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- References [5]
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- Western blot [1]
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- Product number
- 14995-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14995-1-AP, RRID:AB_10859095
- Product name
- DDA1 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated DDA1 antibody (Cat. #14995-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references CRL4(AMBRA1) is a master regulator of D-type cyclins.
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15.
Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Simoneschi D, Rona G, Zhou N, Jeong YT, Jiang S, Milletti G, Arbini AA, O'Sullivan A, Wang AA, Nithikasem S, Keegan S, Siu Y, Cianfanelli V, Maiani E, Nazio F, Cecconi F, Boccalatte F, Fenyö D, Jones DR, Busino L, Pagano M
Nature 2021 Apr;592(7856):789-793
Nature 2021 Apr;592(7856):789-793
Structural basis of indisulam-mediated RBM39 recruitment to DCAF15 E3 ligase complex.
Bussiere DE, Xie L, Srinivas H, Shu W, Burke A, Be C, Zhao J, Godbole A, King D, Karki RG, Hornak V, Xu F, Cobb J, Carte N, Frank AO, Frommlet A, Graff P, Knapp M, Fazal A, Okram B, Jiang S, Michellys PY, Beckwith R, Voshol H, Wiesmann C, Solomon JM, Paulk J
Nature chemical biology 2020 Jan;16(1):15-23
Nature chemical biology 2020 Jan;16(1):15-23
Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15.
Ting TC, Goralski M, Klein K, Wang B, Kim J, Xie Y, Nijhawan D
Cell reports 2019 Nov 5;29(6):1499-1510.e6
Cell reports 2019 Nov 5;29(6):1499-1510.e6
Cryptochromes-Mediated Inhibition of the CRL4Cop1-Complex Assembly Defines an Evolutionary Conserved Signaling Mechanism.
Rizzini L, Levine DC, Perelis M, Bass J, Peek CB, Pagano M
Current biology : CB 2019 Jun 17;29(12):1954-1962.e4
Current biology : CB 2019 Jun 17;29(12):1954-1962.e4
Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.
Han T, Goralski M, Gaskill N, Capota E, Kim J, Ting TC, Xie Y, Williams NS, Nijhawan D
Science (New York, N.Y.) 2017 Apr 28;356(6336)
Science (New York, N.Y.) 2017 Apr 28;356(6336)
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Supportive validation
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- Proteintech Group (provider)
- Main image
- Experimental details
- The DDA1 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human DDA1. This antibody recognizes human, mouse, rat antigen. The DDA1 antibody has been validated for the following applications: ELISA, WB analysis.
