MAB2463

antibody from R&D Systems

Targeting: TGFB1 CED, DPD1, TGFB, TGFbeta

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

MAB2463

Provider

R&D Systems

Product name

Human LAP (TGF-beta 1) Antibody

Antibody type

Monoclonal

Description

Protein A or G purified from hybridoma culture supernatant. Detects human LAP (TGF-beta 1) in direct ELISAs. In direct ELISAs, this antibody does not cross-react with recombinant human (rh) TGF-beta 1, rhTGF-beta 2, rhTGF-beta 1.2, rhTGF-beta 3, or rhTGF-alpha .

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antigen sequence

P01137


Isotype

IgG

Antibody clone number

27232

Vial size

500 ug

Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution.

References

Submitted references

Association of peripheral NK cell counts with Helios⁺ IFN-γ^- T_regs in patients with good long-term renal allograft function.

Trojan K, Zhu L, Aly M, Weimer R, Bulut N, Morath C, Opelz G, Daniel V
Clinical and experimental immunology 2017 Jun;188(3):467-479

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Induction of latency-associated peptide (transforming growth factor-β(1)) expression on CD4+ T cells reduces Toll-like receptor 4 ligand-induced tumour necrosis factor-α production in a transforming growth factor-β-dependent manner.

Boswell S, Sharif S, Alisa A, Pereira SP, Williams R, Behboudi S
Immunology 2011 Jul;133(3):278-87

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Overexpression of TGF-ß 1 gene induces cell surface localized glucose-regulated protein 78-associated latency-associated peptide/TGF-ß.

Oida T, Weiner HL
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 15;185(6):3529-35

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HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells.

Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, Stingl G, Eppel W, Elbe-Bürger A
The Journal of experimental medicine 2009 Jan 16;206(1):169-81

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Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.

Savage ND, de Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):2220-6

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Human anti-inflammatory macrophages induce Foxp3+ GITR+ CD25+ regulatory T cells, which suppress via membrane-bound TGFbeta-1.

Savage ND, de Boer T, Walburg KV, Joosten SA, van Meijgaarden K, Geluk A, Ottenhoff TH
Journal of immunology (Baltimore, Md. : 1950) 2008 Aug 1;181(3):2220-6

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TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.

Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, Strober W
Journal of immunology (Baltimore, Md. : 1950) 2004 Jan 15;172(2):834-42

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TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.

Nakamura K, Kitani A, Fuss I, Pedersen A, Harada N, Nawata H, Strober W
Journal of immunology (Baltimore, Md. : 1950) 2004 Jan 15;172(2):834-42