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Flow cytometryAntibody data
- Antibody Data
- Antigen structure
- References [10]
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- Validations
- Flow cytometry [1]
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- Product number
- FAB2463P - Provider product page
- Provider
- R&D Systems
- Product name
- Human LAP (TGF-beta 1) PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human LAP (TGF-beta 1) in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF-beta 1, rhTGF-beta 2, rhTGF-beta 1.2, rhTGF-beta 3, or rhTGF-alpha .
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P01137- Isotype
- IgG
- Antibody clone number
- 27232
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references A Cellular MicroRNA Facilitates Regulatory T Lymphocyte Development by Targeting the FOXP3 Promoter TATA-Box Motif.
Suppressive regulatory T cells and latent transforming growth factor-β-expressing macrophages are altered in the peritoneal fluid of patients with endometriosis.
Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells.
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.
Human Regulatory T Cells Mediate Transcriptional Modulation of Dendritic Cell Function.
Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.
Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells.
A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy.
Zhang Y, Liu W, Chen Y, Liu J, Wu K, Su L, Zhang W, Jiang Y, Zhang X, Zhang Y, Liu C, Tao L, Liu B, Zhang H
Journal of immunology (Baltimore, Md. : 1950) 2018 Feb 1;200(3):1053-1063
Journal of immunology (Baltimore, Md. : 1950) 2018 Feb 1;200(3):1053-1063
Suppressive regulatory T cells and latent transforming growth factor-β-expressing macrophages are altered in the peritoneal fluid of patients with endometriosis.
Hanada T, Tsuji S, Nakayama M, Wakinoue S, Kasahara K, Kimura F, Mori T, Ogasawara K, Murakami T
Reproductive biology and endocrinology : RB&E 2018 Feb 1;16(1):9
Reproductive biology and endocrinology : RB&E 2018 Feb 1;16(1):9
Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells.
Lecendreux M, Churlaud G, Pitoiset F, Regnault A, Tran TA, Liblau R, Klatzmann D, Rosenzwajg M
PloS one 2017;12(1):e0169836
PloS one 2017;12(1):e0169836
TGF-beta/atRA-induced Tregs express a selected set of microRNAs involved in the repression of transcripts related to Th17 differentiation.
Schiavinato JLDS, Haddad R, Saldanha-Araujo F, Baiochi J, Araujo AG, Santos Scheucher P, Covas DT, Zago MA, Panepucci RA
Scientific reports 2017 Jun 15;7(1):3627
Scientific reports 2017 Jun 15;7(1):3627
Human Regulatory T Cells Mediate Transcriptional Modulation of Dendritic Cell Function.
Mavin E, Nicholson L, Rafez Ahmed S, Gao F, Dickinson A, Wang XN
Journal of immunology (Baltimore, Md. : 1950) 2017 Jan 1;198(1):138-146
Journal of immunology (Baltimore, Md. : 1950) 2017 Jan 1;198(1):138-146
Impaired circulating CD4+ LAP+ regulatory T cells in patients with acute coronary syndrome and its mechanistic study.
Zhu ZF, Meng K, Zhong YC, Qi L, Mao XB, Yu KW, Zhang W, Zhu PF, Ren ZP, Wu BW, Ji QW, Wang X, Zeng QT
PloS one 2014;9(2):e88775
PloS one 2014;9(2):e88775
Steady state migratory RelB+ langerin+ dermal dendritic cells mediate peripheral induction of antigen-specific CD4+ CD25+ Foxp3+ regulatory T cells.
Azukizawa H, Döhler A, Kanazawa N, Nayak A, Lipp M, Malissen B, Autenrieth I, Katayama I, Riemann M, Weih F, Berberich-Siebelt F, Lutz MB
European journal of immunology 2011 May;41(5):1420-34
European journal of immunology 2011 May;41(5):1420-34
A crucial role for Kupffer cell-derived galectin-9 in regulation of T cell immunity in hepatitis C infection.
Mengshol JA, Golden-Mason L, Arikawa T, Smith M, Niki T, McWilliams R, Randall JA, McMahan R, Zimmerman MA, Rangachari M, Dobrinskikh E, Busson P, Polyak SJ, Hirashima M, Rosen HR
PloS one 2010 Mar 4;5(3):e9504
PloS one 2010 Mar 4;5(3):e9504
The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
Suzuki K, Maruya M, Kawamoto S, Sitnik K, Kitamura H, Agace WW, Fagarasan S
Immunity 2010 Jul 23;33(1):71-83
Immunity 2010 Jul 23;33(1):71-83
Peptide inhibitors of transforming growth factor-beta enhance the efficacy of antitumor immunotherapy.
Llopiz D, Dotor J, Casares N, Bezunartea J, Díaz-Valdés N, Ruiz M, Aranda F, Berraondo P, Prieto J, Lasarte JJ, Borrás-Cuesta F, Sarobe P
International journal of cancer 2009 Dec 1;125(11):2614-23
International journal of cancer 2009 Dec 1;125(11):2614-23
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Supportive validation
- Submitted by
- R&D Systems (provider)
- Main image
- Experimental details
- Detection of LAP (TGF-beta 1) in Human Platelets by Flow Cytometry. Human CD41+ platelets were stained with Mouse Anti-Human LAP (TGF-beta 1) PE-conjugated Monoclonal Antibody (Catalog # FAB2463P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
