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- Antibody Data
- Antigen structure
- References [24]
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- Product number
- 14450-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14450-1-AP, RRID:AB_2208263
- Product name
- TSHR antibody
- Antibody type
- Polyclonal
- Description
- TSHR antibody (Cat. #14450-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: WB, ELISA.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The impact and potential mechanisms of long noncoding RNA ENST00000521141.1 on human white adipocyte differentiation.
Thyroidal expression of ER molecular chaperone GRP170 is required for efficient TSH-mediated thyroid hormone synthesis.
Targeting syndecan-2 inhibits papillary thyroid cancer invasiveness and de-differentiation.
Bispecific aptamers target thyrotropin receptor (TSHR) and insulin growth factor-1 receptor (IGF-1R) for the improvement of orbital fibroblasts activation in the treatment of thyroid-associated ophthalmopathy.
PCSK9 promotes progression of anaplastic thyroid cancer through E-cadherin endocytosis.
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
A TSHR-Targeting Aptamer in Monocytes Correlating with Clinical Activity in TAO.
Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes.
Thyroid cancer risk associated with perfluoroalkyl carboxylate exposure: Assessment using a human dermal fibroblast-derived extracellular matrix-based thyroid cancer organoid.
Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer.
Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice.
Sinomenine Hydrochloride Promotes TSHR-Dependent Redifferentiation in Papillary Thyroid Cancer.
Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation.
TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells.
Patient-Derived Papillary Thyroid Cancer Organoids for Radioactive Iodine Refractory Screening.
Combined tazemetostat and MAPKi enhances differentiation of papillary thyroid cancer cells harbouring BRAF(V600E) by synergistically decreasing global trimethylation of H3K27.
Long Non-coding Antisense RNA TNRC6C-AS1 Is Activated in Papillary Thyroid Cancer and Promotes Cancer Progression by Suppressing TNRC6C Expression.
A somatic mutation of RasGRP3 decreases Na(+)/I(-) symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.
Acute exposure of zebrafish embryo (Danio rerio) to flutolanil reveals its developmental mechanism of toxicity via disrupting the thyroid system and metabolism.
Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves' disease.
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E.
Dominant negative effect of mutated thyroid stimulating hormone receptor (P556L) causes hypothyroidism in C.RF-Tshr(hyt/wild) mice.
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains.
Wu Q, You L, Lin S, Yu T, Yin R, Ye X, Xu L, Liang H, Pang L
The Journal of endocrinology 2026 Apr 1;269(1)
The Journal of endocrinology 2026 Apr 1;269(1)
Thyroidal expression of ER molecular chaperone GRP170 is required for efficient TSH-mediated thyroid hormone synthesis.
Zhang X, Young C, Liao XH, Refetoff S, Mutchler SM, Brodsky JL, Buck TM, Arvan P
JCI insight 2025 Sep 9;10(17)
JCI insight 2025 Sep 9;10(17)
Targeting syndecan-2 inhibits papillary thyroid cancer invasiveness and de-differentiation.
Liu R, Lv X, Wang H, Zhang Y, Cao Z, Zou L, Liu Z, Zhang C
BMC endocrine disorders 2025 Oct 28;25(1):242
BMC endocrine disorders 2025 Oct 28;25(1):242
Bispecific aptamers target thyrotropin receptor (TSHR) and insulin growth factor-1 receptor (IGF-1R) for the improvement of orbital fibroblasts activation in the treatment of thyroid-associated ophthalmopathy.
Xie B, Zhang F, Yin J, Ouyang S, Cao J, Tan Y, Xiong W
International journal of biological macromolecules 2025 Nov;330(Pt 1):147867
International journal of biological macromolecules 2025 Nov;330(Pt 1):147867
PCSK9 promotes progression of anaplastic thyroid cancer through E-cadherin endocytosis.
Zhang Y, Su W, Ji X, Yang Z, Guan Q, Pang Y, Zhong L, Wang Y, Xiang J
Cell death & disease 2025 May 6;16(1):362
Cell death & disease 2025 May 6;16(1):362
TRx0237 induces apoptosis and enhances anti-PD-1 immunotherapeutic efficacy in anaplastic thyroid Cancer.
Ning Q, Liu J, Liu S, Zou Q, Li K, Li Z
International immunopharmacology 2025 May 16;155:114610
International immunopharmacology 2025 May 16;155:114610
A TSHR-Targeting Aptamer in Monocytes Correlating with Clinical Activity in TAO.
Cao J, Zhang F, Chen H, Wu B, Yin J, Chenzhao C, Xiong W
International journal of nanomedicine 2024;19:3577-3588
International journal of nanomedicine 2024;19:3577-3588
Identification and functionalization of thyrotropin receptor antibodies with different antigenic epitopes.
Zheng J, Duan H, Jiang Z, Chen L, You S, Huang L, Huang H
American journal of physiology. Endocrinology and metabolism 2024 Sep 1;327(3):E328-E343
American journal of physiology. Endocrinology and metabolism 2024 Sep 1;327(3):E328-E343
Thyroid cancer risk associated with perfluoroalkyl carboxylate exposure: Assessment using a human dermal fibroblast-derived extracellular matrix-based thyroid cancer organoid.
Yoo MH, Kim Y, Lee BS
Journal of hazardous materials 2024 Nov 5;479:135771
Journal of hazardous materials 2024 Nov 5;479:135771
Epigenetic inhibition of CTCF by HN1 promotes dedifferentiation and stemness of anaplastic thyroid cancer.
Pan Z, Lu X, Xu T, Chen J, Bao L, Li Y, Gong Y, Che Y, Zou X, Tan Z, Huang P, Ge M
Cancer letters 2024 Jan 1;580:216496
Cancer letters 2024 Jan 1;580:216496
Effect of TSH on aromatase expression of ovarian granulosa cells in obese mice.
Zhu L, Zhou X, Ma L, Hu Y
Hormones (Athens, Greece) 2024 Dec;23(4):821-829
Hormones (Athens, Greece) 2024 Dec;23(4):821-829
Sinomenine Hydrochloride Promotes TSHR-Dependent Redifferentiation in Papillary Thyroid Cancer.
Zhang J, Zhao A, Jia X, Li X, Liang Y, Liu Y, Xie X, Qu X, Wang Q, Zhang Y, Gao R, Yu Y, Yang A
International journal of molecular sciences 2022 Sep 14;23(18)
International journal of molecular sciences 2022 Sep 14;23(18)
Role of estrogen receptors in thyroid toxicity induced by mono (2-ethylhexyl) phthalate via endoplasmic reticulum stress: An in vitro mechanistic investigation.
Xu Q, Zhou L, Ri H, Li X, Zhang X, Qi W, Ye L
Environmental toxicology and pharmacology 2022 Nov;96:104007
Environmental toxicology and pharmacology 2022 Nov;96:104007
TSH Combined with TSHR Aggravates Diabetic Peripheral Neuropathy by Promoting Oxidative Stress and Apoptosis in Schwann Cells.
Fan J, Pan Q, Gao Q, Li W, Xiao F, Guo L
Oxidative medicine and cellular longevity 2021;2021:2482453
Oxidative medicine and cellular longevity 2021;2021:2482453
Patient-Derived Papillary Thyroid Cancer Organoids for Radioactive Iodine Refractory Screening.
Sondorp LHJ, Ogundipe VML, Groen AH, Kelder W, Kemper A, Links TP, Coppes RP, Kruijff S
Cancers 2020 Oct 31;12(11)
Cancers 2020 Oct 31;12(11)
Combined tazemetostat and MAPKi enhances differentiation of papillary thyroid cancer cells harbouring BRAF(V600E) by synergistically decreasing global trimethylation of H3K27.
Fu H, Cheng L, Sa R, Jin Y, Chen L
Journal of cellular and molecular medicine 2020 Mar;24(6):3336-3345
Journal of cellular and molecular medicine 2020 Mar;24(6):3336-3345
Long Non-coding Antisense RNA TNRC6C-AS1 Is Activated in Papillary Thyroid Cancer and Promotes Cancer Progression by Suppressing TNRC6C Expression.
Muhanhali D, Zhai T, Jiang J, Ai Z, Zhu W, Ling Y
Frontiers in endocrinology 2018;9:360
Frontiers in endocrinology 2018;9:360
A somatic mutation of RasGRP3 decreases Na(+)/I(-) symporter expression in metastases of radioactive iodine-refractory thyroid cancer by stimulating the Akt signaling pathway.
Song J, Qiu W, Deng X, Qiu Z, Fan Y, Yang Z
American journal of cancer research 2018;8(9):1847-1855
American journal of cancer research 2018;8(9):1847-1855
Acute exposure of zebrafish embryo (Danio rerio) to flutolanil reveals its developmental mechanism of toxicity via disrupting the thyroid system and metabolism.
Teng M, Zhu W, Wang D, Yan J, Qi S, Song M, Wang C
Environmental pollution (Barking, Essex : 1987) 2018 Nov;242(Pt B):1157-1165
Environmental pollution (Barking, Essex : 1987) 2018 Nov;242(Pt B):1157-1165
Serum and thyroid tissue level of let-7b and their correlation with TRAb in Graves' disease.
Chen X, Huang F, Qi Y, Zhou M, Yin Q, Peng Y, Zhou Y, Ning G, Wang S
Journal of translational medicine 2018 Jul 5;16(1):188
Journal of translational medicine 2018 Jul 5;16(1):188
Obatoclax and LY3009120 Efficiently Overcome Vemurafenib Resistance in Differentiated Thyroid Cancer.
Wei WJ, Sun ZK, Shen CT, Song HJ, Zhang XY, Qiu ZL, Luo QY
Theranostics 2017;7(4):987-1001
Theranostics 2017;7(4):987-1001
HER inhibitor promotes BRAF/MEK inhibitor-induced redifferentiation in papillary thyroid cancer harboring BRAFV600E.
Cheng L, Jin Y, Liu M, Ruan M, Chen L
Oncotarget 2017 Mar 21;8(12):19843-19854
Oncotarget 2017 Mar 21;8(12):19843-19854
Dominant negative effect of mutated thyroid stimulating hormone receptor (P556L) causes hypothyroidism in C.RF-Tshr(hyt/wild) mice.
Endo T, Kobayashi T
PloS one 2012;7(8):e42358
PloS one 2012;7(8):e42358
Pleiotropy of glycogen synthase kinase-3 inhibition by CHIR99021 promotes self-renewal of embryonic stem cells from refractory mouse strains.
Ye S, Tan L, Yang R, Fang B, Qu S, Schulze EN, Song H, Ying Q, Li P
PloS one 2012;7(4):e35892
PloS one 2012;7(4):e35892
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The TSHR antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human TSHR. This antibody recognizes human, mouse antigen. The TSHR antibody has been validated for the following applications: ELISA, WB analysis.
