FAB2463A

antibody from R&D Systems

Targeting: TGFB1 CED, DPD1, TGFB, TGFbeta

Flow cytometry (Supportive data in Antibodypedia)

Antibody Data

Product number

FAB2463A

Provider

R&D Systems

Product name

Human LAP (TGF-beta 1) APC-conjugated Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects human LAP (TGF-beta 1) in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF-beta 1, rhTGF-beta 2, rhTGF-beta 1.2, rhTGF-beta 3, or rhTGF-alpha .

Reactivity

Human

Host

Mouse

Conjugate

Red dye

Antigen sequence

P01137


Isotype

IgG

Antibody clone number

27232

Vial size

100 Tests

Storage

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.

References

Submitted references

Lysosomal-associated Transmembrane Protein 4B (LAPTM4B) Decreases Transforming Growth Factor β1 (TGF-β1) Production in Human Regulatory T Cells.

Huygens C, Liénart S, Dedobbeleer O, Stockis J, Gauthy E, Coulie PG, Lucas S
The Journal of biological chemistry 2015 Aug 14;290(33):20105-16

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Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.

Zhu ZF, Meng K, Zhong YC, Qi L, Mao XB, Yu KW, Zhang W, Zhu PF, Ren ZP, Wu BW, Ji QW, Wang X, Zeng QT
PloS one 2014;9(2):e88775

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CD69 regulates type I IFN-induced tolerogenic signals to mucosal CD4 T cells that attenuate their colitogenic potential.

Radulovic K, Manta C, Rossini V, Holzmann K, Kestler HA, Wegenka UM, Nakayama T, Niess JH
Journal of immunology (Baltimore, Md. : 1950) 2012 Feb 15;188(4):2001-13

Flow cytometry

Supportive validation

Submitted by

R&D Systems (provider)

Main image

Experimental details

Detection of LAP (TGF-beta 1) in Human Platelets by Flow Cytometry. Human platelets were stained with Mouse Anti-Human LAP (TGF-beta 1) APC-conjugated Monoclonal Antibody (Catalog # FAB2463A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.