orb386164

antibody from Biorbyt

Targeting: TSHR LGR3

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

orb386164

Provider

Biorbyt

Product name

Thyroid Stimulating Hormone Receptor / TSHR Antibody (beta chain)

Antibody type

Monoclonal

Description

Thyroid-stimulating hormone (TSH, also known as thyrotropin) is a glycoprotein involved in the control of thyroid structure and metabolism, which stimulates the release of the thyroid hormones. TSH is regulated by thyroid hormone (T3) and various retinoid compounds. TSH binds to the thyroid-stimulating hormone receptor (TSHR), which is cleaved into two subunits, A and B, and plays a major role in regulating thyroid function. The third cytoplasmic loop of TSHR has been identified as critical for its role in regulating inositol phosphate and cAMP formation. In Graves disease, an autoimmune disorder, TSHR is activated by autoantibodies, which may be stimulated by the cleavage of the A and B subunits.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Antibody clone number

SPM222

Vial size

20 ug

Storage

Store the TSH Receptor antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).