641402

antibody from BioLegend
Targeting: FOS AP-1, c-fos
Provider product page for 641402
Western blot

Antibody data

Product number
641402 - Provider product page
Provider
BioLegend
Proper citation
BioLegend Cat#641402, RRID:AB_2106629
Product name
Purified anti-c-Fos
Antibody type
Polyclonal
Antigen
c-Fos
Description
The c-fos protein, also known as FBJ murine viral (v-fos) oncogene homolog , is a 62 kD cellular oncogene. The c-fos protein contains a bZIP region with a DNA-binding domain and a leucine zipper domain. Together with c-jun, c-jun proteins form the heterodimeric AP-1 complex that binds to the TRE elements of cellular and viral genes including collagenase, interleukin 2, stromelysin, SV40 and polyoma among others. c-fos is expressed in a variety of normal adult tissues and has been implicated as a critical transcription factor for skeletal formation and maintenance. This transcription factor is modified by phosphorylation by a number of upstream kinases and has been shown to interact with a variety of other proteins involved in transcriptional regulation. c-fos has been implicated in the development of fibrous bone dysplasia and osteosarcoma. The c-fos protein has been shown to interact with a variety of other proteins including c-jun, TFIID, NCOA2, NFAT1, CHOP, ELK1, SRC1, and ETS1. The Poly6244 antibody recognizes human, rat, and mouse c-fos and has been shown to be useful for Western blotting, immunoprecipitation, and immunohistochemistry.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Conjugate
Unconjugated
Vial size
100 µl
Storage
Upon receipt, store at -20°C.
FOS protein structure - 641402 shown in red.