicine 2003 Dec 15;198(12):1875-86
The Journal of experimental medicine 2003 Dec 15;198(12):1875-86
Th2 cytokine regulation of type I collagen gel contraction mediated by human lung mesenchymal cells.
Liu X, Kohyama T, Wang H, Zhu YK, Wen FQ, Kim HJ, Romberger DJ, Rennard SI
American journal of physiology. Lung cellular and molecular physiology 2002 May;282(5):L1049-56
American journal of physiology. Lung cellular and molecular physiology 2002 May;282(5):L1049-56
Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4.
Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL
Journal of immunology (Baltimore, Md. : 1950) 2000 May 15;164(10):5337-43
Journal of immunology (Baltimore, Md. : 1950) 2000 May 15;164(10):5337-43
Repeated exposure induces periportal fibrosis in Schistosoma mansoni-infected baboons: role of TGF-beta and IL-4.
Farah IO, Mola PW, Kariuki TM, Nyindo M, Blanton RE, King CL
Journal of immunology (Baltimore, Md. : 1950) 2000 May 15;164(10):5337-43
Journal of immunology (Baltimore, Md. : 1950) 2000 May 15;164(10):5337-43
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